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Ovariektomi ve ovaryohisterektomi yapılan köpeklerde serum seruloplazmin ve paraoksonaz-1düzeyleri

Year 2015, Volume: 62 Issue: 3, 211 - 215, 01.09.2015
https://doi.org/10.1501/Vetfak_0000002682

Abstract

Bu çalışmanın amaçları köpeklerde ovariektomi (OVE) ve ovaryohisterektomi (OVH) ile ilişkili akut faz yanıtının şiddetinin değerlendirilmesi ve paraoksanaz-1 (PON-1) aktivitesinin araştırılmasıydı. Çalışmada toplam 21 adet sağlıklı dişi köpek kullanıldı. Köpekler rastgele OVH (n=11) ve OVE (n=10) yapılmak üzere iki gruba ayrıldı. Operasyon öncesinde ve operasyon sonrası 4. günde alınan periferal kan örneklerinde serum seruloplazmin düzeyi ve paraoksonaz-1 aktivitesi ölçüldü. Sonuçlar gruplar içerisinde ve gruplar arasında karşılaştırıldı. Paraoksanaz-1 ve seruloplazmin arasında muhtemel korelasyon değerlendirildi. Operasyon öncesi serum seruloplazmin seviyeleri OVE ve OVH gruplarında sırasıyla 0.80±0.17 and 1.65±0.35 U/ml olarak ölçüldü (P>0.05). Operasyon sonrası 4. günde serum seruloplazmin seviyesi OVH grubunda (1.95±0.47 U/ml) OVE grubuna kıyasla daha yüksek bulundu (0.69±0.10 U/ml; P<0.05). Operasyon öncesi ve sonrası serum seruloplazmin seviyesi çalışma grupları içerisinde farklılık göstermedi (P>0.05). Operasyon öncesi ve sonrasında serum PON-1 aktivitesi OVE ve OVH gruplarında sırasıyla 1001.56±44.60 U/ml ve 1119.10±87.99 U/ml olup (P>0.05), operasyon sonrası serum PON-1 aktivitesi OVH grubunda (1065.15±46.00 U/ml) OVE grubuna kıyasla daha yüksekti (941.22±32.57 U/ml; P<0.05). PON-1 aktivitesi ile serum seruloplazmin konsantrasyonu arasında bir korelasyon yoktu (P=.250; r=0.06). Sonuç olarak, OVE grubunda postoperatif akut faz yanıtının şiddeti OVH grubuna göre daha düşüktü. Buna ek olarak, köpeklerde OVE ve OVH operasyonu sonrası 4. günde PON-1 aktivitesinde değişiklik ve PON-1 aktivitesi ile serum seruloplazmin konsantrasyonları arasında bir ilişki bulunmadı

References

  • Ceron JJ, Eckersall PD, Subiela SM (2005): Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol, 34, 85-99. 2. Ceron JJ, spectrophotometric ceruloplasmin in serum. Vet Res, 35, 671-679. for measuring method canine
  • Conner JG, Eckersall PD, Ferguson J, Douglas TA (1988): Acute phase response in the dog following surgical trauma. Res Vet Sci, 45, 107-110.
  • De Tora M, McCarty RJ (2011): Ovariohysterectomy versus ovariectomy for elective sterilization of female dogs and cats: is removal of the uterus necessarry?. JAVMA, 239, 1409-1412. 5. Eckersall PD (2008): Proteins, Proteomics and Dysproteinemias. 117-155. In: JJ Kaneko, JW Harvey, ML Bruss, Clinical Biochemistry of Domestic Animals. 6th Ed, Academic Press, San Diego.
  • Goethem BV, Schaefers-Okkens A, Kirpensteijn J (2006): Making a rational choice between ovariectomy and ovariohysterectomy in the dog: a discussion of the benefits of either technique. Veterinary Surgery, 35, 136- 143.
  • Gunay A, Gunes N, Gunay U (2011): Effect of ovariohysterectomy on lipid peroxidation and levels of some antioxidants and biochemical parameters in bitches. Bull Vet Inst Pulawy, 55, 695-698.
  • Kirpensteijn J (2008): Ovariectomy versus ovariohysterectomy. Is the eternal argument ended. Proceedings of the international SCIVAC Congress, Rimini, Italy, 290-293.
  • Kum C, Voyvoda H, Sekkin S, Karademir U, Tarimcilar T (2013): Effects of carprofen and meloxicam on C-reactive protein, ceruloplasmin, and fibrinogen concentrations in dogs undergoing ovariohysterectomy. Am J Vet Res, 74, 1267-1273.
  • Lee JY, Kim MC (2014): Comparison of oxidative stress status in dogs undergoing laparoscopic and open ovariectomy. J Vet Med Sci, 76, 273-276.
  • Rossi G, Giordano A, Pezzia F, Kjelgaard-Hansen M, Paltrinieri S (2013): Serum paraoxonase 1 activity in dogs: preanalytical and analytical factors and correlation with C-reactive protein and alpha-2-globulin. Vet Clin Pathol, 42, 329-341.
  • Serin G, Kiral F, Serin I (2008): Acute effect of ovariohysterectomy on lipid peroxidation and some antioxidant levels in dogs. Bull Vet Inst Pulawy, 52, 251- 253.
  • Sunderman FW, Nomoto S (1970): Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity. Clin Chem, 16, 903-910.

Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs

Year 2015, Volume: 62 Issue: 3, 211 - 215, 01.09.2015
https://doi.org/10.1501/Vetfak_0000002682

Abstract

The objectives of this study were to evaluate the severity of acute phase reaction and to investigate the paraoxanase-1 (PON-1) activity associated with ovariectomy (OVE) and ovariohysterectomy (OVH) in dogs. A total of 21 adult healthy dogs were included. The dogs were randomly divided into two groups and either ovariectomized (n=10) or ovariohysterectomized (n=11). Peripheral blood samples were collected preoperatively and on postoperative fourth day for serum ceruloplasmin (cp) and paraoxanase-1 activity measurements. Results were compared within and between groups. Potential correlation between paraoxanase-1 and ceruloplasmin was assessed. Preoperative mean serum ceruloplasmin levels in OVE and OVH groups were 0.80±0.17 and 1.65±0.35 U/ml, respectively (P>0.05). On postoperative 4th day, serum ceruloplasmin levels in OVH group (1.95±0.47 U/ml) was higher compared to OVE group (0.69±0.10 U/ml; P<0.05). Pre- and postoperative serum ceruloplasmin levels were not different within study groups (P>0.05). Preoperative serum paraoxanase-1 activity in OVE and OVH groups were 1001.56±44.60 U/ml and 1119.10±87.99 U/ml, respectively (P>0.05). Higher postoperative serum paraoxanase-1 activity was observed in OVH group (1065.15±46.00 U/ml) compared to OVE group (941.22±32.57 U/ml; P<0.05). Pre and postoperative serum paraoxanase-1 activity was not different within study groups (P>0.05). Paraoxanase-1 activity was not correlated with concentration of ceruloplasmin (P=.250; r=0.06). In conclusion, OVE is superior to OVH in terms of reducing the severity of postoperative acute phase response. In addition, OVE and OVH does not alter canine paraoxanase-1 activity on postoperative fourth day and paraoxanase-1 activity is not associated with serum concentration of ceruloplasmin in dogs

References

  • Ceron JJ, Eckersall PD, Subiela SM (2005): Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol, 34, 85-99. 2. Ceron JJ, spectrophotometric ceruloplasmin in serum. Vet Res, 35, 671-679. for measuring method canine
  • Conner JG, Eckersall PD, Ferguson J, Douglas TA (1988): Acute phase response in the dog following surgical trauma. Res Vet Sci, 45, 107-110.
  • De Tora M, McCarty RJ (2011): Ovariohysterectomy versus ovariectomy for elective sterilization of female dogs and cats: is removal of the uterus necessarry?. JAVMA, 239, 1409-1412. 5. Eckersall PD (2008): Proteins, Proteomics and Dysproteinemias. 117-155. In: JJ Kaneko, JW Harvey, ML Bruss, Clinical Biochemistry of Domestic Animals. 6th Ed, Academic Press, San Diego.
  • Goethem BV, Schaefers-Okkens A, Kirpensteijn J (2006): Making a rational choice between ovariectomy and ovariohysterectomy in the dog: a discussion of the benefits of either technique. Veterinary Surgery, 35, 136- 143.
  • Gunay A, Gunes N, Gunay U (2011): Effect of ovariohysterectomy on lipid peroxidation and levels of some antioxidants and biochemical parameters in bitches. Bull Vet Inst Pulawy, 55, 695-698.
  • Kirpensteijn J (2008): Ovariectomy versus ovariohysterectomy. Is the eternal argument ended. Proceedings of the international SCIVAC Congress, Rimini, Italy, 290-293.
  • Kum C, Voyvoda H, Sekkin S, Karademir U, Tarimcilar T (2013): Effects of carprofen and meloxicam on C-reactive protein, ceruloplasmin, and fibrinogen concentrations in dogs undergoing ovariohysterectomy. Am J Vet Res, 74, 1267-1273.
  • Lee JY, Kim MC (2014): Comparison of oxidative stress status in dogs undergoing laparoscopic and open ovariectomy. J Vet Med Sci, 76, 273-276.
  • Rossi G, Giordano A, Pezzia F, Kjelgaard-Hansen M, Paltrinieri S (2013): Serum paraoxonase 1 activity in dogs: preanalytical and analytical factors and correlation with C-reactive protein and alpha-2-globulin. Vet Clin Pathol, 42, 329-341.
  • Serin G, Kiral F, Serin I (2008): Acute effect of ovariohysterectomy on lipid peroxidation and some antioxidant levels in dogs. Bull Vet Inst Pulawy, 52, 251- 253.
  • Sunderman FW, Nomoto S (1970): Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity. Clin Chem, 16, 903-910.
There are 11 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Other ID JA73AV75TN
Journal Section Research Article
Authors

Ayhan Baştan

Halit Kanca

İdil Baştan

Seçkin Salar

Kübra Karakaş

Hasan Alkan

Tevhide Sel

Publication Date September 1, 2015
Published in Issue Year 2015Volume: 62 Issue: 3

Cite

APA Baştan, A., Kanca, H., Baştan, İ., Salar, S., et al. (2015). Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 62(3), 211-215. https://doi.org/10.1501/Vetfak_0000002682
AMA Baştan A, Kanca H, Baştan İ, Salar S, Karakaş K, Alkan H, Sel T. Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs. Ankara Univ Vet Fak Derg. September 2015;62(3):211-215. doi:10.1501/Vetfak_0000002682
Chicago Baştan, Ayhan, Halit Kanca, İdil Baştan, Seçkin Salar, Kübra Karakaş, Hasan Alkan, and Tevhide Sel. “Serum Ceruloplasmin and Paraoxonase-1 Levels in Ovariectomized and Ovariohysterectomized Dogs”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 62, no. 3 (September 2015): 211-15. https://doi.org/10.1501/Vetfak_0000002682.
EndNote Baştan A, Kanca H, Baştan İ, Salar S, Karakaş K, Alkan H, Sel T (September 1, 2015) Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs. Ankara Üniversitesi Veteriner Fakültesi Dergisi 62 3 211–215.
IEEE A. Baştan, “Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs”, Ankara Univ Vet Fak Derg, vol. 62, no. 3, pp. 211–215, 2015, doi: 10.1501/Vetfak_0000002682.
ISNAD Baştan, Ayhan et al. “Serum Ceruloplasmin and Paraoxonase-1 Levels in Ovariectomized and Ovariohysterectomized Dogs”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 62/3 (September 2015), 211-215. https://doi.org/10.1501/Vetfak_0000002682.
JAMA Baştan A, Kanca H, Baştan İ, Salar S, Karakaş K, Alkan H, Sel T. Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs. Ankara Univ Vet Fak Derg. 2015;62:211–215.
MLA Baştan, Ayhan et al. “Serum Ceruloplasmin and Paraoxonase-1 Levels in Ovariectomized and Ovariohysterectomized Dogs”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 62, no. 3, 2015, pp. 211-5, doi:10.1501/Vetfak_0000002682.
Vancouver Baştan A, Kanca H, Baştan İ, Salar S, Karakaş K, Alkan H, Sel T. Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs. Ankara Univ Vet Fak Derg. 2015;62(3):211-5.