Letter to Editor
Year 2013,
Volume: 60 Issue: 1, 53 - 58, 01.03.2013
Abstract
The purpose of this study was to evaluate the prognostic usefulness of some parameters in dogs with canine parvovirus (CPV). Fifty-nine animals which consist of 39 ill and 20 healthy puppies were used in the study. All puppies were underwent a complete physical examination and laboratory variables (CBC, serum routine biochemistry profile, cTn-I, TNF-α) on their first admission to clinic and on following every day before treatment until discharge or death. Despite aggressive treatment with available therapy, 14 of 39 dogs died. Non-survivor dogs had significantly lower leukocyte, lymphocyte, monocyte and granulocyte counts but had significantly higher serum urea and creatinine concentrations than those of survivor dogs at presentation (p<0.05). Serum cTn-I concentration level were positive in 11of 14 non-survival dogs and negative in all of the survival dogs. The relative risk of death for the dogs with TNF-α positive was 3,39 times (95% CI:1,53-7,52) higher than that of dogs with TNF-α negative. This study demonstrates that leukocyte, lymphocyte, granulocyte, monocyte counts, serum urea and creatinine concentrations, cTn-I and TNF-α levels are useful parameters for predicting the prognosis of dogs with CPV
Keywords
References
- Agungpriyono DR, Uchida K, Tabura H, Yamaguchi R, Tateyama S (1999): Subacute massive necrotizing myocarditis by canine parvovirus type 2 infection with diffuse leukoencephalomalacia in a puppy. Vet Pathol, 36, 77–80.
- Appel MJ, Scott FW, Carmichael LE (1979): Isolation and immunization studies of a canine parvo-like virus from dogs with hemorrhagic enteritis. Vet Rec, 105, 156–159.
- Atwell RB, Kelly WR (2008): Canine parvovirus: a cause of chronic myocardial fibrosis and adolescent congestive heart failure. J Small Anim Pract, 21, 609–620.
- Cohn LA, Langdon P (2003): Infectious disease. (1094- 1095). In: RV Morgan, R M Bright and M. S. Swartout WB (Ed). Handbook of Small Animal Practice. Saunders. Philadelphia.
- De Francesco TC, Atkins CE, Keene BW (2002): Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital. J Vet Intern Med, 16, 553–557.
- De Laforcade AM, Freeman LM, Shaw SP, Brooks MB, Rozanski EA, Rush JE. (2003): Hemostatic changes in dogs with naturally occurring sepsis. J Vet Intern Med, 17, 674-679.
- Fishbein MC, Wang T, Matijasevic M, Hong L, Apple FS (2003): Myocardial tissue troponins T and I. An immunohistochemical study in experimental models of myocardial ischemia. Cardiovasc Pathol, 12, 65–71.
- Goddard A, Leisewitz MM, Christorher MM, Becker PJ (2008). Prognostic usefulness of blood leucocyte changes in canine parvoviral enteritis. J Vet Intern Med, 22, 309-316.
- Herndon WE, Kittleson MD, Sanderson K, Drobatz KJ, Clifford CA, Gelzer A, Summerfield NJ, Linde A, Sleeper MM (2002): Cardiac troponin I in feline hypertrophic cardiomyopathy. J Vet Intern Med, 16, 558– 564.
- Jacobs, RM, Weiser M, Hall RL (1980): Clinicopathologic features of canine parvoviral enteritis. J Am Hosp Assoc, 16, 809-814.
- Jaffe A S, Babuin L, Apple FS (2006): Biomarkers in Acute Cardiac Disease. J Am Coll Cardiol, 48, 1-11.
- Kim, Y, Huh J W, Lim C, Koh Y, Hong SB (2012): Comparison of acute kidney injury classifications in patients with severe sepsis and septic shock. Am J Med Sci, 12, (Epub ahead of print)
- Legrand M, Bezemer R, Kandil A, Demirci C, Payen D, Ince C (2011): The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. Intensive Care Med, 37, 1534–1542.
- Lobetti R, Dvir E, Pearson J (2002): Cardiac troponins in canine babesiosis. J Vet Intern Med, 16, 63–68.
- Macintire DK, Smith-Carr S (1997) Canine parvovirus. Part II. Clinical signs, diagnosis, and treatment. Comp Cont Vet Educ Pract, 19, 291-302.
- Mantione NL, Otto CM (2005): Characterization of the use of antiemetic agents in dogs with parvoviral enteritis treated at a veterinary teaching hospital: 77 cases (1997- 2000). JAVMA, 227, 1787-1793.
- Mason MJ, Gillett NA, Buggenburg BA (1987): Clinical, pathological, and epidemiological aspects of canine parvovirus enteritis in an unvaccinated closed beagle colony 1978-1985. J Am Anim Hosp Assoc, 23, 183-192.
- Mccaw DL, Harrington DP, Jones BD (1996): A retrospective study of canine parvovirus gastroenteritis: 89 cases. J Vet Intern Med, 10, 157.
- Mira JP, Cariou A, Grall F, Delclaux C, Losser MR,
- Heshmati F, Cheval C, Monchi M, Teboul JL, Riche F, Leleu G, Arbibe L, Mignon A, Delpech M, Dhainaut JF (1999): Association of TNF2, a TNF-α promoter polymorphism, with septic shock susceptibility and mortality. JAMA, 282, 561-568.
- Miyamoto T, Fujinaga T, Yamashita K, Hagio M (1996): Changes of serum cytokine activities and other parameters in dogs with experimentally induced endotoxic shock. Jpn J Vet Res, 44, 107-118.
- Nappert G, Duphy E, Ruben D, Mann FA (2002): Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis. The Can J Vet Res, 66, 15-18.
- Nemzek JA, Agrodnia MD, Hauptman JG (2007): Breed specific pro-inflammatory cytokine production as a predisposing factor for susceptibility to sepsis in the dog. J Vet Emerg Critic Care, 17, 368–372
- O’Brien PJ (1997): Deficiencies of myocardial troponin-T and creatine kinase MB isoenzyme in dogs with idiopathic dilated cardiomyopathy. Am J Vet Res, 58, 11–16.
- O’Sullivan G, Durham PJK, Smith JR, Campbell RSF (1984): Experimentally induced severe canine parvoviral enteritis. Aust Vet J, 6, 1–4.
- Otto C (2007): Sepsis in veterinary patients: what do we know and where can we go? J Vet Emerg Critic Care, 17 (4), 329-332
- Otto CM, Drobatz KJ, Soter C (1997): Endotoxemia and tumor necrosis factor activity in dogs with naturally occurring parvoviral enteritis. J Vet Intern Med, 11, 65- 70.
- Ozkul A, Keles I, Karaoglu T, Çabalar M, Burgu I (2002): Detection and rflp analysis of canine parvovirus (cpv) dna by polymerase chain reaction (pcr) in a dog. Turk J Vet Anim Sci, 6, 1201–1203.
- Pelander L, Ragnvi H, Haggstrom J (2008): Concentrations of cardiac troponin I before and after ovariohysterectomy in 46 female dogs with pyometra. Acta Vet Scand, 50, 35.
- Prittie J (2004): Canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care, 14, 167-176.
- Remppis A, Ehlermann P, Giannitsis E (2000): Cardiac troponin T levels at 96 hours reflect myocardial infarct size: a pathoanatomical study. Cardiol, 93, 249–253.
- Ricchiuti V, Sharkey SW, Murakami MM (1998): Cardiac tro-ponin I and T alterations in dog hearts with myocardial infarction: correlation with infarct size. Am J Clin Pathol, 110, 241–247.
- Sleeper MM, Clifford CA, Laster LL (2001): Cardiac troponin I in the normal dog and cat. J Vet Intern Med, 15, 501–503.
- Spratt DP, Mellanby RJ, Drury N, Archer J (2005): Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog. J Small Anim Pract, 46, 139-145.
- Turk J, Miller M, Brown T, Fales W, Fischer J, Gosser H, Nelson S, Shaw D, Solorzano R (1990): Coliform septicemia and pulmonary disease associat ed with canine parvoviral enteritis: 88cases (1987–1988). JAVMA, 196(5), 771– 773.
- Turk J, Fales W, Miller M., Pace L, Fischer J, Johnson G, Kreeger J, Turnquist S, Pittman L, Rottinghaus A (1992): Enteric Clostridium perfringens infection associated with parvoviral enteritis in dogs: 74 cases (1987–1990). JAVMA, 200, 991– 994.
- Van Rensburg IB, Meintjes R (1986): Bacterial myocarditis secondary to parvovirus enteritis in a puppy. JS Afr Vet Assoc, 57, 115–156.
- Willard MD (2003): Canine parvoviral enteritis. 433-435. In: Nelson RW, Couto CG (Ed) Small Animal Internal Medicine. Mosby Comp. Philadelphia.
- Woods CB, Pollack RVH, Carmichael LE (1980): Canine parvoviral enteritis. JAAHA, 16, 171–179.
- Yilmaz Z, Senturk Z (2007): Characterization of lipid profiles in dogs with parvoviral enteritis. J Small Anim Pract, 48, 643-650.
Year 2013,
Volume: 60 Issue: 1, 53 - 58, 01.03.2013
Abstract
Bu çalışmanın amacı kanin parvoviruslu köpeklerde (CPV) prognostik yararı olan bazı parametlerin değerlendirilmesidir. Bu çalışmada 39’u hasta, 20’si sağlıklı olmak üzere toplam 59 köpek kullanıldı. Bütün köpeklerin fiziksel muayene ve laboratuar (CBC, serum routine biochemistry profile, cTn-I, TNF-α) verileri kayıt altına alındı. Uygulanan agresif tedaviye rağmen 39 köpeğin 14’ü öldü. Ölen köpeklerde lökosit, lenfosit, monosit ve granülosit sayısı önemli derecede düşük; üre ve kreatinin konsantrasyonu ise iyileşen köpeklere oranla önemli derecede yüksek bulundu (p<0.05). Serum cTn-I konsantrasyonu, ölen 14 köpeğin 11’inde pozitif, iyileşen köpeklerin tamamında negatif bulundu. TNF-α pozitif olan köpeklerin ölme olasılığının iyileşenlere göre 3,39 kat daha fazla olduğu saptandı (95% CI:1,53-7,52). Bu çalışma; lökosit, lenfosit, granülosit, monosit sayılarının; serum üre ve kreatinin konsantrasyonlarının; cTn-I ve TNF-α değerlerinin, CPV’li köpeklerde prognozun belirlenmesinde önemli parametreler olduğunu gösterdi
Keywords
References
- Agungpriyono DR, Uchida K, Tabura H, Yamaguchi R, Tateyama S (1999): Subacute massive necrotizing myocarditis by canine parvovirus type 2 infection with diffuse leukoencephalomalacia in a puppy. Vet Pathol, 36, 77–80.
- Appel MJ, Scott FW, Carmichael LE (1979): Isolation and immunization studies of a canine parvo-like virus from dogs with hemorrhagic enteritis. Vet Rec, 105, 156–159.
- Atwell RB, Kelly WR (2008): Canine parvovirus: a cause of chronic myocardial fibrosis and adolescent congestive heart failure. J Small Anim Pract, 21, 609–620.
- Cohn LA, Langdon P (2003): Infectious disease. (1094- 1095). In: RV Morgan, R M Bright and M. S. Swartout WB (Ed). Handbook of Small Animal Practice. Saunders. Philadelphia.
- De Francesco TC, Atkins CE, Keene BW (2002): Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital. J Vet Intern Med, 16, 553–557.
- De Laforcade AM, Freeman LM, Shaw SP, Brooks MB, Rozanski EA, Rush JE. (2003): Hemostatic changes in dogs with naturally occurring sepsis. J Vet Intern Med, 17, 674-679.
- Fishbein MC, Wang T, Matijasevic M, Hong L, Apple FS (2003): Myocardial tissue troponins T and I. An immunohistochemical study in experimental models of myocardial ischemia. Cardiovasc Pathol, 12, 65–71.
- Goddard A, Leisewitz MM, Christorher MM, Becker PJ (2008). Prognostic usefulness of blood leucocyte changes in canine parvoviral enteritis. J Vet Intern Med, 22, 309-316.
- Herndon WE, Kittleson MD, Sanderson K, Drobatz KJ, Clifford CA, Gelzer A, Summerfield NJ, Linde A, Sleeper MM (2002): Cardiac troponin I in feline hypertrophic cardiomyopathy. J Vet Intern Med, 16, 558– 564.
- Jacobs, RM, Weiser M, Hall RL (1980): Clinicopathologic features of canine parvoviral enteritis. J Am Hosp Assoc, 16, 809-814.
- Jaffe A S, Babuin L, Apple FS (2006): Biomarkers in Acute Cardiac Disease. J Am Coll Cardiol, 48, 1-11.
- Kim, Y, Huh J W, Lim C, Koh Y, Hong SB (2012): Comparison of acute kidney injury classifications in patients with severe sepsis and septic shock. Am J Med Sci, 12, (Epub ahead of print)
- Legrand M, Bezemer R, Kandil A, Demirci C, Payen D, Ince C (2011): The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. Intensive Care Med, 37, 1534–1542.
- Lobetti R, Dvir E, Pearson J (2002): Cardiac troponins in canine babesiosis. J Vet Intern Med, 16, 63–68.
- Macintire DK, Smith-Carr S (1997) Canine parvovirus. Part II. Clinical signs, diagnosis, and treatment. Comp Cont Vet Educ Pract, 19, 291-302.
- Mantione NL, Otto CM (2005): Characterization of the use of antiemetic agents in dogs with parvoviral enteritis treated at a veterinary teaching hospital: 77 cases (1997- 2000). JAVMA, 227, 1787-1793.
- Mason MJ, Gillett NA, Buggenburg BA (1987): Clinical, pathological, and epidemiological aspects of canine parvovirus enteritis in an unvaccinated closed beagle colony 1978-1985. J Am Anim Hosp Assoc, 23, 183-192.
- Mccaw DL, Harrington DP, Jones BD (1996): A retrospective study of canine parvovirus gastroenteritis: 89 cases. J Vet Intern Med, 10, 157.
- Mira JP, Cariou A, Grall F, Delclaux C, Losser MR,
- Heshmati F, Cheval C, Monchi M, Teboul JL, Riche F, Leleu G, Arbibe L, Mignon A, Delpech M, Dhainaut JF (1999): Association of TNF2, a TNF-α promoter polymorphism, with septic shock susceptibility and mortality. JAMA, 282, 561-568.
- Miyamoto T, Fujinaga T, Yamashita K, Hagio M (1996): Changes of serum cytokine activities and other parameters in dogs with experimentally induced endotoxic shock. Jpn J Vet Res, 44, 107-118.
- Nappert G, Duphy E, Ruben D, Mann FA (2002): Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis. The Can J Vet Res, 66, 15-18.
- Nemzek JA, Agrodnia MD, Hauptman JG (2007): Breed specific pro-inflammatory cytokine production as a predisposing factor for susceptibility to sepsis in the dog. J Vet Emerg Critic Care, 17, 368–372
- O’Brien PJ (1997): Deficiencies of myocardial troponin-T and creatine kinase MB isoenzyme in dogs with idiopathic dilated cardiomyopathy. Am J Vet Res, 58, 11–16.
- O’Sullivan G, Durham PJK, Smith JR, Campbell RSF (1984): Experimentally induced severe canine parvoviral enteritis. Aust Vet J, 6, 1–4.
- Otto C (2007): Sepsis in veterinary patients: what do we know and where can we go? J Vet Emerg Critic Care, 17 (4), 329-332
- Otto CM, Drobatz KJ, Soter C (1997): Endotoxemia and tumor necrosis factor activity in dogs with naturally occurring parvoviral enteritis. J Vet Intern Med, 11, 65- 70.
- Ozkul A, Keles I, Karaoglu T, Çabalar M, Burgu I (2002): Detection and rflp analysis of canine parvovirus (cpv) dna by polymerase chain reaction (pcr) in a dog. Turk J Vet Anim Sci, 6, 1201–1203.
- Pelander L, Ragnvi H, Haggstrom J (2008): Concentrations of cardiac troponin I before and after ovariohysterectomy in 46 female dogs with pyometra. Acta Vet Scand, 50, 35.
- Prittie J (2004): Canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care, 14, 167-176.
- Remppis A, Ehlermann P, Giannitsis E (2000): Cardiac troponin T levels at 96 hours reflect myocardial infarct size: a pathoanatomical study. Cardiol, 93, 249–253.
- Ricchiuti V, Sharkey SW, Murakami MM (1998): Cardiac tro-ponin I and T alterations in dog hearts with myocardial infarction: correlation with infarct size. Am J Clin Pathol, 110, 241–247.
- Sleeper MM, Clifford CA, Laster LL (2001): Cardiac troponin I in the normal dog and cat. J Vet Intern Med, 15, 501–503.
- Spratt DP, Mellanby RJ, Drury N, Archer J (2005): Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog. J Small Anim Pract, 46, 139-145.
- Turk J, Miller M, Brown T, Fales W, Fischer J, Gosser H, Nelson S, Shaw D, Solorzano R (1990): Coliform septicemia and pulmonary disease associat ed with canine parvoviral enteritis: 88cases (1987–1988). JAVMA, 196(5), 771– 773.
- Turk J, Fales W, Miller M., Pace L, Fischer J, Johnson G, Kreeger J, Turnquist S, Pittman L, Rottinghaus A (1992): Enteric Clostridium perfringens infection associated with parvoviral enteritis in dogs: 74 cases (1987–1990). JAVMA, 200, 991– 994.
- Van Rensburg IB, Meintjes R (1986): Bacterial myocarditis secondary to parvovirus enteritis in a puppy. JS Afr Vet Assoc, 57, 115–156.
- Willard MD (2003): Canine parvoviral enteritis. 433-435. In: Nelson RW, Couto CG (Ed) Small Animal Internal Medicine. Mosby Comp. Philadelphia.
- Woods CB, Pollack RVH, Carmichael LE (1980): Canine parvoviral enteritis. JAAHA, 16, 171–179.
- Yilmaz Z, Senturk Z (2007): Characterization of lipid profiles in dogs with parvoviral enteritis. J Small Anim Pract, 48, 643-650.
There are 40 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA37VH96JR |
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 1, 2013 |
| Published in Issue | Year 2013Volume: 60 Issue: 1 |