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Insulinoma with regional lymph node metastasis in a dog

Year 2012, Volume: 59 Issue: 1, 71 - 73, 01.03.2012
https://doi.org/10.1501/Vetfak_0000002504

Abstract

In this case, a female boxer dog, 6-year-old, with tonic-clonic convulsions and hind-limb paresis was evaluated. The serum insulin and serum glucose levels were 58 µU/ml and 5 mg/dl, respectively. In spite of all care, the comatose dog died. At necropsy, one well-circumscribed white-grayish mass, 4x3x2 cm, was found at the caudal edge of right lobe of the pancreas. Subcortical malacic areas in reddish color was seen in the brain. Microscopically, the tumoral mass consisted of neoplastic cells with round shape, basophilic nucleous and granular eosinophilic cytoplasm. In addition to these findings, metastasis to the regional lymph node of the pancreas was observed. Immunohistochemically, the tumor cells from both primary and metastatic tissues showed immunoreactivity to monoclonal mouse anti-insulin antibody. Clinically, histologically and immunohistochemically, functional insulinoma with lymph node metastasis was diagnosed in the present case

References

  • Katsuo M, Hiroyuki N, Nobuhiko O, Ken-ichiro O, Kazuo Y, Kunuhiko S, Reiji T, Kosaku F (1987): Two cases of canine insulinoma. Jpn J Vet Sci, 49, 1151-1153.
  • Lamb CR, Simpson KW, Boswood A, Matthewman LA (1995): Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. Vet Rec, 137, 65- 68.
  • Leifer, CE, Peterson ME, Matus RE (1986): Insulin- secreting tumor: Diagnosis and medical and surgical management in 55 dogs. J Am Vet Med Assoc, 188, 60-64.
  • Petar D, Vesna M, Zoran S, Sven S, Branka A, Zeljko G (2000): Insulinoma in a dog; case report. Veterinarski Arhiv, 70, 13-20.
  • Shimada A, Morita T, Ikeda N, Torii S, Haruna A (2000): Hypoglycaemic brain lesions in a dog with insulinoma. J Comp Path, 122, 67-71.
  • Steiner JM, Bruyette DS (1996): Canine insulinoma. Compend Contin Educ Pract Vet, 18, 13-22.
  • Vallee KI (2003): Insulin-secreting beta cell neoplasia in a 10-year-old dog. Can Vet J, 44, 592-59.

Bir köpekte lenf yumrusu metastazlı insülinoma

Year 2012, Volume: 59 Issue: 1, 71 - 73, 01.03.2012
https://doi.org/10.1501/Vetfak_0000002504

Abstract

Bu olguda tonik-klonik konvulsiyonlar ve arka bacaklarda parezisi olan 6 yaşlı boxer ırkı dişi bir köpek değerlendirildi. Serum insülin ve serum glukoz seviyeleri sırasıyla 58 µU/ml ve 5 mg/dl olarak bulundu. Yapılan tüm müdahalelere rağmen koma halindeki köpek öldü. Nekropside pankreasın sağ lobunun arka ucunda 4x3x2 cm ebadında beyazımsı-gri renkte iyi sınırlı bir kitle görüldü. Beyinde kırmızımsı renkte subkortikal malasik alanlar dikkati çekti. Mikroskobik olarak tümör hücreleri yuvarlak şekilli, bazofilik çekirdekli ve granüler yapıda eozinofilik sitoplazmadan oluşmaktaydı. Bu bulgulara ek olarak pankreasın bölgesel lenf nodunda metastaza rastlandı. İmmunohistokimyasal olarak hem primer hem de metastatik tümör dokusu hücreleri monoklonal fare insüline karşı elde edilen antikor ile pozitif reaksiyon verdi. Sunulan olgu klinik, histolojik ve immunohistokimyasal olarak lenf yumrusu metastazlı fonksiyonel bir insülinoma olarak tanımlandı

References

  • Katsuo M, Hiroyuki N, Nobuhiko O, Ken-ichiro O, Kazuo Y, Kunuhiko S, Reiji T, Kosaku F (1987): Two cases of canine insulinoma. Jpn J Vet Sci, 49, 1151-1153.
  • Lamb CR, Simpson KW, Boswood A, Matthewman LA (1995): Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. Vet Rec, 137, 65- 68.
  • Leifer, CE, Peterson ME, Matus RE (1986): Insulin- secreting tumor: Diagnosis and medical and surgical management in 55 dogs. J Am Vet Med Assoc, 188, 60-64.
  • Petar D, Vesna M, Zoran S, Sven S, Branka A, Zeljko G (2000): Insulinoma in a dog; case report. Veterinarski Arhiv, 70, 13-20.
  • Shimada A, Morita T, Ikeda N, Torii S, Haruna A (2000): Hypoglycaemic brain lesions in a dog with insulinoma. J Comp Path, 122, 67-71.
  • Steiner JM, Bruyette DS (1996): Canine insulinoma. Compend Contin Educ Pract Vet, 18, 13-22.
  • Vallee KI (2003): Insulin-secreting beta cell neoplasia in a 10-year-old dog. Can Vet J, 44, 592-59.
There are 7 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Other ID JA63YJ38AY
Journal Section Research Article
Authors

Mehmet Önder Karayiğit

Yonca B. Kabak

Murat Yarım

Sinan Şirin

M.Yavuz Gülbahar

Publication Date March 1, 2012
Published in Issue Year 2012Volume: 59 Issue: 1

Cite

APA Karayiğit, M. Ö., Kabak, Y. B., Yarım, M., Şirin, S., et al. (2012). Insulinoma with regional lymph node metastasis in a dog. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 59(1), 71-73. https://doi.org/10.1501/Vetfak_0000002504
AMA Karayiğit MÖ, Kabak YB, Yarım M, Şirin S, Gülbahar M. Insulinoma with regional lymph node metastasis in a dog. Ankara Univ Vet Fak Derg. March 2012;59(1):71-73. doi:10.1501/Vetfak_0000002504
Chicago Karayiğit, Mehmet Önder, Yonca B. Kabak, Murat Yarım, Sinan Şirin, and M.Yavuz Gülbahar. “Insulinoma With Regional Lymph Node Metastasis in a Dog”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 59, no. 1 (March 2012): 71-73. https://doi.org/10.1501/Vetfak_0000002504.
EndNote Karayiğit MÖ, Kabak YB, Yarım M, Şirin S, Gülbahar M (March 1, 2012) Insulinoma with regional lymph node metastasis in a dog. Ankara Üniversitesi Veteriner Fakültesi Dergisi 59 1 71–73.
IEEE M. Ö. Karayiğit, Y. B. Kabak, M. Yarım, S. Şirin, and M. Gülbahar, “Insulinoma with regional lymph node metastasis in a dog”, Ankara Univ Vet Fak Derg, vol. 59, no. 1, pp. 71–73, 2012, doi: 10.1501/Vetfak_0000002504.
ISNAD Karayiğit, Mehmet Önder et al. “Insulinoma With Regional Lymph Node Metastasis in a Dog”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 59/1 (March 2012), 71-73. https://doi.org/10.1501/Vetfak_0000002504.
JAMA Karayiğit MÖ, Kabak YB, Yarım M, Şirin S, Gülbahar M. Insulinoma with regional lymph node metastasis in a dog. Ankara Univ Vet Fak Derg. 2012;59:71–73.
MLA Karayiğit, Mehmet Önder et al. “Insulinoma With Regional Lymph Node Metastasis in a Dog”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 59, no. 1, 2012, pp. 71-73, doi:10.1501/Vetfak_0000002504.
Vancouver Karayiğit MÖ, Kabak YB, Yarım M, Şirin S, Gülbahar M. Insulinoma with regional lymph node metastasis in a dog. Ankara Univ Vet Fak Derg. 2012;59(1):71-3.