Investigation of the effects of IOL and/or capsullar tension ring (CTR) on posterior capsullaropasification (PCO) development in rabbits
Abstract
Effects of intraocular lens (IOL) and\or capsullar tension ring (CTR) usage in prevention of posterior capsullar opasification (PCO) formation in rabbits were studied with ophthalmascopic and histopathologic parameters. Lensectomy by phacoemulsification tecnique in 60 eyes of 30 healthy New Zealand rabbits were made. 30 rabbits were divided into 3 groups. In first group (n=10) IOL is placed after lensectomy, in second group (n=10) CTR and in third group (n=10) IOL+CTR is placed in the right eyes after lensectomy. Ophthalmascopic examinations were made in postoperative period and at the end of the 6 months the rabbits are evaluated with histopathology. In histopathologic examination fibrocyte and fibroblast migration and lens epithelium cell proliferations which are signs of the PCO is less commonly seen in CTR\IOL group. After lensectomy with phacoemulsification long term effects of CTR and\or IOL in prevention of PCO was investigated. In conclusion CTR\IOL group was found to be succesfull in prevention of PCO formation
Keywords
Capsullar tension ring (CTR) intraocular lens (IOL) posterior capsullar opasification (PCO)
References
- Dziezyc J (1990): Cataract surgery. Vet Clin North Am Small Anim Pract, 20, 737–753.
- Gayton JL, Apple DJ, Peng Q, Visessook N, Sanders V, Werner L, Pandey SK, Escobar-Gomez M, Hoddinott DS, Van Der Karr M (2000): Interlenticular opasification: clinicopathological correlation of complication of posterior chamber piggy back intraocular lenses. J Cat Ref Surg, 26, 330-336.
- Gilger BC (2003): Lens. 1402-1418. In: D Slatter (Ed), Textbook of Small Animal Surgery. Philadelphia Sounders.
- Kim JH, Kim H, Joo CK (2005): The effect of capsular tension ring on posterior capsular opacity in cataract surgery. Korean J Ophthalmol, 19, 23-28.
- Kurosaka D, Kato K, Nagamato T (1996): Presence of α smooth muscle actin in lens epithelial cells of aphakic rabbit eyes. Br J Opthalmol, 80, 906-910.
- Lanzetta P, Chiodini RG, Polito A, Bandello F (2002): Use of capsular tension ring phacoemulsification. Indications and technique. Indian J Ophthalmol, 50, 333-337.
- Lois N, Dawson R, McKinnon AD, Forrester JV (2004): A New Model of Posterior Capsule Opacification in Rodents. Invest Ophthalmol Vis Sci, 44, 3450-3457.
- Mc Donell PJ, Stark WJ, Green WR (1984): Posterior capsule opacification: a specular microscopic study. Ophthalmology, 91, 853-856.
- Nagamoto T, Eguchi G (1997): Effect of intraocular lens design on migration of lens epithelial cells onto the posterior capsule. Cat Ref Surg, 23, 866-872.
- Özgencil FE (2003): The results of phacofragmentation and aspiration surgery for cataract extraction in dogs. Turk J Vet Anim Sci, 29,165-173.
- Pandey SK, Apple DJ, Werner L, Maloof AJ, Milverton EJ (2004): Posterior capsule opacification: A review of the aetiopathogenesis, experimental and clinical studies and factors for prevention. Indian J Ophtalmol, 52, 99–112.
- Pandey SK, Cochener B, Apple DJ, Colin J, Werner L, Bougaran R, Trivedi RH, Macky TA, İzak AM (2002): Intracapsular ring sustained 5 fluorouracil delivery system for the prevention of posterior capsule opacification in rabbits: a histological study. J Cataract Refr Surg, 28, 139–148.
- Raj SM, Vasavada AR, Johar K, Vasavada V (2007): Post-operative capsular opacification: a review. International Journal of Biomedical Science, 3, 237–250.
- Ridley H (1976): The origin and objectives of intraocular lenticular implants. Trans Am Acad Opthalmol Otolaryngol, 81, 65–66.
- Wormstone IM (2002): Posterior capsule opacification: a cell biological perspective. Exp Eye Res, 74, 337.
Tavşanlarda kapsül germe halkası (KGH)’nın ve/veya intraokuler lens (İOL)’in posterior kapsüller opasifikasyona (PKO) etkisinin değerlendirilmesi
Abstract
Tavşanlarda intraokuler lens (İOL) ve / veya kapsül germe halkalarının (KGH), posterior kapsüller opasifikasyona (PKO) olan etkisinin oftalmaskopik ve histopatolojik parametreler ile araştırılması amaçlandı. Çalışmada 30 adet sağlıklı ergin Yeni Zelanda tavşanının 60 gözüne fakoemülsifikasyon tekniği ile lensektomi uygulandı. Birinci grubun sağ gözüne (n=10) lensektomi sonrası İOL, ikinci grup sağ gözüne (n=10) lensektomi sonrası KGH, üçüncü grupta yine sağ gözlerine (n=10) lensektomi sonrası İOL ve KGH uygulamaları yapıldı. Deneklerin postoperatif dönemde oftalmaskopik muayeneleri yapıldı ve 6 aylık gözlem süresinin sonunda histopatolojik değerlendirmeye alındı. Histopatolojik değerlendirmede PKO’nun göstergesi olan fibrosit ve fibroblast migrasyonu ve lens epitelyum hücrelerinde proliferasyon açısından KGH\İOL grubunun daha üstün olduğu izlendi. Fakoemülsifikasyon tekniği ile lensektomi sonrası PKO’nun engellenmesinde KGH ve /veya İOL lerin uzun dönem etkisi araştırıldı. Sonuçta KGH\IOL birlikte kullanıldığı gruplarda PKO’nun engellendiği ve bu yöntemin daha başarılı olduğu kanısına varıldı
References
- Dziezyc J (1990): Cataract surgery. Vet Clin North Am Small Anim Pract, 20, 737–753.
- Gayton JL, Apple DJ, Peng Q, Visessook N, Sanders V, Werner L, Pandey SK, Escobar-Gomez M, Hoddinott DS, Van Der Karr M (2000): Interlenticular opasification: clinicopathological correlation of complication of posterior chamber piggy back intraocular lenses. J Cat Ref Surg, 26, 330-336.
- Gilger BC (2003): Lens. 1402-1418. In: D Slatter (Ed), Textbook of Small Animal Surgery. Philadelphia Sounders.
- Kim JH, Kim H, Joo CK (2005): The effect of capsular tension ring on posterior capsular opacity in cataract surgery. Korean J Ophthalmol, 19, 23-28.
- Kurosaka D, Kato K, Nagamato T (1996): Presence of α smooth muscle actin in lens epithelial cells of aphakic rabbit eyes. Br J Opthalmol, 80, 906-910.
- Lanzetta P, Chiodini RG, Polito A, Bandello F (2002): Use of capsular tension ring phacoemulsification. Indications and technique. Indian J Ophthalmol, 50, 333-337.
- Lois N, Dawson R, McKinnon AD, Forrester JV (2004): A New Model of Posterior Capsule Opacification in Rodents. Invest Ophthalmol Vis Sci, 44, 3450-3457.
- Mc Donell PJ, Stark WJ, Green WR (1984): Posterior capsule opacification: a specular microscopic study. Ophthalmology, 91, 853-856.
- Nagamoto T, Eguchi G (1997): Effect of intraocular lens design on migration of lens epithelial cells onto the posterior capsule. Cat Ref Surg, 23, 866-872.
- Özgencil FE (2003): The results of phacofragmentation and aspiration surgery for cataract extraction in dogs. Turk J Vet Anim Sci, 29,165-173.
- Pandey SK, Apple DJ, Werner L, Maloof AJ, Milverton EJ (2004): Posterior capsule opacification: A review of the aetiopathogenesis, experimental and clinical studies and factors for prevention. Indian J Ophtalmol, 52, 99–112.
- Pandey SK, Cochener B, Apple DJ, Colin J, Werner L, Bougaran R, Trivedi RH, Macky TA, İzak AM (2002): Intracapsular ring sustained 5 fluorouracil delivery system for the prevention of posterior capsule opacification in rabbits: a histological study. J Cataract Refr Surg, 28, 139–148.
- Raj SM, Vasavada AR, Johar K, Vasavada V (2007): Post-operative capsular opacification: a review. International Journal of Biomedical Science, 3, 237–250.
- Ridley H (1976): The origin and objectives of intraocular lenticular implants. Trans Am Acad Opthalmol Otolaryngol, 81, 65–66.
- Wormstone IM (2002): Posterior capsule opacification: a cell biological perspective. Exp Eye Res, 74, 337.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA85RF38FY |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 1, 2011 |
| Published in Issue | Year 2011Volume: 58 Issue: 4 |