Letter to Editor
The investigation of the plasma monocyte chemoattractant protein-1 and interleukin-1α levels and the relationship between these levels and number of blood lymphocytes and monocytes in calves with foot and mouth disease
Abstract
: In this study, detection of plasma monocyte chemoattractant protein-1 (MCP-1) and interleukin-1 (IL-1α) levels
and correlations between these levels and blood lymphocyte and monocyte numbers was aimed. 1-1.5 years old 16 calves with foot
and mouth disease and 11 calves with healthy were used in study. The levels of MCP-1 and IL-1α in plasma were found to be
significantly increased in calves with foot and mouth disease compared to healthy group (p<0.001). Between the plasma MCP-1 and
IL-1α levels and blood lymphocyte and monocyte numbers were determined to be significantly correlated (p<0.01) in calves with
foot and mouth disease. In the present study, the number of blood lymphocytes and monocytes was positively correlated with plasma
MCP-1 and IL-1α concentrations that suggests MCP-1 and IL-1α are involved in etiopathogenesis of foot and mouth disease
Keywords
References
- Aderka D, Holtmann H, Toker L, Hahn T, Wallach D (1986): Tumor necrosis factor induction by Sendai virus. J Immunol, 136, 2938-2342.
- Apte RN, Voronov E (2002): Interleukin-1--a major pleiotropic cytokine in tumor-host interactions. Semin Cancer Biol, 12, 277-290.
- Baggiolini M, Dewald B, Moser B (1997): Human chemokines: an update. Annu Rev Immunol, 15, 675-705.
- Boring L, Gosling J, Cleary M, Charo IF (1998): Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature, 394, 894– 897.
- Breen EC, Rezai K, Nakajima K, Beall GN, Mitsuyasu RT, Hirano T, Kishimoto T, Martinez-Maza O (1990): Infection with HIV is associated with elevated IL-6 levels and production. J Immunol, 144, 480-484.
- Bubfeld D, Kaufmann A, Meyer RG, Gemsa D, Sprenger H (1998): Differential mononuclear leukocyte attracting chemokine production after stimulation with active and inactivated ınfluenza A virus. Cell Immun, 186, 1-7.
- Cushing SD, Berliner JA, Valente AJ, Territo MC, Navab M, Parhami F, Gerrity R, Schwartz CJ, Fogelman AM (1990): Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc Natl Acad Sci USA, 87, 5134-5138.
- Davies C (1994): Principles. In The Immunoassay Handbook. D. Wild, ed. Stockton Press, New York, p. 3- 47.
- Dinarello CA (1996): Biologic basis for interleukin-1 in disease. Blood, 87, 2095-2147.
- Dinter Z, Morein B (1990): Virus Infections of Ruminants, Elsevier Science Publishers B.V. p. 506-508.
- Dunphy J, Horvath A, Barcham G, Balic A, Bischof R, Meeusen E (2001): Isolation, characterisation and expression of mRNAs encoding the ovine CC chemokines, monocyte chemoattractant protein (MCP)-1alpha and -2. Vet Immunol Immunopathol, 82, 153-164.
- Eckersall PD (2000): Recent advances and future pros- pects for the use of acute phase proteins as markers of dis- ease in animals. Revue Med Vet, 151, 577-584.
- England JM, Rowan RM, van Assendelft OW, Coulter WH, Groner W, Jones AR, Koepke JA, Lewis SM, Shinton NK, Thom R (1984): Protocol for evaluation of automated blood cell counters. International Committee for Standardization in Haematology (ICSH). Clin Lab Haematol, 6, 269-84.
- Gangur V, Birmingham NP, Thanesvorakul S (2002): Chemokines in health and disease. Vet Immunol Immunopathol, 86, 127-136.
- Gu L, Tseng S, Rollins BJ (1999): Monocyte chemoattractant protein-1. Chem Immunol, 72, 7– 29.
- Horadagoda NU, Knox KM, Gibbs HA, Reid SW, Horadagoda A, Edwards SE, Eckersall PD (1999): Acute phase proteins in cattle: discrimination between acute and chronic inflammation. Vet Rec, 17, 144, 437- 441.
- Imhof BA, Dunon D (1995): Leukocyte migration and adhesion. Adv Immunol, 58, 345-416.
- Janeway CA, Medzhitov R (2002): Innate immune rec- ognition. Annu Rev Immunol, 20, 197-216.
- Kuby J (1997): Immunology, 3rd Ed., WH Freeman and Co, New York.
- Lechner F, Machado J, Bertoni G, Seow HF, Dobbelaere DA, Peterhans E (1997): Caprine arthritis encephalitis virus dysregulates the expression of cytokines in macrophages. J Virol, 71, 7488-7497.
- Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, North R, Gerard C, Rollins BJ (1998): Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1- deficient mice. J Exp Med, 187, 601-608.
- Luster AD (1998): Chemokines--chemotactic cytokines that mediate inflammation. N Engl J Med, 338, 436-445.
- Mackay CR (2001): Chemokines: immunology's high impact factors. Nat Immunol, 2, 95-101.
- Mahad DJ, Ransohoff RM (2003): The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Semin Immunol, 15, 23– 32.
- Mc Cullough, KC, Crowther, JR (1986): The protective immune response against foot and mouth disease virus, re- lationship to virion topography. FMD Bulletin, 23, 2-6.
- Rao CR (1973): Linear statistical inference and its appli- cations. John&Sons, New York.
- Reckless J, Rubin EM, Verstuyft JB, Metcalfe JC, Grainger DJ (1999): Monocyte chemoattractant protein-1 but not tumor necrosis factor-alpha is correlated with monocyte infiltration in mouse lipid lesions. Circulation, 99, 2310-2306.
- Sallusto F, Lanzavecchia A, Mackay CR (1998): Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today, 19, 568-574.
- Sorbino F, Saiz M, Jimenez-Clavero MA, Nunez JI, Rosas MF, Baranowski E, Ley V (2001): Foot and Mouth Disease Virus: a long known virus, but a current threat. Vet Res, 32, 1-30.
- Thanawongnuwech R, Young TF, Thacker BJ, Thacker EL (2001): Differential production of proinflammatory cytokines: in vitro PRRSV and Mycoplasma hyopneumoniae co-infection model. Vet Immunol Immunopathol, 79, 115-127.
- Usherwood EJ, Nash AA (1995): Lymphocyte recognition of picornaviruses. J Gen Virol, 76, 499-508.
- Van Reeth, Labarque G, Nauwynck H, Pensaert M (1999): Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity. Res Vet Sci, 67, 47-52.
- Van Reeth K, Van Gucht S, Pensaert M (2002): In vivo studies on cytokine involvement during acute viral respiratory disease of swine: troublesome bu rewarding. Vet Immunol Immunopathol, 87, 161-168.
- Wong CK, Lam CW, Wu AK, Ip WK, Lee NL, Chan IH, Lit LC, Hui DS, Chan MH, Chung SS, Sung JJ (2004): Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol, 136, 95-103.
- Yadav S, Sharma R, Chhabra R (2005): Interleukin-2 potentiates foot-and-mouth disease vaccinal immune responses in mice. Vaccine, 23, 3005-3009.
- Yoshimura T, Robinson EA, Tanaka S, Appella E, Kuratsu J, Leonard EJ (1989): Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J Exp Med, 169, 1449-1459.
- Zoja C, Wang JM, Bettoni S, Sironi M, Renzi D, Chiaffarino F, Abboud HE, Van Damme J, Mantovani A, Remuzzi G (1991): Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony- stimulating factors, and interleukin-6 in human mesengial cells. Am J Pathol, 138, 991-1003.
Şap hastalıklı danalarda plazma monosit kemoatraktan protein-1 ve İnterlökin-1α düzeylerinin ve bu düzeylerle kan lenfosit ve monosit sayıları arasındaki ilişkilerin incelenmesi
Abstract
Bu çalışmada, şap hastalıklı danalarda plazma monosit kemoatraktan protein-1 (MCP-1) ve interlökin 1-α (IL-1α) düzeylerinin ve bu düzeyler ile kandaki lenfosit ve monosit sayıları arasındaki ilişkilerin incelenmesi amaçlandı. Bu amaçla, 1-1.5
yaşlarında 16 adet şap hastalıklı ve 11 adet sağlıklı dana kullanıldı. Şap hastalıklı danalarda plazma MCP-1 ve IL-1α düzeyleri sağlıklı gruba göre önemli derecede yükselmiş bulundu (p<0.001). Şap hastalıklı danalarda plazma MCP-1 ve IL-1α düzeyleri ile kandaki lenfosit ve monosit sayıları arasında önemli derecede ilişki olduğu belirlendi (p<0.01). Kandaki lenfosit ve monosit artışına
paralel olarak plazma MCP-1 ve IL1-α düzeylerinin de önemli derecede artmış olması, MCP-1 ve IL-1α’nın şap hastalığının
patogenezinde rol aldığını düşündürmektedir
References
- Aderka D, Holtmann H, Toker L, Hahn T, Wallach D (1986): Tumor necrosis factor induction by Sendai virus. J Immunol, 136, 2938-2342.
- Apte RN, Voronov E (2002): Interleukin-1--a major pleiotropic cytokine in tumor-host interactions. Semin Cancer Biol, 12, 277-290.
- Baggiolini M, Dewald B, Moser B (1997): Human chemokines: an update. Annu Rev Immunol, 15, 675-705.
- Boring L, Gosling J, Cleary M, Charo IF (1998): Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature, 394, 894– 897.
- Breen EC, Rezai K, Nakajima K, Beall GN, Mitsuyasu RT, Hirano T, Kishimoto T, Martinez-Maza O (1990): Infection with HIV is associated with elevated IL-6 levels and production. J Immunol, 144, 480-484.
- Bubfeld D, Kaufmann A, Meyer RG, Gemsa D, Sprenger H (1998): Differential mononuclear leukocyte attracting chemokine production after stimulation with active and inactivated ınfluenza A virus. Cell Immun, 186, 1-7.
- Cushing SD, Berliner JA, Valente AJ, Territo MC, Navab M, Parhami F, Gerrity R, Schwartz CJ, Fogelman AM (1990): Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc Natl Acad Sci USA, 87, 5134-5138.
- Davies C (1994): Principles. In The Immunoassay Handbook. D. Wild, ed. Stockton Press, New York, p. 3- 47.
- Dinarello CA (1996): Biologic basis for interleukin-1 in disease. Blood, 87, 2095-2147.
- Dinter Z, Morein B (1990): Virus Infections of Ruminants, Elsevier Science Publishers B.V. p. 506-508.
- Dunphy J, Horvath A, Barcham G, Balic A, Bischof R, Meeusen E (2001): Isolation, characterisation and expression of mRNAs encoding the ovine CC chemokines, monocyte chemoattractant protein (MCP)-1alpha and -2. Vet Immunol Immunopathol, 82, 153-164.
- Eckersall PD (2000): Recent advances and future pros- pects for the use of acute phase proteins as markers of dis- ease in animals. Revue Med Vet, 151, 577-584.
- England JM, Rowan RM, van Assendelft OW, Coulter WH, Groner W, Jones AR, Koepke JA, Lewis SM, Shinton NK, Thom R (1984): Protocol for evaluation of automated blood cell counters. International Committee for Standardization in Haematology (ICSH). Clin Lab Haematol, 6, 269-84.
- Gangur V, Birmingham NP, Thanesvorakul S (2002): Chemokines in health and disease. Vet Immunol Immunopathol, 86, 127-136.
- Gu L, Tseng S, Rollins BJ (1999): Monocyte chemoattractant protein-1. Chem Immunol, 72, 7– 29.
- Horadagoda NU, Knox KM, Gibbs HA, Reid SW, Horadagoda A, Edwards SE, Eckersall PD (1999): Acute phase proteins in cattle: discrimination between acute and chronic inflammation. Vet Rec, 17, 144, 437- 441.
- Imhof BA, Dunon D (1995): Leukocyte migration and adhesion. Adv Immunol, 58, 345-416.
- Janeway CA, Medzhitov R (2002): Innate immune rec- ognition. Annu Rev Immunol, 20, 197-216.
- Kuby J (1997): Immunology, 3rd Ed., WH Freeman and Co, New York.
- Lechner F, Machado J, Bertoni G, Seow HF, Dobbelaere DA, Peterhans E (1997): Caprine arthritis encephalitis virus dysregulates the expression of cytokines in macrophages. J Virol, 71, 7488-7497.
- Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, North R, Gerard C, Rollins BJ (1998): Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1- deficient mice. J Exp Med, 187, 601-608.
- Luster AD (1998): Chemokines--chemotactic cytokines that mediate inflammation. N Engl J Med, 338, 436-445.
- Mackay CR (2001): Chemokines: immunology's high impact factors. Nat Immunol, 2, 95-101.
- Mahad DJ, Ransohoff RM (2003): The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Semin Immunol, 15, 23– 32.
- Mc Cullough, KC, Crowther, JR (1986): The protective immune response against foot and mouth disease virus, re- lationship to virion topography. FMD Bulletin, 23, 2-6.
- Rao CR (1973): Linear statistical inference and its appli- cations. John&Sons, New York.
- Reckless J, Rubin EM, Verstuyft JB, Metcalfe JC, Grainger DJ (1999): Monocyte chemoattractant protein-1 but not tumor necrosis factor-alpha is correlated with monocyte infiltration in mouse lipid lesions. Circulation, 99, 2310-2306.
- Sallusto F, Lanzavecchia A, Mackay CR (1998): Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today, 19, 568-574.
- Sorbino F, Saiz M, Jimenez-Clavero MA, Nunez JI, Rosas MF, Baranowski E, Ley V (2001): Foot and Mouth Disease Virus: a long known virus, but a current threat. Vet Res, 32, 1-30.
- Thanawongnuwech R, Young TF, Thacker BJ, Thacker EL (2001): Differential production of proinflammatory cytokines: in vitro PRRSV and Mycoplasma hyopneumoniae co-infection model. Vet Immunol Immunopathol, 79, 115-127.
- Usherwood EJ, Nash AA (1995): Lymphocyte recognition of picornaviruses. J Gen Virol, 76, 499-508.
- Van Reeth, Labarque G, Nauwynck H, Pensaert M (1999): Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity. Res Vet Sci, 67, 47-52.
- Van Reeth K, Van Gucht S, Pensaert M (2002): In vivo studies on cytokine involvement during acute viral respiratory disease of swine: troublesome bu rewarding. Vet Immunol Immunopathol, 87, 161-168.
- Wong CK, Lam CW, Wu AK, Ip WK, Lee NL, Chan IH, Lit LC, Hui DS, Chan MH, Chung SS, Sung JJ (2004): Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol, 136, 95-103.
- Yadav S, Sharma R, Chhabra R (2005): Interleukin-2 potentiates foot-and-mouth disease vaccinal immune responses in mice. Vaccine, 23, 3005-3009.
- Yoshimura T, Robinson EA, Tanaka S, Appella E, Kuratsu J, Leonard EJ (1989): Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J Exp Med, 169, 1449-1459.
- Zoja C, Wang JM, Bettoni S, Sironi M, Renzi D, Chiaffarino F, Abboud HE, Van Damme J, Mantovani A, Remuzzi G (1991): Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony- stimulating factors, and interleukin-6 in human mesengial cells. Am J Pathol, 138, 991-1003.
There are 37 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2006 |
| Published in Issue | Year 2006Volume: 53 Issue: 2 |