Case Report
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Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome

Year 2019, Volume: 66 Issue: 4, 417 - 421, 09.09.2019

Zeynep Günay Uçmak İsmail Kırşan Melih Uçmak Özge Erdoğan Bamaç Aydın Gürel

https://doi.org/10.33988/auvfd.568858
Cited By: 2

Abstract

A 25 kg, 4 years old,
Boxer breed bitch which had ovariohysterectomy section 2 years ago, was
presented with weakness, loss of appetite, masses on abdominal and inguinal
mammary glands and vaginal bleeding. Transmissible venereal tumor (TVT) was
diagnosed with vaginal cytology. Intra-abdominal mass around the iliac artery
and remnant ovary behind the right kidney were determined on ultrasonographic
examination. The remnant ovary and the masses on mammary glands were removed by
surgical approach. However, intra-abdominal mass could not be extirpated
because of its localization during the same laparotomy. A biopsy was taken from
the vaginal mass. According to histopathology, TVT and collagenous hamartoma
were detected on mammary glands. Also, TVT was observed in vaginal and
intra-abdominal masses. Chemotherapy protocol was arranged for intra-abdominal
mass and vaginal TVT which occupied for ten weeks. Hemogram, vaginal smear and
transabdominal ultrasonography were repeated before each chemotherapy course.
Size of the intra-abdominal mass, pulsatility index (PI) and relative index
(RI) values of iliac artery were evaluated with B-mode ultrasonography and
doppler ultrasonography during the treatment, respectively. As a result,
positive correlation between PI and RI values were determined. In the presented
case, TVT and its metastases were successfully treated with both surgery and
chemotherapy. It was concluded that evaluation of the metastases with doppler
ultrasonography will be favorable to reveal the hemodynamic alterations of
related organs or tissues.  

Keywords

Canine metastasis transmissible veneral tumor

References

  • 1. Amber EI, Henderson RA, Adeyanju JB, et al (1990): Single-drug chemotherapy of canine transmissible venereal tumour with cyclophosphamide, methotrexate or vincristine. J Vet Intern Med, 4, 144–147.
  • 2. Bartyzel BJ, Max A, Gruszczynska J, et al (2017): Hamartoma: a rare developmental disorder. Med Weter, 73(4), 202-207.
  • 3. Baştan A, Baki Acar D, Cengiz M (2008): Uterine and ovarian metastasis of transmissible venereal tumor in bitch. Turk J Vet Anim Sci, 32(1), 65-66.
  • 4. Behera SK, Kurade NP, Monsang SW, et al (2012): Clinico-pathological findings in a case of canine cutaneous metastatic transmissible venereal tumor. Vet Arhiv, 82(4), 401-410.
  • 5. Betamuzi EK (1992): Risk factors associated with canine TVT in Tanzania. Prevent Vet Med, 13, 13-17.
  • 6. Boscos CM, Ververidis HN (2004): TVT-Clinical findings, diagnosis and treatment. Proceedings of the 29th World Congress of the World Small Animal Veterinary Association.
  • 7. Castro KF, Strakova A, Tinucci-Costa M, et al (2017): Evaluation of a genetic assay for canine transmissible venereal tumour diagnosis in Brazil. Vet Comp Oncol, 15(2), 615-618.
  • 8. Champour M, Ojrati N, Nikrou A, et al (2014): First report of diffuse cutaneous canine transmissible venereal tumor in Iran. Comp Clin Pathol, DOI 10.1007/s00580-014-1973-z
  • 9. Çizmeci SÜ, Köse AM, Aydın İ, et al (2012): Transmissible venereal tümörlü dişi köpeklerde otojen aşı uygulaması. Eurasian J Vet Sci, 28(4), 220-223.
  • 10. Çizmeci SÜ, Köse AM, Aydın İ, et al (2012): Clinical efficiency of Doxorubicin and Cisplatin in treatment of transmissible venereal tumor of bitches. Revue Méd Vét, 163(11), 516-521.
  • 11. Das U, Das AK (2000): Review of canine transmissible venereal sarcoma. Vet Res Commun, 24, 545-556.
  • 12. Ferreira AJA, Jaggy A, Varejao AP, et al (2000): Brain and ocular metastases from a transmissible venereal tumour in a dog. J Small Anim Pract, 41, 165-168.
  • 13. Ganguly B, Das U, Das AK (2016): Canine transmissible venereal tumour: a review. Vet Comp Oncol, 14(1), 1-12.
  • 14. Gurel A, Kuscu B, Gulanber G, et al (2002): Transmissible venereal tumors detected in the extragenital organs of dogs. Israel J Vet Med, 57(2), 23-26.
  • 15. Jacob A, Bhanuprakash AG, Choudhary SS, et al (2015): Therapeutic management of transmissible venereal tumor in canine. Indian J Vet Med, 35(1), 81-85.
  • 16. Kevin AH (2002): Veterinary oncology: the practical veterinarian. Butterworth-Heinemann, Elsevier, USA.
  • 17. Liao KW, Lin ZY, Pao HN, et al (2003): Identification of canine transmissible venereal tumor cells using in situ polymerase chain reaction and the stable sequence of the long interspersed nuclear element. J Vet Diagn Invest, 15(5), 399-406.
  • 18. Mello Martins MI, Ferreira de Souza F, Gobello C (2005): The canine transmissible venereal tumor: Etiology, pathology, diagnosis and treatment. IVIS, A1233.0405.
  • 19. Nak D, Mısırlıoğlu D, Nak Y, et al (2004): Transmissible venereal tumor with mammary gland metastase in a bitch. Vet Bilimleri Derg, 20, 99–102.
  • 20. Nelson TR, Pretorius DH (1988): The doppler signal: where does it come from and what does it mean? Am J Roent, 151(3), 439-447.
  • 21. Ojeda J, Mieres M, Soto F, et al (2018): Computer tomographic imaging in 4 dogs with primary nasal canine transmissible venereal tumor and differing cellular phenotype. J Vet Int Med, DOI: 10.1111/jvim.15125.
  • 22. Purohit G (2008): Canine transmissible venereal tumor: A review. Internet J Vet Med, 6(1), 1-7.
  • 23. Richardson RC (1981): Canine transmissible venereal tumor. Comp Contin Educ Pract Vet, 3, 951-956.
  • 24. Turna Yılmaz O, Uçmak M, Gunay Z, et al (2013): Vaginal fold prolapse and transmissible venereal tumour related to ovarian remnant syndrome in a bitch: a case report. Vet Med, 58(12), 628-632.
  • 25. Turna O, Karabağlı M, Cetin AC, et al (2017): Metastasis of canine transmissible venereal tumor to median iliac lymph nodes and evaluation of treatment with computed tomography. Proceedings of 4th International VETIstanbul Group Congress.
  • 26. Uçar M (2016): Transmissible venereal tumor: a review. Kocatepe Vet J, 9(3), 230-235.
  • 27. Yang TJ (1988): Immunobiology of a spontaneously regressive tumor, the canine transmissible venereal sarcoma. Anticancer Res, 8(1), 93-95.

Year 2019, Volume: 66 Issue: 4, 417 - 421, 09.09.2019

Zeynep Günay Uçmak İsmail Kırşan Melih Uçmak Özge Erdoğan Bamaç Aydın Gürel

https://doi.org/10.33988/auvfd.568858
Cited By: 2

Abstract


References

  • 1. Amber EI, Henderson RA, Adeyanju JB, et al (1990): Single-drug chemotherapy of canine transmissible venereal tumour with cyclophosphamide, methotrexate or vincristine. J Vet Intern Med, 4, 144–147.
  • 2. Bartyzel BJ, Max A, Gruszczynska J, et al (2017): Hamartoma: a rare developmental disorder. Med Weter, 73(4), 202-207.
  • 3. Baştan A, Baki Acar D, Cengiz M (2008): Uterine and ovarian metastasis of transmissible venereal tumor in bitch. Turk J Vet Anim Sci, 32(1), 65-66.
  • 4. Behera SK, Kurade NP, Monsang SW, et al (2012): Clinico-pathological findings in a case of canine cutaneous metastatic transmissible venereal tumor. Vet Arhiv, 82(4), 401-410.
  • 5. Betamuzi EK (1992): Risk factors associated with canine TVT in Tanzania. Prevent Vet Med, 13, 13-17.
  • 6. Boscos CM, Ververidis HN (2004): TVT-Clinical findings, diagnosis and treatment. Proceedings of the 29th World Congress of the World Small Animal Veterinary Association.
  • 7. Castro KF, Strakova A, Tinucci-Costa M, et al (2017): Evaluation of a genetic assay for canine transmissible venereal tumour diagnosis in Brazil. Vet Comp Oncol, 15(2), 615-618.
  • 8. Champour M, Ojrati N, Nikrou A, et al (2014): First report of diffuse cutaneous canine transmissible venereal tumor in Iran. Comp Clin Pathol, DOI 10.1007/s00580-014-1973-z
  • 9. Çizmeci SÜ, Köse AM, Aydın İ, et al (2012): Transmissible venereal tümörlü dişi köpeklerde otojen aşı uygulaması. Eurasian J Vet Sci, 28(4), 220-223.
  • 10. Çizmeci SÜ, Köse AM, Aydın İ, et al (2012): Clinical efficiency of Doxorubicin and Cisplatin in treatment of transmissible venereal tumor of bitches. Revue Méd Vét, 163(11), 516-521.
  • 11. Das U, Das AK (2000): Review of canine transmissible venereal sarcoma. Vet Res Commun, 24, 545-556.
  • 12. Ferreira AJA, Jaggy A, Varejao AP, et al (2000): Brain and ocular metastases from a transmissible venereal tumour in a dog. J Small Anim Pract, 41, 165-168.
  • 13. Ganguly B, Das U, Das AK (2016): Canine transmissible venereal tumour: a review. Vet Comp Oncol, 14(1), 1-12.
  • 14. Gurel A, Kuscu B, Gulanber G, et al (2002): Transmissible venereal tumors detected in the extragenital organs of dogs. Israel J Vet Med, 57(2), 23-26.
  • 15. Jacob A, Bhanuprakash AG, Choudhary SS, et al (2015): Therapeutic management of transmissible venereal tumor in canine. Indian J Vet Med, 35(1), 81-85.
  • 16. Kevin AH (2002): Veterinary oncology: the practical veterinarian. Butterworth-Heinemann, Elsevier, USA.
  • 17. Liao KW, Lin ZY, Pao HN, et al (2003): Identification of canine transmissible venereal tumor cells using in situ polymerase chain reaction and the stable sequence of the long interspersed nuclear element. J Vet Diagn Invest, 15(5), 399-406.
  • 18. Mello Martins MI, Ferreira de Souza F, Gobello C (2005): The canine transmissible venereal tumor: Etiology, pathology, diagnosis and treatment. IVIS, A1233.0405.
  • 19. Nak D, Mısırlıoğlu D, Nak Y, et al (2004): Transmissible venereal tumor with mammary gland metastase in a bitch. Vet Bilimleri Derg, 20, 99–102.
  • 20. Nelson TR, Pretorius DH (1988): The doppler signal: where does it come from and what does it mean? Am J Roent, 151(3), 439-447.
  • 21. Ojeda J, Mieres M, Soto F, et al (2018): Computer tomographic imaging in 4 dogs with primary nasal canine transmissible venereal tumor and differing cellular phenotype. J Vet Int Med, DOI: 10.1111/jvim.15125.
  • 22. Purohit G (2008): Canine transmissible venereal tumor: A review. Internet J Vet Med, 6(1), 1-7.
  • 23. Richardson RC (1981): Canine transmissible venereal tumor. Comp Contin Educ Pract Vet, 3, 951-956.
  • 24. Turna Yılmaz O, Uçmak M, Gunay Z, et al (2013): Vaginal fold prolapse and transmissible venereal tumour related to ovarian remnant syndrome in a bitch: a case report. Vet Med, 58(12), 628-632.
  • 25. Turna O, Karabağlı M, Cetin AC, et al (2017): Metastasis of canine transmissible venereal tumor to median iliac lymph nodes and evaluation of treatment with computed tomography. Proceedings of 4th International VETIstanbul Group Congress.
  • 26. Uçar M (2016): Transmissible venereal tumor: a review. Kocatepe Vet J, 9(3), 230-235.
  • 27. Yang TJ (1988): Immunobiology of a spontaneously regressive tumor, the canine transmissible venereal sarcoma. Anticancer Res, 8(1), 93-95.
There are 27 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Case Report
Authors

Zeynep Günay Uçmak 0000-0003-2530-1291

İsmail Kırşan 0000-0003-0780-0118

Melih Uçmak 0000-0002-8688-127X

Özge Erdoğan Bamaç 0000-0002-0352-4841

Aydın Gürel 0000-0002-0266-8771

Publication Date September 9, 2019
Published in Issue Year 2019Volume: 66 Issue: 4

Cite

APA Günay Uçmak, Z., Kırşan, İ., Uçmak, M., Erdoğan Bamaç, Ö., et al. (2019). Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 66(4), 417-421. https://doi.org/10.33988/auvfd.568858
AMA Günay Uçmak Z, Kırşan İ, Uçmak M, Erdoğan Bamaç Ö, Gürel A. Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome. Ankara Univ Vet Fak Derg. September 2019;66(4):417-421. doi:10.33988/auvfd.568858
Chicago Günay Uçmak, Zeynep, İsmail Kırşan, Melih Uçmak, Özge Erdoğan Bamaç, and Aydın Gürel. “Clinical Approaches for Genital and Extragenital Metastasis of Transmissible Venereal Tumor in a Bitch With Ovarian Remnant Syndrome”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 66, no. 4 (September 2019): 417-21. https://doi.org/10.33988/auvfd.568858.
EndNote Günay Uçmak Z, Kırşan İ, Uçmak M, Erdoğan Bamaç Ö, Gürel A (September 1, 2019) Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome. Ankara Üniversitesi Veteriner Fakültesi Dergisi 66 4 417–421.
IEEE Z. Günay Uçmak, İ. Kırşan, M. Uçmak, Ö. Erdoğan Bamaç, and A. Gürel, “Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome”, Ankara Univ Vet Fak Derg, vol. 66, no. 4, pp. 417–421, 2019, doi: 10.33988/auvfd.568858.
ISNAD Günay Uçmak, Zeynep et al. “Clinical Approaches for Genital and Extragenital Metastasis of Transmissible Venereal Tumor in a Bitch With Ovarian Remnant Syndrome”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 66/4 (September 2019), 417-421. https://doi.org/10.33988/auvfd.568858.
JAMA Günay Uçmak Z, Kırşan İ, Uçmak M, Erdoğan Bamaç Ö, Gürel A. Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome. Ankara Univ Vet Fak Derg. 2019;66:417–421.
MLA Günay Uçmak, Zeynep et al. “Clinical Approaches for Genital and Extragenital Metastasis of Transmissible Venereal Tumor in a Bitch With Ovarian Remnant Syndrome”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 66, no. 4, 2019, pp. 417-21, doi:10.33988/auvfd.568858.
Vancouver Günay Uçmak Z, Kırşan İ, Uçmak M, Erdoğan Bamaç Ö, Gürel A. Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome. Ankara Univ Vet Fak Derg. 2019;66(4):417-21.

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