Research Article
Year 2020,
Volume: 67 Issue: 1, 41 - 50, 26.12.2019
Abstract
Keywords
References
- 1. Adamcakova-Dodd A, Stebounova LV, O’Shaughnessy PT, et al (2012): Murine pulmonary responses after sub-chronic exposure to aluminum oxide-based nanowhiskers. Part Fibre Toxicol, 9, 22-36.
- 2. Borm PJA, Robbins D, Haubold S, et al (2006): The potential risks of nanomaterials: A review carried out for ECETOC. Part Fibre Toxicol, 3, 11-46.
- 3. Brown DM, Donaldson K, Borm PJ, et al (2004): Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol, 286, 344-353.
- 4. Brown DM, Donaldson K, Stone V (2004): Effects of PM10 in human peripheral blood monocytes and J774 macrophages. Respir Res, 5, 29-41.
- 5. Buzea C, Blandino IIP, Robbie K (2007): Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases, 2, 17-172.
- 6. Donaldson K, Stone V (2003): Current hypotheses on the mechanisms of toxicity of ultrafine particles. Ann 1st Super Sanita, 39, 405-410.
- 7. Flaherty NL, Chandrasekaran A, Peña MPS, et al (2015): Comparative analysis of redox and inflammatory properties of pristine nanomaterials and commonly used semiconductor manufacturing nano-abrasives. Toxicol Lett, 239, 205-215.
- 8. Gelli K, Porika M, Anreddy RNR (2015): Assessment of pulmonary toxicity of MgO nanoparticles in rats. Environ Toxicol, 30, 308-314.
- 9. Khanna P, Nehru B (2007): Antioxidant enzymatic system in neuronal and glial cells enriched fractions of rat brain after aluminum exposure. Cell Mol Neurobiol, 27, 959-969.
- 10. Khanooki TA, Fazilati M (2014): The toxicity effect of magnesium oxide nanoparticles. Adv Environ Biol, 8, 969-973.
- 11. Kiranmai G, Reddy ARN (2012): Antioxidant status in MgO nanoparticle-exposed rats. Toxicol Ind Health, 29, 897-903.
- 12. Koç F, Baydan E (2003): Nanopartiküller. Erc Üniv Sağ Bil Derg, 12, 65-69.
- 13. Long H, Shi T, Borm PJ, et al (2004): ROS-mediated TNF-α and MIP-2 gene expression in alveolar macrophages exposed to pine dust. Part Fibre Toxicol, 1, 3-11.
- 14. Mangalampalli B, Dumala N, Grover P (2017): Acute oral toxicity study of magnesium oxide nanoparticles and microparticles in female albino wistar rats. Regul Toxicol Pharmacol, 90, 170-184.
- 15. Mirshafa A, Nazari M, Jahani D, et al (2018): Size-dependent neurotoxicity of aluminum oxide particles: A comparison between nano- and micrometer size on the basis of mitochondrial oxidative damage. Biol Trace Elem Res, 183, 261-269.
- 16. Noonan CW, Pfau JC, Larson TC, et al (2006): Nested case-control study of autoimmune disease in an asbestos-exposed population. Environ Health Perspect, 114, 1243-1247.
- 17. Oberdörster G, Oberdörster E, Oberdörster J (2005): Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect, 113, 823-839.
- 18. Organisation for Economic Cooperation and Development (OECD) (1987): Acute dermal toxicity. OECD Guideline for testing of chemicals, Test No 402, 24 Feb 1987.
- 19. OECD-Organisation for Economic Cooperation and Development (2001): Acute oral toxicity-Acute toxic class method. OECD Guideline for testing of chemicals, Test No 423, 17 December 2001.
- 20. Ohkawa H, Ohishi N, Yagi K (1979): Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-358. 21. Park EJ, Sim J, Kim Y, et al (2015): A 13-week repeated-dose oral toxicity and bioaccumulation of aluminum oxide nanoparticles in mice. Arch Toxicol, 89, 371-379.
- 22. Pfau JC, Sentissi JJ, Weller G, et al (2005): Assessment of autoimmune responses associated with asbestos exposure in Libby, Montana, USA. Environ Health Perspect, 113, 25-30.
- 23. Prabhakar PV, Reddy UA, Singh SP, et al (2012): Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in wistar rats. J Appl Toxicol, 32, 436-445.
- 24. Risom L, Møller P, Loft S (2005): Oxidative stress-induced DNA damage by particulate air pollution. Mutat Res, 592, 119-137.
- 25. Roco MC (2005): International perspective on government nanotechnology funding in 2005. J Nanopart Res, 7, 707-712.
- 26. Shim KH, Hulme J, Maeng EH, et al (2014): Analysis of zinc oxide nanoparticles binding proteins in rat blood and brain homogenate. Int J Nanomedicine, 9, 217-224.
- 27. Yang ST, Wang T, Dong E, et al (2012): Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure. Toxicol Res, 1, 69-74.
Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats
Abstract
In
this study, it was aimed to research the effects of cutaneous and oral
exposure to aluminum nanoparticles (Al-NPs) and magnesium nanoparticles
(Mg-NPs) on the brain tissue, which is vitally important in terms of its
structure and functions. The study was performed on Wister-Albino rats, which
were divided into 10 groups, such as control groups (groups 1 and 2),
groups, to which Al and Mg NPs were applied as 500 mg/kg and 1500 mg/kg orally
(groups 3-6) and 1000 mg/kg and 2000 mg/kg cutaneously (groups 7-10). The dosages
were administered as a single dose. While brain tissue and serum MDA levels as
well as brain tissue TNF-α and IL-6 levels have significantly increased in the
group, to which 1500 mg/kg Mg-NPs was applied orally, significant decreases
have also been observed in brain tissue GPX and SOD levels of the same group. Additionally,
meaningful decreases in brain tissue SOD levels and significant increases in
TNF-α and IL-6 levels have been observed in the group, to which 1500 mg/kg
Al-NP was applied orally. On the other hand, it was found that brain tissue GPX
and SOD levels of the group, to which 2000 mg/kg Mg-NP was applied cutaneous,
have been decreased significantly. Histopathological examinations have also
supported these findings. At the end of the study, it was observed that the toxic
effect of Al and Mg NPs has varied, depending on the application method, dosage
and duration.
References
- 1. Adamcakova-Dodd A, Stebounova LV, O’Shaughnessy PT, et al (2012): Murine pulmonary responses after sub-chronic exposure to aluminum oxide-based nanowhiskers. Part Fibre Toxicol, 9, 22-36.
- 2. Borm PJA, Robbins D, Haubold S, et al (2006): The potential risks of nanomaterials: A review carried out for ECETOC. Part Fibre Toxicol, 3, 11-46.
- 3. Brown DM, Donaldson K, Borm PJ, et al (2004): Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol, 286, 344-353.
- 4. Brown DM, Donaldson K, Stone V (2004): Effects of PM10 in human peripheral blood monocytes and J774 macrophages. Respir Res, 5, 29-41.
- 5. Buzea C, Blandino IIP, Robbie K (2007): Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases, 2, 17-172.
- 6. Donaldson K, Stone V (2003): Current hypotheses on the mechanisms of toxicity of ultrafine particles. Ann 1st Super Sanita, 39, 405-410.
- 7. Flaherty NL, Chandrasekaran A, Peña MPS, et al (2015): Comparative analysis of redox and inflammatory properties of pristine nanomaterials and commonly used semiconductor manufacturing nano-abrasives. Toxicol Lett, 239, 205-215.
- 8. Gelli K, Porika M, Anreddy RNR (2015): Assessment of pulmonary toxicity of MgO nanoparticles in rats. Environ Toxicol, 30, 308-314.
- 9. Khanna P, Nehru B (2007): Antioxidant enzymatic system in neuronal and glial cells enriched fractions of rat brain after aluminum exposure. Cell Mol Neurobiol, 27, 959-969.
- 10. Khanooki TA, Fazilati M (2014): The toxicity effect of magnesium oxide nanoparticles. Adv Environ Biol, 8, 969-973.
- 11. Kiranmai G, Reddy ARN (2012): Antioxidant status in MgO nanoparticle-exposed rats. Toxicol Ind Health, 29, 897-903.
- 12. Koç F, Baydan E (2003): Nanopartiküller. Erc Üniv Sağ Bil Derg, 12, 65-69.
- 13. Long H, Shi T, Borm PJ, et al (2004): ROS-mediated TNF-α and MIP-2 gene expression in alveolar macrophages exposed to pine dust. Part Fibre Toxicol, 1, 3-11.
- 14. Mangalampalli B, Dumala N, Grover P (2017): Acute oral toxicity study of magnesium oxide nanoparticles and microparticles in female albino wistar rats. Regul Toxicol Pharmacol, 90, 170-184.
- 15. Mirshafa A, Nazari M, Jahani D, et al (2018): Size-dependent neurotoxicity of aluminum oxide particles: A comparison between nano- and micrometer size on the basis of mitochondrial oxidative damage. Biol Trace Elem Res, 183, 261-269.
- 16. Noonan CW, Pfau JC, Larson TC, et al (2006): Nested case-control study of autoimmune disease in an asbestos-exposed population. Environ Health Perspect, 114, 1243-1247.
- 17. Oberdörster G, Oberdörster E, Oberdörster J (2005): Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect, 113, 823-839.
- 18. Organisation for Economic Cooperation and Development (OECD) (1987): Acute dermal toxicity. OECD Guideline for testing of chemicals, Test No 402, 24 Feb 1987.
- 19. OECD-Organisation for Economic Cooperation and Development (2001): Acute oral toxicity-Acute toxic class method. OECD Guideline for testing of chemicals, Test No 423, 17 December 2001.
- 20. Ohkawa H, Ohishi N, Yagi K (1979): Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-358. 21. Park EJ, Sim J, Kim Y, et al (2015): A 13-week repeated-dose oral toxicity and bioaccumulation of aluminum oxide nanoparticles in mice. Arch Toxicol, 89, 371-379.
- 22. Pfau JC, Sentissi JJ, Weller G, et al (2005): Assessment of autoimmune responses associated with asbestos exposure in Libby, Montana, USA. Environ Health Perspect, 113, 25-30.
- 23. Prabhakar PV, Reddy UA, Singh SP, et al (2012): Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in wistar rats. J Appl Toxicol, 32, 436-445.
- 24. Risom L, Møller P, Loft S (2005): Oxidative stress-induced DNA damage by particulate air pollution. Mutat Res, 592, 119-137.
- 25. Roco MC (2005): International perspective on government nanotechnology funding in 2005. J Nanopart Res, 7, 707-712.
- 26. Shim KH, Hulme J, Maeng EH, et al (2014): Analysis of zinc oxide nanoparticles binding proteins in rat blood and brain homogenate. Int J Nanomedicine, 9, 217-224.
- 27. Yang ST, Wang T, Dong E, et al (2012): Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure. Toxicol Res, 1, 69-74.
There are 26 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 26, 2019 |
| Published in Issue | Year 2020Volume: 67 Issue: 1 |