Evaluation of Von Willebrand Factor in Dogs with Parvoviral Enteritis

Erman Koral; Mutlu Sevinç

doi:10.33988/auvfd.1438635

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Evaluation of Von Willebrand Factor in Dogs with Parvoviral Enteritis

Year 2024, Accepted Papers, 1 - 6

Erman Koral , Mutlu Sevinç

https://doi.org/10.33988/auvfd.1438635

Abstract

Canine parvoviral enteritis may lead to coagulopathy in various ways. In recent years, the importance of von Willebrand factor has become the focus of more attention in infectious diseases. The aim of this study was to determine the importance of von Willebrand factor level and coagulation parameters in dogs with parvoviral enteritis. The experimental group of this study consisted of 20 dogs with parvoviral enteritis of different breeds aged 2-6 months, and the control group consisted of 10 healthy dogs aged 2-6 months. Blood samples were taken from the dogs included in the experimental group at the 0th hour, 24th hour and before discharge, and only at the 0th hour from the healthy puppies in the control group The 0th and 24th hour von Willebrand factor values of the trial were significantly higher than the control group. The 0th hour Prothrombin Time of the trial was significantly prolonged compared to the control group. The 0th hour Activated Partial Thromboplastin Time value of the trial was significantly prolonged compared to the before-discharge and control group. The before-discharge fibrinogen level was determined to be significantly lower than at 0th and 24th hours of the trial. In conclusion, von Willebrand factor concentrations, which increase significantly in dogs with parvoviral enteritis compared to healty animals, can be evaluated as an acute phase protein. Prolongation of Prothrombin Time and Activated Partial Thromboplastin Time and no significant change in fibrinogen and D-dimer values demonstrated that dogs with parvoviral enteritis were in hypercoagulation state without dissemine intravascular coagulation.

Keywords

acute phase protein, canine, coagulation profile, parvoviral enteritis, von Willebrand factor

Supporting Institution

Selçuk üniversitesi bilimsel araştırma projeleri (BAP)

Project Number

17202064

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