Research Article
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Year 2025, Accepted Papers, 1 - 12

Mohammadjavad Haratizadeh Zahra Moosavi , Hasan Baghshani

https://doi.org/10.33988/auvfd.1661628

Abstract

Project Number

3/58245

References

  • Abdel-Daim MM, Abdellatief SA (2018): Attenuating effects of caffeic acid phenethyl ester and betaine on abamectin-induced hepatotoxicity and nephrotoxicity. Environ Sci Pollut Res, 25, 15909-15917.
  • Abo-Salem OM, El-Edel RH, Harisa G, et al (2009): Experimental diabetic nephropathy can be prevented by propolis: Effect on metabolic disturbances and renal oxidative parameters. Pak J Pharm Sci, 22, 205-210.
  • Ahrari Roodi P, Moosavi Z, Afkhami Goli A, et al (2018): histopathological study of protective effects of honey on subacute toxicity of acrylamide-induced tissue lesions in rats’ brain and liver. Iran J Toxicol, 12, 1-8.
  • Aldahmash BA, El-Nagar DM, Ibrahim KE (2016): Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in Swiss albino mice. Nefrología, 36, 643-652.
  • Alkhalaf MI (2020): Diosmin protects against acrylamide-induced toxicity in rats: Roles of oxidative stress and inflammation. J King Saud Univ Sci, 32, 1510-1515.
  • Arias C, Salazar LA (2023): Ethanolic extract of propolis modulates autophagy-related micrornas in osteoarthritic chondrocytes. Int J Mol Sci, 24, 14767.
  • Babatunde IR, Abdulbasit A, Oladayo MI, et al (2015): Hepatoprotective and pancreatoprotective properties of the ethanolic extract of Nigerian propolis. J Intercult Ethnopharmacol, 4, 102.
  • Banagozar Mohammadi A, Noshad H, Ostadi A, et al. (2015): Successful treatment of acute lethal dose of acrylamide poisoning. Iran J Toxicol, 9, 1284–1286.
  • Bankova V, Galabov A, Antonova D, et al (2014): Chemical composition of propolis extract ACF® and activity against herpes simplex virus. Phytomedicine, 21, 1432-1438.
  • Bankova VS, de Castro SL, Marcucci MC (2000): Propolis: Recent advances in chemistry and plant origin. Apidologie, 31, 3-15.
  • Barangi S, Mehri S, Moosavi Z, et al (2020): Melatonin inhibits benzo(a)pyrene-induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver. Ecotoxicol Environ Saf, 196, 110556.
  • Batoryna M, Semla-Kurzawa M, Zyśk B, et al (2019): Acrylamide-induced alterations in lungs of mice in relation to oxidative stress indicators. J Environ Sci Health B, 54, 745-751.
  • Bazo AP, Rodrigues MAM, Sforcin JM, et al (2002): Protective action of propolis on the rat colon carcinogenesis. Teratog Carcinog Mutagen, 22, 183-194.
  • Benzie IF, Strain JJ (1996): The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP assay. Anal Biochem, 239, 70-76.
  • Berretta AA, Silveira MAD, Cóndor Capcha JM, et al (2020): Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease. Biomedicine & Pharmacotherapy, 131, 110622.
  • Bhadauria M (2012): Propolis prevents hepatorenal injury induced by chronic exposure to carbon tetrachloride. Evid Based Complement Alternat Med, 2012, 235358.
  • Brownlee M (2005): The pathobiology of diabetic complications: A unifying mechanism. Diabetes, 54, 1615-1625.
  • Cebi A (2024): Acrylamide Intake, Its Effects on Tissues and Cancer. 65–93. In: Acrylamide in Food. Academic Press.
  • Chopra S, Pillai K, Husain S, et al (1995): Propolis protects against doxorubicin-induced myocardiopathy in rats. Exp Mol Pathol, 62, 190-198.
  • Da Silva SS, Mizokami SS, Fanti JR, et al (2016): Propolis reduces Leishmania amazonensis-induced inflammation in the liver of BALB/c mice. Parasitol Res, 115, 1557-1566.
  • De Castro, S. (2001): Propolis: Biological and pharmacological activities. Therapeutic uses of this bee-product. ARBS Annu Rev Biomed Sci, 3, 49–83.
  • Elhelaly AE, AlBasher G, Alfarraj S, et al (2019): Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats. Environ Sci Pollut Res, 26, 35151-35162.
  • Ghazi A, Ulaiwi Jary S. (2013): The role of local propolis extract against harmful effects of acrylamide on some male reproductive parameters in rats. QJVMS, 12, 1–7.
  • Gökmen V, Şenyuva HZ (2007): Acrylamide formation is prevented by divalent cations during the Maillard reaction. Food Chem, 103, 196-203.
  • Greenwald RA (2018): Handbook Methods for Oxygen Radical Research. 1st ed. CRC Press, Boca Raton, FL.
  • Havsteen BH (2002): The biochemistry and medical significance of the flavonoids. Pharmacol Ther, 96, 67-202.
  • Hori JI, Zamboni DS, Carrão DB, et al (2013): The inhibition of inflammasome by Brazilian propolis (EPP-AF). eCAM, 2013, 418508.
  • Jiang G, Zhang L, Wang H, et al (2018): Protective effects of a ganoderma atrum polysaccharide against acrylamide induced oxidative damage via a mitochondria mediated intrinsic apoptotic pathway in IEC-6 cells. Food Funct, 9, 1133-1143.
  • Kaya E, Yılmaz S, Ceribasi S (2019): Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats. J Vet Res, 63, 423-431.
  • Khaled S, Makled MN, Nader MA (2022): Protective effects of propolis extract against nicotine-evoked pulmonary and hepatic damage. Environ Sci Pollut Res, 29, 5812-5826.
  • Kitamura H, Saito N, Fujimoto J, et al (2018): Brazilian propolis ethanol extract and its component kaempferol induce myeloid-derived suppressor cells from macrophages of mice in vivo and in vitro. BMC Complement Altern Med, 18, 138.
  • Kumar J, Das S, Teoh SL (2018): Dietary acrylamide and the risks of developing cancer: Facts to ponder. Front Nutr, 5, 323710.
  • Laaroussi H, Bakour M, Ousaaid D, et al (2020): Effect of antioxidant-rich propolis and bee pollen extracts against D-glucose induced type 2 diabetes in rats. Food Res Int, 138, 109802.
  • Lushchak VI (2012): Glutathione homeostasis and functions: Potential targets for medical interventions. J Amino Acids, 2012, 736837.
  • Magnavacca A, Sangiovanni E, Racagni G, et al (2022): The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases. Med Res Rev, 42, 897-945.
  • Marcucci MC, Ferreres F, García-Viguera C, et al (2001): Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol, 74, 105-112.
  • Murad J, Calvi S, Soares A, et al (2002): Effects of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccidioides brasiliensis. J Ethnopharmacol, 79, 331-334.
  • Ni J, Wu Z, Meng J, et al (2017): The neuroprotective effects of brazilian green propolis on neurodegenerative damage in human neuronal SH-SY5Y cells. Oxid Med Cell Longev, 2017, 7984327.
  • Nikbaf-Shandiz M, Tutunchi H, Khoshbaten M, et al (2022): Propolis supplementation in obese patients with non-alcoholic fatty liver disease: Effects on glucose homeostasis, lipid profile, liver function, anthropometric indices and meta-inflammation. Food Funct, 13, 11568-11578.
  • Omar NA, Abu-Almaaty AH, Abd El-Aziz YM, et al (2019): Impacts of Egyptian propolis extract on rat cerebellum intoxicated by aluminum silicate: Histopathological studies. Environ Sci Pollut Res, 26, 22061-22068.
  • Oršolić N, Benković V, Lisičić D, et al (2010): Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan. Med Oncol, 27, 1346-1358.
  • Radwan RA, Mohamed SA, Gebril SM, et al (2023): Toxic effects of acrylamide on human health: A review article. Egypt J Hosp Med, 90, 2929-2931.
  • Sameni HR, Ramhormozi P, Bandegi AR, et al (2016): Effects of ethanol extract of propolis on histopathological changes and anti-oxidant defense of kidney in a rat model for type 1 diabetes mellitus. J Diabetes Investig, 7, 506-513.
  • Sforcin J, Fernandes Jr A, Lopes C, et al (2000): Seasonal effect on Brazilian propolis antibacterial activity. J Ethnopharmacol, 73, 243-249.
  • Sottile J (2004): Regulation of angiogenesis by extracellular matrix. Biochim Biophys Acta Rev Cancer, 1654, 13-22.
  • Sumner A, Asbury A (1974): Acrylamide neuropathy: Selective vulnerability of sensory fibers. Trans Am Neurol Assoc, 99, 79-83.
  • Sumner SC, Williams CC, Snyder RW, et al (2003): Acrylamide: A comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure. Toxicol Sci, 75, 260-270.
  • Tepe Y, Çebi A (2019): Acrylamide in environmental water: A review on sources, exposure, and public health risks. Expo Health, 11, 3-12.
  • Todorova I, Simeonova G, Kyuchukova D, et al (2005): Reference values of oxidative stress parameters (MDA, SOD, CAT) in dogs and cats. Comp Clin Pathol, 13, 190-194.
  • Wang B, Wang X, Yu L, et al (2022): Acrylamide exposure increases cardiovascular risk of general adult population probably by inducing oxidative stress, inflammation, and TGF-β1: A prospective cohort study. Environ Int, 164, 107261.
  • Won Seo K, Park M, Jung Song Y, et al (2003): The protective effects of propolis on hepatic injury and its mechanism. Phytother Res, 17, 250-253.
  • Yousef M, El-Demerdash F (2006): Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicology, 219, 133-141.
  • Zamani E, Shokrzadeh M, Ziar A, et al (2018): Acrylamide attenuated immune tissues’ function via induction of apoptosis and oxidative stress: Protection by l-carnitine. Hum Exp Toxicol, 37, 859-869.
  • Zhu YJ, Zeng T, Zhu YB, et al (2008): Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat. Neurochem Res, 33, 2310-2317.

The evaluation of the protective effect of propolis extract against acrylamide induced injury on the brain, lung, liver, and kidney of mice

Year 2025, Accepted Papers, 1 - 12

Mohammadjavad Haratizadeh Zahra Moosavi , Hasan Baghshani

https://doi.org/10.33988/auvfd.1661628

Abstract

Propolis is a complex chemical compound, made by honeybees, and is known for its varied biological properties, including antitumor, antibacterial, immunomodulatory, antiviral, anti-parasitic, anti-inflammatory, and organ-protective effects. Acrylamide, a water-soluble chemical used in a variety of industrial products and created in hot foods, is a group 2A carcinogen with adverse effects on many body systems. The protective consequences of propolis extract on mice exposed to acrylamide are examined in this research. A total of 28 male C57BL/6 mice were randomly allocated into four treatment groups: control, acrylamide-treated alone, acrylamide plus propolis extract, and propolis-treated extract alone. A propolis extract is obtained by dissolving crude propolis in ethanol. Mice were administered 50 mg/kg acrylamide and 100 mg/kg propolis extract intraperitoneally for 11 days. Histopathological and biochemical analyses, focusing on oxidative stress markers (SOD, GPx, GSH, MDA, FRAP, and catalase), were performed on liver, kidney, lung, and brain tissues. In all tissues studied, acrylamide administration markedly increased oxidative stress and pathological lesions. The group that received propolis extract and acrylamide mitigated these effects, showing a notable decline in tissue lesions and improved oxidative stress parameters. Additionally, propolis extract injection reduced gliosis, edema, pneumonia, necrosis, and other tissue lesions. It also enhanced antioxidant enzyme activities and decreased MDA levels, indicating reduced lipid peroxidation. This research suggests propolis could act as a therapeutic agent to mitigate the harmful effects of acrylamide.

Keywords

Acrylamide Histopathology Mice. Oxidative Stress Propolis extract

Project Number

3/58245

References

  • Abdel-Daim MM, Abdellatief SA (2018): Attenuating effects of caffeic acid phenethyl ester and betaine on abamectin-induced hepatotoxicity and nephrotoxicity. Environ Sci Pollut Res, 25, 15909-15917.
  • Abo-Salem OM, El-Edel RH, Harisa G, et al (2009): Experimental diabetic nephropathy can be prevented by propolis: Effect on metabolic disturbances and renal oxidative parameters. Pak J Pharm Sci, 22, 205-210.
  • Ahrari Roodi P, Moosavi Z, Afkhami Goli A, et al (2018): histopathological study of protective effects of honey on subacute toxicity of acrylamide-induced tissue lesions in rats’ brain and liver. Iran J Toxicol, 12, 1-8.
  • Aldahmash BA, El-Nagar DM, Ibrahim KE (2016): Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in Swiss albino mice. Nefrología, 36, 643-652.
  • Alkhalaf MI (2020): Diosmin protects against acrylamide-induced toxicity in rats: Roles of oxidative stress and inflammation. J King Saud Univ Sci, 32, 1510-1515.
  • Arias C, Salazar LA (2023): Ethanolic extract of propolis modulates autophagy-related micrornas in osteoarthritic chondrocytes. Int J Mol Sci, 24, 14767.
  • Babatunde IR, Abdulbasit A, Oladayo MI, et al (2015): Hepatoprotective and pancreatoprotective properties of the ethanolic extract of Nigerian propolis. J Intercult Ethnopharmacol, 4, 102.
  • Banagozar Mohammadi A, Noshad H, Ostadi A, et al. (2015): Successful treatment of acute lethal dose of acrylamide poisoning. Iran J Toxicol, 9, 1284–1286.
  • Bankova V, Galabov A, Antonova D, et al (2014): Chemical composition of propolis extract ACF® and activity against herpes simplex virus. Phytomedicine, 21, 1432-1438.
  • Bankova VS, de Castro SL, Marcucci MC (2000): Propolis: Recent advances in chemistry and plant origin. Apidologie, 31, 3-15.
  • Barangi S, Mehri S, Moosavi Z, et al (2020): Melatonin inhibits benzo(a)pyrene-induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver. Ecotoxicol Environ Saf, 196, 110556.
  • Batoryna M, Semla-Kurzawa M, Zyśk B, et al (2019): Acrylamide-induced alterations in lungs of mice in relation to oxidative stress indicators. J Environ Sci Health B, 54, 745-751.
  • Bazo AP, Rodrigues MAM, Sforcin JM, et al (2002): Protective action of propolis on the rat colon carcinogenesis. Teratog Carcinog Mutagen, 22, 183-194.
  • Benzie IF, Strain JJ (1996): The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP assay. Anal Biochem, 239, 70-76.
  • Berretta AA, Silveira MAD, Cóndor Capcha JM, et al (2020): Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease. Biomedicine & Pharmacotherapy, 131, 110622.
  • Bhadauria M (2012): Propolis prevents hepatorenal injury induced by chronic exposure to carbon tetrachloride. Evid Based Complement Alternat Med, 2012, 235358.
  • Brownlee M (2005): The pathobiology of diabetic complications: A unifying mechanism. Diabetes, 54, 1615-1625.
  • Cebi A (2024): Acrylamide Intake, Its Effects on Tissues and Cancer. 65–93. In: Acrylamide in Food. Academic Press.
  • Chopra S, Pillai K, Husain S, et al (1995): Propolis protects against doxorubicin-induced myocardiopathy in rats. Exp Mol Pathol, 62, 190-198.
  • Da Silva SS, Mizokami SS, Fanti JR, et al (2016): Propolis reduces Leishmania amazonensis-induced inflammation in the liver of BALB/c mice. Parasitol Res, 115, 1557-1566.
  • De Castro, S. (2001): Propolis: Biological and pharmacological activities. Therapeutic uses of this bee-product. ARBS Annu Rev Biomed Sci, 3, 49–83.
  • Elhelaly AE, AlBasher G, Alfarraj S, et al (2019): Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats. Environ Sci Pollut Res, 26, 35151-35162.
  • Ghazi A, Ulaiwi Jary S. (2013): The role of local propolis extract against harmful effects of acrylamide on some male reproductive parameters in rats. QJVMS, 12, 1–7.
  • Gökmen V, Şenyuva HZ (2007): Acrylamide formation is prevented by divalent cations during the Maillard reaction. Food Chem, 103, 196-203.
  • Greenwald RA (2018): Handbook Methods for Oxygen Radical Research. 1st ed. CRC Press, Boca Raton, FL.
  • Havsteen BH (2002): The biochemistry and medical significance of the flavonoids. Pharmacol Ther, 96, 67-202.
  • Hori JI, Zamboni DS, Carrão DB, et al (2013): The inhibition of inflammasome by Brazilian propolis (EPP-AF). eCAM, 2013, 418508.
  • Jiang G, Zhang L, Wang H, et al (2018): Protective effects of a ganoderma atrum polysaccharide against acrylamide induced oxidative damage via a mitochondria mediated intrinsic apoptotic pathway in IEC-6 cells. Food Funct, 9, 1133-1143.
  • Kaya E, Yılmaz S, Ceribasi S (2019): Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats. J Vet Res, 63, 423-431.
  • Khaled S, Makled MN, Nader MA (2022): Protective effects of propolis extract against nicotine-evoked pulmonary and hepatic damage. Environ Sci Pollut Res, 29, 5812-5826.
  • Kitamura H, Saito N, Fujimoto J, et al (2018): Brazilian propolis ethanol extract and its component kaempferol induce myeloid-derived suppressor cells from macrophages of mice in vivo and in vitro. BMC Complement Altern Med, 18, 138.
  • Kumar J, Das S, Teoh SL (2018): Dietary acrylamide and the risks of developing cancer: Facts to ponder. Front Nutr, 5, 323710.
  • Laaroussi H, Bakour M, Ousaaid D, et al (2020): Effect of antioxidant-rich propolis and bee pollen extracts against D-glucose induced type 2 diabetes in rats. Food Res Int, 138, 109802.
  • Lushchak VI (2012): Glutathione homeostasis and functions: Potential targets for medical interventions. J Amino Acids, 2012, 736837.
  • Magnavacca A, Sangiovanni E, Racagni G, et al (2022): The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases. Med Res Rev, 42, 897-945.
  • Marcucci MC, Ferreres F, García-Viguera C, et al (2001): Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol, 74, 105-112.
  • Murad J, Calvi S, Soares A, et al (2002): Effects of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccidioides brasiliensis. J Ethnopharmacol, 79, 331-334.
  • Ni J, Wu Z, Meng J, et al (2017): The neuroprotective effects of brazilian green propolis on neurodegenerative damage in human neuronal SH-SY5Y cells. Oxid Med Cell Longev, 2017, 7984327.
  • Nikbaf-Shandiz M, Tutunchi H, Khoshbaten M, et al (2022): Propolis supplementation in obese patients with non-alcoholic fatty liver disease: Effects on glucose homeostasis, lipid profile, liver function, anthropometric indices and meta-inflammation. Food Funct, 13, 11568-11578.
  • Omar NA, Abu-Almaaty AH, Abd El-Aziz YM, et al (2019): Impacts of Egyptian propolis extract on rat cerebellum intoxicated by aluminum silicate: Histopathological studies. Environ Sci Pollut Res, 26, 22061-22068.
  • Oršolić N, Benković V, Lisičić D, et al (2010): Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan. Med Oncol, 27, 1346-1358.
  • Radwan RA, Mohamed SA, Gebril SM, et al (2023): Toxic effects of acrylamide on human health: A review article. Egypt J Hosp Med, 90, 2929-2931.
  • Sameni HR, Ramhormozi P, Bandegi AR, et al (2016): Effects of ethanol extract of propolis on histopathological changes and anti-oxidant defense of kidney in a rat model for type 1 diabetes mellitus. J Diabetes Investig, 7, 506-513.
  • Sforcin J, Fernandes Jr A, Lopes C, et al (2000): Seasonal effect on Brazilian propolis antibacterial activity. J Ethnopharmacol, 73, 243-249.
  • Sottile J (2004): Regulation of angiogenesis by extracellular matrix. Biochim Biophys Acta Rev Cancer, 1654, 13-22.
  • Sumner A, Asbury A (1974): Acrylamide neuropathy: Selective vulnerability of sensory fibers. Trans Am Neurol Assoc, 99, 79-83.
  • Sumner SC, Williams CC, Snyder RW, et al (2003): Acrylamide: A comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure. Toxicol Sci, 75, 260-270.
  • Tepe Y, Çebi A (2019): Acrylamide in environmental water: A review on sources, exposure, and public health risks. Expo Health, 11, 3-12.
  • Todorova I, Simeonova G, Kyuchukova D, et al (2005): Reference values of oxidative stress parameters (MDA, SOD, CAT) in dogs and cats. Comp Clin Pathol, 13, 190-194.
  • Wang B, Wang X, Yu L, et al (2022): Acrylamide exposure increases cardiovascular risk of general adult population probably by inducing oxidative stress, inflammation, and TGF-β1: A prospective cohort study. Environ Int, 164, 107261.
  • Won Seo K, Park M, Jung Song Y, et al (2003): The protective effects of propolis on hepatic injury and its mechanism. Phytother Res, 17, 250-253.
  • Yousef M, El-Demerdash F (2006): Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicology, 219, 133-141.
  • Zamani E, Shokrzadeh M, Ziar A, et al (2018): Acrylamide attenuated immune tissues’ function via induction of apoptosis and oxidative stress: Protection by l-carnitine. Hum Exp Toxicol, 37, 859-869.
  • Zhu YJ, Zeng T, Zhu YB, et al (2008): Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat. Neurochem Res, 33, 2310-2317.
There are 54 citations in total.

Details

Primary Language English
Subjects Veterinary Biochemistry, Veterinary Pathology
Journal Section Research Article
Authors

Mohammadjavad Haratizadeh 0000-0003-2181-9253

Zahra Moosavi 0000-0002-8388-2699

Hasan Baghshani 0000-0001-9692-0415

Project Number 3/58245
Early Pub Date July 24, 2025
Publication Date
Submission Date March 20, 2025
Acceptance Date July 14, 2025
Published in Issue Year 2025Accepted Papers

Cite

APA Haratizadeh, M., Moosavi, Z., & Baghshani, H. (2025). The evaluation of the protective effect of propolis extract against acrylamide induced injury on the brain, lung, liver, and kidney of mice. Ankara Üniversitesi Veteriner Fakültesi Dergisi1-12. https://doi.org/10.33988/auvfd.1661628
AMA Haratizadeh M, Moosavi Z, Baghshani H. The evaluation of the protective effect of propolis extract against acrylamide induced injury on the brain, lung, liver, and kidney of mice. Ankara Univ Vet Fak Derg. Published online July 1, 2025:1-12. doi:10.33988/auvfd.1661628
Chicago Haratizadeh, Mohammadjavad, Zahra Moosavi, and Hasan Baghshani. “The Evaluation of the Protective Effect of Propolis Extract Against Acrylamide Induced Injury on the Brain, Lung, Liver, and Kidney of Mice”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, July (July 2025), 1-12. https://doi.org/10.33988/auvfd.1661628.
EndNote Haratizadeh M, Moosavi Z, Baghshani H (July 1, 2025) The evaluation of the protective effect of propolis extract against acrylamide induced injury on the brain, lung, liver, and kidney of mice. Ankara Üniversitesi Veteriner Fakültesi Dergisi 1–12.
IEEE M. Haratizadeh, Z. Moosavi, and H. Baghshani, “The evaluation of the protective effect of propolis extract against acrylamide induced injury on the brain, lung, liver, and kidney of mice”, Ankara Univ Vet Fak Derg, pp. 1–12, July 2025, doi: 10.33988/auvfd.1661628.
ISNAD Haratizadeh, Mohammadjavad et al. “The Evaluation of the Protective Effect of Propolis Extract Against Acrylamide Induced Injury on the Brain, Lung, Liver, and Kidney of Mice”. Ankara Üniversitesi Veteriner Fakültesi Dergisi. July 2025. 1-12. https://doi.org/10.33988/auvfd.1661628.
JAMA Haratizadeh M, Moosavi Z, Baghshani H. The evaluation of the protective effect of propolis extract against acrylamide induced injury on the brain, lung, liver, and kidney of mice. Ankara Univ Vet Fak Derg. 2025;:1–12.
MLA Haratizadeh, Mohammadjavad et al. “The Evaluation of the Protective Effect of Propolis Extract Against Acrylamide Induced Injury on the Brain, Lung, Liver, and Kidney of Mice”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2025, pp. 1-12, doi:10.33988/auvfd.1661628.
Vancouver Haratizadeh M, Moosavi Z, Baghshani H. The evaluation of the protective effect of propolis extract against acrylamide induced injury on the brain, lung, liver, and kidney of mice. Ankara Univ Vet Fak Derg. 2025:1-12.