Research Article
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Year 2018, Volume: 65 Issue: 4, 341 - 348, 09.11.2018

Hikmet Keleş , Mehmet Fatih Bozkurt Aykut Ulucan Hasan Hüseyin Demirel Hayati Yüksel Erkan Karadaş Ayhan Özkul

https://doi.org/10.1501/Vetfak_0000002866
Cited By: 1

Abstract

References

  • 1. Ambrosio V, Borzacchiello G, Bruno F, et al. (2001): Uroplakin expression in the urothelial tumors of cows. Vet Pathol, 38, 657-660.
  • 2. Aruoma OI, Halliwell B (1995): 13-DNA Damage by Free Radicals: Carcinogenic Implications. 199-214. In: D Blake, G Paul (Eds), Immunopharmacology of Free Radical Species. Academic Press, London.
  • 3. Campo MS, Jarrett WF, Barron R, et al. (1992): Association of bovine papillomavirus type 2 and bracken fern with bladder cancer in cattle. Cancer Res, 52, 6898- 6904.
  • 4. Carvalho T, Naydan D, Nunes T, et al. (2009): Immunohistochemical evaluation of vascular urinary bladder tumors from cows with enzootic hematuria. Vet Pathol, 46, 211-221.
  • 5. Chang A, Hammond TG, Sun TT, et al. (1994): Permeability properties of the mammalian bladder apical membrane. Am J Physiol, 267, 1483-1492.
  • 6. Cohen GM (1997): Caspases: the executioners of apoptosis. Biochem J, 326, 1-16.
  • 7. Dawra RK, Sharma OP (2001): Enzootic bovine haematuria- Past, Present and Future. Vet Bull, 71, 1R- 27R.
  • 8. Dong Z, Staroselsky AH, Qi X, et al. (1994): Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res, 54, 789-793.
  • 9. Forrester K, Ambs S, Lupold SE, et al. (1996): Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci USA, 93, 2442-2447.
  • 10. Geller DA, Billiar TR (1998): Molecular biology of nitric oxide synthases. Cancer Metastasis Rev, 17, 7-23.
  • 11. Hahm KB, Lee KJ, Choi SY, et al. (1997): Possibility of chemoprevention by the eradication of Helicobacter pylori: oxidative DNA damage and apoptosis in H. pylori infection. Am J Gastroenterol, 92, 1853-1857.
  • 12. Hayashi H, Kuwahara M, Fujisaki N, et al. (2001): Immunohistochemical findings of nitric oxide synthase expression in urothelial transitional cell carcinoma including dysplasia. Oncol Rep, 8, 1275-1279.
  • 13. Hu P, Meyers S, Liang F-X, et al. (2002): Role of membrane proteins in permeability barrier function:uroplakin ablation elevates urothelial permeability. Am J Physiol Renal Physiol, 283, F1200-1207.
  • 14. Jadeski LC, Chakraborty C, Lala PK (2002): Role of nitric oxide in tumour progression with special reference to a murine breast cancer model. Can J Physiol Pharmacol, 80, 125-135.
  • 15. Keles I, Bozkurt MF, Cemek M, et al. (2014): Prevention of cyclophosphamide-induced hemorrhagic cystitis by resveratrol: a comparative experimental study with mesna. Int Urol Nephrol, 46, 2301-2310.
  • 16. Kiang JG, Bowman PD, Wu BW, et al. (2004): Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70. J Appl Physiol, 97, 564-569.
  • 17. Klotz T, Bloch W, Volberg C, et al. (1998): Selective expression of inducible nitric oxide synthase in human prostate carcinoma. Cancer, 82, 1897-1903.
  • 18. Lobban ED, Smith BA, Hall GD, et al. (1998): Uroplakin gene expression by normal and neoplastic human urothelium. Am J Pathol, 153, 1957-1967.
  • 19. Marletta MA, Yoon PS, Iyengar R, et al. (1988): Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry (Mosc), 27, 8706-8711.
  • 20. Matsumoto M, Furihata M, Kurabayashi A, et al. (2003): Association between inducible nitric oxide synthase expression and p53 status in human esophageal squamous cell carcinoma. Oncology, 64, 90-96.
  • 21. McCarthy NJ, Whyte MK, Gilbert CS, et al. (1997): Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl- 2 homologue Bak. J Cell Biol, 136, 215-227.
  • 22. Moll R, Wu XR, Lin JH, et al. (1995): Uroplakins, specific membrane proteins of urothelial umbrella cells, as histological markers of metastatic transitional cell carcinomas. Am J Pathol, 147, 1383-1397.
  • 23. Moll UM, Ostermeyer AG, Haladay R, et al. (1996): Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol Cell Biol, 16, 1126-1137.
  • 24. Özkul IA, Aydin Y (1996): Tumours of the urinary bladder in cattle and water buffalo in the Black Sea region of Turkey. Br Vet J, 152, 473-475.
  • 25. Peña-Llopis S, Ferrando MD, Peña JB (2003): Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine. Aquat Toxicol Amst Neth, 65, 337-360.
  • 26. Perutz MF (1996): Blood. Taking the pressure off. Nature, 380, 205-206.
  • 27. Peter S (1993): Ultrastructure of the Urothelium. 23-33. In: P Rathert, S Roth, M Soloway (Eds), Urinary Cytology. 2nd Ed. Springer-Verlag, Berlin-Heidelberg.
  • 28. Qu L, Huang S, Baltzis D, et al. (2004): Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev, 18, 261-277.
  • 29. Ramos-Vara JA, Miller MA, Boucher M, et al. (2003): Immunohistochemical detection of uroplakin III, cytokeratin 7, and cytokeratin 20 in canine urothelial tumors. Vet Pathol, 40, 55-62.
  • 30. Romih R, Korosec P, Sedmak B, et al. (2008): Mitochondrial localization of nitric oxide synthase in partially differentiated urothelial cells of urinary bladder lesions. Appl Immunohistochem Mol Morphol AIMM, 16, 239-245.
  • 31. Roperto S, Borzacchiello G, Brun R, et al. (2010): A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder. J Comp Pathol, 142, 95-108.
  • 32. Schlamp CL, Poulsen GL, Nork TM, et al. (1997): Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells. J Natl Cancer Inst, 89, 1530-1536.
  • 33. Stamler JS (1994): Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell, 78, 931-936.
  • 34. Sun TT, Liang FX, Wu XR (1999): Uroplakins as markers of urothelial differentiation. 7-18. In: LS Baskin, SW Hayward (Eds), Advances in Bladder Research. Plenum Publishers Corporation, New York.
  • 35. Thomsen LL, Miles DW (1998): Role of nitric oxide in tumour progression: Lessons from human tumours. Cancer Metastasis Rev, 17, 107-118.
  • 36. Thomsen LL, Scott JM, Topley P, et al. (1997): Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res, 57, 3300-3304.
  • 37. Weinberg RA (2007): The Biology of Cancer. 307-356. Garlan Science, New York.
  • 38. Wiseman H, Halliwell B (1996): Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J, 313, 17-29.
  • 39. Wolf H, Haeckel C, Roessner A (2000): Inducible nitric oxide synthase expression in human urinary bladder cancer. Virchows Arch Int J Pathol, 437, 662-666.
  • 40. Wu LL, Chiou CC, Chang PY, et al. (2004): Urinary 8- OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta, 339, 1-9.
  • 41. Wu XR, Lin JH, Walz T, et al. (1994): Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem, 269, 13716-13724.
  • 42. Xu W, Liu LZ, Loizidou M, et al. (2002): The role of nitric oxide in cancer. Cell Res, 12, 311-320.
  • 43. Yu J, Manabe M, Wu XR, et al. (1990): Uroplakin I: a 27- kD protein associated with the asymmetric unit membrane of mammalian urothelium. J Cell Biol, 111, 1207-1216.
  • 44. Zhang L, Yu D, Hu M, et al. (2000): Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res, 60, 3655-3661.
  • 45. Zheng JH, Viacava Follis A, Kriwacki RW, et al. (2016): Discoveries and controversies in BCL-2 protein-mediated apoptosis. FEBS J, 283, 2690-2700.

The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III

Year 2018, Volume: 65 Issue: 4, 341 - 348, 09.11.2018

Hikmet Keleş , Mehmet Fatih Bozkurt Aykut Ulucan Hasan Hüseyin Demirel Hayati Yüksel Erkan Karadaş Ayhan Özkul

https://doi.org/10.1501/Vetfak_0000002866
Cited By: 1

Abstract

Changes in uroplakin secretion in the urothelium leads a gradual ability lost in neoplastic conditions. Urothelium is
one of the target regions where nitric oxide can damage. Therefore, in this study, the presence of iNOS and UPIII were investigated in
bovine enzootic hematuria cases. The results were supported by comparing them with those achieved by critical markers for malignancy
of tumor such as caspase 3, Bax, p53, PCNA, and VEGF. The presence of 8-OHDG, a good marker for oxidative DNA damage, was
also investigated. For this purpose, urinary bladders with enzootic hematuria were collected from the slaughterhouses. In
histopathological examinations, neoplastic, pre-neoplastic, and inflammatory lesions were observed in these urinary bladders. In
immunohistochemical examinations, iNOS reacts as negative in the UPIII positive healthy urothelium which preserves the structure of
AUM. On the other hand positive reaction has been observed in AUM modified and UPIII negative urothelium. In these cases, as an
indicator of oxidative damage, 8-OHdG positivity was observed in the UPIII negative and iNOS positive areas. Additionally, increased
cell proliferation, decreased apoptosis as well as p53 disorganization were clearly observed in most of the cases. Thus, the active role
of nitric oxide, as a free radical derivative, has been shown in the enzootic hematuria cases of cattle.  

Keywords

Bovine enzootic hematuria iNOS nitric oxide urinary bladder uroplakin III

References

  • 1. Ambrosio V, Borzacchiello G, Bruno F, et al. (2001): Uroplakin expression in the urothelial tumors of cows. Vet Pathol, 38, 657-660.
  • 2. Aruoma OI, Halliwell B (1995): 13-DNA Damage by Free Radicals: Carcinogenic Implications. 199-214. In: D Blake, G Paul (Eds), Immunopharmacology of Free Radical Species. Academic Press, London.
  • 3. Campo MS, Jarrett WF, Barron R, et al. (1992): Association of bovine papillomavirus type 2 and bracken fern with bladder cancer in cattle. Cancer Res, 52, 6898- 6904.
  • 4. Carvalho T, Naydan D, Nunes T, et al. (2009): Immunohistochemical evaluation of vascular urinary bladder tumors from cows with enzootic hematuria. Vet Pathol, 46, 211-221.
  • 5. Chang A, Hammond TG, Sun TT, et al. (1994): Permeability properties of the mammalian bladder apical membrane. Am J Physiol, 267, 1483-1492.
  • 6. Cohen GM (1997): Caspases: the executioners of apoptosis. Biochem J, 326, 1-16.
  • 7. Dawra RK, Sharma OP (2001): Enzootic bovine haematuria- Past, Present and Future. Vet Bull, 71, 1R- 27R.
  • 8. Dong Z, Staroselsky AH, Qi X, et al. (1994): Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res, 54, 789-793.
  • 9. Forrester K, Ambs S, Lupold SE, et al. (1996): Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci USA, 93, 2442-2447.
  • 10. Geller DA, Billiar TR (1998): Molecular biology of nitric oxide synthases. Cancer Metastasis Rev, 17, 7-23.
  • 11. Hahm KB, Lee KJ, Choi SY, et al. (1997): Possibility of chemoprevention by the eradication of Helicobacter pylori: oxidative DNA damage and apoptosis in H. pylori infection. Am J Gastroenterol, 92, 1853-1857.
  • 12. Hayashi H, Kuwahara M, Fujisaki N, et al. (2001): Immunohistochemical findings of nitric oxide synthase expression in urothelial transitional cell carcinoma including dysplasia. Oncol Rep, 8, 1275-1279.
  • 13. Hu P, Meyers S, Liang F-X, et al. (2002): Role of membrane proteins in permeability barrier function:uroplakin ablation elevates urothelial permeability. Am J Physiol Renal Physiol, 283, F1200-1207.
  • 14. Jadeski LC, Chakraborty C, Lala PK (2002): Role of nitric oxide in tumour progression with special reference to a murine breast cancer model. Can J Physiol Pharmacol, 80, 125-135.
  • 15. Keles I, Bozkurt MF, Cemek M, et al. (2014): Prevention of cyclophosphamide-induced hemorrhagic cystitis by resveratrol: a comparative experimental study with mesna. Int Urol Nephrol, 46, 2301-2310.
  • 16. Kiang JG, Bowman PD, Wu BW, et al. (2004): Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70. J Appl Physiol, 97, 564-569.
  • 17. Klotz T, Bloch W, Volberg C, et al. (1998): Selective expression of inducible nitric oxide synthase in human prostate carcinoma. Cancer, 82, 1897-1903.
  • 18. Lobban ED, Smith BA, Hall GD, et al. (1998): Uroplakin gene expression by normal and neoplastic human urothelium. Am J Pathol, 153, 1957-1967.
  • 19. Marletta MA, Yoon PS, Iyengar R, et al. (1988): Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry (Mosc), 27, 8706-8711.
  • 20. Matsumoto M, Furihata M, Kurabayashi A, et al. (2003): Association between inducible nitric oxide synthase expression and p53 status in human esophageal squamous cell carcinoma. Oncology, 64, 90-96.
  • 21. McCarthy NJ, Whyte MK, Gilbert CS, et al. (1997): Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl- 2 homologue Bak. J Cell Biol, 136, 215-227.
  • 22. Moll R, Wu XR, Lin JH, et al. (1995): Uroplakins, specific membrane proteins of urothelial umbrella cells, as histological markers of metastatic transitional cell carcinomas. Am J Pathol, 147, 1383-1397.
  • 23. Moll UM, Ostermeyer AG, Haladay R, et al. (1996): Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol Cell Biol, 16, 1126-1137.
  • 24. Özkul IA, Aydin Y (1996): Tumours of the urinary bladder in cattle and water buffalo in the Black Sea region of Turkey. Br Vet J, 152, 473-475.
  • 25. Peña-Llopis S, Ferrando MD, Peña JB (2003): Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine. Aquat Toxicol Amst Neth, 65, 337-360.
  • 26. Perutz MF (1996): Blood. Taking the pressure off. Nature, 380, 205-206.
  • 27. Peter S (1993): Ultrastructure of the Urothelium. 23-33. In: P Rathert, S Roth, M Soloway (Eds), Urinary Cytology. 2nd Ed. Springer-Verlag, Berlin-Heidelberg.
  • 28. Qu L, Huang S, Baltzis D, et al. (2004): Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev, 18, 261-277.
  • 29. Ramos-Vara JA, Miller MA, Boucher M, et al. (2003): Immunohistochemical detection of uroplakin III, cytokeratin 7, and cytokeratin 20 in canine urothelial tumors. Vet Pathol, 40, 55-62.
  • 30. Romih R, Korosec P, Sedmak B, et al. (2008): Mitochondrial localization of nitric oxide synthase in partially differentiated urothelial cells of urinary bladder lesions. Appl Immunohistochem Mol Morphol AIMM, 16, 239-245.
  • 31. Roperto S, Borzacchiello G, Brun R, et al. (2010): A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder. J Comp Pathol, 142, 95-108.
  • 32. Schlamp CL, Poulsen GL, Nork TM, et al. (1997): Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells. J Natl Cancer Inst, 89, 1530-1536.
  • 33. Stamler JS (1994): Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell, 78, 931-936.
  • 34. Sun TT, Liang FX, Wu XR (1999): Uroplakins as markers of urothelial differentiation. 7-18. In: LS Baskin, SW Hayward (Eds), Advances in Bladder Research. Plenum Publishers Corporation, New York.
  • 35. Thomsen LL, Miles DW (1998): Role of nitric oxide in tumour progression: Lessons from human tumours. Cancer Metastasis Rev, 17, 107-118.
  • 36. Thomsen LL, Scott JM, Topley P, et al. (1997): Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res, 57, 3300-3304.
  • 37. Weinberg RA (2007): The Biology of Cancer. 307-356. Garlan Science, New York.
  • 38. Wiseman H, Halliwell B (1996): Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J, 313, 17-29.
  • 39. Wolf H, Haeckel C, Roessner A (2000): Inducible nitric oxide synthase expression in human urinary bladder cancer. Virchows Arch Int J Pathol, 437, 662-666.
  • 40. Wu LL, Chiou CC, Chang PY, et al. (2004): Urinary 8- OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta, 339, 1-9.
  • 41. Wu XR, Lin JH, Walz T, et al. (1994): Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem, 269, 13716-13724.
  • 42. Xu W, Liu LZ, Loizidou M, et al. (2002): The role of nitric oxide in cancer. Cell Res, 12, 311-320.
  • 43. Yu J, Manabe M, Wu XR, et al. (1990): Uroplakin I: a 27- kD protein associated with the asymmetric unit membrane of mammalian urothelium. J Cell Biol, 111, 1207-1216.
  • 44. Zhang L, Yu D, Hu M, et al. (2000): Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res, 60, 3655-3661.
  • 45. Zheng JH, Viacava Follis A, Kriwacki RW, et al. (2016): Discoveries and controversies in BCL-2 protein-mediated apoptosis. FEBS J, 283, 2690-2700.
There are 45 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Research Article
Authors

Hikmet Keleş

Mehmet Fatih Bozkurt

Aykut Ulucan

Hasan Hüseyin Demirel

Hayati Yüksel

Erkan Karadaş

Ayhan Özkul

Publication Date November 9, 2018
Published in Issue Year 2018Volume: 65 Issue: 4

Cite

APA Keleş, H., Bozkurt, M. F., Ulucan, A., Demirel, H. H., et al. (2018). The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 65(4), 341-348. https://doi.org/10.1501/Vetfak_0000002866
AMA Keleş H, Bozkurt MF, Ulucan A, Demirel HH, Yüksel H, Karadaş E, Özkul A. The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Univ Vet Fak Derg. November 2018;65(4):341-348. doi:10.1501/Vetfak_0000002866
Chicago Keleş, Hikmet, Mehmet Fatih Bozkurt, Aykut Ulucan, Hasan Hüseyin Demirel, Hayati Yüksel, Erkan Karadaş, and Ayhan Özkul. “The Role of Inducible Nitric Oxide Synthase in Urinary Bladders of Cattle With Enzootic Hematuria and Its Struggle With Uroplakin III”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 65, no. 4 (November 2018): 341-48. https://doi.org/10.1501/Vetfak_0000002866.
EndNote Keleş H, Bozkurt MF, Ulucan A, Demirel HH, Yüksel H, Karadaş E, Özkul A (November 1, 2018) The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Üniversitesi Veteriner Fakültesi Dergisi 65 4 341–348.
IEEE H. Keleş, M. F. Bozkurt, A. Ulucan, H. H. Demirel, H. Yüksel, E. Karadaş, and A. Özkul, “The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III”, Ankara Univ Vet Fak Derg, vol. 65, no. 4, pp. 341–348, 2018, doi: 10.1501/Vetfak_0000002866.
ISNAD Keleş, Hikmet et al. “The Role of Inducible Nitric Oxide Synthase in Urinary Bladders of Cattle With Enzootic Hematuria and Its Struggle With Uroplakin III”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 65/4 (November 2018), 341-348. https://doi.org/10.1501/Vetfak_0000002866.
JAMA Keleş H, Bozkurt MF, Ulucan A, Demirel HH, Yüksel H, Karadaş E, Özkul A. The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Univ Vet Fak Derg. 2018;65:341–348.
MLA Keleş, Hikmet et al. “The Role of Inducible Nitric Oxide Synthase in Urinary Bladders of Cattle With Enzootic Hematuria and Its Struggle With Uroplakin III”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 65, no. 4, 2018, pp. 341-8, doi:10.1501/Vetfak_0000002866.
Vancouver Keleş H, Bozkurt MF, Ulucan A, Demirel HH, Yüksel H, Karadaş E, Özkul A. The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Univ Vet Fak Derg. 2018;65(4):341-8.

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https://doi.org/10.31196/huvfd.508994