Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar

Damla Arslan Acaröz; Nalan Baysu Sözbilir

doi:10.33988/auvfd.561824

Research Article

Year 2020, Volume: 67 Issue: 2, 137 - 142, 03.03.2020

Damla Arslan Acaröz , Nalan Baysu Sözbilir

https://doi.org/10.33988/auvfd.561824

Cited By: 11

Abstract

References

1. Acaroz U, Arslan-Acaroz D, Gurler Z (2016): Immunoassay Development for the Detection of Antibiotic Residues in Foods. Kocatepe Vet J, 9, 122–126.
2. Acaroz U, Gurler Z, Kara R, et al (2018): Presence of Salmonella spp. in Chicken Meat and Giblets Marketed in Afyonkarahisar Province. Kocatepe Vet J, 11, 1–5.
3. Anonymus (2019): Kalıntı İzleme Planı. Available at https://www.tarimorman.gov.tr/Konular/ Gida-Ve-Yem-Hizmetleri/Gida-Hizmetleri/Kalinti-Izleme. (Accessed Sept 09, 2019).
4. Aslam B, Kousar N, Javed I, et al (2016): Determination of Enrofloxacin Residues in Commercial Broilers Using High Performance Liquid Chromatography. Int J Food Prop, 19, 2463–2470.
5. Attari VE, Abbasi MM, Abedimanesh N, et al (2014): Investigation of Enrofloxacin and Chloramphenicol Residues in Broiler Chickens Carcasses Collected From Local Markets of Tabriz, Northwestern Iran. Heal Promot Perspect, 4, 151–157.
6. Bonassa KPD, Miragliotta MY, Simas RC, et al (2017): Tissue depletion study of enrofloxacin and its metabolite ciprofloxacin in broiler chickens after oral administration of a new veterinary pharmaceutical formulation containing enrofloxacin. Food Chem Toxicol, 105, 8-13.
7. EU COMMISSION REGULATION (2010): No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin.
8. Fàbrega A, Sánchez-Céspedes J, Soto S, et al (2008): Quinolone resistance in the food chain. Int J Antimicrob Agents, 31, 307-315.
9. Faten SH, Mousa MM, Mahomud AH, et al (2016): Ciprofloxacin residues in chicken and turkey carcasses. Benha Vet Med J, 31, 136-143.
10. Gbylik-Sikorska M, Posyniak A, Sniegocki T, et al (2016): Influence of enrofloxacin traces in drinking water to doxycycline tissue pharmacokinetics in healthy and infected by Mycoplasma gallisepticum broiler chickens. Food Chem Toxicol, 90, 123-129.
11. Kaufmann A, Butcher P, Maden K (2012): Determination of aminoglycoside residues by liquid chromatography and tandem mass spectrometry in a variety of matrices. Anal Chim Acta, 711, 46-53.
12. Kirbis A, Marinsek J, Flajs VC (2005): Introduction of the HPLC method for the determination of quinolone residues in various muscle tissues. Biomed Chromatogr, 19, 259-265.
13. Kirrella GAK, Deeb AMM, Abdallah RMI (2017): Safety of frozen liver for human consumption. J Food Drug Anal, 25, 520-524.
14. Lolo M, Pedreira S, Miranda JM, et al (2006): Effect of cooking on enrofloxacin residues in chicken tissue. Food Addit Contam, 23, 988–993.
15. Magdelaine P, Spiess MP, Valceschini E (2008): Poultry meat consumption trends in Europe. Worlds Poult Sci J, 64, 53–63.
16. Martins MT, Barreto F, Hoff RB, et al (2015): Determination of quinolones and fluoroquinolones, tetracyclines and sulfonamides in bovine, swine and poultry liver using LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 32, 333–341.
17. Metli M, Yakar Y, Tekeli Y (2015): Determination of Antibiotic Residues in Chicken Liver by Liquid Chromatography-Tandem Mass Spectrometry. Adıyaman Uni J Sci, 5, 120-131.
18. Moema D, Nindi MM, Dube S (2012): Development of a dispersive liquid-liquid microextraction method for the determination of fluoroquinolones in chicken liver by high performance liquid chromatography. Anal Chim Acta, 730, 80-86.
19. Naeem M, Khan K, Rafiq S (2006): Determination of Residues of Quinolones in Poultry Products by High Pressure Liquid Chromatography. J Appl Sci, 6, 373-379.
20. Nizamlıoğlu F, Aydın H (2012): Quinolone antibiotic residues in raw milk and chicken liver in Konya. Eurasian J Vet Sci, 28, 154-158.
21. Panzenhagen PHN, Aguiar WS, Gouvêa R, et al (2016): Investigation of enrofloxacin residues in broiler tissues using ELISA and LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 33, 639–643.
22. Rezaee N, Rafie S, Javadi A, et al (2018): Determination of Enrofloxacin and Ciprofloxacin Residues in Five Different Kinds of Chicken Tissues by Dispersive Liquid – Liquid Microextraction Coupled with HPLC. Iran J Pharm Res, 17, 1182–1190.
23. Salehzadeh F, Salehzadeh A, Rokni N, et al (2007): Enrofloxacin Residue in Chicken Tissues from Tehran Slaughterhouses in Iran. Pakistan J Nutr, 6, 409-413.
24. San Martin B, Cornejo J, Lapierre L, et al (2010): Withdrawal time of four pharmaceutical formulations of enrofloxacin in poultry according to different maximum residues limits. J Vet Pharmacol Ther, 33, 246–251.
25. Sarker YA, Hasan MM, Paul TK, et al (2018): Screening of antibiotic residues in chicken meat in Bangladesh by thin layer chromatography. J Adv Vet Anim Res, 5, 140.
26. Sattar S, Hassan MM, Islam SKMA, et al (2014): Antibiotic residues in broiler and layer meat in Chittagong district of Bangladesh. Vet World, 7, 738-743.
27. Sultan IA (2014): Detection of Enrofloxacin Residue in Livers of Livestock Animals Obtained from a Slaughterhouse in Mosul City. J Vet Sci Technol, 5, 2-4.
28. Toldrá F, Reig M (2006): Methods for rapid detection of chemical and veterinary drug residues in animal foods. Trends Food Sci Technol, 17, 482–489.
29. Trouchon T, Lefebvre S (2017): A Review of Enrofloxacin for Veterinary Use. Open J Vet Med, 6, 40–58.
30. Younus M, Abbas T, Zafar M, et al (2017): Quantification of enrofloxacin residues in broiler chicken tissues using competitive enzyme-linked immunosorbent assay. Indian J Anim Sci, 87, 659–661.

Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar

Year 2020, Volume: 67 Issue: 2, 137 - 142, 03.03.2020

Damla Arslan Acaröz , Nalan Baysu Sözbilir

https://doi.org/10.33988/auvfd.561824

Cited By: 11

Abstract

Antibiotic residues can remain in animal source foods, mainly in the liver. Enrofloxacin (ENR) is a synthetic fluoroquinolone antimicrobial agent which is extensively used to treat bacterial infections in poultry. This study aimed to evaluate ENR and its main metabolite ciprofloxacin (CIP) occurrence in 100 chicken livers marketed Afyonkarahisar, Turkey. Chicken liver samples were analyzed by LC-MS/MS method with limits of detection for 1.17 μg/kg (ENR) and 1.24 μg/kg (CIP). ENR and CIP were detected in 39% and in 31% of samples, respectively. However, the total sum of both antibiotic residue levels was found to be far below the established maximum residue level (200 μg/kg) in all of chicken liver samples. In conclusion, according to the results of this study, chicken livers marketed in Afyonkarahisar city are safe for public health regarding ENR and CIP residues. Nonetheless, periodical control of chicken liver is advised due to the high incidence of these antibiotics.

Keywords

Antibiotic residue, chicken liver, ciprofloxacin, enrofloxacin, LC-MS/MS

References

1. Acaroz U, Arslan-Acaroz D, Gurler Z (2016): Immunoassay Development for the Detection of Antibiotic Residues in Foods. Kocatepe Vet J, 9, 122–126.
2. Acaroz U, Gurler Z, Kara R, et al (2018): Presence of Salmonella spp. in Chicken Meat and Giblets Marketed in Afyonkarahisar Province. Kocatepe Vet J, 11, 1–5.
3. Anonymus (2019): Kalıntı İzleme Planı. Available at https://www.tarimorman.gov.tr/Konular/ Gida-Ve-Yem-Hizmetleri/Gida-Hizmetleri/Kalinti-Izleme. (Accessed Sept 09, 2019).
4. Aslam B, Kousar N, Javed I, et al (2016): Determination of Enrofloxacin Residues in Commercial Broilers Using High Performance Liquid Chromatography. Int J Food Prop, 19, 2463–2470.
5. Attari VE, Abbasi MM, Abedimanesh N, et al (2014): Investigation of Enrofloxacin and Chloramphenicol Residues in Broiler Chickens Carcasses Collected From Local Markets of Tabriz, Northwestern Iran. Heal Promot Perspect, 4, 151–157.
6. Bonassa KPD, Miragliotta MY, Simas RC, et al (2017): Tissue depletion study of enrofloxacin and its metabolite ciprofloxacin in broiler chickens after oral administration of a new veterinary pharmaceutical formulation containing enrofloxacin. Food Chem Toxicol, 105, 8-13.
7. EU COMMISSION REGULATION (2010): No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin.
8. Fàbrega A, Sánchez-Céspedes J, Soto S, et al (2008): Quinolone resistance in the food chain. Int J Antimicrob Agents, 31, 307-315.
9. Faten SH, Mousa MM, Mahomud AH, et al (2016): Ciprofloxacin residues in chicken and turkey carcasses. Benha Vet Med J, 31, 136-143.
10. Gbylik-Sikorska M, Posyniak A, Sniegocki T, et al (2016): Influence of enrofloxacin traces in drinking water to doxycycline tissue pharmacokinetics in healthy and infected by Mycoplasma gallisepticum broiler chickens. Food Chem Toxicol, 90, 123-129.
11. Kaufmann A, Butcher P, Maden K (2012): Determination of aminoglycoside residues by liquid chromatography and tandem mass spectrometry in a variety of matrices. Anal Chim Acta, 711, 46-53.
12. Kirbis A, Marinsek J, Flajs VC (2005): Introduction of the HPLC method for the determination of quinolone residues in various muscle tissues. Biomed Chromatogr, 19, 259-265.
13. Kirrella GAK, Deeb AMM, Abdallah RMI (2017): Safety of frozen liver for human consumption. J Food Drug Anal, 25, 520-524.
14. Lolo M, Pedreira S, Miranda JM, et al (2006): Effect of cooking on enrofloxacin residues in chicken tissue. Food Addit Contam, 23, 988–993.
15. Magdelaine P, Spiess MP, Valceschini E (2008): Poultry meat consumption trends in Europe. Worlds Poult Sci J, 64, 53–63.
16. Martins MT, Barreto F, Hoff RB, et al (2015): Determination of quinolones and fluoroquinolones, tetracyclines and sulfonamides in bovine, swine and poultry liver using LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 32, 333–341.
17. Metli M, Yakar Y, Tekeli Y (2015): Determination of Antibiotic Residues in Chicken Liver by Liquid Chromatography-Tandem Mass Spectrometry. Adıyaman Uni J Sci, 5, 120-131.
18. Moema D, Nindi MM, Dube S (2012): Development of a dispersive liquid-liquid microextraction method for the determination of fluoroquinolones in chicken liver by high performance liquid chromatography. Anal Chim Acta, 730, 80-86.
19. Naeem M, Khan K, Rafiq S (2006): Determination of Residues of Quinolones in Poultry Products by High Pressure Liquid Chromatography. J Appl Sci, 6, 373-379.
20. Nizamlıoğlu F, Aydın H (2012): Quinolone antibiotic residues in raw milk and chicken liver in Konya. Eurasian J Vet Sci, 28, 154-158.
21. Panzenhagen PHN, Aguiar WS, Gouvêa R, et al (2016): Investigation of enrofloxacin residues in broiler tissues using ELISA and LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 33, 639–643.
22. Rezaee N, Rafie S, Javadi A, et al (2018): Determination of Enrofloxacin and Ciprofloxacin Residues in Five Different Kinds of Chicken Tissues by Dispersive Liquid – Liquid Microextraction Coupled with HPLC. Iran J Pharm Res, 17, 1182–1190.
23. Salehzadeh F, Salehzadeh A, Rokni N, et al (2007): Enrofloxacin Residue in Chicken Tissues from Tehran Slaughterhouses in Iran. Pakistan J Nutr, 6, 409-413.
24. San Martin B, Cornejo J, Lapierre L, et al (2010): Withdrawal time of four pharmaceutical formulations of enrofloxacin in poultry according to different maximum residues limits. J Vet Pharmacol Ther, 33, 246–251.
25. Sarker YA, Hasan MM, Paul TK, et al (2018): Screening of antibiotic residues in chicken meat in Bangladesh by thin layer chromatography. J Adv Vet Anim Res, 5, 140.
26. Sattar S, Hassan MM, Islam SKMA, et al (2014): Antibiotic residues in broiler and layer meat in Chittagong district of Bangladesh. Vet World, 7, 738-743.
27. Sultan IA (2014): Detection of Enrofloxacin Residue in Livers of Livestock Animals Obtained from a Slaughterhouse in Mosul City. J Vet Sci Technol, 5, 2-4.
28. Toldrá F, Reig M (2006): Methods for rapid detection of chemical and veterinary drug residues in animal foods. Trends Food Sci Technol, 17, 482–489.
29. Trouchon T, Lefebvre S (2017): A Review of Enrofloxacin for Veterinary Use. Open J Vet Med, 6, 40–58.
30. Younus M, Abbas T, Zafar M, et al (2017): Quantification of enrofloxacin residues in broiler chicken tissues using competitive enzyme-linked immunosorbent assay. Indian J Anim Sci, 87, 659–661.

There are 30 citations in total.

Details

Primary Language	English
Subjects	Veterinary Surgery
Journal Section	Research Article
Authors	Damla Arslan Acaröz 0000-0001-9230-6725 Nalan Baysu Sözbilir 0000-0002-2270-8312
Publication Date	March 3, 2020
Published in Issue	Year 2020Volume: 67 Issue: 2

Cite

APA	Arslan Acaröz, D., & Baysu Sözbilir, N. (2020). Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 67(2), 137-142. https://doi.org/10.33988/auvfd.561824
AMA	Arslan Acaröz D, Baysu Sözbilir N. Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar. Ankara Univ Vet Fak Derg. March 2020;67(2):137-142. doi:10.33988/auvfd.561824
Chicago	Arslan Acaröz, Damla, and Nalan Baysu Sözbilir. “Investigation of Enrofloxacin and Ciprofloxacin Residues by LC-MS/MS in Chicken Liver Marketed in Afyonkarahisar”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 67, no. 2 (March 2020): 137-42. https://doi.org/10.33988/auvfd.561824.
EndNote	Arslan Acaröz D, Baysu Sözbilir N (March 1, 2020) Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar. Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 2 137–142.
IEEE	D. Arslan Acaröz and N. Baysu Sözbilir, “Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar”, Ankara Univ Vet Fak Derg, vol. 67, no. 2, pp. 137–142, 2020, doi: 10.33988/auvfd.561824.
ISNAD	Arslan Acaröz, Damla - Baysu Sözbilir, Nalan. “Investigation of Enrofloxacin and Ciprofloxacin Residues by LC-MS/MS in Chicken Liver Marketed in Afyonkarahisar”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 67/2 (March 2020), 137-142. https://doi.org/10.33988/auvfd.561824.
JAMA	Arslan Acaröz D, Baysu Sözbilir N. Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar. Ankara Univ Vet Fak Derg. 2020;67:137–142.
MLA	Arslan Acaröz, Damla and Nalan Baysu Sözbilir. “Investigation of Enrofloxacin and Ciprofloxacin Residues by LC-MS/MS in Chicken Liver Marketed in Afyonkarahisar”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 67, no. 2, 2020, pp. 137-42, doi:10.33988/auvfd.561824.
Vancouver	Arslan Acaröz D, Baysu Sözbilir N. Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar. Ankara Univ Vet Fak Derg. 2020;67(2):137-42.