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Year 2020, Volume: 67 Issue: 3, 257 - 263, 03.06.2020

Uğur Özdek Bekir Oğuz , Ahmet Ufuk Kömüroğlu , Yeter Değer

https://doi.org/10.33988/auvfd.603305
Cited By: 3

Abstract

References

  • 1. Akış ME, Dede S (2009): Babesiosisli koyunlarda çinko ve bakır konsantrasyonları ve karbonik anhidraz enzim aktivitesinin saptanması. YYU Vet Fak Derg, 20, 33-37.
  • 2. Akkoyun Z, Oğuz B (2019): Seroprevalance of Theileria equi and Babesia caballi in horses of Mus province, Turkey. AJVS, 60, 22-29.
  • 3. Ambawat HK, Malhotra DV, Kumar S, et al (1999): Erythrocyte associated haemato-biological changes in Babesia equi infection experimentally induced in donkeys. Vet Parasitol, 85, 319-324.
  • 4. Asri RS, Dalir-Naghadeh B (2006): Evaluation of antioxidant status andoxidative stress in cattle naturally infected with Theileria annulata. Vet Parasitol, 142, 179–186.
  • 5. Bildik A, Kargın F, Seyrek K, et al (2004): Oxidative stress andnon-enzymatic antioxidative status in dogs with visceral Leishmaniasis. Res Vet Sci, 77, 63–66.
  • 6. Bozukluhan K, Merhan O, Büyük F, et al (2016): Determination of some acute phase proteins level in cattle with brucellosis. Ankara Univ Vet Fak Derg, 63, 13–16.
  • 7. Camacho AT, Guitian FJ, Pallas E, et al (2005): Theileria (Babesia) equi and Babesia caballi infections in horses in Galicia, Spain. Trop Anim Health Prod, 37, 293-302.
  • 8. Cingi CC, Utuk AE, Karafakioglu YS, et al (2012): Serum lipid and protein oxidation and anti-oxidant status in horses naturally infected with Theileria equi. Rev Med Vet-Toulouse, 163, 183-186.
  • 9. Col R, Uslu U (2007): Changes in selected serum coponents in cattle naturally infected with Theileria annulata. Bull Vet Inst Pulawy, 51, 15-18.
  • 10. Da Silva AS, Radavelli WM, Moura AB, et al (2014): Horses seropositive for Neospora spp.: immunoglobulins, cytokines, and C-Reactive protein levels. J Equine Vet Sci, 34, 1240-1243.
  • 11. Da Silva AS, Duarte MMMF, Moresco RN, et al (2013): Increased ınflammatory mediators in horses naturally ınfected with Trypanosoma vivax. A preliminary study. J Equine Vet Sci, 33, 827-830.
  • 12. De Waal DT, Van Heerden J, Potgieter FT (1987): An investiga-tion into the clinical pathological changes and serological response in horses experimentally infected with Babesia equi and Babesia caballi. Onderstepoort J Vet Res, 54, 561–568.
  • 13. Dede S, Deger Y, Deger S, et al (2008): Plasma levels of zinc, copper, copper/zinc ratio, and activity of carbonic anhydrase in equine piroplasmosis. Biol Trace Elem Res, 125, 41-45.
  • 14. Deger S, Deger Y, Bicek K, et al (2009): Status of lipid peroxidation, antioxidant and oxidation products of nitric oxide equine babesiosis: status of antioxidant and oxidant in equine babesiosis. J Equine Vet Sci, 29, 743-747.
  • 15. Dinerallo CA (2000): Proinflammatory cytokines. Chest, 118, 503-508.
  • 16. Do Carmo GM, Da Silva AS, Klauck V, et al (2015): Immunological response and markers of cell damage in seropositive horses for Toxoplasma gondii. Comp Immunol Microbiol Infect Dis, 38, 9-13.
  • 17. Garba UM, Sackey AKB, Agbede RIS, et al (2012): Plasma total protein, serum calcium and inorganic phosphate levels in Nigerian horses with natural piroplasmosis. J Phys Pharm Adv, 2, 117-121.
  • 18. Goff WL, Jonhson WC, Valdez RA (2002): 12-14 and TL-10 inhibitation of IFN-gama and TNF-alfa dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merazoites. Vet Immun Immunopathol, 84, 237-251.
  • 19. Goth L (1991): A simple method for determi-nation of serum catalase activity and revision of reference range, Clin Chim Acta, 196, 143-152.
  • 20. Hanafusa Y, Cho KO, Kanemaru T, et al (1998): Pathogenesis of Babesia caballi infection in experimental horses. J Vet Med Scı, 60, 1127-1132.
  • 21. Heerden JV (1996): Equine babesiosis in South Africa: a report of two cases. Equine Vet Educ, 8, 3-5.
  • 22. Hemmer RM, Ferrick DA, Conrad PA (2000): Up-regulation of tumor necrosis factor-alpha and interferon-gamma expression in the spleen and lungs of mice infected with the human Babesia isolate WA1. Parasitol Res, 86, 121–128.
  • 23. Karagül H, Altıntaş A, Fidancı UR, et al (2000): Klinik Biyokimya, Medisan Yayınları, Ankara.
  • 24. Khaki Z, Yasini SP, Jalali SM (2018): A survey of biochemical and acute phase proteins changes in sheep experimentally infected with Anaplasma ovis. Asian Pac. J Trop Biomed, 8, 565-570.
  • 25. Krause PJ, Daily J, Telford SR, et al (2007): Shared features in the pathobiology of babesiosis and malaria. Trends Parasitol, 23, 605-610.
  • 26. Placer ZA, Cushman LL, Johnson BC (1966): Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem, 16, 359-364.
  • 27. Radakovic, M, Davitkov D, Borozan S, et al (2016): Oxidative stress and DNA damage in horses naturally infected with Theileria equi. Vet J, 217, 112-118.
  • 28. Rahal, A, Kumar A, Singh V, et al (2014): Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int, 2014, 1-19.
  • 29. Rothschild CM (2013): Equine piroplasmosis. J Equine Vet Sci, 33, 497-508.
  • 30. Salem N, El-Sherif M (2015): Malondialdehyde status, trace minerals and hematologic results of anemic-T. equi infected Egyptian horses. IJVS, 4, 118-122.
  • 31. Salib FA, Youssef RR, Rizk LG, et al (2013): Epidemiology, diagnosis and therapy of Theileria equi infection in Giza, Egypt. Vet World, 6, 76-82.
  • 32. Sedlak J, Lindsay RH (1968): Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem, 25, 192-205.
  • 33. Sengul Y, Mert H, Mert N (2017): Determination of serum lipid profile and lipoprotein levels of sheep with naturally acute babesiosis. Van Vet J, 28, 1-4.
  • 34. Shoda KM, Palmer GH, Florin-Chiristensen J, et al (2000): Babesia bovis-stimulated macrophages express interleukin-1β, interleukin-12, tumor necrosis factor alpha, and nitric oxide and inhibit parasite replication in vitro. Infect Immun, 68, 5139-5145.
  • 35. Sumbria D, Singla LD, Sharma A, et al (2017): Molecular survey in relation to risk factors and haemato-biochemical alteration in Theileria equi infection of equines in Punjab Province, India Vet Parasit Reg Stud Rep, 8, 43-50.
  • 36. Takeet M, Adeleye A, Adebayo O, et al (2009): Haematology and serum biochemical alteration in stress induced equine theileriosis. A case report. SWJ, 4, 19-21.
  • 37. Taylor MA, Coop RL, Wall RL (2007): Veterinary Parasitology. Blackwell Publishing, Oxford.
  • 38. Thrall MA, Weiser G, Allison R, et al (2012): Veterinary Hematology and Clinical Chemistry. In: Ames, IA (Ed), Wiley-Blackwell, USA.
  • 39. Vidhyalakshmi TM, Raval SK, Parikh PV, et al (2018): Biochemical alterations in Horses Infected with Theileria equi. IJVSBT, 14, 30-33
  • 40. Weiss DJ, Wardrop JK (2010): Schalm’s Veterinary Hematology. Wiley-Blackwell, Oxford.
  • 41. Yamaguchi T, Yamanaka M, Ikehara S, et al (2010): Generation of IFN-gamma-producing cells that recognize the major piroplasm surface protein in Theileria orientalis-infected bovines. Vet Parasitol, 171, 207-215.
  • 42. Zaeemi M, Razmi G.R, Mohammadi G.R, et al (2016): Evaluation of serum biochemical profile in Turkoman horses and donkeys infected with Theileria equi. Rev Méd Vét, 167, 301–309.
  • 43. Zobba R, Ardu M, Niccolini S, et al (2008): Clinical and laboratory findings in equine piroplasmosis. J Equine Vet Sci, 28, 301-308.
  • 44. Zygner W, Gojska-Zygner O, Baska P, et al (2014): Increased concentration of serum TNF alpha and its correlations with arterial blood pressure and indices of renal damage in dogs infected with Babesia canis. Parasitol Res, 113, 1499–1503.

Determination of the levels of serum oxidative indicator, cytokine and some biochemical parameters in horses naturally infected with Theileria equi

Year 2020, Volume: 67 Issue: 3, 257 - 263, 03.06.2020

Uğur Özdek Bekir Oğuz , Ahmet Ufuk Kömüroğlu , Yeter Değer

https://doi.org/10.33988/auvfd.603305
Cited By: 3

Abstract

Equine theileriosis is considered as a serious problem because of harmful effects on the health and performance of equids. Despite the importance of this disease, there are few studies in related to clinical pathologic changes in equine theileriosis especially in horses. In this study, the oxidative stress biomarkers, cytokines, enzymes, lipid profile, electrolytes, minerals and some metabolites were evaluated in horses naturally infected with Theileria equi (n=22) and healthy (n=7). In infected horses, the serum concentrations of MDA, IFN-γ, total protein, globulin, bilirubin (total, direct, indirect), triglyceride, glucose, iron, chloride, sodium and copper with enzyme activities of ALP, AST and GGT were found significantly higher, however concentrations of GSH, albumin, total cholesterol, HDL, TIBC, calcium, phosphorus, magnesium, potassium, zinc and manganese with enzyme activity of CAT were found lower when compared to the healthy horses (P<0.05). The changes in TNF-α, creatinine, urea and LDL concentrations were not statistically significant (P>0.05).The results indicate that there are significant changes in the oxidative indicator, cytokine, and biochemical parameters of horses in T. equi infection and that these changes may be useful in the evaluation of the diagnosis, prognosis and treatment of theileriosis. In addition, comprehensive studies are needed to better understand the role of cytokines in the pathogenesis of theileriosis.

Keywords

Biochemical parameter cytokine Theileria equi oxidative stress

References

  • 1. Akış ME, Dede S (2009): Babesiosisli koyunlarda çinko ve bakır konsantrasyonları ve karbonik anhidraz enzim aktivitesinin saptanması. YYU Vet Fak Derg, 20, 33-37.
  • 2. Akkoyun Z, Oğuz B (2019): Seroprevalance of Theileria equi and Babesia caballi in horses of Mus province, Turkey. AJVS, 60, 22-29.
  • 3. Ambawat HK, Malhotra DV, Kumar S, et al (1999): Erythrocyte associated haemato-biological changes in Babesia equi infection experimentally induced in donkeys. Vet Parasitol, 85, 319-324.
  • 4. Asri RS, Dalir-Naghadeh B (2006): Evaluation of antioxidant status andoxidative stress in cattle naturally infected with Theileria annulata. Vet Parasitol, 142, 179–186.
  • 5. Bildik A, Kargın F, Seyrek K, et al (2004): Oxidative stress andnon-enzymatic antioxidative status in dogs with visceral Leishmaniasis. Res Vet Sci, 77, 63–66.
  • 6. Bozukluhan K, Merhan O, Büyük F, et al (2016): Determination of some acute phase proteins level in cattle with brucellosis. Ankara Univ Vet Fak Derg, 63, 13–16.
  • 7. Camacho AT, Guitian FJ, Pallas E, et al (2005): Theileria (Babesia) equi and Babesia caballi infections in horses in Galicia, Spain. Trop Anim Health Prod, 37, 293-302.
  • 8. Cingi CC, Utuk AE, Karafakioglu YS, et al (2012): Serum lipid and protein oxidation and anti-oxidant status in horses naturally infected with Theileria equi. Rev Med Vet-Toulouse, 163, 183-186.
  • 9. Col R, Uslu U (2007): Changes in selected serum coponents in cattle naturally infected with Theileria annulata. Bull Vet Inst Pulawy, 51, 15-18.
  • 10. Da Silva AS, Radavelli WM, Moura AB, et al (2014): Horses seropositive for Neospora spp.: immunoglobulins, cytokines, and C-Reactive protein levels. J Equine Vet Sci, 34, 1240-1243.
  • 11. Da Silva AS, Duarte MMMF, Moresco RN, et al (2013): Increased ınflammatory mediators in horses naturally ınfected with Trypanosoma vivax. A preliminary study. J Equine Vet Sci, 33, 827-830.
  • 12. De Waal DT, Van Heerden J, Potgieter FT (1987): An investiga-tion into the clinical pathological changes and serological response in horses experimentally infected with Babesia equi and Babesia caballi. Onderstepoort J Vet Res, 54, 561–568.
  • 13. Dede S, Deger Y, Deger S, et al (2008): Plasma levels of zinc, copper, copper/zinc ratio, and activity of carbonic anhydrase in equine piroplasmosis. Biol Trace Elem Res, 125, 41-45.
  • 14. Deger S, Deger Y, Bicek K, et al (2009): Status of lipid peroxidation, antioxidant and oxidation products of nitric oxide equine babesiosis: status of antioxidant and oxidant in equine babesiosis. J Equine Vet Sci, 29, 743-747.
  • 15. Dinerallo CA (2000): Proinflammatory cytokines. Chest, 118, 503-508.
  • 16. Do Carmo GM, Da Silva AS, Klauck V, et al (2015): Immunological response and markers of cell damage in seropositive horses for Toxoplasma gondii. Comp Immunol Microbiol Infect Dis, 38, 9-13.
  • 17. Garba UM, Sackey AKB, Agbede RIS, et al (2012): Plasma total protein, serum calcium and inorganic phosphate levels in Nigerian horses with natural piroplasmosis. J Phys Pharm Adv, 2, 117-121.
  • 18. Goff WL, Jonhson WC, Valdez RA (2002): 12-14 and TL-10 inhibitation of IFN-gama and TNF-alfa dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merazoites. Vet Immun Immunopathol, 84, 237-251.
  • 19. Goth L (1991): A simple method for determi-nation of serum catalase activity and revision of reference range, Clin Chim Acta, 196, 143-152.
  • 20. Hanafusa Y, Cho KO, Kanemaru T, et al (1998): Pathogenesis of Babesia caballi infection in experimental horses. J Vet Med Scı, 60, 1127-1132.
  • 21. Heerden JV (1996): Equine babesiosis in South Africa: a report of two cases. Equine Vet Educ, 8, 3-5.
  • 22. Hemmer RM, Ferrick DA, Conrad PA (2000): Up-regulation of tumor necrosis factor-alpha and interferon-gamma expression in the spleen and lungs of mice infected with the human Babesia isolate WA1. Parasitol Res, 86, 121–128.
  • 23. Karagül H, Altıntaş A, Fidancı UR, et al (2000): Klinik Biyokimya, Medisan Yayınları, Ankara.
  • 24. Khaki Z, Yasini SP, Jalali SM (2018): A survey of biochemical and acute phase proteins changes in sheep experimentally infected with Anaplasma ovis. Asian Pac. J Trop Biomed, 8, 565-570.
  • 25. Krause PJ, Daily J, Telford SR, et al (2007): Shared features in the pathobiology of babesiosis and malaria. Trends Parasitol, 23, 605-610.
  • 26. Placer ZA, Cushman LL, Johnson BC (1966): Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem, 16, 359-364.
  • 27. Radakovic, M, Davitkov D, Borozan S, et al (2016): Oxidative stress and DNA damage in horses naturally infected with Theileria equi. Vet J, 217, 112-118.
  • 28. Rahal, A, Kumar A, Singh V, et al (2014): Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int, 2014, 1-19.
  • 29. Rothschild CM (2013): Equine piroplasmosis. J Equine Vet Sci, 33, 497-508.
  • 30. Salem N, El-Sherif M (2015): Malondialdehyde status, trace minerals and hematologic results of anemic-T. equi infected Egyptian horses. IJVS, 4, 118-122.
  • 31. Salib FA, Youssef RR, Rizk LG, et al (2013): Epidemiology, diagnosis and therapy of Theileria equi infection in Giza, Egypt. Vet World, 6, 76-82.
  • 32. Sedlak J, Lindsay RH (1968): Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem, 25, 192-205.
  • 33. Sengul Y, Mert H, Mert N (2017): Determination of serum lipid profile and lipoprotein levels of sheep with naturally acute babesiosis. Van Vet J, 28, 1-4.
  • 34. Shoda KM, Palmer GH, Florin-Chiristensen J, et al (2000): Babesia bovis-stimulated macrophages express interleukin-1β, interleukin-12, tumor necrosis factor alpha, and nitric oxide and inhibit parasite replication in vitro. Infect Immun, 68, 5139-5145.
  • 35. Sumbria D, Singla LD, Sharma A, et al (2017): Molecular survey in relation to risk factors and haemato-biochemical alteration in Theileria equi infection of equines in Punjab Province, India Vet Parasit Reg Stud Rep, 8, 43-50.
  • 36. Takeet M, Adeleye A, Adebayo O, et al (2009): Haematology and serum biochemical alteration in stress induced equine theileriosis. A case report. SWJ, 4, 19-21.
  • 37. Taylor MA, Coop RL, Wall RL (2007): Veterinary Parasitology. Blackwell Publishing, Oxford.
  • 38. Thrall MA, Weiser G, Allison R, et al (2012): Veterinary Hematology and Clinical Chemistry. In: Ames, IA (Ed), Wiley-Blackwell, USA.
  • 39. Vidhyalakshmi TM, Raval SK, Parikh PV, et al (2018): Biochemical alterations in Horses Infected with Theileria equi. IJVSBT, 14, 30-33
  • 40. Weiss DJ, Wardrop JK (2010): Schalm’s Veterinary Hematology. Wiley-Blackwell, Oxford.
  • 41. Yamaguchi T, Yamanaka M, Ikehara S, et al (2010): Generation of IFN-gamma-producing cells that recognize the major piroplasm surface protein in Theileria orientalis-infected bovines. Vet Parasitol, 171, 207-215.
  • 42. Zaeemi M, Razmi G.R, Mohammadi G.R, et al (2016): Evaluation of serum biochemical profile in Turkoman horses and donkeys infected with Theileria equi. Rev Méd Vét, 167, 301–309.
  • 43. Zobba R, Ardu M, Niccolini S, et al (2008): Clinical and laboratory findings in equine piroplasmosis. J Equine Vet Sci, 28, 301-308.
  • 44. Zygner W, Gojska-Zygner O, Baska P, et al (2014): Increased concentration of serum TNF alpha and its correlations with arterial blood pressure and indices of renal damage in dogs infected with Babesia canis. Parasitol Res, 113, 1499–1503.
There are 44 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Research Article
Authors

Uğur Özdek 0000-0002-0709-1545

Bekir Oğuz 0000-0001-8720-3940

Ahmet Ufuk Kömüroğlu 0000-0002-0371-9251

Yeter Değer 0000-0002-9023-0699

Publication Date June 3, 2020
Published in Issue Year 2020Volume: 67 Issue: 3

Cite

APA Özdek, U., Oğuz, B., Kömüroğlu, A. U., Değer, Y. (2020). Determination of the levels of serum oxidative indicator, cytokine and some biochemical parameters in horses naturally infected with Theileria equi. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 67(3), 257-263. https://doi.org/10.33988/auvfd.603305
AMA Özdek U, Oğuz B, Kömüroğlu AU, Değer Y. Determination of the levels of serum oxidative indicator, cytokine and some biochemical parameters in horses naturally infected with Theileria equi. Ankara Univ Vet Fak Derg. June 2020;67(3):257-263. doi:10.33988/auvfd.603305
Chicago Özdek, Uğur, Bekir Oğuz, Ahmet Ufuk Kömüroğlu, and Yeter Değer. “Determination of the Levels of Serum Oxidative Indicator, Cytokine and Some Biochemical Parameters in Horses Naturally Infected With Theileria Equi”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 67, no. 3 (June 2020): 257-63. https://doi.org/10.33988/auvfd.603305.
EndNote Özdek U, Oğuz B, Kömüroğlu AU, Değer Y (June 1, 2020) Determination of the levels of serum oxidative indicator, cytokine and some biochemical parameters in horses naturally infected with Theileria equi. Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 3 257–263.
IEEE U. Özdek, B. Oğuz, A. U. Kömüroğlu, and Y. Değer, “Determination of the levels of serum oxidative indicator, cytokine and some biochemical parameters in horses naturally infected with Theileria equi”, Ankara Univ Vet Fak Derg, vol. 67, no. 3, pp. 257–263, 2020, doi: 10.33988/auvfd.603305.
ISNAD Özdek, Uğur et al. “Determination of the Levels of Serum Oxidative Indicator, Cytokine and Some Biochemical Parameters in Horses Naturally Infected With Theileria Equi”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 67/3 (June 2020), 257-263. https://doi.org/10.33988/auvfd.603305.
JAMA Özdek U, Oğuz B, Kömüroğlu AU, Değer Y. Determination of the levels of serum oxidative indicator, cytokine and some biochemical parameters in horses naturally infected with Theileria equi. Ankara Univ Vet Fak Derg. 2020;67:257–263.
MLA Özdek, Uğur et al. “Determination of the Levels of Serum Oxidative Indicator, Cytokine and Some Biochemical Parameters in Horses Naturally Infected With Theileria Equi”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 67, no. 3, 2020, pp. 257-63, doi:10.33988/auvfd.603305.
Vancouver Özdek U, Oğuz B, Kömüroğlu AU, Değer Y. Determination of the levels of serum oxidative indicator, cytokine and some biochemical parameters in horses naturally infected with Theileria equi. Ankara Univ Vet Fak Derg. 2020;67(3):257-63.

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