Year 2020, Volume 67 , Issue 4, Pages 387 - 392 2020-09-01

The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes

Hüseyin ÖZKAN [1] , Tuncer KUTLU [2]


The use of fructose as converted sugar in the food industry is quite common. Steatosis and degeneration occur due to the use of fructose in the liver where sugar is primarily metabolized. However, there is not enough information about the level of MDA and the expression levels of COX-2 and NRF-2 in the liver with low and high fructose consumption. The aim of the study is to evaluate the effect of different concentrations of fructose solutions on the expression levels of COX-2 and NRF-2 genes as well as MDA levels in the livers of rats. In this study, the effects of different fructose solution [F15; (15%) F30; (30%) and F60; (60%)] consumption for 10 weeks in rats on the MDA levels also COX-2 and NRF-2 genes expression levels in the liver were investigated. The MDA level and COX-2 gene expression level in F60 group were higher than the control and other groups (P<0.01). These findings suggest that MDA elevation in the liver may be due to inflammation. However, no change was observed in total NRF-2 gene expression. Also, a positive correlation was found between levels of COX-2 and NRF-2 expressions in F30 (0.965; P<0.01). These findings may be attributed to inflammation of liver. This may have been due to an increase in nuclear formation of NRF-2. As a result, the use of high concentration fructose solution has been found to increase the level of MDA in the liver due to inflammation.
COX-2, Fructose, Gene Expression, MDA, NRF-2
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Primary Language en
Subjects Veterinary
Journal Section Research Article
Authors

Orcid: 0000-0001-5753-8985
Author: Hüseyin ÖZKAN (Primary Author)
Institution: Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Genetics
Country: Turkey


Orcid: 0000-0002-8771-1256
Author: Tuncer KUTLU
Institution: Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Pathology
Country: Turkey


Dates

Publication Date : September 1, 2020

Bibtex @research article { auvfd645713, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {}, eissn = {1308-2817}, address = {}, publisher = {Ankara University}, year = {2020}, volume = {67}, pages = {387 - 392}, doi = {10.33988/auvfd.645713}, title = {The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes}, key = {cite}, author = {Özkan, Hüseyin and Kutlu, Tuncer} }
APA Özkan, H , Kutlu, T . (2020). The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 67 (4) , 387-392 . DOI: 10.33988/auvfd.645713
MLA Özkan, H , Kutlu, T . "The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2020 ): 387-392 <http://vetjournal.ankara.edu.tr/en/pub/issue/56621/645713>
Chicago Özkan, H , Kutlu, T . "The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2020 ): 387-392
RIS TY - JOUR T1 - The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes AU - Hüseyin Özkan , Tuncer Kutlu Y1 - 2020 PY - 2020 N1 - doi: 10.33988/auvfd.645713 DO - 10.33988/auvfd.645713 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 387 EP - 392 VL - 67 IS - 4 SN - -1308-2817 M3 - doi: 10.33988/auvfd.645713 UR - https://doi.org/10.33988/auvfd.645713 Y2 - 2020 ER -
EndNote %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes %A Hüseyin Özkan , Tuncer Kutlu %T The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes %D 2020 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P -1308-2817 %V 67 %N 4 %R doi: 10.33988/auvfd.645713 %U 10.33988/auvfd.645713
ISNAD Özkan, Hüseyin , Kutlu, Tuncer . "The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 / 4 (September 2020): 387-392 . https://doi.org/10.33988/auvfd.645713
AMA Özkan H , Kutlu T . The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes. Ankara Univ Vet Fak Derg. 2020; 67(4): 387-392.
Vancouver Özkan H , Kutlu T . The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2020; 67(4): 387-392.
IEEE H. Özkan and T. Kutlu , "The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes", Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 67, no. 4, pp. 387-392, Sep. 2020, doi:10.33988/auvfd.645713