Case Report
Year 2021,
Volume: 68 Issue: 1, 77 - 81, 25.12.2020
Abstract
References
- 1. Argiris A (2002): Update on chemoradiotherapy for head and neck cancer. Curr Opin Oncol 14, 323-329.
- 2. Boyer SN, Wazer DE, Band V (1996): E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res, 56, 4620-4624.
- 3. Bregman CL, Hirth RS, Sundberg JP, et al (1987): Cutaneous neoplasms in dogs associated with canine oral papilloma virus vaccine. Vet Pathol 24, 477-487.
- 4. Chambers VC, Evans CA (1959): Canine oral papillomatosis I. Virus assay and observations on the various stages of the experimental infection. Cancer Res, 19, 1188-1195.
- 5. De Villiers EM, Fauquet C, Broker TR, et al (2004): Classification of papillomaviruses. Virology 324, 17–27.
- 6. De Vos JP, Burm AGD, Focker AF, et al (2005): Piroxicam and carboplatin as a combination treatment of canine oral non-tonsillar squamous cell carcinoma: a pilot study and a literature review of a canine model of human head and neck squamous cell carcinoma. Vet Comp Oncol, 3,16-24.
- 7. Gillison ML (2007): Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head Neck, 29, 779-792.
- 8. Grier CK, Mayer MN (2007). Radiation therapy of canine nontonsillar squamous cell carcinoma. Can Vet J, 48,1189-1191.
- 9. Harrus S, Kenny M, Miara L, et al (2004). Comparison of simultaneous splenic sample pcr with blood sample pcr for diagnosis and treatment of experimental ehrlichia canis infection. Antimicrob Agents Chemother, 48, 4488–4490.
- 10. Hennequin C, Favaudon V (2002): Biological basis for chemo-radiotherapy interactions. Eur J Cancer, 38, 230-233.
- 11. Konig F, Krekeler G, Hönig JF, et al (2007). Relation between human papillomavirus positivity and p16 expression in head and neck carcinomas – A tissue microarray study. Anticancer Res, 27, 283-288.
- 12. Lange CE, Favrot C (2011). Canine papillomaviruses. Vet Clin Small Anim, 41, 1183-1195.
- 13. Mas A, Blackwood L, Cripps P, et al (2011). Canine tonsillar squamous cell carcinoma – a multi-centre retrospective review of 44 clinical cases. J Small Anim Pract, 52, 359-365.
- 14. McCaw DL, Pope ER, Payne JT, et al (2000): Treatment of canine oral squamous cell carcinomas with photodynamic therapy. Br J Cancer, 82, 1297-1299.
- 15. Munday JS, Dunowska M, De Grey S (2009): Detection of two different papillomaviruses within a feline cutaneous squamous cell carcinoma. N Z Vet J, 57, 248-51.
- 16. Munday JS, French A, Harvey CJ (2015a): Molecular and immuohistochemical studies do not support a role for papillomaviruses in canine oral squamous cell carcinoma development. Vet J, 204, 223-225.
- 17. Munday JS, Kiupel M, French AF, et al (2008): Amplification of papillomaviral DNA sequences from a high proportion of feline cutaneous in situ and invasive squamous cell carcinomas using a nested polymerase chain reaction. Vet Dermatol, 19, 259-263.
- 18. Munday JS, Knight CG, French AF (2011). Evaluation of feline oral squamous cell carcinomas for p16CDKN2A protein immunoreactivity and the presence of papillomaviral DNA. Res Vet Sci, 90, 280-283.
- 19. Munday JS, Löhr CV, Kiupel M (2017): Tumors of the alimentary tract. 500-507. In: Meuten DJ (ed.): Tumors in Domestic Animals. John Wiley & Sons, Inc. Ames, Iowa.
- 20. Munday JS, Tucker RS, Kiupel M, et al (2015b): Multiple oral carcinomas associated with novel papillomavirus in a dog. J Vet Diagn Invest, 27, 221-225.
- 21. Parry D, Bates S, Mann DJ, et al (1995): Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4IMTS1 tumor suppressor gene product. EMBO J, 14, 503-511.
- 22. Rejec A, Benoit J, Tutt C, et al (2015): Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal squamous cell carcinoma in 5 cats and 3 dogs. J Vet Dent, 4, 212-221.
- 23. Smeets SJ, Hesselink AT, Spell EJM, et al (2007): A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer, 121, 2465–2472.
- 24. Sunberg JP, Smith EK, Herron AJ, et al (1994): Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in a chinese shar pei dog. Vet Pathol, 31, 183-187.
- 25. Sykes J, Luff JA (2014): Viral papillomatosis. 261-268. In: Skyes JE (ed.), Canine and Feline Infectious Diseases. Saunders, Elsevier, Missouri.
- 26. Teifke JP, Löhr CV, Shirasawa H (1998): Detection of canine oral papillomavirus-DNA in canine oral squamous cell carcinomas and p53 overexpressing skin papillomas of the dog using the polymerase chain reaction and non-radioactive in situ hybridization. Vet Microbiol, 60, 119-130.
Year 2021,
Volume: 68 Issue: 1, 77 - 81, 25.12.2020
Abstract
Canine oral papillomas is a benign tumor of young dogs and caused by papillomavirus. The possible role of papillomavirus infection in the development of oral squamous cell carcinoma has recently been studied, but it has not been elucidated in veterinary medicine yet. One-year-old, mixed, spayed, a female dog was presented with severely disseminated oral lesions, lethargy, and weight loss. Physical examination of the patient revealed severely disseminated oral papillomatous lesions in the entire oral cavity and the complete blood test showed mild non-regenerative anemia and pancytopenia. In addition, the patient was found seropositive by the SNAP 4Dx Plus test for Ehrlichia canis. Histopathologic examination of oral lesions was performed using Hematoxylin and Eosin (HE) staining and immunohistochemistry for p16 antibody which increases in infections caused by papillomavirus. Histopathology revealed the histologic features of oral papilloma in association with squamous cell carcinoma. Cytoplasmic and nuclear positive reactions for p16 protein were observed within the neoplastic cells in the immunohistochemical examination. Thereafter, the dog was treated with combined therapy of vincristine, antibiotic, radiotherapy, and high doses of vitamin C. After long-term treatment, the dog completely recovered from the lesions. In this report, it was aimed to present a possible role of papilloma in the development of oral squamous cell carcinoma with the clinical, histopathological, immunohistochemical findings and treatment procedure.
References
- 1. Argiris A (2002): Update on chemoradiotherapy for head and neck cancer. Curr Opin Oncol 14, 323-329.
- 2. Boyer SN, Wazer DE, Band V (1996): E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res, 56, 4620-4624.
- 3. Bregman CL, Hirth RS, Sundberg JP, et al (1987): Cutaneous neoplasms in dogs associated with canine oral papilloma virus vaccine. Vet Pathol 24, 477-487.
- 4. Chambers VC, Evans CA (1959): Canine oral papillomatosis I. Virus assay and observations on the various stages of the experimental infection. Cancer Res, 19, 1188-1195.
- 5. De Villiers EM, Fauquet C, Broker TR, et al (2004): Classification of papillomaviruses. Virology 324, 17–27.
- 6. De Vos JP, Burm AGD, Focker AF, et al (2005): Piroxicam and carboplatin as a combination treatment of canine oral non-tonsillar squamous cell carcinoma: a pilot study and a literature review of a canine model of human head and neck squamous cell carcinoma. Vet Comp Oncol, 3,16-24.
- 7. Gillison ML (2007): Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head Neck, 29, 779-792.
- 8. Grier CK, Mayer MN (2007). Radiation therapy of canine nontonsillar squamous cell carcinoma. Can Vet J, 48,1189-1191.
- 9. Harrus S, Kenny M, Miara L, et al (2004). Comparison of simultaneous splenic sample pcr with blood sample pcr for diagnosis and treatment of experimental ehrlichia canis infection. Antimicrob Agents Chemother, 48, 4488–4490.
- 10. Hennequin C, Favaudon V (2002): Biological basis for chemo-radiotherapy interactions. Eur J Cancer, 38, 230-233.
- 11. Konig F, Krekeler G, Hönig JF, et al (2007). Relation between human papillomavirus positivity and p16 expression in head and neck carcinomas – A tissue microarray study. Anticancer Res, 27, 283-288.
- 12. Lange CE, Favrot C (2011). Canine papillomaviruses. Vet Clin Small Anim, 41, 1183-1195.
- 13. Mas A, Blackwood L, Cripps P, et al (2011). Canine tonsillar squamous cell carcinoma – a multi-centre retrospective review of 44 clinical cases. J Small Anim Pract, 52, 359-365.
- 14. McCaw DL, Pope ER, Payne JT, et al (2000): Treatment of canine oral squamous cell carcinomas with photodynamic therapy. Br J Cancer, 82, 1297-1299.
- 15. Munday JS, Dunowska M, De Grey S (2009): Detection of two different papillomaviruses within a feline cutaneous squamous cell carcinoma. N Z Vet J, 57, 248-51.
- 16. Munday JS, French A, Harvey CJ (2015a): Molecular and immuohistochemical studies do not support a role for papillomaviruses in canine oral squamous cell carcinoma development. Vet J, 204, 223-225.
- 17. Munday JS, Kiupel M, French AF, et al (2008): Amplification of papillomaviral DNA sequences from a high proportion of feline cutaneous in situ and invasive squamous cell carcinomas using a nested polymerase chain reaction. Vet Dermatol, 19, 259-263.
- 18. Munday JS, Knight CG, French AF (2011). Evaluation of feline oral squamous cell carcinomas for p16CDKN2A protein immunoreactivity and the presence of papillomaviral DNA. Res Vet Sci, 90, 280-283.
- 19. Munday JS, Löhr CV, Kiupel M (2017): Tumors of the alimentary tract. 500-507. In: Meuten DJ (ed.): Tumors in Domestic Animals. John Wiley & Sons, Inc. Ames, Iowa.
- 20. Munday JS, Tucker RS, Kiupel M, et al (2015b): Multiple oral carcinomas associated with novel papillomavirus in a dog. J Vet Diagn Invest, 27, 221-225.
- 21. Parry D, Bates S, Mann DJ, et al (1995): Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4IMTS1 tumor suppressor gene product. EMBO J, 14, 503-511.
- 22. Rejec A, Benoit J, Tutt C, et al (2015): Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal squamous cell carcinoma in 5 cats and 3 dogs. J Vet Dent, 4, 212-221.
- 23. Smeets SJ, Hesselink AT, Spell EJM, et al (2007): A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer, 121, 2465–2472.
- 24. Sunberg JP, Smith EK, Herron AJ, et al (1994): Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in a chinese shar pei dog. Vet Pathol, 31, 183-187.
- 25. Sykes J, Luff JA (2014): Viral papillomatosis. 261-268. In: Skyes JE (ed.), Canine and Feline Infectious Diseases. Saunders, Elsevier, Missouri.
- 26. Teifke JP, Löhr CV, Shirasawa H (1998): Detection of canine oral papillomavirus-DNA in canine oral squamous cell carcinomas and p53 overexpressing skin papillomas of the dog using the polymerase chain reaction and non-radioactive in situ hybridization. Vet Microbiol, 60, 119-130.
There are 26 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Case Report |
| Authors | |
| Publication Date | December 25, 2020 |
| Published in Issue | Year 2021Volume: 68 Issue: 1 |
