Research Article
Year 2021,
Volume: 68 Issue: 1, 53 - 59, 25.12.2020
Abstract
Felis catus gammaherpesvirus-1 (FcaGHV-1) is a newly discovered feline virus, and its effects on the health of cats are not certainly known. Known feline viruses act a huge role in ocular disorders in domestic and wild cats. Also, emerging viruses may be responsible for ophthalmic diseases of cats. We aimed to investigate the presence of FcaGHV-1, Feline calicivirus (FCV), Feline herpesvirus -1 (FHV-1), Feline immunodeficiency virus (FIV), Feline infectious peritonitis virus (FIPV), Feline leukemia virus (FeLV), Feline panleukopenia virus (FPV) in cats in Turkey by molecular methods, and to examine the relationship between the virus and ocular disorders by obtained data. Swab, blood and biopsy samples were collected from 45 owned cats with ocular disorders. Molecular techniques including viral genome amplification and sequencing were used in this study. Both blood-swabs and biopsy samples were in two out of 45 cats (2/45; 4.4%) found to be FcaGHV-1 and FIV positive. Our two sequences and a reference sequence from Japan (LC437925) have constructed a separated subgroup in the molecular phylogenetic tree. In this study, we have not found a tight relationship between ocular disorders and FcaGHV-1. This is the first study exhibiting the presence of FcaGHV-1 and its molecular status in Turkey. Acquired knowledge suggests performing further studies on FcaGHV-1.
Keywords
Supporting Institution
-
Project Number
-
Thanks
-
References
- 1. Battilani M, Balboni A, Ustulin M, et al (2011): Genetic complexity and multiple infections with more Parvovirus species in naturally infected cats. Vet Res, 42, 1-9.
- 2. Beatty JA, Troyer RM, Carver S, et al (2014): Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats. Virology, 460-461, 100-107.
- 3. Beatty JA, Sharp CR, Duprex WP, et al (2019): Novel feline viruses: Emerging significance of gammaherpesvirus and morbillivirus infections. J Feline Med Surg, 21, 5-11.
- 4. Caringella F, Desario C, Lorusso E, et al (2019): Prevalence and risk factors for Felis catus gammaherpesvirus 1 detection in domestic cats in Italy. Vet Microbiol, 238, 108426.
- 5. Chomczynski P, Sacchi N (2006): The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on. Nat Protoc, 1, 581-585.
- 6. Ehlers B, Dural G, Yasmum N, et al (2008): Novel mammalian herpesviruses and Lineages within the gammaherpesvirinae: cospeciation and interspecies transfer. J Virol, 82, 3509-3516.
- 7. Endo Y, Cho KW, Nishigaki K, et al (1997): Molecular characteristics of malignant lymphomas in cats naturally infected with feline immunodeficiency virus. Vet Immunol Immunopathol, 57, 153-167.
- 8. Ertl R, Korb M, Langbein-Detsch I, et al (2015): Prevalence and risk factors of gammaherpesvirus infection in domestic cats in Central Europe Herpes viruses. Virol J, 12, 146.
- 9. Hartmann K (2012): Clinical aspects of feline retroviruses: A review. Viruses, 4, 2684-2710.
- 10. Henzel A, Brum MCS, Lautert C, et al (2012): Isolation and identification of feline calicivirus and feline herpesvirus in Southern Brazil. Brazilian J Microbiol, 43, 560-568.
- 11. Kumar S, Stecher G, Li M, et al (2018): MEGA X: Molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol, 35, 1547-1549.
- 12. Kurissio JK, Rodrigues MV, Taniwaki SA, et al (2018): Felis catus gammaherpesvirus 1 (FcaGHV1) and coinfections with feline viral pathogens in domestic cats in Brazil. Ciência Rural, 48, e20170480.
- 13. Lewin AC, Kolb AW, McLellan GJ, et al (2018): Genomic, recombinational and phylogenetic characterization of global feline herpesvirus 1 isolates. Virology, 518, 385-397.
- 14. Makundi I, Koshida Y, Endo Y, et al (2018): Identification of felis catus gammaherpesvirus 1 in Tsushima leopard cats (Prionailurus bengalensis euptilurus) on Tsushima Island, Japan. Viruses, 10, 378.
- 15. McLuckie AJ, Barrs VR, Smith AL, et al (2016): Detection of Felis catus gammaherpesvirus 1 (FcaGHV1) in peripheral blood B- and T-lymphocytes in asymptomatic, naturally-infected domestic cats. Virology, 497, 211-216.
- 16. McLuckie AJ, Barrs VR, Lindsay S, et al (2018): Molecular diagnosis of Felis catus gammaherpesvirus 1 (FcaGHV1) infection in cats of known retrovirus status with and without lymphoma. Viruses, 10, 128.
- 17. McLuckie AJ, Barrs VR, Wilson B, et al (2017): Felis catus gammaherpesvirus 1 DNAemia in whole blood from therapeutically immunosuppressed or retrovirus-infected cats. Vet Sci, 4, 16.
- 18. Novacco M, Kohan NR, Stirn M, et al (2019): Prevalence, geographic distribution, risk factors and co-infections of feline gammaherpesvirus infections in domestic cats in Switzerland. Viruses, 11, 721.
- 19. Ravi M, Wobeser GA, Taylor SM, et al (2010): Naturally acquired feline immunodeficiency virus (FIV) infection in cats from western Canada: Prevalence, disease associations, and survival analysis. Can Vet J, 51, 271-276.
- 20. Roca AL, Nash WG, Menninger JC, et al (2005): Insertional polymorphisms of endogenous feline leukemia viruses. J Virol, 79, 3979-3986.
- 21. Rushton JO, Kolodziejek J, Tichy A, et al (2013): Detection of equid herpesviruses 2 and 5 in a herd of 266 Lipizzaners in association with ocular findings. Vet Microbiol, 164, 139-144.
- 22. Simons FA, Vennema H, Rofina JE, et al (2005): A mRNA PCR for the diagnosis of feline infectious peritonitis. J Virol Methods, 124, 111-116.
- 23. Stiles J (2014): Ocular manifestations of feline viral diseases. Vet J, 201, 166-173. 24. Tateno M, Takahashi M, Miyake E, et al (2017): Molecular epidemiological study of gammaherpesvirus in domestic cats in Japan. J Vet Med Sci, 79, 1735-1740.
- 25. Troyer RM, Lee JS, Vuyisich M, et al (2015): First complete genome sequence of Felis catus gammaherpesvirus 1. Genome Announc, 3, e01192-15.
- 26. Vögtlin A, Fraefel C, Albini S, et al (2002): Quantification of feline herpesvirus 1 DNA in ocular fluid samples of clinically diseased cats by real-time TaqMan PCR. J Clin Microbiol, 40, 519-523.
Year 2021,
Volume: 68 Issue: 1, 53 - 59, 25.12.2020
Abstract
Project Number
-
References
- 1. Battilani M, Balboni A, Ustulin M, et al (2011): Genetic complexity and multiple infections with more Parvovirus species in naturally infected cats. Vet Res, 42, 1-9.
- 2. Beatty JA, Troyer RM, Carver S, et al (2014): Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats. Virology, 460-461, 100-107.
- 3. Beatty JA, Sharp CR, Duprex WP, et al (2019): Novel feline viruses: Emerging significance of gammaherpesvirus and morbillivirus infections. J Feline Med Surg, 21, 5-11.
- 4. Caringella F, Desario C, Lorusso E, et al (2019): Prevalence and risk factors for Felis catus gammaherpesvirus 1 detection in domestic cats in Italy. Vet Microbiol, 238, 108426.
- 5. Chomczynski P, Sacchi N (2006): The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on. Nat Protoc, 1, 581-585.
- 6. Ehlers B, Dural G, Yasmum N, et al (2008): Novel mammalian herpesviruses and Lineages within the gammaherpesvirinae: cospeciation and interspecies transfer. J Virol, 82, 3509-3516.
- 7. Endo Y, Cho KW, Nishigaki K, et al (1997): Molecular characteristics of malignant lymphomas in cats naturally infected with feline immunodeficiency virus. Vet Immunol Immunopathol, 57, 153-167.
- 8. Ertl R, Korb M, Langbein-Detsch I, et al (2015): Prevalence and risk factors of gammaherpesvirus infection in domestic cats in Central Europe Herpes viruses. Virol J, 12, 146.
- 9. Hartmann K (2012): Clinical aspects of feline retroviruses: A review. Viruses, 4, 2684-2710.
- 10. Henzel A, Brum MCS, Lautert C, et al (2012): Isolation and identification of feline calicivirus and feline herpesvirus in Southern Brazil. Brazilian J Microbiol, 43, 560-568.
- 11. Kumar S, Stecher G, Li M, et al (2018): MEGA X: Molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol, 35, 1547-1549.
- 12. Kurissio JK, Rodrigues MV, Taniwaki SA, et al (2018): Felis catus gammaherpesvirus 1 (FcaGHV1) and coinfections with feline viral pathogens in domestic cats in Brazil. Ciência Rural, 48, e20170480.
- 13. Lewin AC, Kolb AW, McLellan GJ, et al (2018): Genomic, recombinational and phylogenetic characterization of global feline herpesvirus 1 isolates. Virology, 518, 385-397.
- 14. Makundi I, Koshida Y, Endo Y, et al (2018): Identification of felis catus gammaherpesvirus 1 in Tsushima leopard cats (Prionailurus bengalensis euptilurus) on Tsushima Island, Japan. Viruses, 10, 378.
- 15. McLuckie AJ, Barrs VR, Smith AL, et al (2016): Detection of Felis catus gammaherpesvirus 1 (FcaGHV1) in peripheral blood B- and T-lymphocytes in asymptomatic, naturally-infected domestic cats. Virology, 497, 211-216.
- 16. McLuckie AJ, Barrs VR, Lindsay S, et al (2018): Molecular diagnosis of Felis catus gammaherpesvirus 1 (FcaGHV1) infection in cats of known retrovirus status with and without lymphoma. Viruses, 10, 128.
- 17. McLuckie AJ, Barrs VR, Wilson B, et al (2017): Felis catus gammaherpesvirus 1 DNAemia in whole blood from therapeutically immunosuppressed or retrovirus-infected cats. Vet Sci, 4, 16.
- 18. Novacco M, Kohan NR, Stirn M, et al (2019): Prevalence, geographic distribution, risk factors and co-infections of feline gammaherpesvirus infections in domestic cats in Switzerland. Viruses, 11, 721.
- 19. Ravi M, Wobeser GA, Taylor SM, et al (2010): Naturally acquired feline immunodeficiency virus (FIV) infection in cats from western Canada: Prevalence, disease associations, and survival analysis. Can Vet J, 51, 271-276.
- 20. Roca AL, Nash WG, Menninger JC, et al (2005): Insertional polymorphisms of endogenous feline leukemia viruses. J Virol, 79, 3979-3986.
- 21. Rushton JO, Kolodziejek J, Tichy A, et al (2013): Detection of equid herpesviruses 2 and 5 in a herd of 266 Lipizzaners in association with ocular findings. Vet Microbiol, 164, 139-144.
- 22. Simons FA, Vennema H, Rofina JE, et al (2005): A mRNA PCR for the diagnosis of feline infectious peritonitis. J Virol Methods, 124, 111-116.
- 23. Stiles J (2014): Ocular manifestations of feline viral diseases. Vet J, 201, 166-173. 24. Tateno M, Takahashi M, Miyake E, et al (2017): Molecular epidemiological study of gammaherpesvirus in domestic cats in Japan. J Vet Med Sci, 79, 1735-1740.
- 25. Troyer RM, Lee JS, Vuyisich M, et al (2015): First complete genome sequence of Felis catus gammaherpesvirus 1. Genome Announc, 3, e01192-15.
- 26. Vögtlin A, Fraefel C, Albini S, et al (2002): Quantification of feline herpesvirus 1 DNA in ocular fluid samples of clinically diseased cats by real-time TaqMan PCR. J Clin Microbiol, 40, 519-523.
There are 25 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Research Article |
| Authors | |
| Project Number | - |
| Publication Date | December 25, 2020 |
| Published in Issue | Year 2021Volume: 68 Issue: 1 |
