Heparin - Compound 48/80 interaetion was investigated. It was found
that Compound 48/80 inhibited the metachromatic staining of mast edl granules of mesenterie tissue of the rat and eommereial heparin by toluidine blue. Compound 48/80 has alsa
inhibited the antieoagı.ılant effect of heparin. The results indicate that a ehemieal interaction between heparin 'and Compound 48/80 may be present.
it is eonc1uded that, same of the heparin may be inaetivated by Compound 48/80
when this substanee is used to degranulate mast eells. The findings support the idea that heparin proteets the organism against the toxie effeet of Compound 48/80.
Primary Language | English |
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Subjects | Veterinary Surgery |
Journal Section | Research Article |
Authors | |
Publication Date | January 1, 1971 |
Published in Issue | Year 1971Volume: 18 Issue: 02 |