The aim of this study was to investigated anti-proliferative and anti-apoptotic effects of coenzyme Q10 (CoQ10) in the prevention of radioiodine-131 (RAI) (I131) induced kidney damage. A total of 24 Wistar albino rats were separated into equal three groups (n = 8/group): Group 1 (control): untreated group; Group 2 (RAI): 3 mCi/kg RAI oral route; Group 3 (RAI+CoQ10): 3 mCi/kg RAI oral route and intraperitoneally 30 mg/kg/day CoQ10. CoQ10 treatment was started two days before RAI administration and was continued five days once daily after RAI. Pathomorphological parameters of kidneys were measured using hematoxylin–eosin and Masson’s trichrome staining. Immunohistochemically; proliferating cell nuclear antigen (PCNA), caspase 8, caspase 9 and terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) were used to determine proliferation and apoptosis. With the exception of the control group, varying degrees of inflammation, degeneration, necrosis, and interstitial/perivascular fibrosis were detected in the kidneys of all rats. This histopathological damage was found to be significantly less in CoQ10 group versus RAI group (P<0.05). The all immunohistochemical examinations demonstrated that administration of CoQ10 had reduced proliferation and apoptosis (P<0.05). The results of kidney histopathology and immunohistochemistry demonstrated that administration of CoQ10 had reduced inflammation, proliferation, and apoptosis. These findings show CoQ10 can play an important role in the radioprotection of kidneys against RAI-induced damage
Antiapoptotic, antiproliferative, coenzyme Q10, kidney, radioiodine-131
Primary Language | English |
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Subjects | Veterinary |
Journal Section | Research Article |
Authors |
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Thanks | Some part of this article was summarized from the first author’s master thesis. |
Publication Date | June 30, 2022 |
Published in Issue | Year 2022Volume: 69 Issue: 3 |
Bibtex | @research article { auvfd871118, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara University}, year = {2022}, volume = {69}, number = {3}, pages = {265 - 272}, doi = {10.33988/auvfd.871118}, title = {Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage}, key = {cite}, author = {Yumuşak, Nihat and Koca, Gökhan and Akbulut, Aylin and Atılgan, Hasan İkbal and Korkmaz, Meliha} } |
APA | Yumuşak, N. , Koca, G. , Akbulut, A. , Atılgan, H. İ. & Korkmaz, M. (2022). Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 69 (3) , 265-272 . DOI: 10.33988/auvfd.871118 |
MLA | Yumuşak, N. , Koca, G. , Akbulut, A. , Atılgan, H. İ. , Korkmaz, M. "Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 (2022 ): 265-272 <http://vetjournal.ankara.edu.tr/en/pub/issue/70947/871118> |
Chicago | Yumuşak, N. , Koca, G. , Akbulut, A. , Atılgan, H. İ. , Korkmaz, M. "Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 (2022 ): 265-272 |
RIS | TY - JOUR T1 - Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage AU - NihatYumuşak, GökhanKoca, AylinAkbulut, Hasan İkbalAtılgan, MelihaKorkmaz Y1 - 2022 PY - 2022 N1 - doi: 10.33988/auvfd.871118 DO - 10.33988/auvfd.871118 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 265 EP - 272 VL - 69 IS - 3 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.871118 UR - https://doi.org/10.33988/auvfd.871118 Y2 - 2021 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage %A Nihat Yumuşak , Gökhan Koca , Aylin Akbulut , Hasan İkbal Atılgan , Meliha Korkmaz %T Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage %D 2022 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 69 %N 3 %R doi: 10.33988/auvfd.871118 %U 10.33988/auvfd.871118 |
ISNAD | Yumuşak, Nihat , Koca, Gökhan , Akbulut, Aylin , Atılgan, Hasan İkbal , Korkmaz, Meliha . "Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 / 3 (June 2022): 265-272 . https://doi.org/10.33988/auvfd.871118 |
AMA | Yumuşak N. , Koca G. , Akbulut A. , Atılgan H. İ. , Korkmaz M. Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage. Ankara Univ Vet Fak Derg. 2022; 69(3): 265-272. |
Vancouver | Yumuşak N. , Koca G. , Akbulut A. , Atılgan H. İ. , Korkmaz M. Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2022; 69(3): 265-272. |
IEEE | N. Yumuşak , G. Koca , A. Akbulut , H. İ. Atılgan and M. Korkmaz , "Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage", Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 69, no. 3, pp. 265-272, Jun. 2022, doi:10.33988/auvfd.871118 |