Research Article
Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage
Abstract
The aim of this study was to investigated anti-proliferative and anti-apoptotic effects of coenzyme Q10 (CoQ10) in the prevention of radioiodine-131 (RAI) (I131) induced kidney damage. A total of 24 Wistar albino rats were separated into equal three groups (n = 8/group): Group 1 (control): untreated group; Group 2 (RAI): 3 mCi/kg RAI oral route; Group 3 (RAI+CoQ10): 3 mCi/kg RAI oral route and intraperitoneally 30 mg/kg/day CoQ10. CoQ10 treatment was started two days before RAI administration and was continued five days once daily after RAI. Pathomorphological parameters of kidneys were measured using hematoxylin–eosin and Masson’s trichrome staining. Immunohistochemically; proliferating cell nuclear antigen (PCNA), caspase 8, caspase 9 and terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) were used to determine proliferation and apoptosis. With the exception of the control group, varying degrees of inflammation, degeneration, necrosis, and interstitial/perivascular fibrosis were detected in the kidneys of all rats. This histopathological damage was found to be significantly less in CoQ10 group versus RAI group (P<0.05). The all immunohistochemical examinations demonstrated that administration of CoQ10 had reduced proliferation and apoptosis (P<0.05). The results of kidney histopathology and immunohistochemistry demonstrated that administration of CoQ10 had reduced inflammation, proliferation, and apoptosis. These findings show CoQ10 can play an important role in the radioprotection of kidneys against RAI-induced damage
Thanks
Some part of this article was summarized from the first author’s master thesis.
References
- Abitagaoglu S, Akinci SB, Saricaoglu F, et al (2015): Effect of coenzyme Q10 on organ damage in sepsis. Bratisl Med J, 116, 433–439.
- Almeida IV, Dusman E, Heck MC, et al (2013): Cytotoxic and mutagenic effects of iodine–131 and radioprotection of acerola (Malpighia glabra L.) and beta–carotene in vitro. Genet Mol Res, 12, 6402-6413.
- Baradaran–Ghahfarokhi M (2012): Radiation–induced kidney injury. J Renal Inj Prev, 1, 49-50.
- Barlas A, Bag Y, Pekcici M, et al (2017): Melatonin: a hepatoprotective agent against radioiodine toxicity in rats. Bratisl Med J, 118, 95-100.
- Caloglu M, Caloglu VY, Altun GD, et al (2009): Histopathological and scintigraphic comparisons of the protective effects of L–carnitine and amifostine against radiation–induced late renal toxicity in rats. Clin Exp Pharmacol Physiol, 36, 523-530.
- Carrasco J, Anglada FJ, Campos JP, et al (2014): The protective role of coenzyme Q 10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial. BJU Int, 113, 942-950.
- Driver I, Packer S (2001): Radioactive waste discharge quantities for patients undergoing radioactive iodine therapy for thyroid carcinoma. Nucl Med Commun, 22, 1129-1132.
- Fatima S, Al–Mohaimeed N, Al–Shaikh Y, et al (2016): Combined treatment of epigallocatechin gallate and Coenzyme Q10 attenuates cisplatin–induced nephrotoxicity via suppression of oxidative/nitrosative stress, inflammation and cellular damage. Food Chem Toxicol, 94, 213-220.
- Fatima S, Al‐Mohaimeed N, Arjumand S, et al (2015): Effect of Pre‐and Post–Combined Multidoses of Epigallocatechin Gallate and Coenzyme Q10 on Cisplatin‐Induced Oxidative Stress in Rat Kidney. J Biochem Mol Toxicol, 29, 91-97.
- Haugen BR, Alexander EK, Bible KC, et al (2016): Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid, 26, 1-133.
- Hemmi NB, Raj KC (2006): Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res, 40, 445-453.
- Ishikawa A, Kawarazaki H, Ando K, et al (2011): Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. Clin Exp Nephrol, 15, 30-33.
- Kanter M, Tarladacalisir YT, Uzal C (2011): Role of amifostine on acute and late radiation nephrotoxicity: A histopathological study. In Vivo, 25, 77-86.
- Kirdag MK, Tuglu D, Yuvanc E, et al (2019): The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction. Turk J Urol, 45, 70-77.
- Kwong LK, Kamzalov S, Rebrin I, et al (2002): Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med, 33, 627-638.
- Li X, Zhan J, Hou Y, et al (2019): Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H2O2 Induced BMSC Death by Modulating the Nrf–2/NQO–1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury. Oxid Med Cell Longev, 12, 6493081.
- Luna LG (1968): Manual of histologic staining methods of the armed forces. Institute of Pathology. New York: Blakiston, 1-46.
- Mahfoz AM (2019): Renal protective effects of coenzyme Q10 against chromate induced nephrotoxicity in rats. J Applied Sci, 19, 453-458.
- Marx K, Moka D, Schomacker K, et al (2006): Cell death induced by 131I in a differentiated thyroid carcinoma cell line in vitro: Necrosis or apoptosis? Nucl Med Commun, 27, 353-358.
- Okudan N, Revan S, Balci SS, et al (2012): Effects of CoQ10 supplementation and swimming training on exhaustive exercise–induced oxidative stress in rat heart. Bratisl Med J, 113, 393-399.
- Saiki R, Lunceford AL, Shi Y, et al (2008): Coenzyme Q10 supplementation rescues renal disease in Pdss2 kd/kd mice with mutations in prenyl diphosphate synthase subunit 2. Am J Physiol Renal Physiol, 295, 1535-1544.
- Savitskaya MA, Onishchenko GE (2015): Mechanisms of apoptosis. Biochemistry, 80, 1393-1405.
- Soltani R, Alikiaie B, Shafiee F, et al (2020): Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients. Bratisl Med J, 121, 154-158.
- Spitzweg C, Morris JC (2002): The sodium iodide symporter: its pathophysiological and therapeutic implications. Clin Endocrinol (Oxf), 57, 559-574.
- Surucu E, Bekis R, Sengoz T, et al (2013): The effect of radioiodine on the intima media thickness of the carotid artery. Mol Imaging Radionucl Ther, 22, 85-89.
- Ustuner MA, Kaman D, Colakoglu N (2017): Effects of benfotiamine and coenzyme Q10 on kidney damage induced gentamicin. Tissue Cell, 49, 691-696.
- Vakifahmetoglu–Norberg H, Ouchida AT, Norberg E (2017): The role of mitochondria in metabolism and cell death. Biochem Biophys Res Commun, 482, 426-431.
- Yakin M, Eksioglu U, Sadic M, et al (2017): Coenzyme Q10 for the protection of lacrimal gland against high–dose radioiodine therapy–associated oxidative damage: histopathologic and tissue cytokine level assessments in an animal model. Curr Eye Res, 42, 1590-1596.
- Yumusak N, Sadic M, Akbulut A, et al (2019): Beneficial effects of vitamin E on radioiodine induced gastrointestinal damage: an experimental and pathomorphological study. Bratisl Med J, 120, 263-269.
- Yumusak N, Sadic M, Yucel G, et al (2018): Apoptosis and cell proliferation in short–term and long–term effects of radioiodine–131 induced kidney damage: an experimental and immunohistochemical study. Nucl Med Commun, 39, 131-139.
- Zahed NS, Ghassami M, Nikbakht H (2016): Effects of coenzyme Q10 supplementation on C–reactive protein and homocysteine as the inflammatory markers in hemodialysis patients; a randomized clinical trial. J Nephropathol, 5, 38-43
Year 2022,
Volume: 69 Issue: 3, 265 - 272, 30.06.2022
Abstract
References
- Abitagaoglu S, Akinci SB, Saricaoglu F, et al (2015): Effect of coenzyme Q10 on organ damage in sepsis. Bratisl Med J, 116, 433–439.
- Almeida IV, Dusman E, Heck MC, et al (2013): Cytotoxic and mutagenic effects of iodine–131 and radioprotection of acerola (Malpighia glabra L.) and beta–carotene in vitro. Genet Mol Res, 12, 6402-6413.
- Baradaran–Ghahfarokhi M (2012): Radiation–induced kidney injury. J Renal Inj Prev, 1, 49-50.
- Barlas A, Bag Y, Pekcici M, et al (2017): Melatonin: a hepatoprotective agent against radioiodine toxicity in rats. Bratisl Med J, 118, 95-100.
- Caloglu M, Caloglu VY, Altun GD, et al (2009): Histopathological and scintigraphic comparisons of the protective effects of L–carnitine and amifostine against radiation–induced late renal toxicity in rats. Clin Exp Pharmacol Physiol, 36, 523-530.
- Carrasco J, Anglada FJ, Campos JP, et al (2014): The protective role of coenzyme Q 10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial. BJU Int, 113, 942-950.
- Driver I, Packer S (2001): Radioactive waste discharge quantities for patients undergoing radioactive iodine therapy for thyroid carcinoma. Nucl Med Commun, 22, 1129-1132.
- Fatima S, Al–Mohaimeed N, Al–Shaikh Y, et al (2016): Combined treatment of epigallocatechin gallate and Coenzyme Q10 attenuates cisplatin–induced nephrotoxicity via suppression of oxidative/nitrosative stress, inflammation and cellular damage. Food Chem Toxicol, 94, 213-220.
- Fatima S, Al‐Mohaimeed N, Arjumand S, et al (2015): Effect of Pre‐and Post–Combined Multidoses of Epigallocatechin Gallate and Coenzyme Q10 on Cisplatin‐Induced Oxidative Stress in Rat Kidney. J Biochem Mol Toxicol, 29, 91-97.
- Haugen BR, Alexander EK, Bible KC, et al (2016): Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid, 26, 1-133.
- Hemmi NB, Raj KC (2006): Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res, 40, 445-453.
- Ishikawa A, Kawarazaki H, Ando K, et al (2011): Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. Clin Exp Nephrol, 15, 30-33.
- Kanter M, Tarladacalisir YT, Uzal C (2011): Role of amifostine on acute and late radiation nephrotoxicity: A histopathological study. In Vivo, 25, 77-86.
- Kirdag MK, Tuglu D, Yuvanc E, et al (2019): The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction. Turk J Urol, 45, 70-77.
- Kwong LK, Kamzalov S, Rebrin I, et al (2002): Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med, 33, 627-638.
- Li X, Zhan J, Hou Y, et al (2019): Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H2O2 Induced BMSC Death by Modulating the Nrf–2/NQO–1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury. Oxid Med Cell Longev, 12, 6493081.
- Luna LG (1968): Manual of histologic staining methods of the armed forces. Institute of Pathology. New York: Blakiston, 1-46.
- Mahfoz AM (2019): Renal protective effects of coenzyme Q10 against chromate induced nephrotoxicity in rats. J Applied Sci, 19, 453-458.
- Marx K, Moka D, Schomacker K, et al (2006): Cell death induced by 131I in a differentiated thyroid carcinoma cell line in vitro: Necrosis or apoptosis? Nucl Med Commun, 27, 353-358.
- Okudan N, Revan S, Balci SS, et al (2012): Effects of CoQ10 supplementation and swimming training on exhaustive exercise–induced oxidative stress in rat heart. Bratisl Med J, 113, 393-399.
- Saiki R, Lunceford AL, Shi Y, et al (2008): Coenzyme Q10 supplementation rescues renal disease in Pdss2 kd/kd mice with mutations in prenyl diphosphate synthase subunit 2. Am J Physiol Renal Physiol, 295, 1535-1544.
- Savitskaya MA, Onishchenko GE (2015): Mechanisms of apoptosis. Biochemistry, 80, 1393-1405.
- Soltani R, Alikiaie B, Shafiee F, et al (2020): Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients. Bratisl Med J, 121, 154-158.
- Spitzweg C, Morris JC (2002): The sodium iodide symporter: its pathophysiological and therapeutic implications. Clin Endocrinol (Oxf), 57, 559-574.
- Surucu E, Bekis R, Sengoz T, et al (2013): The effect of radioiodine on the intima media thickness of the carotid artery. Mol Imaging Radionucl Ther, 22, 85-89.
- Ustuner MA, Kaman D, Colakoglu N (2017): Effects of benfotiamine and coenzyme Q10 on kidney damage induced gentamicin. Tissue Cell, 49, 691-696.
- Vakifahmetoglu–Norberg H, Ouchida AT, Norberg E (2017): The role of mitochondria in metabolism and cell death. Biochem Biophys Res Commun, 482, 426-431.
- Yakin M, Eksioglu U, Sadic M, et al (2017): Coenzyme Q10 for the protection of lacrimal gland against high–dose radioiodine therapy–associated oxidative damage: histopathologic and tissue cytokine level assessments in an animal model. Curr Eye Res, 42, 1590-1596.
- Yumusak N, Sadic M, Akbulut A, et al (2019): Beneficial effects of vitamin E on radioiodine induced gastrointestinal damage: an experimental and pathomorphological study. Bratisl Med J, 120, 263-269.
- Yumusak N, Sadic M, Yucel G, et al (2018): Apoptosis and cell proliferation in short–term and long–term effects of radioiodine–131 induced kidney damage: an experimental and immunohistochemical study. Nucl Med Commun, 39, 131-139.
- Zahed NS, Ghassami M, Nikbakht H (2016): Effects of coenzyme Q10 supplementation on C–reactive protein and homocysteine as the inflammatory markers in hemodialysis patients; a randomized clinical trial. J Nephropathol, 5, 38-43
There are 31 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 30, 2022 |
| Published in Issue | Year 2022Volume: 69 Issue: 3 |
