Case Report
Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata)
Year 2022, Volume: 69 Issue: 3, 341 - 345, 30.06.2022Abstract
A 2-year-old Asian Houbara bustard was presented with a solitary well-defined, firm cutaneous mass on the hock region. Grossly, the mass protruded from the surface was located on the hairless and unpigmented areas of the right hock joint with ulceration and dried hemorrhagic foci. On microscopic examination, ulceration, hemorrhage, as well as hyperkeratosis were observed. Large round, oval to polygonal neoplastic cells extended into the dermis were arranged to form cords, trabeculae, islands or glandular-like structures without keratin pearls. These pseudoglandular structures were composed of pseudolumina containing acantholytic and detached tumor cells. Necrosis of the neoplastic cells was accompanied by infiltration of inflammatory cells particularly heterophils. Unlike pleomorphic tumor cells, mitosis count was almost frequent. No evidence of other abnormalities and tumor metastasis was found. These gross and microscopic features appeared to be suggestive of a rare histologic variant of squamous cell carcinoma (SCC), acantholytic SCC.
Keywords
Acantholytic squamous cell carcinoma, Chlamydotis undulata, histopathology, Houbara bustard
References
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- Abou-Elmagd Sh, Kotb H, Abdalla K, et al (2011): Prevalence of Candida albicans and Cryptococcus neoformans in Animals from Quena Governorate with Special Reference to RAPD-PCR Patterns. J Am Sci, 7, 20-31.
- Christianson JC, Engber W, Andes D (2003): Primary cutaneous cryptococcosis in immunocompetent and immunocompromised hosts. Med Mycol, 41, 177–188.
- Cushing T, Barnard S, Fleis R, et al (2010): Pseudoangiomatous squamous cell carcinoma in the oral cavity of a dog. J Vet Diagn Invest, 22, 299-302.
- Duperval R, Hermans PE, Brewer NS, et al (1977): Cryptococcosis, with emphasis on the significance of isolation of Cryptococcus neoformans from the respiratory tract. Chest, 72, 13-19.
- Gaylord EA, Choy HL, Doering TL (2020): Dangerous Liaisons: interactions of Cryptococcus neoformans with host phagocytes. Pathogens, 9, 891.
- Goldschmidt MH, Goldschmidt KH (2017): Tumor of the skin and soft tissues. In: Meuten DJ, editor. Tumors in domestic animals. 5th edition, John Wiley and Sons, Inc, P. 88-141.
- Grandi F, Monteiro LN, Fernandes TR, et al (2011): What is your diagnosis? Cutaneous mass in the mammary region of a dog. Vet Clin Pathol, 40, 101-102.
- Gushiken AC, Saharia KK, Baddley JW (2021): Cryptococcosis. Infect Dis Clin North Am, 35, 493-514.
- Jurcic V, Kukovic J, Zidar N (2015): Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin. Histol Histopathol, 30, 945-953.
- Kerawala CJ (2009): Acantholytic squamous cell carcinoma of the oral cavity: a more aggressive entity? Br J Oral Maxillofac Surg, 47, 123-125.
- Kiani K, Dezfoulian O, Sookhthezari A, et al (2010): Acantholytic squamous cell carcinoma in a cow. Vet Clin Pathol, 19, 397-400.
- Longhitano S, Peccerillo F, Odorici G, et al (2019): An unusual presentation of primary cutaneous cryptococcosis. Dermatol Ther, 32, e12942.
- Mallany HP, Curcin N, Borgia S, et al (2021): Squamous cell proliferation as a reactive mechanism to laryngeal cryptococcus infection: a case report. Cureus, 13, e12587.
- Mardi K, Singh N (2014): Acantholytic squamous cell carcinoma of the oral cavity: a rare entity. J Oral Maxillofac Pathol, 18, S128.
- Mohammad M, Wilcox R (2018): Morphologic mimicry: acantholytic squamous cell carcinoma in nondermal locations-a literature review. Ann N Y Acad Sci, 1434, 102-108.
- Neuville S, Dromer F, Morin O, et al (2003): Primary cutaneous cryptococcosis: a distinct clinical entity. Clin Infect Dis, 36, 337-347.
- Noguchi H, Matsumoto T, Kimura U, et al (2019): Cutaneous cryptococcosis. Med Mycol J, 60, 101-107.
- Pui J (2006): Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med, 130, 764.
- Refai MK, El-Hariri M, Alarousy R (2017): Cryptococcosis in animals and birds: A review. Eur J Acad Essays, 4, 202-223.
- Romanucci M, Malatesta D, Marinelli A, et al (2011): Aural carcinoma with chondroid metaplasia at metastatic sites in a dog. Vet Dermatol, 22, 373-377.
- Saleh H, Moawad AA, El- Hariri M, et al (2011): Prevalence of yeasts in human, animals and soil sample in el-fayoum governorate in Egypt. Int J Microbiol, 2, 233-239.
- Silva IC, Sarandy TB, Tamiasso NV, et al (2018): Metastatic submandibular acantholytic squamous cell carcinoma in a dog. Braz J Vet Pathol, 11, 19-23.
- Singh SD, Dash BB (2008): Spontaneous lesions of cryptococcosis in white Leghorn chicken. Indian J Vet Pathol, 32, 68-69.
- Tourenq C, Combreau O, Lawrence M, et al (2005): Alarming houbara bustard population trends in Asia. Biol Conserv, 121, 1-8.
Year 2022, Volume: 69 Issue: 3, 341 - 345, 30.06.2022
Abstract
References
- Abo El-Yazeed H, Ezz-Eldin N, Tawakkol W, et al (2006): Isolation and identification of Cryptococcus neoformans from bird droppings, with special reference to newly formulated differential media based on development of brown colonies. J Egy Vet Med Assoc, 66, 165-179.
- Abou-Elmagd Sh, Kotb H, Abdalla K, et al (2011): Prevalence of Candida albicans and Cryptococcus neoformans in Animals from Quena Governorate with Special Reference to RAPD-PCR Patterns. J Am Sci, 7, 20-31.
- Christianson JC, Engber W, Andes D (2003): Primary cutaneous cryptococcosis in immunocompetent and immunocompromised hosts. Med Mycol, 41, 177–188.
- Cushing T, Barnard S, Fleis R, et al (2010): Pseudoangiomatous squamous cell carcinoma in the oral cavity of a dog. J Vet Diagn Invest, 22, 299-302.
- Duperval R, Hermans PE, Brewer NS, et al (1977): Cryptococcosis, with emphasis on the significance of isolation of Cryptococcus neoformans from the respiratory tract. Chest, 72, 13-19.
- Gaylord EA, Choy HL, Doering TL (2020): Dangerous Liaisons: interactions of Cryptococcus neoformans with host phagocytes. Pathogens, 9, 891.
- Goldschmidt MH, Goldschmidt KH (2017): Tumor of the skin and soft tissues. In: Meuten DJ, editor. Tumors in domestic animals. 5th edition, John Wiley and Sons, Inc, P. 88-141.
- Grandi F, Monteiro LN, Fernandes TR, et al (2011): What is your diagnosis? Cutaneous mass in the mammary region of a dog. Vet Clin Pathol, 40, 101-102.
- Gushiken AC, Saharia KK, Baddley JW (2021): Cryptococcosis. Infect Dis Clin North Am, 35, 493-514.
- Jurcic V, Kukovic J, Zidar N (2015): Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin. Histol Histopathol, 30, 945-953.
- Kerawala CJ (2009): Acantholytic squamous cell carcinoma of the oral cavity: a more aggressive entity? Br J Oral Maxillofac Surg, 47, 123-125.
- Kiani K, Dezfoulian O, Sookhthezari A, et al (2010): Acantholytic squamous cell carcinoma in a cow. Vet Clin Pathol, 19, 397-400.
- Longhitano S, Peccerillo F, Odorici G, et al (2019): An unusual presentation of primary cutaneous cryptococcosis. Dermatol Ther, 32, e12942.
- Mallany HP, Curcin N, Borgia S, et al (2021): Squamous cell proliferation as a reactive mechanism to laryngeal cryptococcus infection: a case report. Cureus, 13, e12587.
- Mardi K, Singh N (2014): Acantholytic squamous cell carcinoma of the oral cavity: a rare entity. J Oral Maxillofac Pathol, 18, S128.
- Mohammad M, Wilcox R (2018): Morphologic mimicry: acantholytic squamous cell carcinoma in nondermal locations-a literature review. Ann N Y Acad Sci, 1434, 102-108.
- Neuville S, Dromer F, Morin O, et al (2003): Primary cutaneous cryptococcosis: a distinct clinical entity. Clin Infect Dis, 36, 337-347.
- Noguchi H, Matsumoto T, Kimura U, et al (2019): Cutaneous cryptococcosis. Med Mycol J, 60, 101-107.
- Pui J (2006): Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med, 130, 764.
- Refai MK, El-Hariri M, Alarousy R (2017): Cryptococcosis in animals and birds: A review. Eur J Acad Essays, 4, 202-223.
- Romanucci M, Malatesta D, Marinelli A, et al (2011): Aural carcinoma with chondroid metaplasia at metastatic sites in a dog. Vet Dermatol, 22, 373-377.
- Saleh H, Moawad AA, El- Hariri M, et al (2011): Prevalence of yeasts in human, animals and soil sample in el-fayoum governorate in Egypt. Int J Microbiol, 2, 233-239.
- Silva IC, Sarandy TB, Tamiasso NV, et al (2018): Metastatic submandibular acantholytic squamous cell carcinoma in a dog. Braz J Vet Pathol, 11, 19-23.
- Singh SD, Dash BB (2008): Spontaneous lesions of cryptococcosis in white Leghorn chicken. Indian J Vet Pathol, 32, 68-69.
- Tourenq C, Combreau O, Lawrence M, et al (2005): Alarming houbara bustard population trends in Asia. Biol Conserv, 121, 1-8.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary |
| Journal Section | Case Report |
| Authors |
|
| Thanks | The authors are truly grateful to Mr. Saeed Hassanzadeh for his technical assistance. |
| Publication Date | June 30, 2022 |
| Published in Issue | Year 2022Volume: 69 Issue: 3 |
Cite
| Bibtex | @case report { auvfd963458, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara University}, year = {2022}, volume = {69}, number = {3}, pages = {341 - 345}, doi = {10.33988/auvfd.963458}, title = {Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata)}, key = {cite}, author = {Kheırandısh, Reza and Alıdadı, Soodeh and Azizi, Shahrzad and Azamı, Atena} } |
| APA | Kheırandısh, R. , Alıdadı, S. , Azizi, S. & Azamı, A. (2022). Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata) . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 69 (3) , 341-345 . DOI: 10.33988/auvfd.963458 |
| MLA | Kheırandısh, R. , Alıdadı, S. , Azizi, S. , Azamı, A. "Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata)" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 (2022 ): 341-345 <http://vetjournal.ankara.edu.tr/en/pub/issue/70947/963458> |
| Chicago | Kheırandısh, R. , Alıdadı, S. , Azizi, S. , Azamı, A. "Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata)". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 (2022 ): 341-345 |
| RIS | TY - JOUR T1 - Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata) AU - RezaKheırandısh, SoodehAlıdadı, ShahrzadAzizi, AtenaAzamı Y1 - 2022 PY - 2022 N1 - doi: 10.33988/auvfd.963458 DO - 10.33988/auvfd.963458 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 341 EP - 345 VL - 69 IS - 3 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.963458 UR - https://doi.org/10.33988/auvfd.963458 Y2 - 2022 ER - |
| EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata) %A Reza Kheırandısh , Soodeh Alıdadı , Shahrzad Azizi , Atena Azamı %T Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata) %D 2022 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 69 %N 3 %R doi: 10.33988/auvfd.963458 %U 10.33988/auvfd.963458 |
| ISNAD | Kheırandısh, Reza , Alıdadı, Soodeh , Azizi, Shahrzad , Azamı, Atena . "Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata)". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 / 3 (June 2022): 341-345 . https://doi.org/10.33988/auvfd.963458 |
| AMA | Kheırandısh R. , Alıdadı S. , Azizi S. , Azamı A. Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata). Ankara Univ Vet Fak Derg. 2022; 69(3): 341-345. |
| Vancouver | Kheırandısh R. , Alıdadı S. , Azizi S. , Azamı A. Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata). Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2022; 69(3): 341-345. |
| IEEE | R. Kheırandısh , S. Alıdadı , S. Azizi and A. Azamı , "Pathologic findings of acantholytic squamous cell carcinoma coexisting with cutaneous cryptococcosis in a Houbara bustard (Chlamydotis undulata)", Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 69, no. 3, pp. 341-345, Jun. 2022, doi:10.33988/auvfd.963458 |
