Research Article
Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis
Year 2023, Volume: 70 Issue: 1, 37 - 42, 30.12.2022Abstract
In this study, it was aimed to investigate the serum levels of ANGPTL4, FGF21, IL-1β, IL-6, SOD, MDA, and serum biochemical and hematological parameters in cows with subclinical ketosis. The mean serum β-hydroxybutyric acid (BHB) level was 1.37 ± 0.04 mmol/L in 10 dairy cows aged 3-5 years that were <21 days postpartum and diagnosed with subclinical ketosis. The mean serum BHB level was 0.40 ± 0.08 mmol/L in 10 healthy dairy cows in the same period and in the same age range. An increase in serum AST (P<0.001) and a decrease in serum albumin levels (P<0.05) indicated altered liver functions. An increase in serum non-esterified fatty acid (P<0.001) and decreases in serum HDL, triglyceride, and total cholesterol levels (P<0.05) were interpreted as indicators of increased metabolic pathology risk due to negative energy balance. Increases in serum ANGPTL4, FGF2, IL-1β, IL-6, and MDA (P<0.001) and SOD levels (P<0.05) were evaluated as indicators of the development of effective metabolic, inflammatory, and oxidative stress.
It was concluded that significant increases in serum ANGPTL4, FGF2, IL-1β, IL-6, and MDA and SOD levels in dairy cows with subclinical ketosis were associated with negative energy balance, effective cytokine responses, and oxidative stress.
References
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- Chen Y, Dong Z, Li R, et al (2018): Changes in selected biochemical parameters (including FGF21) during subclinical and clinical ketosis in dairy cows. Med Weteryn, 74, 727-730.
- Fiore E, Piccione G, Rizzo M, et al (2018): Adaptation of some energetic parameters during transition period in dairy cows, J Appl Anim Res, 46, 402-405.
- Folnozic I, Turk R, Duricic D, et al (2015): Influence of Body Condition on Serum Metabolic Indicators of Lipid Mobilization and Oxidative Stress in Dairy Cows During the Transition Period. Rep Domestic Anim, 50, 910-917.
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- Grummer RR (1993): Etiology of lipid-related metabolic disorders in periparturient dairy cows. J Dairy Sci, 76, 3882-3896.
- Halliwell B (2007): Biochemistry of oxidative stress. Biochem Soci Trans, 35, 1147-1150.
- Ingvartsen KL (2006): Feeding-and management-related diseases in the transition cow: Physiological adaptations around calving and strategies to reduce feeding-related diseases. Anim Feed Sci, Technol, 126, 175–213.
- Issi M, Gül Y, Basbug O (2016): Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis. Turk J Vet Anim Sci, 40, 47-52.
- Karimi N, Mohri M, Azizzadeh M, et al (2015): Relationships between trace elements, oxidative stress and subclinical ketosis during transition period in dairy cows. Iran J Vet Sci Techn, 7, 46-56.
- Lacetera N, Scalia D, Franci O, et al (2004): Short communication: effects of nonesterified fatty acids on lymphocyte function in dairy heifers. J Dairy Sci, 87, 1012–1014.
- Li XB, Zhang ZG, Liu GW, et al (2011): Renal function of dairy cows with subclinical ketosis. Vet Rec, 168, 643.
- Loor JJ, Everts RE, Bionaz M, et al (2007): Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows. Physiol Genomics, 32, 105-116.
- Mamedova LK, Robbins K, Johnson BJ, et al (2010): Tissue expression of angiopoietin-like protein 4 in cattle. J Anim Sci, 88, 124-130.
- Marutsova V, Binev R, Marutsov P (2015): Comparative clinical and haematological investigations in lactating cows with subclinical and cliniıcal ketosis. Mac Vet Rev, 38, 159-166.
- Marutsova VJ, Marutsov PD, Binev RG (2019): Evaluation of some blood liver parameters in cows with subclinical and clinical ketosis. Bulgarian J Vet Med, 22, 314-321.
- Mazur A, Rayssiquier Y (1988): Lipoprotein profile of the lactating cow. Ann Rech Vet, 19, 53-58.
- Opsomer G (2015): Interaction between metabolic challenges and productivity in high yielding dairy cows. Jap J Vet Res, 63, 1-14.
- Rodriguez-Jimenez S, Haerr KJ, Trevisi E, et al (2018): Prepartal standing behavior as a parameter for early detection of postpartal subclinical ketosis associated with inflammation and liver function biomarkers in peripartal dairy cows. Journal of Dairy Science, 101, 8224-8235.
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- Schoenberg KM, Giesy SL, Harvatine KJ, et al (2011): Plasma FGF21 is elevated by the intense lipid mobilization of lactation. Endocrinol, 152, 4652-4661.
- Schulz K, Frahm J, Kersten S, et al (2014): Effects of elevated parameters of subclinical ketosis on the immune system of dairy cows: in vivo and in vitro results. Arch Anim Nutr, 69, 113-127.
- Senoh T, Oikawa S, Nakada K, et al (2019): Increased serum malondialdehyde concentration in cows with subclinical ketosis. J Vet Med Sci, 81, 817-820.
- Sun Y, Wang B, Shu S, et al (2015): Critical thresholds of liver function parameters for ketosis prediction in dairy cows using receiver operating characteristic (ROC) analysis. Vet Quarterly, 35, 159-164.
- Trevisi E, Amadori M, Cogrossi S, et al (2012): Metabolic stress and inflammatory response in high-yielding, periparturient dairy cows. Res Vet Sci, 93, 695-704.
- Trevisi E, Jahan N, Bertoni G, et al (2015): Pro-Inflammatory Cytokine Profile in Dairy Cows: Consequences for New Lactation. Italian J Anim Sci, 14, 3862.
- Turk R, PodpeCan O, Mrkun J, et al (2013): Lipid mobilisation and oxidative stress as metabolic adaptation processes in dairy heifers during transition period. Anim Repr Sci, 141, 109-115.
- Wang J, Zhu X, She G, et al (2018): Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders. BMC Veterinary Research, 14, 236.
- Wankhade PR, Manimaran A, Kumaresan A, et al (2017): Metabolic and immunological changes in transition dairy cows: A review. Vet World, 10, 1367–1377.
- Yang W, Zhang B, Xu C, et al (2019): Effects of ketosis in dairy cows on blood biochemical parameters, milk yield and composition, and digestive capacity. J Vet Res, 63, 555-560.
- Zhang Y, Li X, Zhang H, et al (2018): Non-Esterified Fatty Acids Over-Activate the TLR2/4-NF-Κb Signaling Pathway to Increase Inflammatory Cytokine Synthesis in Neutrophils from Ketotic Cows. Cell Physiol Biochem, 48, 827-837.
Year 2023, Volume: 70 Issue: 1, 37 - 42, 30.12.2022
Abstract
References
- Agalakova NI, Gusev GP (2012): Molecular mechanisms of cytotoxicity and apoptosis induced by inorganic fluoride. ISRN Cell Biol, Article ID 403835.
- Antanaitis R, Juozaitiene V, Malasauskiene D, et al (2019): Can rumination time and some blood biochemical parameters be used as biomarkers for the diagnosis of subclinical acidosis and subclinical ketosis. Vet Anim Sci, 8, 100077.
- Badman MK, Pissios P, Kennedy AR, et al (2007): Hepatic fibroblast growth factor 21 is regulated by PPAR alpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab, 5, 426-437.
- Basbug O, Akar Y, Ercan N (2014): The investigation of the prevalence of subclinical ketosis in Sivas region dairy cows. Eurasian J Vet Sci, 30, 123-128.
- Bernabucci U, Ronchi B, Lacetera N, et al (2005): Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. J Dairy Sci, 88, 2017-2026.
- Bruckmaier RM, Gross JJ (2017): Lactational challenges in transition dairy cows. Anim Prod Sci, 57, 1471-1481.
- Brunner N, Groeger S, Raposo JC, et al (2018): Prevalence of subclinical ketosis and production diseases in dairy cows in Central and South America, Africa, Asia, Australia, New Zealand, and Eastern Europe. Transl Anim Sci, 3, 84-92.
- Chen Y, Dong Z, Li R, et al (2018): Changes in selected biochemical parameters (including FGF21) during subclinical and clinical ketosis in dairy cows. Med Weteryn, 74, 727-730.
- Fiore E, Piccione G, Rizzo M, et al (2018): Adaptation of some energetic parameters during transition period in dairy cows, J Appl Anim Res, 46, 402-405.
- Folnozic I, Turk R, Duricic D, et al (2015): Influence of Body Condition on Serum Metabolic Indicators of Lipid Mobilization and Oxidative Stress in Dairy Cows During the Transition Period. Rep Domestic Anim, 50, 910-917.
- Gavan C, Retea C, Motorga V (2010): Changes in the hematological profile of Holstein primiparous in periparturient period and in early to mid-lactation. Anim Sci Biotec, 43, 244-246.
- Grummer RR (1993): Etiology of lipid-related metabolic disorders in periparturient dairy cows. J Dairy Sci, 76, 3882-3896.
- Halliwell B (2007): Biochemistry of oxidative stress. Biochem Soci Trans, 35, 1147-1150.
- Ingvartsen KL (2006): Feeding-and management-related diseases in the transition cow: Physiological adaptations around calving and strategies to reduce feeding-related diseases. Anim Feed Sci, Technol, 126, 175–213.
- Issi M, Gül Y, Basbug O (2016): Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis. Turk J Vet Anim Sci, 40, 47-52.
- Karimi N, Mohri M, Azizzadeh M, et al (2015): Relationships between trace elements, oxidative stress and subclinical ketosis during transition period in dairy cows. Iran J Vet Sci Techn, 7, 46-56.
- Lacetera N, Scalia D, Franci O, et al (2004): Short communication: effects of nonesterified fatty acids on lymphocyte function in dairy heifers. J Dairy Sci, 87, 1012–1014.
- Li XB, Zhang ZG, Liu GW, et al (2011): Renal function of dairy cows with subclinical ketosis. Vet Rec, 168, 643.
- Loor JJ, Everts RE, Bionaz M, et al (2007): Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows. Physiol Genomics, 32, 105-116.
- Mamedova LK, Robbins K, Johnson BJ, et al (2010): Tissue expression of angiopoietin-like protein 4 in cattle. J Anim Sci, 88, 124-130.
- Marutsova V, Binev R, Marutsov P (2015): Comparative clinical and haematological investigations in lactating cows with subclinical and cliniıcal ketosis. Mac Vet Rev, 38, 159-166.
- Marutsova VJ, Marutsov PD, Binev RG (2019): Evaluation of some blood liver parameters in cows with subclinical and clinical ketosis. Bulgarian J Vet Med, 22, 314-321.
- Mazur A, Rayssiquier Y (1988): Lipoprotein profile of the lactating cow. Ann Rech Vet, 19, 53-58.
- Opsomer G (2015): Interaction between metabolic challenges and productivity in high yielding dairy cows. Jap J Vet Res, 63, 1-14.
- Rodriguez-Jimenez S, Haerr KJ, Trevisi E, et al (2018): Prepartal standing behavior as a parameter for early detection of postpartal subclinical ketosis associated with inflammation and liver function biomarkers in peripartal dairy cows. Journal of Dairy Science, 101, 8224-8235.
- Sahoo SS, Patra RC, Behera PC, et al (2009): Oxidative stress indices in the erythrocytes from lactating cows after treatment for subclinical ketosis with antioxidant incorporated in the therapeutic regime. Vet Res Commun, 33, 281-290.
- Sato S, Kohno M, Ono H (2005): Relation between blood β-hydroxybutyric acid and glucose, non-esterified fatty acid and aspartate aminotransferase in dairy cows with subclinical ketosis. Jap J Vet Clin, 28, 7-13.
- Schlegel G, Ringseis R, Keller J, et al (2013): Expression of fibroblast growth factor 21 in the liver of dairy cows in the transition period and during lactation. J Anim Physiol Anim Nutr, 97, 820–829.
- Schoenberg KM, Giesy SL, Harvatine KJ, et al (2011): Plasma FGF21 is elevated by the intense lipid mobilization of lactation. Endocrinol, 152, 4652-4661.
- Schulz K, Frahm J, Kersten S, et al (2014): Effects of elevated parameters of subclinical ketosis on the immune system of dairy cows: in vivo and in vitro results. Arch Anim Nutr, 69, 113-127.
- Senoh T, Oikawa S, Nakada K, et al (2019): Increased serum malondialdehyde concentration in cows with subclinical ketosis. J Vet Med Sci, 81, 817-820.
- Sun Y, Wang B, Shu S, et al (2015): Critical thresholds of liver function parameters for ketosis prediction in dairy cows using receiver operating characteristic (ROC) analysis. Vet Quarterly, 35, 159-164.
- Trevisi E, Amadori M, Cogrossi S, et al (2012): Metabolic stress and inflammatory response in high-yielding, periparturient dairy cows. Res Vet Sci, 93, 695-704.
- Trevisi E, Jahan N, Bertoni G, et al (2015): Pro-Inflammatory Cytokine Profile in Dairy Cows: Consequences for New Lactation. Italian J Anim Sci, 14, 3862.
- Turk R, PodpeCan O, Mrkun J, et al (2013): Lipid mobilisation and oxidative stress as metabolic adaptation processes in dairy heifers during transition period. Anim Repr Sci, 141, 109-115.
- Wang J, Zhu X, She G, et al (2018): Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders. BMC Veterinary Research, 14, 236.
- Wankhade PR, Manimaran A, Kumaresan A, et al (2017): Metabolic and immunological changes in transition dairy cows: A review. Vet World, 10, 1367–1377.
- Yang W, Zhang B, Xu C, et al (2019): Effects of ketosis in dairy cows on blood biochemical parameters, milk yield and composition, and digestive capacity. J Vet Res, 63, 555-560.
- Zhang Y, Li X, Zhang H, et al (2018): Non-Esterified Fatty Acids Over-Activate the TLR2/4-NF-Κb Signaling Pathway to Increase Inflammatory Cytokine Synthesis in Neutrophils from Ketotic Cows. Cell Physiol Biochem, 48, 827-837.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary |
| Journal Section | Research Article |
| Authors |
|
| Supporting Institution | This study was supported by Ankara University Scientific Research Grant (grant no. 20B0239002). |
| Project Number | Grant no. 20B0239002 |
| Thanks | This study is not produced from a doctoral-PhD or master’s thesis or presented at scientific meetings. |
| Publication Date | December 30, 2022 |
| Published in Issue | Year 2023Volume: 70 Issue: 1 |
Cite
| Bibtex | @research article { auvfd907076, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara University}, year = {2023}, volume = {70}, number = {1}, pages = {37 - 42}, doi = {10.33988/auvfd.907076}, title = {Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis}, key = {cite}, author = {Kurtdede, Efe and Kurtdede, Arif and Öcal, Naci and Kara, Erdal} } |
| APA | Kurtdede, E. , Kurtdede, A. , Öcal, N. & Kara, E. (2023). Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 70 (1) , 37-42 . DOI: 10.33988/auvfd.907076 |
| MLA | Kurtdede, E. , Kurtdede, A. , Öcal, N. , Kara, E. "Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 70 (2023 ): 37-42 <http://vetjournal.ankara.edu.tr/en/pub/issue/74067/907076> |
| Chicago | Kurtdede, E. , Kurtdede, A. , Öcal, N. , Kara, E. "Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis". Ankara Üniversitesi Veteriner Fakültesi Dergisi 70 (2023 ): 37-42 |
| RIS | TY - JOUR T1 - Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis AU - EfeKurtdede, ArifKurtdede, NaciÖcal, ErdalKara Y1 - 2023 PY - 2023 N1 - doi: 10.33988/auvfd.907076 DO - 10.33988/auvfd.907076 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 37 EP - 42 VL - 70 IS - 1 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.907076 UR - https://doi.org/10.33988/auvfd.907076 Y2 - 2021 ER - |
| EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis %A Efe Kurtdede , Arif Kurtdede , Naci Öcal , Erdal Kara %T Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis %D 2023 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 70 %N 1 %R doi: 10.33988/auvfd.907076 %U 10.33988/auvfd.907076 |
| ISNAD | Kurtdede, Efe , Kurtdede, Arif , Öcal, Naci , Kara, Erdal . "Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis". Ankara Üniversitesi Veteriner Fakültesi Dergisi 70 / 1 (December 2022): 37-42 . https://doi.org/10.33988/auvfd.907076 |
| AMA | Kurtdede E. , Kurtdede A. , Öcal N. , Kara E. Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis. Ankara Univ Vet Fak Derg. 2023; 70(1): 37-42. |
| Vancouver | Kurtdede E. , Kurtdede A. , Öcal N. , Kara E. Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2023; 70(1): 37-42. |
| IEEE | E. Kurtdede , A. Kurtdede , N. Öcal and E. Kara , "Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis", Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 70, no. 1, pp. 37-42, Dec. 2022, doi:10.33988/auvfd.907076 |
