Musculoskeletal injuries as a kind of trauma that the human body is exposed to, adversely affect the quality of life and workforce of individuals due to restriction of movement function. This study aimed to evaluate the effects of dose-dependent ascorbic acid (AA) administration on the repair process after gastrocnemius muscle injury in rats. In this study, 5-month-old 66 male Wistar Albino rats were used and rats were randomly divided into 6 groups of 11 each [control, muscle injury, healthy (with 5 mg/10 mg/kg/day AA-treated group), injury (with 5 mg/10 mg/kg/day AA-treated group)]. A linear incision was made in the gastrocnemius muscle of thirty-three animals included in the muscle injury groups. AA (5-10 mg/kg/day) was administered to the four groups intraperitoneally just after surgery once a day. Animals were sacrificed twenty-one days later. Blood and tissue samples were used for cytokine, collagen, and histological measurements. It was found that a dose of 5 mg/kg/day AA administration reduced serum IL-6 and muscle tissue TNF-α levels, and increased liver tissue IL-10 levels. Muscle tissue collagen levels were not statistically different between the groups in parallel with our histological results. In our study, it was demonstrated that vitamin C has effects on inflammatory mediators during muscle tissue repair to explain the mechanism detailed molecular analyzes are needed.
ascorbic acid, collagen, inflammation mediators, muscle, wound healing
This study was financially supported by Ankara University Scientific Research Projects Coordinator (Project number: 19L0230013).
This manuscript is based on master’s thesis of Sibel IŞIN.
Primary Language | English |
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Subjects | Veterinary Surgery, Veterinary Medicine |
Journal Section | Research Article |
Authors |
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Project Number | 19L0230013 |
Publication Date | June 23, 2023 |
Published in Issue | Year 2023Volume: 70 Issue: 3 |
Bibtex | @research article { auvfd1019201, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara University}, year = {2023}, volume = {70}, number = {3}, pages = {303 - 308}, doi = {10.33988/auvfd.1019201}, title = {Effect of ascorbic acid on collagen and some inflammatory mediators in rats}, key = {cite}, author = {Işın, Sibel and Yazıhan, Nuray and Kesikli, Burcu and Biriken, Derya and Akdaş, Sevginur and Topal Celikkan, Ferda and Bakırarar, Batuhan and Arıbal-ayral, Pelin} } |
APA | Işın, S. , Yazıhan, N. , Kesikli, B. , Biriken, D. , Akdaş, S. , Topal Celikkan, F. , Bakırarar, B. & Arıbal-ayral, P. (2023). Effect of ascorbic acid on collagen and some inflammatory mediators in rats . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 70 (3) , 303-308 . DOI: 10.33988/auvfd.1019201 |
MLA | Işın, S. , Yazıhan, N. , Kesikli, B. , Biriken, D. , Akdaş, S. , Topal Celikkan, F. , Bakırarar, B. , Arıbal-ayral, P. "Effect of ascorbic acid on collagen and some inflammatory mediators in rats" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 70 (2023 ): 303-308 <http://vetjournal.ankara.edu.tr/en/pub/issue/78151/1019201> |
Chicago | Işın, S. , Yazıhan, N. , Kesikli, B. , Biriken, D. , Akdaş, S. , Topal Celikkan, F. , Bakırarar, B. , Arıbal-ayral, P. "Effect of ascorbic acid on collagen and some inflammatory mediators in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 70 (2023 ): 303-308 |
RIS | TY - JOUR T1 - Effect of ascorbic acid on collagen and some inflammatory mediators in rats AU - SibelIşın, NurayYazıhan, BurcuKesikli, DeryaBiriken, SevginurAkdaş, FerdaTopal Celikkan, BatuhanBakırarar, PelinArıbal-ayral Y1 - 2023 PY - 2023 N1 - doi: 10.33988/auvfd.1019201 DO - 10.33988/auvfd.1019201 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 303 EP - 308 VL - 70 IS - 3 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.1019201 UR - https://doi.org/10.33988/auvfd.1019201 Y2 - 2022 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Effect of ascorbic acid on collagen and some inflammatory mediators in rats %A Sibel Işın , Nuray Yazıhan , Burcu Kesikli , Derya Biriken , Sevginur Akdaş , Ferda Topal Celikkan , Batuhan Bakırarar , Pelin Arıbal-ayral %T Effect of ascorbic acid on collagen and some inflammatory mediators in rats %D 2023 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 70 %N 3 %R doi: 10.33988/auvfd.1019201 %U 10.33988/auvfd.1019201 |
ISNAD | Işın, Sibel , Yazıhan, Nuray , Kesikli, Burcu , Biriken, Derya , Akdaş, Sevginur , Topal Celikkan, Ferda , Bakırarar, Batuhan , Arıbal-ayral, Pelin . "Effect of ascorbic acid on collagen and some inflammatory mediators in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 70 / 3 (June 2023): 303-308 . https://doi.org/10.33988/auvfd.1019201 |
AMA | Işın S. , Yazıhan N. , Kesikli B. , Biriken D. , Akdaş S. , Topal Celikkan F. , Bakırarar B. , Arıbal-ayral P. Effect of ascorbic acid on collagen and some inflammatory mediators in rats. Ankara Univ Vet Fak Derg. 2023; 70(3): 303-308. |
Vancouver | Işın S. , Yazıhan N. , Kesikli B. , Biriken D. , Akdaş S. , Topal Celikkan F. , Bakırarar B. , Arıbal-ayral P. Effect of ascorbic acid on collagen and some inflammatory mediators in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2023; 70(3): 303-308. |
IEEE | S. Işın , N. Yazıhan , B. Kesikli , D. Biriken , S. Akdaş , F. Topal Celikkan , B. Bakırarar and P. Arıbal-ayral , "Effect of ascorbic acid on collagen and some inflammatory mediators in rats", Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 70, no. 3, pp. 303-308, Jun. 2023, doi:10.33988/auvfd.1019201 |