Research Article
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Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye

Year 2024, Volume: 71 Issue: 3, 321 - 328

Ceyhan Özbeyaz Melike Özcan

https://doi.org/10.33988/auvfd.1295330

Abstract

Türkiye is exposed to international animal and semen movements. For this reason, Türkiye is very affected by diseases and hereditary disorders. State Farms is a state organization that raises and distributes breeding cattle. This study was aimed at investigating the presence and distribution of mutant alleles causing cholesterol deficiency (CD) disorder in Holstein cattle on state farms. For this purpose, blood and sperm samples were collected from 466 Holstein cattle. The real-time PCR method was used for genotyping. A total of seven cattle were found to be heterozygous. The frequency of the mutant allele was determined to be 0.75%. The kinship of four cattle carrying the mutant allele with Mauglin Storm, the bull in which this disease was first detected, was determined. The presence of cattle carrying the mutant allele in Türkiye is quite low compared to other countries. The Apolipoprotein-B (APOB) mutant allele was found at low frequencies and detected for the first time at the State Farms in Türkiye. Therefore, it is necessary to develop control programs by screening other Holstein herds.

Keywords

Apolipoprotein-B Cattle Cholestrol Deficiency Holstein Mutation

Ethical Statement

This study was carried out after the animal experiment was approved by Ankara University Local Ethics Committee (Decision number: 2017-10-88).

Supporting Institution

This research was supported by Ankara University BAP (Scientific Research Projects) with project number 18L0239012.

Project Number

18L0239012

Thanks

This article was produced from the PhD thesis of the second author under the consultation of the first author. The authors wish to thank the General Directorate of Agricultural Enterprises, Republic of Türkiye Ministry of Agriculture and Forestry. We thank Prof. Dr. Metin Erdoğan for his contributions to genetic analysis.

References

  • Anonymous (2023): STgenetics. Available at https://www.stgen.com. (Accessed Feb 15, 2023).
  • Anonymous (2023): Altagenetics. Available at https://bullsearch.altagenetics.com. (Accessed Feb 15, 2023).
  • Basiel BL, Macrina AL, Dechow HCD (2020): Cholesterol deficiency carriers have lowered serum cholesterol and perform well at an elite cattle show. JDS Communications, 1, 6-9.
  • Doormaal BV, Beavers L (2015): Discovering genetic anomalies from genotyping. Available at https://www.HCDn.ca. (Accessed May 5, 2016).
  • Doormaal BV, Beavers L (2015): HCD: Haplotype associated with Cholesterol Deficiency. Available at https://www.HCDn.ca. (Accessed May 5, 2016).
  • Doormaal BV, Beavers L (2016): Mananing recessives & haplotypes. Available at https://www.HCDn.ca. (Accessed July 8, 2016).
  • Doormaal BV, Beavers L (2019): Current Status on Haplotypes and Genetic Recessives. Available at https://www.HCDn.ca. (Accessed April 1, 2019).
  • Gurses M, Dere N (2023): Identification of the ERV insertion of APOB gene and deletion of TFB1M gene associated with lethal haplotypes of Holstein cattle reared in Balıkesir province, Türkiye. Kafkas Univ Vet Fak Derg, 29, 145-150.
  • Hafliger IM, Hofstetter S, Mock T, et al (2019): APOB- associated cholesterol deficiency in Holstein cattle is not a simple recessive disease. Anim Genet, 50, 372-375.
  • İnal Ş, Çam M (2016): Hereditary defects in bulls whose semen was imported to Türkiye in 2015. Eurasian J Vet Sci, 4, 278-284.
  • Kaminski S, Rusc A (2016): Cholesterol Deficiency–new genetic defect transmitted to Polish Holstein-Friesian cattle. Pol J Vet Sci, 19, 885-887.
  • Khan YA, Omar AI, He Y, et al (2021): Prevalance of nine genetic defects in Chinese Holstein Cattle. Vet Med Sci, 7, 1728-1735.
  • Kipp S, Segelke D, Schierenbeck S, et al (2015): A new holstein haplotype affecting calf survival. Interbull Bull, 49, 49-53.
  • Kumar A, Gupta ID, Kumar S, et al (2021): First report of cholesterol deficiency associated APOB mutation causing calf mortality in Indian Holstein Friesian population. Indian J Anim Sci, 91, 148-150.
  • Li Y, Fang L, Liu L, et al (2018): The cholesterol-deficiency associated mutation in APOB segregates at low frequency in Chinese Holstein cattle. Life J Anim Sci, 99, 332–335.
  • Liaw RB, Chen JC, Tsay SS, et al (2017): Genotype screening on cholesterol deficiency of dairy cattle herds in Taiwan. Journal of Taiwan Livestock, 50, 265-270.
  • Menzi F, Besuchet-Schmutz N, Fragniere M, et al (2016): A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle. Anim Genet, 47, 253-257.
  • Mock T, Mehinagic K, Menzi F, et al (2016): Clinicopathological phenotype of autosomal recessive cholesterol deficiency in Holstein cattle. Journal of Veterinary Internal Medicine, 30, 1369-1375.
  • Pozovnikova MV, Lihacheva TE, Kudinov AA, et al (2018): Cholesterol deficiency mutation HCD does not impact milk productivity and blood levels of cholesterol and triglycerides in Russian Holstein black and white cattle. Agricultural Biology, 53, 1142-1151.
  • Pozovnikova MV, Gladyr EA, Romanenkova OS, et al (2020): Screening of haplotype for cholesterol deficiency genetic defect in Russian Holstein cattle population. Pol J Vet Sci, 23, 313-315.
  • Rodriguez BC, Romero A, Llambi S, et al (2021): Lethal and semi-lethal mutations in Holstein calves in Uruguay. Animal Production Cienc Rural, 51.
  • Schutz E, Wehrhahn C, Wanjek M, et al (2016): The Holstein Friesian lethal haplotype 5 (HH5) results from a complete deletion of TBF1M and cholesterol deficiency (CDH) from an ERV - (LTR) insertion into the coding region of APOB. Plos One, 11.
  • VanRaden P, Null D (2015): Holstein haplotype for cholesterol deficiency (HCD). Available at https//:www.CDcb.us/reference/changes/HCD_inheritance.pdf. (Accessed May 5, 2016).
  • Wang M, Do ND, Peignier C, et al (2019): Cholesterol deficiency haplotype frequency and its impact on milk production and milk cholesterol content in Canadian Holstein cows. Can J Anim Sci, 100, 786-791.
  • Zimina AA, Romanenkova OS (2020): Main genetic defects of improving breeds in the population of Sychevsky cattle of the Smolensk region. E3S Web of Conferences, 222, 03017.

Year 2024, Volume: 71 Issue: 3, 321 - 328

Ceyhan Özbeyaz Melike Özcan

https://doi.org/10.33988/auvfd.1295330

Abstract

Project Number

18L0239012

References

  • Anonymous (2023): STgenetics. Available at https://www.stgen.com. (Accessed Feb 15, 2023).
  • Anonymous (2023): Altagenetics. Available at https://bullsearch.altagenetics.com. (Accessed Feb 15, 2023).
  • Basiel BL, Macrina AL, Dechow HCD (2020): Cholesterol deficiency carriers have lowered serum cholesterol and perform well at an elite cattle show. JDS Communications, 1, 6-9.
  • Doormaal BV, Beavers L (2015): Discovering genetic anomalies from genotyping. Available at https://www.HCDn.ca. (Accessed May 5, 2016).
  • Doormaal BV, Beavers L (2015): HCD: Haplotype associated with Cholesterol Deficiency. Available at https://www.HCDn.ca. (Accessed May 5, 2016).
  • Doormaal BV, Beavers L (2016): Mananing recessives & haplotypes. Available at https://www.HCDn.ca. (Accessed July 8, 2016).
  • Doormaal BV, Beavers L (2019): Current Status on Haplotypes and Genetic Recessives. Available at https://www.HCDn.ca. (Accessed April 1, 2019).
  • Gurses M, Dere N (2023): Identification of the ERV insertion of APOB gene and deletion of TFB1M gene associated with lethal haplotypes of Holstein cattle reared in Balıkesir province, Türkiye. Kafkas Univ Vet Fak Derg, 29, 145-150.
  • Hafliger IM, Hofstetter S, Mock T, et al (2019): APOB- associated cholesterol deficiency in Holstein cattle is not a simple recessive disease. Anim Genet, 50, 372-375.
  • İnal Ş, Çam M (2016): Hereditary defects in bulls whose semen was imported to Türkiye in 2015. Eurasian J Vet Sci, 4, 278-284.
  • Kaminski S, Rusc A (2016): Cholesterol Deficiency–new genetic defect transmitted to Polish Holstein-Friesian cattle. Pol J Vet Sci, 19, 885-887.
  • Khan YA, Omar AI, He Y, et al (2021): Prevalance of nine genetic defects in Chinese Holstein Cattle. Vet Med Sci, 7, 1728-1735.
  • Kipp S, Segelke D, Schierenbeck S, et al (2015): A new holstein haplotype affecting calf survival. Interbull Bull, 49, 49-53.
  • Kumar A, Gupta ID, Kumar S, et al (2021): First report of cholesterol deficiency associated APOB mutation causing calf mortality in Indian Holstein Friesian population. Indian J Anim Sci, 91, 148-150.
  • Li Y, Fang L, Liu L, et al (2018): The cholesterol-deficiency associated mutation in APOB segregates at low frequency in Chinese Holstein cattle. Life J Anim Sci, 99, 332–335.
  • Liaw RB, Chen JC, Tsay SS, et al (2017): Genotype screening on cholesterol deficiency of dairy cattle herds in Taiwan. Journal of Taiwan Livestock, 50, 265-270.
  • Menzi F, Besuchet-Schmutz N, Fragniere M, et al (2016): A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle. Anim Genet, 47, 253-257.
  • Mock T, Mehinagic K, Menzi F, et al (2016): Clinicopathological phenotype of autosomal recessive cholesterol deficiency in Holstein cattle. Journal of Veterinary Internal Medicine, 30, 1369-1375.
  • Pozovnikova MV, Lihacheva TE, Kudinov AA, et al (2018): Cholesterol deficiency mutation HCD does not impact milk productivity and blood levels of cholesterol and triglycerides in Russian Holstein black and white cattle. Agricultural Biology, 53, 1142-1151.
  • Pozovnikova MV, Gladyr EA, Romanenkova OS, et al (2020): Screening of haplotype for cholesterol deficiency genetic defect in Russian Holstein cattle population. Pol J Vet Sci, 23, 313-315.
  • Rodriguez BC, Romero A, Llambi S, et al (2021): Lethal and semi-lethal mutations in Holstein calves in Uruguay. Animal Production Cienc Rural, 51.
  • Schutz E, Wehrhahn C, Wanjek M, et al (2016): The Holstein Friesian lethal haplotype 5 (HH5) results from a complete deletion of TBF1M and cholesterol deficiency (CDH) from an ERV - (LTR) insertion into the coding region of APOB. Plos One, 11.
  • VanRaden P, Null D (2015): Holstein haplotype for cholesterol deficiency (HCD). Available at https//:www.CDcb.us/reference/changes/HCD_inheritance.pdf. (Accessed May 5, 2016).
  • Wang M, Do ND, Peignier C, et al (2019): Cholesterol deficiency haplotype frequency and its impact on milk production and milk cholesterol content in Canadian Holstein cows. Can J Anim Sci, 100, 786-791.
  • Zimina AA, Romanenkova OS (2020): Main genetic defects of improving breeds in the population of Sychevsky cattle of the Smolensk region. E3S Web of Conferences, 222, 03017.
There are 25 citations in total.

Details

Primary Language English
Subjects Animal Science, Genetics and Biostatistics
Journal Section Research Article
Authors

Ceyhan Özbeyaz 0000-0002-3748-9992

Melike Özcan 0000-0003-3493-308X

Project Number 18L0239012
Early Pub Date October 27, 2023
Publication Date
Published in Issue Year 2024Volume: 71 Issue: 3

Cite

APA Özbeyaz, C., & Özcan, M. (n.d.). Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 71(3), 321-328. https://doi.org/10.33988/auvfd.1295330
AMA Özbeyaz C, Özcan M. Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye. Ankara Univ Vet Fak Derg. 71(3):321-328. doi:10.33988/auvfd.1295330
Chicago Özbeyaz, Ceyhan, and Melike Özcan. “Investigation of Hereditary Cholesterol Deficiency (CD) in Holstein Cattle at the State Farms in Türkiye”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71, no. 3 n.d.: 321-28. https://doi.org/10.33988/auvfd.1295330.
EndNote Özbeyaz C, Özcan M Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71 3 321–328.
IEEE C. Özbeyaz and M. Özcan, “Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye”, Ankara Univ Vet Fak Derg, vol. 71, no. 3, pp. 321–328, doi: 10.33988/auvfd.1295330.
ISNAD Özbeyaz, Ceyhan - Özcan, Melike. “Investigation of Hereditary Cholesterol Deficiency (CD) in Holstein Cattle at the State Farms in Türkiye”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71/3 (n.d.), 321-328. https://doi.org/10.33988/auvfd.1295330.
JAMA Özbeyaz C, Özcan M. Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye. Ankara Univ Vet Fak Derg.;71:321–328.
MLA Özbeyaz, Ceyhan and Melike Özcan. “Investigation of Hereditary Cholesterol Deficiency (CD) in Holstein Cattle at the State Farms in Türkiye”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 71, no. 3, pp. 321-8, doi:10.33988/auvfd.1295330.
Vancouver Özbeyaz C, Özcan M. Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye. Ankara Univ Vet Fak Derg. 71(3):321-8.
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