Case Report
Year 2025,
Volume: 72 Issue: 1, 113 - 116
Abstract
A 9-year-old female crossbred dog was referred due to a tongue neoformation. A marginal resection was performed to proceed with the histopathological examination, which indicated malignant round cell neoplasia, and immunohistochemical staining diagnosed the mass as plasmacytoma. The owner refused another surgical intervention to extend margins and approach another growth verified on the ventral surface of the base of the tongue. Thus, the patient underwent three months of metronomic chemotherapy with melphalan. The disease progression was not detected after two years of follow-up. This report shows that daily low-dose melphalan may be used as an adjuvant treatment option for oral plasmacytoma in dogs when clean margins cannot be achieved.
Supporting Institution
This work was supported by Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil (Financing Code 001).
Thanks
The authors thank for the support of the Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil.
References
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- Clarck GN, Berg J, Engler SJ, et al (1992): Extramedullary plasmacytomas in dogs: results of surgical excision in 131 cases. J Am Anim Hosp Assoc, 28, 105–111.
- Culp WTN, Ehrhart N, Withrow SJ, et al (2013): Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases (1995–2008). J Am Vet Med Assoc, 242, 1392–1397.
- Cunha RMC, Lavalle GE, Caires CET, et al (2017): Electrochemotherapy treatment of oral extramedullary plasmacytoma of the tongue: a retrospective study of three dogs. Cienc Rural, 47, 12.
- Elmenhorst K, Tappin S, Nelissen P, et al (2018): Tracheal plasmacytoma in a dog. Vet Rec Case Rep, 6, 1.
- Fernández R, Chon E (2018): Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs. J Vet Intern Med, 32, 1060–1069.
- Hayes AM, Gregory SP, Murphy S, et al (2007): Solitary extramedullary plasmacytoma of the canine larynx. J Small Anim Pract, 48, 288–291.
- Kupanoff AP, Popovitch CA, Goldschmidt MH (2006): Colorectal Plasmacytomas: A Retrospective Study of Nine Dogs. J Am Anim Hosp Assoc, 42, 37–43.
- Majzoub M, Breuer W, Platz SJ, et al (2003): Histopathologic and Immunophenotypic Characterization of Extramedullary Plasmacytomas in Nine Cats. Vet Pathol, 40, 249–253.
- Mathé G, Rappaport H, O’Conor GT, et al (1976): Histological and cytological typing of neoplastic diseases of haematopoietic and lymphoid tissues. World Health Organization, Geneva.
- Mcgavin MD, Zachary JF (2009): Bases da Patologia em Veterinária. Elsevier, Rio de Janeiro.
- Pazdzior-Czapula K, Mikiewicz M, Gesek M, et al (2019): Diagnostic immunohistochemistry for canine cutaneous round cell tumours - retrospective analysis of 60 cases. Folia Histochem Cyto, 57, 146–154.
- Platz SJ, Breuer W, Pfleghaar S, et al (1999): Prognostic value of histopathological grading in canine extramedullary plasmacytomas. Vet Pathol, 36, 23–27.
- Rakich PM, Latimer KS, Weiss R, et al (1989): Mucocutaneous plasmacytomas in dogs: 75 cases (1980-1987). J Am Vet Med Assoc, 194, 803–810.
- Ramos-Vara JA, Miller MA, Valli VEO (2007): Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20. Vet Pathol, 44, 875–884.
- Schrenzel MD, Naydan DK, Moore PF (1998): Leukocyte differentiation antigens in canine cutaneous and oral plasmacytomas. Vet Dermatol, 9, 33–41.
- Simsek C, Esin E, Yalcin S (2019): Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience. J Oncol, 2019, 5483791.
- Trevor PB, Saunders GK, Waldron DR, et al (1993): Metastatic extramedullary plasmacytoma of the colon and rectum in a dog. J Am Vet Med Assoc, 203, 406–409.
- Vail D, Thamm D, Liptak J (2020): Withrow and MacEwen’s small animal clinical oncology. Elsevier, New York.
- Witham A, French A, Hill K (2012): Extramedullary laryngeal plasmacytoma in a dog. N Z Vet J, 60, 61–64.
- Wright ZM, Rogers KS, Mansell J (2008): Survival Data for Canine Oral Extramedullary Plasmacytomas: A Retrospective Analysis (1996–2006). J Am Anim Hosp Assoc, 44, 75–81.
Year 2025,
Volume: 72 Issue: 1, 113 - 116
Abstract
References
- Boostrom BO, Moore AS, Deregis J, et al (2017): Canine Cutaneous Plasmacytosis: 21 Cases (2005-2015). J Vet Intern Med, 31, 1074–1080.
- Clarck GN, Berg J, Engler SJ, et al (1992): Extramedullary plasmacytomas in dogs: results of surgical excision in 131 cases. J Am Anim Hosp Assoc, 28, 105–111.
- Culp WTN, Ehrhart N, Withrow SJ, et al (2013): Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases (1995–2008). J Am Vet Med Assoc, 242, 1392–1397.
- Cunha RMC, Lavalle GE, Caires CET, et al (2017): Electrochemotherapy treatment of oral extramedullary plasmacytoma of the tongue: a retrospective study of three dogs. Cienc Rural, 47, 12.
- Elmenhorst K, Tappin S, Nelissen P, et al (2018): Tracheal plasmacytoma in a dog. Vet Rec Case Rep, 6, 1.
- Fernández R, Chon E (2018): Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs. J Vet Intern Med, 32, 1060–1069.
- Hayes AM, Gregory SP, Murphy S, et al (2007): Solitary extramedullary plasmacytoma of the canine larynx. J Small Anim Pract, 48, 288–291.
- Kupanoff AP, Popovitch CA, Goldschmidt MH (2006): Colorectal Plasmacytomas: A Retrospective Study of Nine Dogs. J Am Anim Hosp Assoc, 42, 37–43.
- Majzoub M, Breuer W, Platz SJ, et al (2003): Histopathologic and Immunophenotypic Characterization of Extramedullary Plasmacytomas in Nine Cats. Vet Pathol, 40, 249–253.
- Mathé G, Rappaport H, O’Conor GT, et al (1976): Histological and cytological typing of neoplastic diseases of haematopoietic and lymphoid tissues. World Health Organization, Geneva.
- Mcgavin MD, Zachary JF (2009): Bases da Patologia em Veterinária. Elsevier, Rio de Janeiro.
- Pazdzior-Czapula K, Mikiewicz M, Gesek M, et al (2019): Diagnostic immunohistochemistry for canine cutaneous round cell tumours - retrospective analysis of 60 cases. Folia Histochem Cyto, 57, 146–154.
- Platz SJ, Breuer W, Pfleghaar S, et al (1999): Prognostic value of histopathological grading in canine extramedullary plasmacytomas. Vet Pathol, 36, 23–27.
- Rakich PM, Latimer KS, Weiss R, et al (1989): Mucocutaneous plasmacytomas in dogs: 75 cases (1980-1987). J Am Vet Med Assoc, 194, 803–810.
- Ramos-Vara JA, Miller MA, Valli VEO (2007): Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20. Vet Pathol, 44, 875–884.
- Schrenzel MD, Naydan DK, Moore PF (1998): Leukocyte differentiation antigens in canine cutaneous and oral plasmacytomas. Vet Dermatol, 9, 33–41.
- Simsek C, Esin E, Yalcin S (2019): Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience. J Oncol, 2019, 5483791.
- Trevor PB, Saunders GK, Waldron DR, et al (1993): Metastatic extramedullary plasmacytoma of the colon and rectum in a dog. J Am Vet Med Assoc, 203, 406–409.
- Vail D, Thamm D, Liptak J (2020): Withrow and MacEwen’s small animal clinical oncology. Elsevier, New York.
- Witham A, French A, Hill K (2012): Extramedullary laryngeal plasmacytoma in a dog. N Z Vet J, 60, 61–64.
- Wright ZM, Rogers KS, Mansell J (2008): Survival Data for Canine Oral Extramedullary Plasmacytomas: A Retrospective Analysis (1996–2006). J Am Anim Hosp Assoc, 44, 75–81.
There are 21 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery, Veterinary Medicine |
| Journal Section | Case Report |
| Authors | |
| Early Pub Date | March 19, 2024 |
| Publication Date | |
| Published in Issue | Year 2025Volume: 72 Issue: 1 |
