Öz
Even the incidence of a drug-induced pancreatitis is rare there are more than 85 different drugs have been reported that induces pancreatitis. FDA have been reported that propofol administration resulted in pancreatitis in 25 human cases. Even though there are several reports pointed out an increase in blood lipid and triglyceride levels after propofol administration, there are no studies investigated the possible association between the use of propofol and consequently occuring pancreatitis in veterinary medicine. The aim of this study was to evaluate the possible side-effects of propofol administration on pancreatic tissue in dogs. Twenty healty dogs were anesthetized for at least one hour. Bloods were collected to evaluate the serum amylase, lipase, ALP, AST, GGT, cPLI, cholesterol, triglyceride, Ca and glucose levels before and after propofol administration, during recovery period and after 4th and 24th hour. It was recorded that the serum glucose, calcium and triglyceride levels were increased during anesthesia, on the contrary serum amylase, lipase, ALP, AST, GGT, and cholesterol levels were decreased. The alterations in cPLI was insignificant. Clinical evaluation is not revealed any evidence of pancreatitis in neither of the animals. As a result, it was concluded that although the triglyceride levels were found to be elevated during propofol administration, it did not cause any clinical manifestations regarding pancreatic activity
Anahtar Kelimeler
Kaynakça
- Beier SL, de Araujo Aguiar AJ, Vianna PT ve ark. (2009): Effect of remifentanil on requirements for propofol administered by use of a target-controlled infusion system for maintaining anesthesia in dogs. Am J Vet Res, 70, 703- 709.
- Branson KR (2007): Injectable and Alternative Anesthetic Techniques. Lumb & Jones’ Veterinary Anesthesia and Analgesia, 4. baskı, Editörler: Tranquilli W.J., Thurmon J.C., Grimm K.A., 273-299.
- Bustamante SE, Appachi E (2006): Acute pancreatitis af- ter anesthesia with propofol in a child with glycogen sto- rage disease type IA. Pediatric Anesthesia, 16, 680-683.
- Calmarza P, Cordero J (2011): Lipemia interferences in routine clinical biochemical tests. Biochemia Medica, 21, 160-166.
- Cockshott ID, Douglas EJ, Plummer GF ve ark. (1992): The pharmacokinetics of propofol in laboratory animals. Xenobiotica, 22, 369-375.
- Gimenes AM, Aguiar AJA, Perri SHV ve ark. (2011): Effect of intravenous propofol and remifentanil on heart rate, blood pressure and nociceptive response in acepromazine premedicated dogs. Vet Anaesth Analg, 38, 54-62.
- Glowaski MM, Wetmore LA (1999): Propofol: Application in veterinary sedation and anesthesia. Clin Tech in Small Anim Pract, 14, 1-9.
- Gottschling S, Larsen R, Meyer S ve ark. (2005): Acute pancreatitis induced by short-term propofol administration. Pediatric Anesthesia, 15, 1006-1008.
- Gottschling S, Meyer S, Krenn T ve ark. (2005): Effects of short-term propofol administration on pancreatic enzymes and triglyceride levels in children. Anaesthesia, 60, 660-663.
- Günay C, Balikci E (2001): Köpeklerde isofluran ve pro- pofol anesteziklerinin bazı klinik ve elektrokardiyografik (EKG) bulgular üzerine etkilerinin karşılaştırılması. Kafkas Üniv Vet Fak Derg, 7, 87-93.
- Kürüm K, Pekcan Z, Kalender H ve ark. (2013): Comparison of propofol-remifentanil and propofol-entanyl anesthesia during ovariohysterectomy in dogs. Kafkas Univ Vet Fak Derg, 19 (Suppl-A), A33-A40.
- Leisure GS, O’Flaherty JMD, Green L ve ark. (1996): Propofol and postoperative pancreatitis. Anesthesiology, 84, 224-227.
- Lerche P, Nolan AM, Reid J (2000): Comparative study of propofol or propofol and ketamine for the induction of anesthesia in dogs. Vet Rec, 146, 571-574.
- Martin FM, Lima JR, Ezquerra LJ ve ark. (2001): Prolonged anesthesia with desflurane and fentanyl in dogs during conventional and laparoscopic surgery. J Am Vet Med Assoc, 219, 941-945.
- Mix K, Jones C (2006): Diagnosing Acute Pancreatitis in Dogs. [http://www.idexx.com/pubwebresources/pdf/en_us/ March: 226-233. Erişim: T (2008): Canine Pancreatitis. Eri- şim:[http://www.vin.com/proceedings/ CID=WSAVA2008&PID=23846&O=Generic], Erişim ta- rihi: 10.03.2010. Proceedings.plx?
- Steiner JM (2006): Is it pancreatitis? Veterinary Medicine. Erişim: [http: //veterinarymedicine.dvm360.com/vetmed/ Medicine/ArticleStandard/Article/detail/313764], tarihi: 01.04.2010. Erişim
- Steiner JM (2008): New Concepts in Canine Pancreatitis. Erişim:[http://www. Steiner.pdf], Erişim tarihi: 03.04.2010.
- Watkins SB, Hall LW, Clarke KW (1987): Propofol as an intravenous anesthetic agent in dogs. Vet Rec, 120, 326- 329. Geliş tarihi: 07.12.2015 /Kabul tarihi: 09.08.2016
Öz
İlaca bağlı pankreatitis şekillenmesi nadir olmakla beraber bugüne kadar 85’in üzerinde değişik ilacın pankreatitise neden olduğu bildirilmiştir. Yakın tarihte FDA’ya propofol uygulanmasından sonra pankreatitis geliştiğini bildiren 25 ayrı vaka bildirimi vardır. Veteriner çalışmalarında ise propofol uygulaması sonrasında hiperlipidemi ve trigliserid seviyesinde yükselmeler olduğu bildirilmesine rağmen, pankreas üzerine muhtemel etkisi araştırılmamıştır. Bu çalışmanın amacı, propofol uygulanmasının pankreas üzerine etkilerini değerlendirmektir. Çalışmada 20 sağlıklı köpek en az bir saat süre ile anesteziye alındı. Hayvanlardan anestezi öncesinde ve sırasında, uyanma sırasında, uyandıktan 4 ve 24 saat sonra kan alınarak serum amilaz, lipaz, kolesterol, trigliserid, ALP, AST, GGT, cPLI, kalsiyum ve glikoz seviyeleri değerlendirildi. Buna göre anestezi sırasında serum glikoz, kalsiyum ve trigliserid değerleri yükselirken amilaz, lipaz, ALP, AST, kolesterol ve GGT değerlerinin düştüğü kaydedildi. Serum cPLI analizlerinde ise istatistiksel olarak anlamlı bir değişiklik kaydedilmedi. Klinik olarak değerlendirildiğinde ise propofol uygulaması sonrasında hiçbir hayvanda pankreatitis bulgusuna rastlanmadı. Sonuç olarak bir saat süre ile uygulanan propofolun, serum trigliserid düzeyini yükselttiği, ancak pankreas üzerine etkisi değerlendirildiğinde klinik açıdan güvenli olduğu kanısına varılmıştır
Anahtar Kelimeler
Kaynakça
- Beier SL, de Araujo Aguiar AJ, Vianna PT ve ark. (2009): Effect of remifentanil on requirements for propofol administered by use of a target-controlled infusion system for maintaining anesthesia in dogs. Am J Vet Res, 70, 703- 709.
- Branson KR (2007): Injectable and Alternative Anesthetic Techniques. Lumb & Jones’ Veterinary Anesthesia and Analgesia, 4. baskı, Editörler: Tranquilli W.J., Thurmon J.C., Grimm K.A., 273-299.
- Bustamante SE, Appachi E (2006): Acute pancreatitis af- ter anesthesia with propofol in a child with glycogen sto- rage disease type IA. Pediatric Anesthesia, 16, 680-683.
- Calmarza P, Cordero J (2011): Lipemia interferences in routine clinical biochemical tests. Biochemia Medica, 21, 160-166.
- Cockshott ID, Douglas EJ, Plummer GF ve ark. (1992): The pharmacokinetics of propofol in laboratory animals. Xenobiotica, 22, 369-375.
- Gimenes AM, Aguiar AJA, Perri SHV ve ark. (2011): Effect of intravenous propofol and remifentanil on heart rate, blood pressure and nociceptive response in acepromazine premedicated dogs. Vet Anaesth Analg, 38, 54-62.
- Glowaski MM, Wetmore LA (1999): Propofol: Application in veterinary sedation and anesthesia. Clin Tech in Small Anim Pract, 14, 1-9.
- Gottschling S, Larsen R, Meyer S ve ark. (2005): Acute pancreatitis induced by short-term propofol administration. Pediatric Anesthesia, 15, 1006-1008.
- Gottschling S, Meyer S, Krenn T ve ark. (2005): Effects of short-term propofol administration on pancreatic enzymes and triglyceride levels in children. Anaesthesia, 60, 660-663.
- Günay C, Balikci E (2001): Köpeklerde isofluran ve pro- pofol anesteziklerinin bazı klinik ve elektrokardiyografik (EKG) bulgular üzerine etkilerinin karşılaştırılması. Kafkas Üniv Vet Fak Derg, 7, 87-93.
- Kürüm K, Pekcan Z, Kalender H ve ark. (2013): Comparison of propofol-remifentanil and propofol-entanyl anesthesia during ovariohysterectomy in dogs. Kafkas Univ Vet Fak Derg, 19 (Suppl-A), A33-A40.
- Leisure GS, O’Flaherty JMD, Green L ve ark. (1996): Propofol and postoperative pancreatitis. Anesthesiology, 84, 224-227.
- Lerche P, Nolan AM, Reid J (2000): Comparative study of propofol or propofol and ketamine for the induction of anesthesia in dogs. Vet Rec, 146, 571-574.
- Martin FM, Lima JR, Ezquerra LJ ve ark. (2001): Prolonged anesthesia with desflurane and fentanyl in dogs during conventional and laparoscopic surgery. J Am Vet Med Assoc, 219, 941-945.
- Mix K, Jones C (2006): Diagnosing Acute Pancreatitis in Dogs. [http://www.idexx.com/pubwebresources/pdf/en_us/ March: 226-233. Erişim: T (2008): Canine Pancreatitis. Eri- şim:[http://www.vin.com/proceedings/ CID=WSAVA2008&PID=23846&O=Generic], Erişim ta- rihi: 10.03.2010. Proceedings.plx?
- Steiner JM (2006): Is it pancreatitis? Veterinary Medicine. Erişim: [http: //veterinarymedicine.dvm360.com/vetmed/ Medicine/ArticleStandard/Article/detail/313764], tarihi: 01.04.2010. Erişim
- Steiner JM (2008): New Concepts in Canine Pancreatitis. Erişim:[http://www. Steiner.pdf], Erişim tarihi: 03.04.2010.
- Watkins SB, Hall LW, Clarke KW (1987): Propofol as an intravenous anesthetic agent in dogs. Vet Rec, 120, 326- 329. Geliş tarihi: 07.12.2015 /Kabul tarihi: 09.08.2016
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Diğer ID | JA23PG34UN |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Haziran 2017 |
| Yayımlandığı Sayı | Yıl 2017Cilt: 64 Sayı: 2 |