In this study, it was aimed to research the effects of cutaneous and oral exposure to aluminum nanoparticles (Al-NPs) and magnesium nanoparticles (Mg-NPs) on the brain tissue, which is vitally important in terms of its structure and functions. The study was performed on Wister-Albino rats, which were divided into 10 groups, such as control groups (groups 1 and 2), groups, to which Al and Mg NPs were applied as 500 mg/kg and 1500 mg/kg orally (groups 3-6) and 1000 mg/kg and 2000 mg/kg cutaneously (groups 7-10). The dosages were administered as a single dose. While brain tissue and serum MDA levels as well as brain tissue TNF-α and IL-6 levels have significantly increased in the group, to which 1500 mg/kg Mg-NPs was applied orally, significant decreases have also been observed in brain tissue GPX and SOD levels of the same group. Additionally, meaningful decreases in brain tissue SOD levels and significant increases in TNF-α and IL-6 levels have been observed in the group, to which 1500 mg/kg Al-NP was applied orally. On the other hand, it was found that brain tissue GPX and SOD levels of the group, to which 2000 mg/kg Mg-NP was applied cutaneous, have been decreased significantly. Histopathological examinations have also supported these findings. At the end of the study, it was observed that the toxic effect of Al and Mg NPs has varied, depending on the application method, dosage and duration.
Aluminum nanoparticle, brain toxicity, cutaneous, magnesium nanoparticle, rat
Birincil Dil | İngilizce |
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Konular | Veteriner Hekimlik |
Bölüm | Makaleler |
Yazarlar |
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Yayımlanma Tarihi | 26 Aralık 2019 |
Yayınlandığı Sayı | Yıl 2020, Cilt 67, Sayı 1 |
Bibtex | @araştırma makalesi { auvfd569990, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2019}, volume = {67}, number = {1}, pages = {41 - 50}, doi = {10.33988/auvfd.569990}, title = {Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats}, key = {cite}, author = {Arslanbaş, Emre and Coşar, Zekeriya} } |
APA | Arslanbaş, E. & Coşar, Z. (2019). Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 67 (1) , 41-50 . DOI: 10.33988/auvfd.569990 |
MLA | Arslanbaş, E. , Coşar, Z. "Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2019 ): 41-50 <http://vetjournal.ankara.edu.tr/tr/pub/issue/48774/569990> |
Chicago | Arslanbaş, E. , Coşar, Z. "Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2019 ): 41-50 |
RIS | TY - JOUR T1 - Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats AU - EmreArslanbaş, ZekeriyaCoşar Y1 - 2019 PY - 2019 N1 - doi: 10.33988/auvfd.569990 DO - 10.33988/auvfd.569990 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 41 EP - 50 VL - 67 IS - 1 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.569990 UR - https://doi.org/10.33988/auvfd.569990 Y2 - 2019 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats %A Emre Arslanbaş , Zekeriya Coşar %T Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats %D 2019 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 67 %N 1 %R doi: 10.33988/auvfd.569990 %U 10.33988/auvfd.569990 |
ISNAD | Arslanbaş, Emre , Coşar, Zekeriya . "Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 / 1 (Aralık 2019): 41-50 . https://doi.org/10.33988/auvfd.569990 |
AMA | Arslanbaş E. , Coşar Z. Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats. Ankara Univ Vet Fak Derg. 2019; 67(1): 41-50. |
Vancouver | Arslanbaş E. , Coşar Z. Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2019; 67(1): 41-50. |
IEEE | E. Arslanbaş ve Z. Coşar , "Toxic effects of cutaneous and oral exposure to aluminum and magnesium nanoparticles on brain tissue in rats", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 67, sayı. 1, ss. 41-50, Ara. 2019, doi:10.33988/auvfd.569990 |