Olgu Sunumu
Polycythemia, emperipolesis and extramedullary haematopoiesis caused by acute shock: the first record in the Northern white-breasted hedgehog Erinaceus roumanicus Barrett-Hamilton, 1900
Öz
An adult female hedgehog Erinaceus roumanicus, was found in a city traffic zone with serious injuries, most likely from a vehicle impact. Rapid diagnostics, including X-ray imaging, were performed at the veterinarian clinic to rescue the animal. Due to multiple traumatic injuries and poor prognosis, the animal was anesthetized for blood sampling and then euthanized. Polycythaemia, platelet aggregation, rare megakaryoblasts, neutrophilia, lymphocytosis, and a high red blood cell (RBC) and white blood cell (WBC) count were found in peripheral blood. Eosinophilia and the physiological phenomenon of emperipolesis were detected in the femur bone marrow, while the liver biopsy confirmed the extramedullary haematopoiesis (EMH). It has been noted that acute hypovolemic shock results in rapid changes in haematological and biochemical parameters. Given the increased vulnerability of small mammal fauna due to expanding urbanization, this finding may significantly improve care for their welfare and conservation.
Anahtar Kelimeler
Acute shock Emperipolesis Erinaceus roumanicus Extramedullary haematopoiesis Polycithaemia
Destekleyen Kurum
Ministry of Education, Science and Youth of Sarajevo Canton
Proje Numarası
27-02-11-4375-2/21
Kaynakça
- Alamo IG, Kannan KB, Loftus TJ, et al (2017): Severe trauma and chronic stress activates extramedullary erythropoiesis. J Trauma Acute Care Surg, 83, 144-150.
- Baldridge MT, King KY, Boles NC, et al (2010): Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection. Nature, 465, 793–797.
- Bible LE, Pasupuleti LV, Gore AV, et al (2015): Daily propranolol prevents prolonged mobilization of hematopoietic progenitor cells in a rat model of lung contusion, hemorrhagic shock, and chronic stress. Surgery, 158, 595–601.
- Bozzini CE, Barrio Rendo ME, Devoto FC, et al (1970): Studies on medullary and extramedullary erythropoiesis in the adult mouse. Am J Physiol, 219, 724–728.
- Cunin P, Bouslama R, Machlus KR, et al (2019): Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. Elife, 8, e44031.
- Garcês A, Soeiro V, Lóio S, et al (2020): Outcomes, Mortality Causes, and Pathological Findings in European Hedgehogs (Erinaceus europeus, Linnaeus 1758): A Seventeen Year Retrospective Analysis in the North of Portugal. Animals, 10, 1305.
- Glazer JM, Rivers EP, Gunnerson KJ (2016): Shock BT - Surgical Intensive Care Medicine. 61-79. In: O’Donnell JM, Nácul FE (Eds), Springer International Publishing.
- Grebien F, Kerenyi MA, Kovacic B, et al (2008): Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood, 111, 4511–4522.
- Gupta N, Jadhav K, Shah V (2017): Emperipolesis, entosis and cell cannibalism: Demystifying the cloud. J Oral Maxillofac Pathol, 21, 92-98.
- Johns J, Christopher M (2012): Extramedullary Hematopoiesis: A New Look at the Underlying Stem Cell Niche, Theories of Development, and Occurrence in Animals. Vet Pathol, 49, 508–523.
- Kim C (2010): Homeostatic and pathogenic extramedullary hematopoiesis. J Blood Med, 1, 13–19.
- Lee WB, Erm SK, Kim KY, et al (1999): Emperipolesis of erythroblasts within Kupffer cells during hepatic hemopoiesis in human fetus. Anat Rec, 256, 158–164.
- Lewis JH (1976): Comparative hematology—Studies on hedgehogs (Erinaceus europaeus). Comp Biochem Physiol Part A Physiol, 53, 237–240.
- Lewis J, Norcott M, Frost L, et al (2002): Normal haematological values of European hedgehogs (Erinaceus europaeus) from an English rehabilitation centre. Vet Rec, 15, 567–569.
- Lichtenberger M (2004): Principles of shock and fluid therapy in special species. Semin Avian Exot Pet Med, 13, 142–153.
- Livingston DH, Anjaria D, Wu J, et al (2003): Bone Marrow Failure Following Severe Injury in Humans. Ann Surg, 238, 748-753.
- Rastogi V, Sharma R, Misra S, et al (2014): Emperipolesis – A Review. J Clin Diagn Res, 8, ZM01–2.
- Suljević D, Filipić F, Islamagić E (2019): Emperipolesis: Sternal and femoral microenvironment induces megakaryiocyte emperipolesis in the Wistar strain. Mac Vet Rev, 42, 71–77.
- Mohammed OB, Amor NMS, Omer SA, et al (2021): Haematology and biochemistry panels in the Ethiopian hedgehog, Paraechinus aethiopicus (Ehrenberg, 1833) from central Saudi Arabia: Establishing reference intervals and assessing variability across sex and hibernation. J King Saud Univ – Sci, 33, 101228.
- Moore LJ, Petrovan SO, Baker PJ, et al (2020): Impacts and Potential Mitigation of Road Mortality for Hedgehogs in Europe. Animals, 10, 1523.
- Okada K, Kondo H, Sumi A, et al (2018): A retrospective study of disease incidence in African pygmy hedgehogs (Atelerix albiventris). J Vet Med Sci, 80, 1504–1510.
- Okorie-Kanu CO, Onoja RI, Achegbulu EE, et al (2015): Normal haematological and serum biochemistry values of African hedgehog (Atelerix albiventris). Comp Clin Path, 24, 127–132.
- Ozparlak H, Celik I, Sur E, et al (2011): A study of peripheral blood in hedgehogs in Turkey. J Zoo Wildl Med, 42, 392–398.
- Pfäffle M, Petney T, Elgas M, et al (2009): Tick-induced blood loss leads to regenerative anaemia in the European hedgehog (Erinaceus europaeus). Parasitology, 136, 443–452.
- Raymond J, White M (1999): Necropsy and histopathologic findings in 14 African hedgehogs (Atelerix albiventris): a retrospective study. J Zoo Wildl Med, 30, 273–277.
- Rossi G, Mangiagalli G, Paracchini G, et al (2014): Hematologic and biochemical variables of hedgehogs (Erinaceus europaeus) after overwintering in rehabilitation centers. Vet Clin Pathol, 43, 6–14.
- Silva GF, Rêma A, Teixeira S, et al (2022): Pathological Findings in African Pygmy Hedgehogs Admitted into a Portuguese Rehabilitation Center. Animals, 12, 1361.
- Suljević D, Fočak M, Filipić F, et al (2018): Haematopoiesis in the European common toad Bufo bufo (Linnaeus, 1758): new methodological insights to study general, seasonal, and sexual haematopoietic distribution and maturation pattern. Turkish J Zool, 42, 198–206.
- Quilliam TA, Clarke JA, Salsbury AJ (1971): The ecological significance of certain new haematological findings in the mole and hedgehog. Comp Biochem Physiol Part A Physiol, 40, 89–102.
- Vadonlesõ G, Berndt M, Lukács A, et al (2019): Urban hedgehogs (Erinaceus roumanicus) in Budapest: Live or let die. Hungarian Agric Res, 3, 20–26.
Yıl 2024,
Accepted Papers, 1 - 7
Öz
Proje Numarası
27-02-11-4375-2/21
Kaynakça
- Alamo IG, Kannan KB, Loftus TJ, et al (2017): Severe trauma and chronic stress activates extramedullary erythropoiesis. J Trauma Acute Care Surg, 83, 144-150.
- Baldridge MT, King KY, Boles NC, et al (2010): Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection. Nature, 465, 793–797.
- Bible LE, Pasupuleti LV, Gore AV, et al (2015): Daily propranolol prevents prolonged mobilization of hematopoietic progenitor cells in a rat model of lung contusion, hemorrhagic shock, and chronic stress. Surgery, 158, 595–601.
- Bozzini CE, Barrio Rendo ME, Devoto FC, et al (1970): Studies on medullary and extramedullary erythropoiesis in the adult mouse. Am J Physiol, 219, 724–728.
- Cunin P, Bouslama R, Machlus KR, et al (2019): Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. Elife, 8, e44031.
- Garcês A, Soeiro V, Lóio S, et al (2020): Outcomes, Mortality Causes, and Pathological Findings in European Hedgehogs (Erinaceus europeus, Linnaeus 1758): A Seventeen Year Retrospective Analysis in the North of Portugal. Animals, 10, 1305.
- Glazer JM, Rivers EP, Gunnerson KJ (2016): Shock BT - Surgical Intensive Care Medicine. 61-79. In: O’Donnell JM, Nácul FE (Eds), Springer International Publishing.
- Grebien F, Kerenyi MA, Kovacic B, et al (2008): Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood, 111, 4511–4522.
- Gupta N, Jadhav K, Shah V (2017): Emperipolesis, entosis and cell cannibalism: Demystifying the cloud. J Oral Maxillofac Pathol, 21, 92-98.
- Johns J, Christopher M (2012): Extramedullary Hematopoiesis: A New Look at the Underlying Stem Cell Niche, Theories of Development, and Occurrence in Animals. Vet Pathol, 49, 508–523.
- Kim C (2010): Homeostatic and pathogenic extramedullary hematopoiesis. J Blood Med, 1, 13–19.
- Lee WB, Erm SK, Kim KY, et al (1999): Emperipolesis of erythroblasts within Kupffer cells during hepatic hemopoiesis in human fetus. Anat Rec, 256, 158–164.
- Lewis JH (1976): Comparative hematology—Studies on hedgehogs (Erinaceus europaeus). Comp Biochem Physiol Part A Physiol, 53, 237–240.
- Lewis J, Norcott M, Frost L, et al (2002): Normal haematological values of European hedgehogs (Erinaceus europaeus) from an English rehabilitation centre. Vet Rec, 15, 567–569.
- Lichtenberger M (2004): Principles of shock and fluid therapy in special species. Semin Avian Exot Pet Med, 13, 142–153.
- Livingston DH, Anjaria D, Wu J, et al (2003): Bone Marrow Failure Following Severe Injury in Humans. Ann Surg, 238, 748-753.
- Rastogi V, Sharma R, Misra S, et al (2014): Emperipolesis – A Review. J Clin Diagn Res, 8, ZM01–2.
- Suljević D, Filipić F, Islamagić E (2019): Emperipolesis: Sternal and femoral microenvironment induces megakaryiocyte emperipolesis in the Wistar strain. Mac Vet Rev, 42, 71–77.
- Mohammed OB, Amor NMS, Omer SA, et al (2021): Haematology and biochemistry panels in the Ethiopian hedgehog, Paraechinus aethiopicus (Ehrenberg, 1833) from central Saudi Arabia: Establishing reference intervals and assessing variability across sex and hibernation. J King Saud Univ – Sci, 33, 101228.
- Moore LJ, Petrovan SO, Baker PJ, et al (2020): Impacts and Potential Mitigation of Road Mortality for Hedgehogs in Europe. Animals, 10, 1523.
- Okada K, Kondo H, Sumi A, et al (2018): A retrospective study of disease incidence in African pygmy hedgehogs (Atelerix albiventris). J Vet Med Sci, 80, 1504–1510.
- Okorie-Kanu CO, Onoja RI, Achegbulu EE, et al (2015): Normal haematological and serum biochemistry values of African hedgehog (Atelerix albiventris). Comp Clin Path, 24, 127–132.
- Ozparlak H, Celik I, Sur E, et al (2011): A study of peripheral blood in hedgehogs in Turkey. J Zoo Wildl Med, 42, 392–398.
- Pfäffle M, Petney T, Elgas M, et al (2009): Tick-induced blood loss leads to regenerative anaemia in the European hedgehog (Erinaceus europaeus). Parasitology, 136, 443–452.
- Raymond J, White M (1999): Necropsy and histopathologic findings in 14 African hedgehogs (Atelerix albiventris): a retrospective study. J Zoo Wildl Med, 30, 273–277.
- Rossi G, Mangiagalli G, Paracchini G, et al (2014): Hematologic and biochemical variables of hedgehogs (Erinaceus europaeus) after overwintering in rehabilitation centers. Vet Clin Pathol, 43, 6–14.
- Silva GF, Rêma A, Teixeira S, et al (2022): Pathological Findings in African Pygmy Hedgehogs Admitted into a Portuguese Rehabilitation Center. Animals, 12, 1361.
- Suljević D, Fočak M, Filipić F, et al (2018): Haematopoiesis in the European common toad Bufo bufo (Linnaeus, 1758): new methodological insights to study general, seasonal, and sexual haematopoietic distribution and maturation pattern. Turkish J Zool, 42, 198–206.
- Quilliam TA, Clarke JA, Salsbury AJ (1971): The ecological significance of certain new haematological findings in the mole and hedgehog. Comp Biochem Physiol Part A Physiol, 40, 89–102.
- Vadonlesõ G, Berndt M, Lukács A, et al (2019): Urban hedgehogs (Erinaceus roumanicus) in Budapest: Live or let die. Hungarian Agric Res, 3, 20–26.
Toplam 30 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Proje Numarası | 27-02-11-4375-2/21 |
| Erken Görünüm Tarihi | 27 Ekim 2023 |
| Yayımlanma Tarihi | |
| Yayımlandığı Sayı | Yıl 2024Accepted Papers |