Changes in uroplakin secretion in the urothelium leads a gradual ability lost in neoplastic conditions. Urothelium is
one of the target regions where nitric oxide can damage. Therefore, in this study, the presence of iNOS and UPIII were investigated in
bovine enzootic hematuria cases. The results were supported by comparing them with those achieved by critical markers for malignancy
of tumor such as caspase 3, Bax, p53, PCNA, and VEGF. The presence of 8-OHDG, a good marker for oxidative DNA damage, was
also investigated. For this purpose, urinary bladders with enzootic hematuria were collected from the slaughterhouses. In
histopathological examinations, neoplastic, pre-neoplastic, and inflammatory lesions were observed in these urinary bladders. In
immunohistochemical examinations, iNOS reacts as negative in the UPIII positive healthy urothelium which preserves the structure of
AUM. On the other hand positive reaction has been observed in AUM modified and UPIII negative urothelium. In these cases, as an
indicator of oxidative damage, 8-OHdG positivity was observed in the UPIII negative and iNOS positive areas. Additionally, increased
cell proliferation, decreased apoptosis as well as p53 disorganization were clearly observed in most of the cases. Thus, the active role
of nitric oxide, as a free radical derivative, has been shown in the enzootic hematuria cases of cattle.
Bovine enzootic hematuria, iNOS, nitric oxide, urinary bladder, uroplakin III
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Cerrahi |
Bölüm | Araştırma Makalesi |
Yazarlar |
|
Yayımlanma Tarihi | 9 Kasım 2018 |
Yayınlandığı Sayı | Yıl 2018Cilt: 65 Sayı: 4 |
Bibtex | @araştırma makalesi { auvfd635432, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2018}, volume = {65}, number = {4}, pages = {341 - 348}, doi = {10.1501/Vetfak\_0000002866}, title = {The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III}, key = {cite}, author = {Keleş, Hikmet and Bozkurt, Mehmet Fatih and Ulucan, Aykut and Demirel, Hasan Hüseyin and Yüksel, Hayati and Karadaş, Erkan and Özkul, Ayhan} } |
APA | Keleş, H. , Bozkurt, M. F. , Ulucan, A. , Demirel, H. H. , Yüksel, H. , Karadaş, E. & Özkul, A. (2018). The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 65 (4) , 341-348 . DOI: 10.1501/Vetfak_0000002866 |
MLA | Keleş, H. , Bozkurt, M. F. , Ulucan, A. , Demirel, H. H. , Yüksel, H. , Karadaş, E. , Özkul, A. "The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 65 (2018 ): 341-348 <http://vetjournal.ankara.edu.tr/tr/pub/issue/49588/635432> |
Chicago | Keleş, H. , Bozkurt, M. F. , Ulucan, A. , Demirel, H. H. , Yüksel, H. , Karadaş, E. , Özkul, A. "The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III". Ankara Üniversitesi Veteriner Fakültesi Dergisi 65 (2018 ): 341-348 |
RIS | TY - JOUR T1 - The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III AU - HikmetKeleş, Mehmet FatihBozkurt, AykutUlucan, Hasan HüseyinDemirel, HayatiYüksel, ErkanKaradaş, AyhanÖzkul Y1 - 2018 PY - 2018 N1 - doi: 10.1501/Vetfak_0000002866 DO - 10.1501/Vetfak_0000002866 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 341 EP - 348 VL - 65 IS - 4 SN - 1300-0861-1308-2817 M3 - doi: 10.1501/Vetfak_0000002866 UR - https://doi.org/10.1501/Vetfak_0000002866 Y2 - 2017 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III %A Hikmet Keleş , Mehmet Fatih Bozkurt , Aykut Ulucan , Hasan Hüseyin Demirel , Hayati Yüksel , Erkan Karadaş , Ayhan Özkul %T The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III %D 2018 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 65 %N 4 %R doi: 10.1501/Vetfak_0000002866 %U 10.1501/Vetfak_0000002866 |
ISNAD | Keleş, Hikmet , Bozkurt, Mehmet Fatih , Ulucan, Aykut , Demirel, Hasan Hüseyin , Yüksel, Hayati , Karadaş, Erkan , Özkul, Ayhan . "The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III". Ankara Üniversitesi Veteriner Fakültesi Dergisi 65 / 4 (Kasım 2018): 341-348 . https://doi.org/10.1501/Vetfak_0000002866 |
AMA | Keleş H. , Bozkurt M. F. , Ulucan A. , Demirel H. H. , Yüksel H. , Karadaş E. , Özkul A. The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Univ Vet Fak Derg. 2018; 65(4): 341-348. |
Vancouver | Keleş H. , Bozkurt M. F. , Ulucan A. , Demirel H. H. , Yüksel H. , Karadaş E. , Özkul A. The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2018; 65(4): 341-348. |
IEEE | H. Keleş , M. F. Bozkurt , A. Ulucan , H. H. Demirel , H. Yüksel , E. Karadaş ve A. Özkul , "The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 65, sayı. 4, ss. 341-348, Kas. 2018, doi:10.1501/Vetfak_0000002866 |