Araştırma Makalesi
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Yıl 2020, Cilt 67, Sayı 2, 137 - 142, 03.03.2020
https://doi.org/10.33988/auvfd.561824

Öz

Kaynakça

  • 1. Acaroz U, Arslan-Acaroz D, Gurler Z (2016): Immunoassay Development for the Detection of Antibiotic Residues in Foods. Kocatepe Vet J, 9, 122–126.
  • 2. Acaroz U, Gurler Z, Kara R, et al (2018): Presence of Salmonella spp. in Chicken Meat and Giblets Marketed in Afyonkarahisar Province. Kocatepe Vet J, 11, 1–5.
  • 3. Anonymus (2019): Kalıntı İzleme Planı. Available at https://www.tarimorman.gov.tr/Konular/ Gida-Ve-Yem-Hizmetleri/Gida-Hizmetleri/Kalinti-Izleme. (Accessed Sept 09, 2019).
  • 4. Aslam B, Kousar N, Javed I, et al (2016): Determination of Enrofloxacin Residues in Commercial Broilers Using High Performance Liquid Chromatography. Int J Food Prop, 19, 2463–2470.
  • 5. Attari VE, Abbasi MM, Abedimanesh N, et al (2014): Investigation of Enrofloxacin and Chloramphenicol Residues in Broiler Chickens Carcasses Collected From Local Markets of Tabriz, Northwestern Iran. Heal Promot Perspect, 4, 151–157.
  • 6. Bonassa KPD, Miragliotta MY, Simas RC, et al (2017): Tissue depletion study of enrofloxacin and its metabolite ciprofloxacin in broiler chickens after oral administration of a new veterinary pharmaceutical formulation containing enrofloxacin. Food Chem Toxicol, 105, 8-13.
  • 7. EU COMMISSION REGULATION (2010): No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin.
  • 8. Fàbrega A, Sánchez-Céspedes J, Soto S, et al (2008): Quinolone resistance in the food chain. Int J Antimicrob Agents, 31, 307-315.
  • 9. Faten SH, Mousa MM, Mahomud AH, et al (2016): Ciprofloxacin residues in chicken and turkey carcasses. Benha Vet Med J, 31, 136-143.
  • 10. Gbylik-Sikorska M, Posyniak A, Sniegocki T, et al (2016): Influence of enrofloxacin traces in drinking water to doxycycline tissue pharmacokinetics in healthy and infected by Mycoplasma gallisepticum broiler chickens. Food Chem Toxicol, 90, 123-129.
  • 11. Kaufmann A, Butcher P, Maden K (2012): Determination of aminoglycoside residues by liquid chromatography and tandem mass spectrometry in a variety of matrices. Anal Chim Acta, 711, 46-53.
  • 12. Kirbis A, Marinsek J, Flajs VC (2005): Introduction of the HPLC method for the determination of quinolone residues in various muscle tissues. Biomed Chromatogr, 19, 259-265.
  • 13. Kirrella GAK, Deeb AMM, Abdallah RMI (2017): Safety of frozen liver for human consumption. J Food Drug Anal, 25, 520-524.
  • 14. Lolo M, Pedreira S, Miranda JM, et al (2006): Effect of cooking on enrofloxacin residues in chicken tissue. Food Addit Contam, 23, 988–993.
  • 15. Magdelaine P, Spiess MP, Valceschini E (2008): Poultry meat consumption trends in Europe. Worlds Poult Sci J, 64, 53–63.
  • 16. Martins MT, Barreto F, Hoff RB, et al (2015): Determination of quinolones and fluoroquinolones, tetracyclines and sulfonamides in bovine, swine and poultry liver using LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 32, 333–341.
  • 17. Metli M, Yakar Y, Tekeli Y (2015): Determination of Antibiotic Residues in Chicken Liver by Liquid Chromatography-Tandem Mass Spectrometry. Adıyaman Uni J Sci, 5, 120-131.
  • 18. Moema D, Nindi MM, Dube S (2012): Development of a dispersive liquid-liquid microextraction method for the determination of fluoroquinolones in chicken liver by high performance liquid chromatography. Anal Chim Acta, 730, 80-86.
  • 19. Naeem M, Khan K, Rafiq S (2006): Determination of Residues of Quinolones in Poultry Products by High Pressure Liquid Chromatography. J Appl Sci, 6, 373-379.
  • 20. Nizamlıoğlu F, Aydın H (2012): Quinolone antibiotic residues in raw milk and chicken liver in Konya. Eurasian J Vet Sci, 28, 154-158.
  • 21. Panzenhagen PHN, Aguiar WS, Gouvêa R, et al (2016): Investigation of enrofloxacin residues in broiler tissues using ELISA and LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 33, 639–643.
  • 22. Rezaee N, Rafie S, Javadi A, et al (2018): Determination of Enrofloxacin and Ciprofloxacin Residues in Five Different Kinds of Chicken Tissues by Dispersive Liquid – Liquid Microextraction Coupled with HPLC. Iran J Pharm Res, 17, 1182–1190.
  • 23. Salehzadeh F, Salehzadeh A, Rokni N, et al (2007): Enrofloxacin Residue in Chicken Tissues from Tehran Slaughterhouses in Iran. Pakistan J Nutr, 6, 409-413.
  • 24. San Martin B, Cornejo J, Lapierre L, et al (2010): Withdrawal time of four pharmaceutical formulations of enrofloxacin in poultry according to different maximum residues limits. J Vet Pharmacol Ther, 33, 246–251.
  • 25. Sarker YA, Hasan MM, Paul TK, et al (2018): Screening of antibiotic residues in chicken meat in Bangladesh by thin layer chromatography. J Adv Vet Anim Res, 5, 140.
  • 26. Sattar S, Hassan MM, Islam SKMA, et al (2014): Antibiotic residues in broiler and layer meat in Chittagong district of Bangladesh. Vet World, 7, 738-743.
  • 27. Sultan IA (2014): Detection of Enrofloxacin Residue in Livers of Livestock Animals Obtained from a Slaughterhouse in Mosul City. J Vet Sci Technol, 5, 2-4.
  • 28. Toldrá F, Reig M (2006): Methods for rapid detection of chemical and veterinary drug residues in animal foods. Trends Food Sci Technol, 17, 482–489.
  • 29. Trouchon T, Lefebvre S (2017): A Review of Enrofloxacin for Veterinary Use. Open J Vet Med, 6, 40–58.
  • 30. Younus M, Abbas T, Zafar M, et al (2017): Quantification of enrofloxacin residues in broiler chicken tissues using competitive enzyme-linked immunosorbent assay. Indian J Anim Sci, 87, 659–661.

Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar

Yıl 2020, Cilt 67, Sayı 2, 137 - 142, 03.03.2020
https://doi.org/10.33988/auvfd.561824

Öz

Antibiotic residues can remain in animal source foods, mainly in the liver. Enrofloxacin (ENR) is a synthetic fluoroquinolone antimicrobial agent which is extensively used to treat bacterial infections in poultry. This study aimed to evaluate ENR and its main metabolite ciprofloxacin (CIP) occurrence in 100 chicken livers marketed Afyonkarahisar, Turkey. Chicken liver samples were analyzed by LC-MS/MS method with limits of detection for 1.17 μg/kg (ENR) and 1.24 μg/kg (CIP). ENR and CIP were detected in 39% and in 31% of samples, respectively. However, the total sum of both antibiotic residue levels was found to be far below the established maximum residue level (200 μg/kg) in all of chicken liver samples. In conclusion, according to the results of this study, chicken livers marketed in Afyonkarahisar city are safe for public health regarding ENR and CIP residues. Nonetheless, periodical control of chicken liver is advised due to the high incidence of these antibiotics.

Kaynakça

  • 1. Acaroz U, Arslan-Acaroz D, Gurler Z (2016): Immunoassay Development for the Detection of Antibiotic Residues in Foods. Kocatepe Vet J, 9, 122–126.
  • 2. Acaroz U, Gurler Z, Kara R, et al (2018): Presence of Salmonella spp. in Chicken Meat and Giblets Marketed in Afyonkarahisar Province. Kocatepe Vet J, 11, 1–5.
  • 3. Anonymus (2019): Kalıntı İzleme Planı. Available at https://www.tarimorman.gov.tr/Konular/ Gida-Ve-Yem-Hizmetleri/Gida-Hizmetleri/Kalinti-Izleme. (Accessed Sept 09, 2019).
  • 4. Aslam B, Kousar N, Javed I, et al (2016): Determination of Enrofloxacin Residues in Commercial Broilers Using High Performance Liquid Chromatography. Int J Food Prop, 19, 2463–2470.
  • 5. Attari VE, Abbasi MM, Abedimanesh N, et al (2014): Investigation of Enrofloxacin and Chloramphenicol Residues in Broiler Chickens Carcasses Collected From Local Markets of Tabriz, Northwestern Iran. Heal Promot Perspect, 4, 151–157.
  • 6. Bonassa KPD, Miragliotta MY, Simas RC, et al (2017): Tissue depletion study of enrofloxacin and its metabolite ciprofloxacin in broiler chickens after oral administration of a new veterinary pharmaceutical formulation containing enrofloxacin. Food Chem Toxicol, 105, 8-13.
  • 7. EU COMMISSION REGULATION (2010): No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin.
  • 8. Fàbrega A, Sánchez-Céspedes J, Soto S, et al (2008): Quinolone resistance in the food chain. Int J Antimicrob Agents, 31, 307-315.
  • 9. Faten SH, Mousa MM, Mahomud AH, et al (2016): Ciprofloxacin residues in chicken and turkey carcasses. Benha Vet Med J, 31, 136-143.
  • 10. Gbylik-Sikorska M, Posyniak A, Sniegocki T, et al (2016): Influence of enrofloxacin traces in drinking water to doxycycline tissue pharmacokinetics in healthy and infected by Mycoplasma gallisepticum broiler chickens. Food Chem Toxicol, 90, 123-129.
  • 11. Kaufmann A, Butcher P, Maden K (2012): Determination of aminoglycoside residues by liquid chromatography and tandem mass spectrometry in a variety of matrices. Anal Chim Acta, 711, 46-53.
  • 12. Kirbis A, Marinsek J, Flajs VC (2005): Introduction of the HPLC method for the determination of quinolone residues in various muscle tissues. Biomed Chromatogr, 19, 259-265.
  • 13. Kirrella GAK, Deeb AMM, Abdallah RMI (2017): Safety of frozen liver for human consumption. J Food Drug Anal, 25, 520-524.
  • 14. Lolo M, Pedreira S, Miranda JM, et al (2006): Effect of cooking on enrofloxacin residues in chicken tissue. Food Addit Contam, 23, 988–993.
  • 15. Magdelaine P, Spiess MP, Valceschini E (2008): Poultry meat consumption trends in Europe. Worlds Poult Sci J, 64, 53–63.
  • 16. Martins MT, Barreto F, Hoff RB, et al (2015): Determination of quinolones and fluoroquinolones, tetracyclines and sulfonamides in bovine, swine and poultry liver using LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 32, 333–341.
  • 17. Metli M, Yakar Y, Tekeli Y (2015): Determination of Antibiotic Residues in Chicken Liver by Liquid Chromatography-Tandem Mass Spectrometry. Adıyaman Uni J Sci, 5, 120-131.
  • 18. Moema D, Nindi MM, Dube S (2012): Development of a dispersive liquid-liquid microextraction method for the determination of fluoroquinolones in chicken liver by high performance liquid chromatography. Anal Chim Acta, 730, 80-86.
  • 19. Naeem M, Khan K, Rafiq S (2006): Determination of Residues of Quinolones in Poultry Products by High Pressure Liquid Chromatography. J Appl Sci, 6, 373-379.
  • 20. Nizamlıoğlu F, Aydın H (2012): Quinolone antibiotic residues in raw milk and chicken liver in Konya. Eurasian J Vet Sci, 28, 154-158.
  • 21. Panzenhagen PHN, Aguiar WS, Gouvêa R, et al (2016): Investigation of enrofloxacin residues in broiler tissues using ELISA and LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 33, 639–643.
  • 22. Rezaee N, Rafie S, Javadi A, et al (2018): Determination of Enrofloxacin and Ciprofloxacin Residues in Five Different Kinds of Chicken Tissues by Dispersive Liquid – Liquid Microextraction Coupled with HPLC. Iran J Pharm Res, 17, 1182–1190.
  • 23. Salehzadeh F, Salehzadeh A, Rokni N, et al (2007): Enrofloxacin Residue in Chicken Tissues from Tehran Slaughterhouses in Iran. Pakistan J Nutr, 6, 409-413.
  • 24. San Martin B, Cornejo J, Lapierre L, et al (2010): Withdrawal time of four pharmaceutical formulations of enrofloxacin in poultry according to different maximum residues limits. J Vet Pharmacol Ther, 33, 246–251.
  • 25. Sarker YA, Hasan MM, Paul TK, et al (2018): Screening of antibiotic residues in chicken meat in Bangladesh by thin layer chromatography. J Adv Vet Anim Res, 5, 140.
  • 26. Sattar S, Hassan MM, Islam SKMA, et al (2014): Antibiotic residues in broiler and layer meat in Chittagong district of Bangladesh. Vet World, 7, 738-743.
  • 27. Sultan IA (2014): Detection of Enrofloxacin Residue in Livers of Livestock Animals Obtained from a Slaughterhouse in Mosul City. J Vet Sci Technol, 5, 2-4.
  • 28. Toldrá F, Reig M (2006): Methods for rapid detection of chemical and veterinary drug residues in animal foods. Trends Food Sci Technol, 17, 482–489.
  • 29. Trouchon T, Lefebvre S (2017): A Review of Enrofloxacin for Veterinary Use. Open J Vet Med, 6, 40–58.
  • 30. Younus M, Abbas T, Zafar M, et al (2017): Quantification of enrofloxacin residues in broiler chicken tissues using competitive enzyme-linked immunosorbent assay. Indian J Anim Sci, 87, 659–661.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Hekimlik
Bölüm Araştırma Makalesi
Yazarlar

Damla ARSLAN ACARÖZ> (Sorumlu Yazar)
Afyon Kocatepe University, Bayat Vocational School
0000-0001-9230-6725
Türkiye


Nalan BAYSU SÖZBİLİR Bu kişi benim
Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Biochemistry
0000-0002-2270-8312
Türkiye

Yayımlanma Tarihi 3 Mart 2020
Yayınlandığı Sayı Yıl 2020, Cilt 67, Sayı 2

Kaynak Göster

Bibtex @araştırma makalesi { auvfd561824, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2020}, volume = {67}, number = {2}, pages = {137 - 142}, doi = {10.33988/auvfd.561824}, title = {Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar}, key = {cite}, author = {Arslan Acaröz, Damla and Baysu Sözbilir, Nalan} }
APA Arslan Acaröz, D. & Baysu Sözbilir, N. (2020). Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 67 (2) , 137-142 . DOI: 10.33988/auvfd.561824
MLA Arslan Acaröz, D. , Baysu Sözbilir, N. "Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2020 ): 137-142 <http://vetjournal.ankara.edu.tr/tr/pub/issue/52756/561824>
Chicago Arslan Acaröz, D. , Baysu Sözbilir, N. "Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2020 ): 137-142
RIS TY - JOUR T1 - Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar AU - Damla Arslan Acaröz , Nalan Baysu Sözbilir Y1 - 2020 PY - 2020 N1 - doi: 10.33988/auvfd.561824 DO - 10.33988/auvfd.561824 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 137 EP - 142 VL - 67 IS - 2 SN - -1308-2817 M3 - doi: 10.33988/auvfd.561824 UR - https://doi.org/10.33988/auvfd.561824 Y2 - 2019 ER -
EndNote %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar %A Damla Arslan Acaröz , Nalan Baysu Sözbilir %T Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar %D 2020 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P -1308-2817 %V 67 %N 2 %R doi: 10.33988/auvfd.561824 %U 10.33988/auvfd.561824
ISNAD Arslan Acaröz, Damla , Baysu Sözbilir, Nalan . "Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 / 2 (Mart 2020): 137-142 . https://doi.org/10.33988/auvfd.561824
AMA Arslan Acaröz D. , Baysu Sözbilir N. Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar. Ankara Univ Vet Fak Derg. 2020; 67(2): 137-142.
Vancouver Arslan Acaröz D. , Baysu Sözbilir N. Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2020; 67(2): 137-142.
IEEE D. Arslan Acaröz ve N. Baysu Sözbilir , "Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 67, sayı. 2, ss. 137-142, Mar. 2020, doi:10.33988/auvfd.561824