Heparin - Compound 48/80 interaetion was investigated. It was found
that Compound 48/80 inhibited the metachromatic staining of mast edl granules of mesenterie tissue of the rat and eommereial heparin by toluidine blue. Compound 48/80 has alsa
inhibited the antieoagı.ılant effect of heparin. The results indicate that a ehemieal interaction between heparin 'and Compound 48/80 may be present.
it is eonc1uded that, same of the heparin may be inaetivated by Compound 48/80
when this substanee is used to degranulate mast eells. The findings support the idea that heparin proteets the organism against the toxie effeet of Compound 48/80.
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Cerrahi |
Bölüm | Araştırma Makalesi |
Yazarlar | |
Yayımlanma Tarihi | 1 Ocak 1971 |
Yayımlandığı Sayı | Yıl 1971Cilt: 18 Sayı: 02 |