Letter to Editor
Effects of dietary zinc supplemetation on plasma leptin, insulin and thyroid hormones concentrationwith some biochemical parameters in sheep species
Abstract
In the present study, an experiment was designed to investigate how zinc supplementation affect plasma leptin, insulin, total triiodothyronine (T3), thyroxine (T4) and free triiodothyronine (FT3), free thyroxine (FT4) and some biochemical parameters between Akkaraman sheep as fat-tailed breed and Merino sheep as thin-tailed breed. The animals were equally divided into four groups of 24 animals each. Group I (control Akkaraman) and group III (control Merino) were fed with a basis diet (roughages such as alfalfa hay + concentrate feed). Group II (Zn-Akkaraman) and group IV (Zn-Merino) were fed a at 250 mg/kg Zn ( ZnSO4. 7H2O) added to basis diet. The experimental study was lasted for 30 days and blood samples were taken from the animals to determine plasma concentrations of leptin, insulin, free triiodothyronine (FT3), free tetraiodothyronine (FT4), total triiodothyronine (T3), tiroxin (T4), urea, glucose, malondialdehyde (MDA), glutation (GSH), total antioxidant activity (TAA), β-karoten and vitamin A at the end of trial. Both sheep species in the Zn groups had significantly higher plasma Zn values than the controls throughout the experimental period. The levels of plasma leptin, insulin, thyroid hormones, glucose, urea, MDA, GSH, TAA and vitamin A were insignificant changed both Akkaraman and Merino in the Zn groups. However, the concentrations of plasma glucose, urea and ßcaroten were higher in Merino control group than those of Akkaraman control group. This results indicated that there was no effect of dietary zinc supplemantation on the plasma leptin, insulin and thyroid hormones and another parameters in both sheep species with different tail types
Keywords
References
- Connie KL: Role of trace minerals in animal production.What do I need to know about trace minerals for beef and dairy cattle, horses, sheep and goats? Erişim tarihi: 26.11.2011 Erişim adresi: http://www.progressivedairy.com/index.php?option= comcontent&view=article &id
- Chan S, Gerson B, Subramaniam S (1998): The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin. Lab. Med., 18, 673-685.
- Coleman JE (1992): Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins. Ann. Rev. Biochem., 61, 897-946.
- Mantzoros CS, Prasad AS, Beck FWJ, Grabowski S, Kaplan J, Adair C, Brewer GJ (1998): Zinc may regulate serum leptin concentrations in humans. Journal of the American College of Nutrition, 17, 270–275 In: Prasad AS (1996): Zinc: the biology and therapeutics of an ion. Ann. Intern. Med., 125, 142-144.
- Mangian HF, Lee RT, Paul GL, Emmert JL, Shay NF (1998): Zinc deficiency suppresses plasma leptin concentrations in rats. J. Nutr. Biochem. 9, 47-51.
- Ott ES, Shay NF (2001): Zinc deficiency reduces leptin gene expression and leptin secretion in rat adipocytes. Exp. Biol. Med., 226, 841–846.
- Delavaud C, Bocquier F, Chilliard Y, Keisler DH, Gertler A, Kann G (2000): Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep. J. Endocrinol., 165, 519-526.
- Chilliard Y, Delavaud C, Bonnet M (2005): Leptin expression in ruminants. Nutritional and physiological regulations in relation with energy metabolism. Dom. Anim. Endocrinol., 29: 3-22.
- Maffei M, Halaas J, Ravussin E, Pratley RE, LeeGH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, KernPA, Friedman JM (1995): Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine, 1, 1155-1161.
- Garcia MR, Amstalden M, Keisler DH, Raver N, Gertler A, Williams GL (2004): Leptin attenuates the acute effects of centrally administered neuropeptide Y on somatotropin but not gonadotropin secretion in ovariectomized cows. Domest. Anim. Endocrinol., 27, 89.
- Delavaud C, Ferlay A, Faulconnier Y, Bocquier F, Kann G, Chilliard Y (2002): Plasma leptin concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J. Anim. Sci., 80, 1317-1328.
- Kumar B, Francis SM, Suttie JM, Thompson MP (1998): Expression of obese mRNA in genetically lean and fat selection lines of sheep. Comp. Biochem. Physiol. Part B, 120, 543-548.
- Beutler E, Olga D, Barbara MR (1963): Improved method for the determination of blood glutatione. J Lab Clin Med., 61, 882-888.
- Draper HH, Hardley M (1990): Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol., 186, 421-30.
- Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001): Method for the measurement of antioxidant activity in human fluids. J Clin Pathol, 54, 356-361.
- Suzuki J, Katoh NA (1990): Simple and cheap methods for measuring serum vitamin-A in cattle using only a spectrophotometer. Nippon Juigaku Zasshi, 52, 1281-1283.
- Daniel, W.W. (1991): Bioistatistics: A Faundation for Analysis in the Health Sciences. 5th ed. John Wiley & Sons Inc., Canada.
- NCR (1981): Nutrient requirements of goats. National Academy Pres,Washington DC, USA.
- Altıntaş A, Fidancı UR (1993): Evcil hayvanlarda ve insanlarda kanın biyokimyasal normal değerleri. A.Ü. Vet. Fak. Derg., 40, 173-186.
- Wright CL, Spears JW (2004): Effect of zinc source and dietary level on zinc metabolism in holstein calves. ADSA, 87, 1085-1091.
- Ren, MQ, Wegner J, Bellmann O, Brockmann GA, Schneıder F, Teuscher F, Ender K (2002): Comparing mRNA levels of genes encoding leptin, leptin receptor, and lipoprotein lipase between dairy and beef cattle. Domest. Anim. Endocrinol., 23, 371-381.
- Eryavuz A, Avcı G, Kucukkurt I, Fidan AF (2007): Comparison of Plasma Leptin, Insulin and Thyroid Hormone Concentrations and Some Biochemical Parameters Between Fat-Tailed and Thin-Tailed Sheep Breeds. Revue Méd. Vét., 158, 244-249.
- Zabrocka L, Klımek J, Swıerczynskı J (2006): Evidence that triiodo-thyronine decreases rat serum leptin concentration by downregulation of leptin gene expression in white adipose tissue. Life Sci., 79,1114-20.
- Kececi T, Keskin E (2005): Zinc supplementation decreases total thyroid hormone concentration in small ruminants. Biol. Trace Elem. Res., 104, 41-46.
- Keçeci T (2003): Effect of low birthweight on serum thyroid hormones, glucose, urea and blood pH in newborn lambs. Turk. J. Vet. Anim. Sci., 27, 395-399.
- Eryavuz A, Dundar Y, Özdemir M, Aslan R, Tekerli M (2003): Effects of adding urea and sulfur on performance of faunate and defaunate Ramlic lambs, and some rumen and blood parameters. Anim.Feed Sci.Technol., 109, 35- 46.
- Altunok V, Başpınar N (2000): Merinos, Akkaraman, İvesi ve Koriedale ırkı koçlarda bazı biyokimyasal parametrelerin karşılaştırılması. Vet. Bil. Derg., 16, 1.
- Franchis SM, Veenvliet BA, Littlejohn RP, Suttie JM (1999). Plasma Glucose and Insulin Levels in Genetically Lean and Fat Sheep. Gen.Comp. Endoc., 116,104-113.
- Arelovich HM, Owens FN, Horn GW, Vizcarra JA (1998): Urea utilization by cattle fed prairie hay and supplemented with zinc. Anim. Sci. Res. Rep., 194-198.
- Arelovich HM, Owens FN, Horn GW, Vizcarra JA (1997): Effects of zinc and manganese concentrations on in vitro urea degradation and prairie hay disappearance. J. Anim. Sci.,75 (Suppl. 1).
- Kraus A, Roth HP, Kirchgessner M (1997): Supplementation with Vitamin C, Vitamin E or ß-carotene Influences Osmotic Fragility and Oxidative Damage of Erythrocytes of Zinc-Deficient Rats. J. Nutr., 127, 1290- 1296.
- Hu HL, Chen RD, Ma LH (1992): Protective effect of zinc on liver injury induced by D-galactosamine in rats. Biol Trace Elem Res. 34, 27-33.
- Knight TW, Death AF, Wyeth TK (1996): Effect of dietary zinc oxide on the plasma carotenoid concentration of steers. NZJA, 39, 293-296. Geliş tarihi: 17.02.2012 / Kabul tarihi: 28.06.2012
Farklı ırk koyunlarda rasyona çinko ilave edilmesinin plazma leptin, insulin ve tiroid hormon düzeyleri ile bazı biyokimyasal parametreler üzerine etkisi
Abstract
Bu araştırmada yağlı kuyruklu Akkaraman ve yağsız kuyruklu Anadolu Merinos koyun ırklarının rasyonuna çinko ilave edilmesinin leptin, insulin, tiroid hormonları ile bazı biyokimyasal parametrelere etkisinin belirlenmesi amaçlanmıştır. Araştırmada kullanılan Akkaraman ve Merinos ırkı toplam 24 baş koyun 4 gruba ayrılmıştır. Grup I (kontrol Akkaraman) ve grup III (kontrol Merinos) temel rasyon (kaba yem olarak kuru yonca+karma yem) ile beslenirken, Grup II (Zn-Akkaraman) ve grup IV (Zn-Merinos) temel rasyonuna 250 mg/kg Zn (ZnSO4. 7H2O) ilave edilmiştir. Bir aylık deneme süresi sonunda alınan kanda leptin, insulin, serbest triiyodotironin (FT3) ve tetraiyodotironin (FT4), total triiyodotironin (T3) ve tiroksin (T4) hormonları ile üre, glikoz, malondialdehit (MDA), glutasyon (GSH), total antioksidan aktivite (TAA), β-karoten ve vitamin A düzeyleri ölçülmüştür. Plazma çinko düzeyi kontrol gruplarına göre her 2 ırkın çinkolu gruplarında yüksek bulunmuştur. Kontrollerine göre her iki ırkın çinkolu gruplarında plazma leptin, insulin, tiroid hormonları, glikoz, üre, MDA, GSH, TAA ve vitamin A düzeylerindeki değişimler istatistiki olarak önemsiz bulunmuştur. Kontrol Merinoslarda glikoz, üre ve ß-karoten düzeyleri Akkaramanlardan yüksek tespit edilmiştir. Bu sonuçlar rasyona ilave edilen çinkonun, farklı kuyruk yapısına sahip her iki koyun ırkında da plazma leptin, insulin ve tiroid hormonları ile diğer parametrelere etkisinin olmadığını göstermektedir
References
- Connie KL: Role of trace minerals in animal production.What do I need to know about trace minerals for beef and dairy cattle, horses, sheep and goats? Erişim tarihi: 26.11.2011 Erişim adresi: http://www.progressivedairy.com/index.php?option= comcontent&view=article &id
- Chan S, Gerson B, Subramaniam S (1998): The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin. Lab. Med., 18, 673-685.
- Coleman JE (1992): Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins. Ann. Rev. Biochem., 61, 897-946.
- Mantzoros CS, Prasad AS, Beck FWJ, Grabowski S, Kaplan J, Adair C, Brewer GJ (1998): Zinc may regulate serum leptin concentrations in humans. Journal of the American College of Nutrition, 17, 270–275 In: Prasad AS (1996): Zinc: the biology and therapeutics of an ion. Ann. Intern. Med., 125, 142-144.
- Mangian HF, Lee RT, Paul GL, Emmert JL, Shay NF (1998): Zinc deficiency suppresses plasma leptin concentrations in rats. J. Nutr. Biochem. 9, 47-51.
- Ott ES, Shay NF (2001): Zinc deficiency reduces leptin gene expression and leptin secretion in rat adipocytes. Exp. Biol. Med., 226, 841–846.
- Delavaud C, Bocquier F, Chilliard Y, Keisler DH, Gertler A, Kann G (2000): Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep. J. Endocrinol., 165, 519-526.
- Chilliard Y, Delavaud C, Bonnet M (2005): Leptin expression in ruminants. Nutritional and physiological regulations in relation with energy metabolism. Dom. Anim. Endocrinol., 29: 3-22.
- Maffei M, Halaas J, Ravussin E, Pratley RE, LeeGH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, KernPA, Friedman JM (1995): Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine, 1, 1155-1161.
- Garcia MR, Amstalden M, Keisler DH, Raver N, Gertler A, Williams GL (2004): Leptin attenuates the acute effects of centrally administered neuropeptide Y on somatotropin but not gonadotropin secretion in ovariectomized cows. Domest. Anim. Endocrinol., 27, 89.
- Delavaud C, Ferlay A, Faulconnier Y, Bocquier F, Kann G, Chilliard Y (2002): Plasma leptin concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J. Anim. Sci., 80, 1317-1328.
- Kumar B, Francis SM, Suttie JM, Thompson MP (1998): Expression of obese mRNA in genetically lean and fat selection lines of sheep. Comp. Biochem. Physiol. Part B, 120, 543-548.
- Beutler E, Olga D, Barbara MR (1963): Improved method for the determination of blood glutatione. J Lab Clin Med., 61, 882-888.
- Draper HH, Hardley M (1990): Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol., 186, 421-30.
- Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001): Method for the measurement of antioxidant activity in human fluids. J Clin Pathol, 54, 356-361.
- Suzuki J, Katoh NA (1990): Simple and cheap methods for measuring serum vitamin-A in cattle using only a spectrophotometer. Nippon Juigaku Zasshi, 52, 1281-1283.
- Daniel, W.W. (1991): Bioistatistics: A Faundation for Analysis in the Health Sciences. 5th ed. John Wiley & Sons Inc., Canada.
- NCR (1981): Nutrient requirements of goats. National Academy Pres,Washington DC, USA.
- Altıntaş A, Fidancı UR (1993): Evcil hayvanlarda ve insanlarda kanın biyokimyasal normal değerleri. A.Ü. Vet. Fak. Derg., 40, 173-186.
- Wright CL, Spears JW (2004): Effect of zinc source and dietary level on zinc metabolism in holstein calves. ADSA, 87, 1085-1091.
- Ren, MQ, Wegner J, Bellmann O, Brockmann GA, Schneıder F, Teuscher F, Ender K (2002): Comparing mRNA levels of genes encoding leptin, leptin receptor, and lipoprotein lipase between dairy and beef cattle. Domest. Anim. Endocrinol., 23, 371-381.
- Eryavuz A, Avcı G, Kucukkurt I, Fidan AF (2007): Comparison of Plasma Leptin, Insulin and Thyroid Hormone Concentrations and Some Biochemical Parameters Between Fat-Tailed and Thin-Tailed Sheep Breeds. Revue Méd. Vét., 158, 244-249.
- Zabrocka L, Klımek J, Swıerczynskı J (2006): Evidence that triiodo-thyronine decreases rat serum leptin concentration by downregulation of leptin gene expression in white adipose tissue. Life Sci., 79,1114-20.
- Kececi T, Keskin E (2005): Zinc supplementation decreases total thyroid hormone concentration in small ruminants. Biol. Trace Elem. Res., 104, 41-46.
- Keçeci T (2003): Effect of low birthweight on serum thyroid hormones, glucose, urea and blood pH in newborn lambs. Turk. J. Vet. Anim. Sci., 27, 395-399.
- Eryavuz A, Dundar Y, Özdemir M, Aslan R, Tekerli M (2003): Effects of adding urea and sulfur on performance of faunate and defaunate Ramlic lambs, and some rumen and blood parameters. Anim.Feed Sci.Technol., 109, 35- 46.
- Altunok V, Başpınar N (2000): Merinos, Akkaraman, İvesi ve Koriedale ırkı koçlarda bazı biyokimyasal parametrelerin karşılaştırılması. Vet. Bil. Derg., 16, 1.
- Franchis SM, Veenvliet BA, Littlejohn RP, Suttie JM (1999). Plasma Glucose and Insulin Levels in Genetically Lean and Fat Sheep. Gen.Comp. Endoc., 116,104-113.
- Arelovich HM, Owens FN, Horn GW, Vizcarra JA (1998): Urea utilization by cattle fed prairie hay and supplemented with zinc. Anim. Sci. Res. Rep., 194-198.
- Arelovich HM, Owens FN, Horn GW, Vizcarra JA (1997): Effects of zinc and manganese concentrations on in vitro urea degradation and prairie hay disappearance. J. Anim. Sci.,75 (Suppl. 1).
- Kraus A, Roth HP, Kirchgessner M (1997): Supplementation with Vitamin C, Vitamin E or ß-carotene Influences Osmotic Fragility and Oxidative Damage of Erythrocytes of Zinc-Deficient Rats. J. Nutr., 127, 1290- 1296.
- Hu HL, Chen RD, Ma LH (1992): Protective effect of zinc on liver injury induced by D-galactosamine in rats. Biol Trace Elem Res. 34, 27-33.
- Knight TW, Death AF, Wyeth TK (1996): Effect of dietary zinc oxide on the plasma carotenoid concentration of steers. NZJA, 39, 293-296. Geliş tarihi: 17.02.2012 / Kabul tarihi: 28.06.2012
There are 33 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA62ZP39UH |
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 1, 2013 |
| Published in Issue | Year 2013 |