Abstract
A contagious disease characterized with severe pruritis, weight loss and alopecia was observed in laboratory mice in Experimental Animal Breeding Unit in University of Akdeniz, Turkey, after recently transferring the animals from Israel. Twenty out of 100 mice were referred to the clinics of the Department of Internal Medicine, Faculty of Veterinary Medicine University of Mehmet Akif Ersoy, for a diagnosis. Alopecia and severe itching were observed all over the body, particularly on the abdominal area. Skin scrapings were obtained from affected sites of the skin for a parasitological examination. At the examination of the skin scrapings, treated with 10 % of potassium hydroxide, numerous mange agents and eggs were observed. Agents were diagnosed as Myocoptes musculinus according to their morphological characteristics. Five mice were euthanatized and examined pathologically. At the histopathological examination of the skin samples taken from alopecia and pruritic areas, numerous mange agents were seen in the tunnels in the epidermis. Mild inflammatory reaction including lymphocyte and neutrophil leukocytes were observed in the dermis. After diagnosis, mice were treated with ivermectin (Vilmectin) solution via drinking water (8 mg/L drinking water once a week for 3 wks). All animals were successfully recovered after the treatment
Keywords
References
- Baker DG (1998): Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev, 11, 231–266.
- Campbell WC (1985): Ivermectin, AN update. Parasitology Today, 1, 10-16.
- Csiza CK, McMartin DN (1976): Apparent acaridal dermatitis in a C57BL/6 Nya Mouse colony. Lab Anim Sci, 26, 781-787.
- Dinçer Ş (1987): Studies on the occurrence of mites of albino mice and rats, and their control. Ankara Univ Vet Fak Derg, 35, 389-406.
- Donnelly TM (2004): Disease problems of small rodents. In: Ferrets, Rabbits, and Rodents Clinical Medicine and surgery. 2nd edition. Quesenberry KE. Carpenter JW Saunders, USA.
- Flynn RJ (1973): Parasites of laboratory animals. Ames: lows State University Pres. Fox, Anderson, et al 2nd edition: Laboratory Animal Medicine.
- Jones TC, Hunt RD, King NW (1997): Disease caused by parasitic helmints and arthropods. pp 677. In: Veterinary Pathology, Pennsylvania. Williams & Wilkins.
- Lallon M T (1996): Rats and mice. 1-38. In: Handbook of Rodent and Rabbit Medicine. 1st edition. Laber-Laird, K.; Swindle; M.M.; Flecknell, P. Pergamon veterinary handbook series. Elsevier UK.
- Papini R, Marconcini A (1991): Treatment with ivermectin in drinking water against Myobia musculi and Myocoptes musculinus mange in naturally infected laboratory mice. Angew Parasitol, 32, 11-13.
- Wall R, Shearer D (1997): Veterinary Entomology. Chapman & Hall, London. Geliş tarihi: 03.06.2008 / Kabul tarihi: 25.11.2008 Address for correspondence Dr. Sima Sahinduran Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy 15100/Burdur- Turkey sahinduran@mehmetakif.edu.tr
Abstract
Akdeniz Üniversitesi deney hayvanları ünitesine İsrail’den getirilen laboratuvar farelerinde deride şiddetli kaşıntı, kilo kaybı ve alopesiyle karakterize bir hastalık saptandı. Yüz fareden 20’si teşhis için Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalına getirildi. Bütün vücutta özellikle karın bölgesinde alopesi ve kaşıntı gözlendi. Parazitolojik muayene için kaşıntılı bölgelerden deri kazıntısı alındı. Potasyum hidroksit ile (%10’luk) muamele edilen deri kazıntılarının parazitolojik incelemesinde çok sayıda akar ve yumurtalarına rastlandı. Akarlar morfolojik karakterlerine göre Myocoptes musculinus olarak teşhis edildi. Farelerden beşi ötenazi edilerek patolojik olarak incelendi. Kaşıntılı ve alopesik sahalardan alınan deri örneklerinin histopatolojik yoklamasında epidermisteki tüneller içerisinde çok sayıda akar’a rastlandı. Dermiste lenfosit ve nötrofil lökositlerden oluşan hafif yangısal reaksiyon saptandı. Teşhisten sonra fareler, içme sularına ivermectin solusyonu (Vilmectin) 8 mg/L dozunda karıştırılarak haftada 1 kez olmak üzere üç defa verilerek tedavi edildi. Sağaltımdan sonra hayvanların tümü iyileşti
Keywords
References
- Baker DG (1998): Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev, 11, 231–266.
- Campbell WC (1985): Ivermectin, AN update. Parasitology Today, 1, 10-16.
- Csiza CK, McMartin DN (1976): Apparent acaridal dermatitis in a C57BL/6 Nya Mouse colony. Lab Anim Sci, 26, 781-787.
- Dinçer Ş (1987): Studies on the occurrence of mites of albino mice and rats, and their control. Ankara Univ Vet Fak Derg, 35, 389-406.
- Donnelly TM (2004): Disease problems of small rodents. In: Ferrets, Rabbits, and Rodents Clinical Medicine and surgery. 2nd edition. Quesenberry KE. Carpenter JW Saunders, USA.
- Flynn RJ (1973): Parasites of laboratory animals. Ames: lows State University Pres. Fox, Anderson, et al 2nd edition: Laboratory Animal Medicine.
- Jones TC, Hunt RD, King NW (1997): Disease caused by parasitic helmints and arthropods. pp 677. In: Veterinary Pathology, Pennsylvania. Williams & Wilkins.
- Lallon M T (1996): Rats and mice. 1-38. In: Handbook of Rodent and Rabbit Medicine. 1st edition. Laber-Laird, K.; Swindle; M.M.; Flecknell, P. Pergamon veterinary handbook series. Elsevier UK.
- Papini R, Marconcini A (1991): Treatment with ivermectin in drinking water against Myobia musculi and Myocoptes musculinus mange in naturally infected laboratory mice. Angew Parasitol, 32, 11-13.
- Wall R, Shearer D (1997): Veterinary Entomology. Chapman & Hall, London. Geliş tarihi: 03.06.2008 / Kabul tarihi: 25.11.2008 Address for correspondence Dr. Sima Sahinduran Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy 15100/Burdur- Turkey sahinduran@mehmetakif.edu.tr
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA63HR26MM |
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 1, 2010 |
| Published in Issue | Year 2010 |