Letter to Editor
Year 2014,
Volume: 61 Issue: 1, 29 - 34, 01.03.2014
Abstract
A 17-year-old male, mongrel dog was evaluated for a primary mass localized between perianal and sacral region and metastatic foci on lung. It was also encountered coincidentally with another mass taking place between distal esophagus and cardia of stomach and metastatic foci in kidney. In histopathological examination, perianal localization of mass and metastatic foci on lung were diagnosed as hepatoid gland carcinoma while esophagogastric mass and metastatic foci in kidney were diagnosed as leiomyosarcoma. In immunohistochemical examination, Ki-67 marker gave positive reaction in nuclei of anaplastic hepatoid gland cells in spite of vimentin and α-smooth actin positivity were found in reserve cells of the tumor. But, there was only positive with actin marker in leiomyosarcoma. It is considered useful to share results of the two different concurrent tumor in same dog
Keywords
References
- Bruecker KA, Withrow SJ (1988): Intestinal leiomyosarcoma in six dogs. J Am Anim Hosp Assoc, 24, 281-284.
- Cohen M, Post GS, Wright JC (2003): Gastrointestinal leiomyosarcoma in 14 dogs. J Vet Intern Med, 17, 107- 110.
- Crawshaw J, Berg J, Sardinas JC, Engler SJ, Rand WM, Ogilvie GK, Spodnick GJ, Petterino C, Martini M, Castagnaro M (2004): Immunohistochemical detection of growth (GH) in canine hepatoid gland tumors. J Vet Med Sci, 66, 569-572.
- Farese JP, Bacon JP, Ehrhart NP, Bush J, Ehrhart EJ, Withrow SJ (2008): Oesophageal leiomyosarcoma in dogs: surgical management and clinical outcome of four cases. Vet Comp Oncol, 6, 31-38.
- Genevois JP (1980): Pathologie ano-rectale et perineale. I Circumnalomes. Rev Med Vet, 131, 697-705.
- Gillespie V, Baer K, Farelly J, Craft D, Luong R (2011): Canine Gastrointestinal Stromal Tumors: Immunohistochemical Expression of CD34 and Examination of Prognostic Indicatorts Including Proliferation Markers Ki67 and AgNOR. Vet Pathol, 48, 283.
- Ginn PE, Mansell JEKL, Rakich PM (2007): Skin and appendages. 756-757. In: Maxie MG. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Chapter 5. 5th ed., vol 1, Saunders Elsevier, Philadelphia-USA.
- Goldschmidt MH, Hendrick MJ (2002): Tumors of the Skin and Soft Tissues. 68-70. In Meuten DJ. Tumors in Domestic Animals, Chapter 2, 4th edition. Iowa state pres Ames, IA, USA.
- Grubeck-Loebenstein B, Wick G (2002): The aging of the immune system. Adv Immunol, 80, 243-84.
- Hayden DW, Nielsen SW (1973): Canine alimentary neoplasia. Zbl Vet Med, 20A, 1-22.
- Head KW, Else RW, Dubielzig RR (2002): Tumors of the Alimentary Tract. 440-441, 458-459. In: Meuten DJ (Ed). Tumors in Domestic Animals, 4th ed. Iowa state pres, Ames, IA, USA.
- Jakab C, Rusvai M, Galfi P, Kulka J (2010): Expression of claudin-7 molecule in canine perianal gland tumours. Acta Vet Brno, 79, 127-133.
- Jakab C, Rusvai M, Galfi P, Mandoki M, Demeter Z, Szabo Z, Kulka J (2010): Expression of claudin-5 in hepatoid gland biopsies. Vet Dermatol, 21, 276-281.
- Jakab C, Rusvai M, Szabo Z, Szabara A, Kulka J (2009): Expression of the claudin-4 molecule in benign and malignant canine hepatoid gland tumours. Acta Vet Hung, 57, 463-475.
- Kapatkin AS, Mullen HS, Mathiesen DT, Patnaik AK (1992): Leiomyosarcoma in dogs: 44 cases (1983–1988). J Am Vet Med Assoc, 201, 1077-1079.
- LaRock RG, Ginn PE (1997): Immunohistochemical Staining Characteristic of Canine Gastrointestinal Stromal Tumors. Vet Pathol, 34, 303-311.
- Maita K, Ishida K (1975): Structure and development of the perianal gland of the dog. Jpn J Vet Sci, 37, 349-356.
- Müller GH, Kirk RW, Scott DW (1983): Perianal Gland Tumors. 736-738. In Small Animals Dermatology. 3rd ed., Saunder Co, Philadelphia.
- Ovens JM, Russel WO (1951): Concurrent leiomyosarcoma and squamous carcinoma of the esophagus. AMA Arch Pathol, 51, 560-564.
- Park C, Yoo JH, Kim HJ, Lim CY, Kim JW, Lee SY, Kim JH, Jang JI, Park, HM (2010): Cyclosporine treatment of perianal gland adenoma concurrent with benign prostatic hyperplasia in a dog. Can Vet J, 51, 1279-1282.
- Patnaik AK, Hurvitz AI, Johnson GF (1977): Canine Gastrointestinal Neoplasms. Vet Pathol, 14, 547-555.
- Pisani G, Millanta F, Lorenzi D, Vannozzi I, Poli A (2006): Androgen receptor expression in normal, hyperplastic and neoplastic hepatoid glands in the dog. Res Vet Sci, 81, 231-236.
- Rella AJ, Farrell JT, Comer JV (1965): Concurrent leiomyosarcoma and squamous cell carcinoma of esophagus. N Y State J Med, 15, 1254-1256.
- Rolfe DS, Twedt DC, Seim HB (1994): Chronic regurgitation or vomiting caused esophagal leiomyoma in three dogs. J Amer Anim Hosp Assoc, 30, 425-430.
- Stannard AA, Pulley LT (1978): Perianal Gland Tumors. 59-62. In: Moulton JE. Tumors in Domestic Animals, 2nd ed., University of California Press. Ltd. London-England.
- Swan HW, Hol DE (2002): Canine Gastric Adenocarcinoma and Leiomyosarcoma: A retrospective study of 21 cases (1986-1999) and literature review. J Am Anim Hosp Assoc, 38, 157-164.
- The Merck Veterinary Manual (2011): Hepatoid Gland Tumors (Perianal gland tumors, circumanal gland tumors. Online access: http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/ bc/72212.htm, Access date: 19.12.2012.
- Vail DM, Withrow SJ, Schwarz PD, Powers BE (1990): Perianal adenocarcinomas in the canine male: a retrospective study of 41 cases. J Am Anim Hosp Assoc, 26, 329-334.
- Vos JH, van den Ingh TS, Ramaekers FC, Molenbeek RF, de Neijs M, van Mil FN, Ivanyi D (1993): The expression of keratins, vimentin, neurofilament proteins, smooth muscle actin, neuron-specific enolase, and synaptophysin in tumors of the specific glands in the canine anal region. Vet Pathol, 30, 352-361.
Year 2014,
Volume: 61 Issue: 1, 29 - 34, 01.03.2014
Abstract
17 yaşlı erkek bir köpekte perianal ve sakral bölge arasında lokalize olan primer bir kitle ile akciğerdeki metastatik odaklar değerlendirildi. Rastlantısal olarak distal özefagus ve midenin kardiyası arasında yer alan diğer bir kitleyle birlikte böbrekte benzer odaklara rastlandı. Histopatolojik incelemede özefagogastrik yerleşimli ve böbrekte bulunan kitlelerin leiomyosarkom olarak tanılandırılmasına karşın, perianal bölgedeki kitle ile akciğerdeki metastatik odaklar hepatoid bez karsinomu olarak tanılandırıldı. İmmunohistokimyasal incelemede, vimentin ve α-smooth actin tümör rezerv hücrelerinde pozitif bulunmasına rağmen, Ki67 anaplastik hepatoid bez hücrelerinde pozitif reaksiyon verdi. Fakat leiomyosarkom sadece α-smooth actin ile pozitifti. Aynı köpekte iki farklı tümöre rastlanması açısından sonuçların paylaşılmasının yararlı olduğu düşünüldü
Keywords
References
- Bruecker KA, Withrow SJ (1988): Intestinal leiomyosarcoma in six dogs. J Am Anim Hosp Assoc, 24, 281-284.
- Cohen M, Post GS, Wright JC (2003): Gastrointestinal leiomyosarcoma in 14 dogs. J Vet Intern Med, 17, 107- 110.
- Crawshaw J, Berg J, Sardinas JC, Engler SJ, Rand WM, Ogilvie GK, Spodnick GJ, Petterino C, Martini M, Castagnaro M (2004): Immunohistochemical detection of growth (GH) in canine hepatoid gland tumors. J Vet Med Sci, 66, 569-572.
- Farese JP, Bacon JP, Ehrhart NP, Bush J, Ehrhart EJ, Withrow SJ (2008): Oesophageal leiomyosarcoma in dogs: surgical management and clinical outcome of four cases. Vet Comp Oncol, 6, 31-38.
- Genevois JP (1980): Pathologie ano-rectale et perineale. I Circumnalomes. Rev Med Vet, 131, 697-705.
- Gillespie V, Baer K, Farelly J, Craft D, Luong R (2011): Canine Gastrointestinal Stromal Tumors: Immunohistochemical Expression of CD34 and Examination of Prognostic Indicatorts Including Proliferation Markers Ki67 and AgNOR. Vet Pathol, 48, 283.
- Ginn PE, Mansell JEKL, Rakich PM (2007): Skin and appendages. 756-757. In: Maxie MG. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Chapter 5. 5th ed., vol 1, Saunders Elsevier, Philadelphia-USA.
- Goldschmidt MH, Hendrick MJ (2002): Tumors of the Skin and Soft Tissues. 68-70. In Meuten DJ. Tumors in Domestic Animals, Chapter 2, 4th edition. Iowa state pres Ames, IA, USA.
- Grubeck-Loebenstein B, Wick G (2002): The aging of the immune system. Adv Immunol, 80, 243-84.
- Hayden DW, Nielsen SW (1973): Canine alimentary neoplasia. Zbl Vet Med, 20A, 1-22.
- Head KW, Else RW, Dubielzig RR (2002): Tumors of the Alimentary Tract. 440-441, 458-459. In: Meuten DJ (Ed). Tumors in Domestic Animals, 4th ed. Iowa state pres, Ames, IA, USA.
- Jakab C, Rusvai M, Galfi P, Kulka J (2010): Expression of claudin-7 molecule in canine perianal gland tumours. Acta Vet Brno, 79, 127-133.
- Jakab C, Rusvai M, Galfi P, Mandoki M, Demeter Z, Szabo Z, Kulka J (2010): Expression of claudin-5 in hepatoid gland biopsies. Vet Dermatol, 21, 276-281.
- Jakab C, Rusvai M, Szabo Z, Szabara A, Kulka J (2009): Expression of the claudin-4 molecule in benign and malignant canine hepatoid gland tumours. Acta Vet Hung, 57, 463-475.
- Kapatkin AS, Mullen HS, Mathiesen DT, Patnaik AK (1992): Leiomyosarcoma in dogs: 44 cases (1983–1988). J Am Vet Med Assoc, 201, 1077-1079.
- LaRock RG, Ginn PE (1997): Immunohistochemical Staining Characteristic of Canine Gastrointestinal Stromal Tumors. Vet Pathol, 34, 303-311.
- Maita K, Ishida K (1975): Structure and development of the perianal gland of the dog. Jpn J Vet Sci, 37, 349-356.
- Müller GH, Kirk RW, Scott DW (1983): Perianal Gland Tumors. 736-738. In Small Animals Dermatology. 3rd ed., Saunder Co, Philadelphia.
- Ovens JM, Russel WO (1951): Concurrent leiomyosarcoma and squamous carcinoma of the esophagus. AMA Arch Pathol, 51, 560-564.
- Park C, Yoo JH, Kim HJ, Lim CY, Kim JW, Lee SY, Kim JH, Jang JI, Park, HM (2010): Cyclosporine treatment of perianal gland adenoma concurrent with benign prostatic hyperplasia in a dog. Can Vet J, 51, 1279-1282.
- Patnaik AK, Hurvitz AI, Johnson GF (1977): Canine Gastrointestinal Neoplasms. Vet Pathol, 14, 547-555.
- Pisani G, Millanta F, Lorenzi D, Vannozzi I, Poli A (2006): Androgen receptor expression in normal, hyperplastic and neoplastic hepatoid glands in the dog. Res Vet Sci, 81, 231-236.
- Rella AJ, Farrell JT, Comer JV (1965): Concurrent leiomyosarcoma and squamous cell carcinoma of esophagus. N Y State J Med, 15, 1254-1256.
- Rolfe DS, Twedt DC, Seim HB (1994): Chronic regurgitation or vomiting caused esophagal leiomyoma in three dogs. J Amer Anim Hosp Assoc, 30, 425-430.
- Stannard AA, Pulley LT (1978): Perianal Gland Tumors. 59-62. In: Moulton JE. Tumors in Domestic Animals, 2nd ed., University of California Press. Ltd. London-England.
- Swan HW, Hol DE (2002): Canine Gastric Adenocarcinoma and Leiomyosarcoma: A retrospective study of 21 cases (1986-1999) and literature review. J Am Anim Hosp Assoc, 38, 157-164.
- The Merck Veterinary Manual (2011): Hepatoid Gland Tumors (Perianal gland tumors, circumanal gland tumors. Online access: http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/ bc/72212.htm, Access date: 19.12.2012.
- Vail DM, Withrow SJ, Schwarz PD, Powers BE (1990): Perianal adenocarcinomas in the canine male: a retrospective study of 41 cases. J Am Anim Hosp Assoc, 26, 329-334.
- Vos JH, van den Ingh TS, Ramaekers FC, Molenbeek RF, de Neijs M, van Mil FN, Ivanyi D (1993): The expression of keratins, vimentin, neurofilament proteins, smooth muscle actin, neuron-specific enolase, and synaptophysin in tumors of the specific glands in the canine anal region. Vet Pathol, 30, 352-361.
There are 29 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA49BA43RN |
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 1, 2014 |
| Published in Issue | Year 2014Volume: 61 Issue: 1 |