Ankara Üniversitesi Veteriner Fakültesi Dergisi
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Serum Cardiac Troponin-I in dogs with CPV-2 infection

Year 2013, Volume: 60 Issue: 4, 251 - 255, 01.12.2013

İdil BASTAN Arif KURTDEDE Tevhide SEL Doğukan ÖZEN Nihat YUMUŞAK M. Özkan TIMURKAN Ahmet BAYDIN

https://doi.org/10.1501/Vetfak_0000002588
Cited By: 1

Abstract

The objective of study was to determine the clinical significance of serum cTn-I level in dogs infected with Canine parvovirus-2 (CPV-2). The study material consisted of 4- to 10-week-old puppies of either sexes and 8 different breeds of twenty five dogs with CPV-2. Control group consisted of 4- to 10-week-old puppies of either sexes and 7 different breeds of twenty five dogs. Although treatment, 12 of the dogs with serum cTn-I level > 0.8 ng/mL died within 24 hours of admission. Remaining 13 dogs, had the serum cTn-I level <0.156 ng/mL (cut-off). Of 13 dogs, 4 died within 24-72 hours of admission and 9 were recovered. In terms of cTn-I concentration, whether below 0.156 ng/mL or above 0.8 ng/mL there was a statistically significant difference between survivor and non-survivor animals (p<0.001). Construction of Kaplan-Meier, survival curves revealed dogs with a cTn-I concentration > 0.8 ng/mL had survival time of 1 day, whereas dogs with a cTn-I concentration <0.156 ng/mL had a median survival time of 2.5 days (p<0,001). No statistically significant difference was determined between the mean ages of two groups (dogs with cTn-I concentration <0.156 and > 0.8 ng/mL) (p>0.05). At necropsy, the histopathological examination of the heart revealed the presence of pathological myocarditis findings in 12 of the non-survivor dogs (cTn-I > 0.8 ng/mL), whilst in the other non-survivor 4 dogs (cTn-I<0.156), no pathological alteration was observed in the myocardium. The present study demonstrated that serum cTn-I concentrations > 0.8 ng/mL were indicators of poor prognosis and increased serum cTn-I concentrations were consistent with short survival times in dogs with CPV-2

Keywords

Canine parvovirus, cardiac troponin I, myocarditis

References

  • Babuin L, Jaffe AS (2005): Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association , 173: 1191–1202.
  • Baumwart RD, Orvalho J, Meurs KM (2007). Evaluation of serum cardiac troponin I concentration in Boxers with arrhythmogenic cardiomyopathy. Am J Vet Res, 68: 524-8. right ventricular
  • DeFrancesco TC, Atkins CE, Keene BW, Coats JR, Hauck ML (2002). Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital. J Vet Intern Med, 1: 553–557.
  • Diniz PPVP, Morais HSA, Breitschwerdt EB, Schwartz (2008): Serun Cardiac Troponin I Concentration in Dogs with Erlichiosis. J Vet Intern Med, 22: 1136-1143.
  • Fonfara S, Loureiro J, Swift S, James R, Cripps P, Dukes-McEwan J (2010): Cardiac troponin I as a marker for severity and prognosis of cardiac disease in dogs. Vet J, 184: 334-9.
  • Goddard A, Leisewitz MM (2010). Canine Parvovirus Vet Clin North Am Small Anim Pract. 4: 1041-53.
  • Guglielmini C, Civitella C, Diana A, Di Tommaso M, Cipone M, Luciani A (2010): Serum Cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension. J Vet Intern Med, 24: 145-52.
  • Hoskins JD (1997): Update on canine parvoviral enteritis. Vet Med, 92, 694–709.
  • Lenghaus C, Studdert MJ (1982): Acute and chronic viral myocarditis. Acute diffuse nonsuppurative myocarditis and residual myocardial scarring following infection with canine parvovirus. Am J Pathol, 115: 316–319.
  • Lobetti R, Dvir E, Pearson J (2002). Cardiac troponins in canine babesiosis. J Vet Intern Med, 16:63–68.
  • McCandlish IAP (1999): Specific Infactions of the dog. 921-958. In: Dunn J Textbook Small Animal Medicine.
  • Mellor PJ, Richard JM, Elizabeth AB, Elizabeth JV, Joy A, Michael E H (2006). High serum troponin I concentration as a marker of severe myocardial damage in a case of suspected exertional heatstroke in a dog. Journal or Veterinary Cardiology, 8: 55-62.
  • Nappert G, Duphy E, Ruben D, Mann FA (2002). Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis. The Canadian Journal of Veterinary Research, 66: 15-18.
  • Nelson RW (2009) :Small Animal Internal Medicine, fourt edition, Elsevier, China.
  • Noszczyk-Nowak A (2011): NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure. Pol J Vet Sci, 14: 551-6.
  • Porciello F, Rishniw WM, Herndon W, Birettoni F, Antognooni MT, Simpson KW (2008): Cardiac troponin I is elevated in dogs and cats with azotemia renal failure and in dogs with non-cardiac systemic disease. Australian Veterinary Journal, 86, 10: 390-394.
  • Prittie J (2004): Canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care, 14: 167-176
  • Ricchiuti V, Sharkey SW, Murakami MM, Voss EM, Apple FS (1998). Cardiac troponin I and T alterations in dog hearts with myocardial infarction: correlation with infarct size. Am J Clin Pathol, 110: 241–247.
  • Robinson WF, Huxtable CR, Pass DA, Howell JM (1979). Clinical and electrocardiographic findings in suspected viral myocarditis of pups. Aust Vet J, 55: 3.
  • Schober KE, Cornand C, Kirbach B, Aupperle H, Oechtering G (2002): Serum cardiac tro-ponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus. J Am Vet Med Assoc, 221: 381–388.
  • Schober KE, Kirbach B, Oechtering G (1999). Noninvasive assessment of myocardial cell injury in dogs with suspected cardiac contusion. J Vet Cardiol,1: 17–25.
  • Shih AC, Maisenbacher HW, Barreirinha A, Adin DB, Schmidt MK, Prosek R, Estrada AH (2009): Effect of routine cardiovascular catheterization in dogs. Journal of Veterinary Cardiology, 11: 87-92.
  • Spratt DP, Mellanby RJ, Drury N, Archer J (2005): Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog. J Small Anim Pract, 46: 139-145.
  • Turk J, Fales W, Miller M, Pace L, Fischer J, Johnson G, Kreeger J, Turnquist S, Pittman L, Rottinghaus A (1992). Enteric Clostridium perfringens infection associated with parvoviral enteritis in dogs: 74 cases (1987-1990). J Am Vet Med Assoc, 200: 991-4.
  • Turk J, Miller M, Brown T, Fales W, Fischer J, Gosser H, Nelson S, Shaw D, Solorzano R (1990). Coliform septicemia and pulmonary disease associated with canine parvoviral enteritis: 88 cases (1987-1988). J Am Vet Med Assoc, 196: 771-3.
  • Oyama MA, Sisson DD (2004). Cardiac troponin-I concentration in dogs with cardiac disease. J Vet Intern Med, 18: 831-9.
  • Ozkul A, Keles I, Karaoglu T, Çabalar M, Burgu I (2002): Detection and rflp analysis of canine parvovirus (cpv) dna by polymerase chain reaction (pcr) in a dog. Turk J Vet Anim Sci, 6: 1201–1203.

CPV-2 infeksiyonlu köpeklerde Serum Kardiyak Troponin-I

Year 2013, Volume: 60 Issue: 4, 251 - 255, 01.12.2013

İdil BASTAN Arif KURTDEDE Tevhide SEL Doğukan ÖZEN Nihat YUMUŞAK M. Özkan TIMURKAN Ahmet BAYDIN

https://doi.org/10.1501/Vetfak_0000002588
Cited By: 1

Abstract

Bu çalışmada, CPV-2’li köpeklerde cTn-I konsantrasyonunun klinik öneminin değerlendirilmesi amaçlandı. Çalışmanın materyalini değişik ırk ve her iki cinsiyetten 4-10 haftalık yaşta 25’i hasta ve 25’i sağlıklı olmak üzere 50 yavru köpek oluşturdu. Sağaltım uygulamasının başlatılmasına rağmen serum cTn-I konsantrasyonu > 0.8 ng/mL olan hasta köpeklerin 12’si kliniğe getirildikten sonraki 24 saat içinde öldü. Kliniğe getirildikten sonra 24-72. saatlerde ölen 4 köpek ile sağaltım sonucu iyileşen 9 köpekte cTn-I konsantrasyonları <0.156 ng/mL (cut-off değeri) bulundu. Sağlıklı köpeklerde serum cTn-I konsantrasyonu 0,156 ng/ml değerinin (cut-off) altında saptandı. CTn-I konsantrasyonu karşılaştırıldığında ölen ve iyileşen köpekler arasında önemli farklılık saptandı (p<0.001). Serum cTn-I konsanrasyonu> 0.8 ng/mL olan köpeklerde yaşam zamanı 1 gün iken cTn-I konsantrasyonı <0.156 ng/mL olan köpeklerde ortalama yaşam süresi 2.5 gün (p<0,001) olarak hesaplandı.Serum cTn-I konsantrasyonu açısından değerlendirildiğinde yaş ortalamaları arasında istatiksel olarak önemli bir farklılık bulunmadı (p>0.05). Ölen 12 köpeğin (cTn-I > 0.8 ng/mL) nekropsisinde kalbin histopatolojik incelemesinde myokarditise bağlı patolojik değişiklikler belirlenirken ölen diğer 4 köpekte (cTn-I<0.156) kalp kasında herhangi bir patolojik değişikliğe rastlanmadı. Sonuç olarak bu çalışma serum cTn-I konsantrasyonunun 0.8 ng/mL’ nin üstünde olması kötü prognozun belirleyicisi olduğunu ve yüksek serum cTnI konsantrasyonu ile kısa yaşam süresi arasında ilişki olduğunu gösterdi

Keywords

Kanin parvovirus, kardiyak troponin- I, miyokarditis

References

  • Babuin L, Jaffe AS (2005): Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association , 173: 1191–1202.
  • Baumwart RD, Orvalho J, Meurs KM (2007). Evaluation of serum cardiac troponin I concentration in Boxers with arrhythmogenic cardiomyopathy. Am J Vet Res, 68: 524-8. right ventricular
  • DeFrancesco TC, Atkins CE, Keene BW, Coats JR, Hauck ML (2002). Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital. J Vet Intern Med, 1: 553–557.
  • Diniz PPVP, Morais HSA, Breitschwerdt EB, Schwartz (2008): Serun Cardiac Troponin I Concentration in Dogs with Erlichiosis. J Vet Intern Med, 22: 1136-1143.
  • Fonfara S, Loureiro J, Swift S, James R, Cripps P, Dukes-McEwan J (2010): Cardiac troponin I as a marker for severity and prognosis of cardiac disease in dogs. Vet J, 184: 334-9.
  • Goddard A, Leisewitz MM (2010). Canine Parvovirus Vet Clin North Am Small Anim Pract. 4: 1041-53.
  • Guglielmini C, Civitella C, Diana A, Di Tommaso M, Cipone M, Luciani A (2010): Serum Cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension. J Vet Intern Med, 24: 145-52.
  • Hoskins JD (1997): Update on canine parvoviral enteritis. Vet Med, 92, 694–709.
  • Lenghaus C, Studdert MJ (1982): Acute and chronic viral myocarditis. Acute diffuse nonsuppurative myocarditis and residual myocardial scarring following infection with canine parvovirus. Am J Pathol, 115: 316–319.
  • Lobetti R, Dvir E, Pearson J (2002). Cardiac troponins in canine babesiosis. J Vet Intern Med, 16:63–68.
  • McCandlish IAP (1999): Specific Infactions of the dog. 921-958. In: Dunn J Textbook Small Animal Medicine.
  • Mellor PJ, Richard JM, Elizabeth AB, Elizabeth JV, Joy A, Michael E H (2006). High serum troponin I concentration as a marker of severe myocardial damage in a case of suspected exertional heatstroke in a dog. Journal or Veterinary Cardiology, 8: 55-62.
  • Nappert G, Duphy E, Ruben D, Mann FA (2002). Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis. The Canadian Journal of Veterinary Research, 66: 15-18.
  • Nelson RW (2009) :Small Animal Internal Medicine, fourt edition, Elsevier, China.
  • Noszczyk-Nowak A (2011): NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure. Pol J Vet Sci, 14: 551-6.
  • Porciello F, Rishniw WM, Herndon W, Birettoni F, Antognooni MT, Simpson KW (2008): Cardiac troponin I is elevated in dogs and cats with azotemia renal failure and in dogs with non-cardiac systemic disease. Australian Veterinary Journal, 86, 10: 390-394.
  • Prittie J (2004): Canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care, 14: 167-176
  • Ricchiuti V, Sharkey SW, Murakami MM, Voss EM, Apple FS (1998). Cardiac troponin I and T alterations in dog hearts with myocardial infarction: correlation with infarct size. Am J Clin Pathol, 110: 241–247.
  • Robinson WF, Huxtable CR, Pass DA, Howell JM (1979). Clinical and electrocardiographic findings in suspected viral myocarditis of pups. Aust Vet J, 55: 3.
  • Schober KE, Cornand C, Kirbach B, Aupperle H, Oechtering G (2002): Serum cardiac tro-ponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus. J Am Vet Med Assoc, 221: 381–388.
  • Schober KE, Kirbach B, Oechtering G (1999). Noninvasive assessment of myocardial cell injury in dogs with suspected cardiac contusion. J Vet Cardiol,1: 17–25.
  • Shih AC, Maisenbacher HW, Barreirinha A, Adin DB, Schmidt MK, Prosek R, Estrada AH (2009): Effect of routine cardiovascular catheterization in dogs. Journal of Veterinary Cardiology, 11: 87-92.
  • Spratt DP, Mellanby RJ, Drury N, Archer J (2005): Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog. J Small Anim Pract, 46: 139-145.
  • Turk J, Fales W, Miller M, Pace L, Fischer J, Johnson G, Kreeger J, Turnquist S, Pittman L, Rottinghaus A (1992). Enteric Clostridium perfringens infection associated with parvoviral enteritis in dogs: 74 cases (1987-1990). J Am Vet Med Assoc, 200: 991-4.
  • Turk J, Miller M, Brown T, Fales W, Fischer J, Gosser H, Nelson S, Shaw D, Solorzano R (1990). Coliform septicemia and pulmonary disease associated with canine parvoviral enteritis: 88 cases (1987-1988). J Am Vet Med Assoc, 196: 771-3.
  • Oyama MA, Sisson DD (2004). Cardiac troponin-I concentration in dogs with cardiac disease. J Vet Intern Med, 18: 831-9.
  • Ozkul A, Keles I, Karaoglu T, Çabalar M, Burgu I (2002): Detection and rflp analysis of canine parvovirus (cpv) dna by polymerase chain reaction (pcr) in a dog. Turk J Vet Anim Sci, 6: 1201–1203.

Details

Primary Language English
Subjects Veterinary Surgery
Other ID JA69HR29CC
Journal Section Research Article
Authors

İdil BASTAN
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

Arif KURTDEDE
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

Tevhide SEL
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

Doğukan ÖZEN
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

Nihat YUMUŞAK
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

M. Özkan TIMURKAN
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

Ahmet BAYDIN
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

Publication Date December 1, 2013
Published in Issue Year 2013Volume: 60 Issue: 4

Cite

Bibtex @letter to editor { auvfd533255, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara University}, year = {2013}, volume = {60}, number = {4}, pages = {251 - 255}, doi = {10.1501/Vetfak\_0000002588}, title = {Serum Cardiac Troponin-I in dogs with CPV-2 infection}, key = {cite}, author = {Bastan, İdil and Kurtdede, Arif and Sel, Tevhide and Özen, Doğukan and Yumuşak, Nihat and Tımurkan, M. Özkan and Baydın, Ahmet} }
APA Bastan, İ. , Kurtdede, A. , Sel, T. , Özen, D. , Yumuşak, N. , Tımurkan, M. Ö. & Baydın, A. (2013). Serum Cardiac Troponin-I in dogs with CPV-2 infection . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 60 (4) , 251-255 . DOI: 10.1501/Vetfak_0000002588
MLA Bastan, İ. , Kurtdede, A. , Sel, T. , Özen, D. , Yumuşak, N. , Tımurkan, M. Ö. , Baydın, A. "Serum Cardiac Troponin-I in dogs with CPV-2 infection" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 60 (2013 ): 251-255 <http://vetjournal.ankara.edu.tr/en/pub/issue/43575/533255>
Chicago Bastan, İ. , Kurtdede, A. , Sel, T. , Özen, D. , Yumuşak, N. , Tımurkan, M. Ö. , Baydın, A. "Serum Cardiac Troponin-I in dogs with CPV-2 infection". Ankara Üniversitesi Veteriner Fakültesi Dergisi 60 (2013 ): 251-255
RIS TY - JOUR T1 - Serum Cardiac Troponin-I in dogs with CPV-2 infection AU - İdilBastan, ArifKurtdede, TevhideSel, DoğukanÖzen, NihatYumuşak, M. ÖzkanTımurkan, AhmetBaydın Y1 - 2013 PY - 2013 N1 - doi: 10.1501/Vetfak_0000002588 DO - 10.1501/Vetfak_0000002588 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 251 EP - 255 VL - 60 IS - 4 SN - 1300-0861-1308-2817 M3 - doi: 10.1501/Vetfak_0000002588 UR - https://doi.org/10.1501/Vetfak_0000002588 Y2 - 2023 ER -
EndNote %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Serum Cardiac Troponin-I in dogs with CPV-2 infection %A İdil Bastan , Arif Kurtdede , Tevhide Sel , Doğukan Özen , Nihat Yumuşak , M. Özkan Tımurkan , Ahmet Baydın %T Serum Cardiac Troponin-I in dogs with CPV-2 infection %D 2013 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 60 %N 4 %R doi: 10.1501/Vetfak_0000002588 %U 10.1501/Vetfak_0000002588
ISNAD Bastan, İdil , Kurtdede, Arif , Sel, Tevhide , Özen, Doğukan , Yumuşak, Nihat , Tımurkan, M. Özkan , Baydın, Ahmet . "Serum Cardiac Troponin-I in dogs with CPV-2 infection". Ankara Üniversitesi Veteriner Fakültesi Dergisi 60 / 4 (December 2013): 251-255 . https://doi.org/10.1501/Vetfak_0000002588
AMA Bastan İ. , Kurtdede A. , Sel T. , Özen D. , Yumuşak N. , Tımurkan M. Ö. , Baydın A. Serum Cardiac Troponin-I in dogs with CPV-2 infection. Ankara Univ Vet Fak Derg. 2013; 60(4): 251-255.
Vancouver Bastan İ. , Kurtdede A. , Sel T. , Özen D. , Yumuşak N. , Tımurkan M. Ö. , Baydın A. Serum Cardiac Troponin-I in dogs with CPV-2 infection. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2013; 60(4): 251-255.
IEEE İ. Bastan , A. Kurtdede , T. Sel , D. Özen , N. Yumuşak , M. Ö. Tımurkan and A. Baydın , "Serum Cardiac Troponin-I in dogs with CPV-2 infection", Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 60, no. 4, pp. 251-255, Dec. 2013, doi:10.1501/Vetfak_0000002588

Cited By

Case report: Long-term survival in puppies assessed with echocardiography, electrocardiography and cardiac troponin I after acute death in littermates due to parvoviral myocarditis
Frontiers in Veterinary Science
https://doi.org/10.3389/fvets.2023.1229756