Abstract
The objective of study was to determine the clinical significance of serum cTn-I level in dogs infected with Canine parvovirus-2 (CPV-2). The study material consisted of 4- to 10-week-old puppies of either sexes and 8 different breeds of twenty five dogs with CPV-2. Control group consisted of 4- to 10-week-old puppies of either sexes and 7 different breeds of twenty five dogs. Although treatment, 12 of the dogs with serum cTn-I level > 0.8 ng/mL died within 24 hours of admission. Remaining 13 dogs, had the serum cTn-I level <0.156 ng/mL (cut-off). Of 13 dogs, 4 died within 24-72 hours of admission and 9 were recovered. In terms of cTn-I concentration, whether below 0.156 ng/mL or above 0.8 ng/mL there was a statistically significant difference between survivor and non-survivor animals (p<0.001). Construction of Kaplan-Meier, survival curves revealed dogs with a cTn-I concentration > 0.8 ng/mL had survival time of 1 day, whereas dogs with a cTn-I concentration <0.156 ng/mL had a median survival time of 2.5 days (p<0,001). No statistically significant difference was determined between the mean ages of two groups (dogs with cTn-I concentration <0.156 and > 0.8 ng/mL) (p>0.05). At necropsy, the histopathological examination of the heart revealed the presence of pathological myocarditis findings in 12 of the non-survivor dogs (cTn-I > 0.8 ng/mL), whilst in the other non-survivor 4 dogs (cTn-I<0.156), no pathological alteration was observed in the myocardium. The present study demonstrated that serum cTn-I concentrations > 0.8 ng/mL were indicators of poor prognosis and increased serum cTn-I concentrations were consistent with short survival times in dogs with CPV-2
References
- Babuin L, Jaffe AS (2005): Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association , 173: 1191–1202.
- Baumwart RD, Orvalho J, Meurs KM (2007). Evaluation of serum cardiac troponin I concentration in Boxers with arrhythmogenic cardiomyopathy. Am J Vet Res, 68: 524-8. right ventricular
- DeFrancesco TC, Atkins CE, Keene BW, Coats JR, Hauck ML (2002). Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital. J Vet Intern Med, 1: 553–557.
- Diniz PPVP, Morais HSA, Breitschwerdt EB, Schwartz (2008): Serun Cardiac Troponin I Concentration in Dogs with Erlichiosis. J Vet Intern Med, 22: 1136-1143.
- Fonfara S, Loureiro J, Swift S, James R, Cripps P, Dukes-McEwan J (2010): Cardiac troponin I as a marker for severity and prognosis of cardiac disease in dogs. Vet J, 184: 334-9.
- Goddard A, Leisewitz MM (2010). Canine Parvovirus Vet Clin North Am Small Anim Pract. 4: 1041-53.
- Guglielmini C, Civitella C, Diana A, Di Tommaso M, Cipone M, Luciani A (2010): Serum Cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension. J Vet Intern Med, 24: 145-52.
- Hoskins JD (1997): Update on canine parvoviral enteritis. Vet Med, 92, 694–709.
- Lenghaus C, Studdert MJ (1982): Acute and chronic viral myocarditis. Acute diffuse nonsuppurative myocarditis and residual myocardial scarring following infection with canine parvovirus. Am J Pathol, 115: 316–319.
- Lobetti R, Dvir E, Pearson J (2002). Cardiac troponins in canine babesiosis. J Vet Intern Med, 16:63–68.
- McCandlish IAP (1999): Specific Infactions of the dog. 921-958. In: Dunn J Textbook Small Animal Medicine.
- Mellor PJ, Richard JM, Elizabeth AB, Elizabeth JV, Joy A, Michael E H (2006). High serum troponin I concentration as a marker of severe myocardial damage in a case of suspected exertional heatstroke in a dog. Journal or Veterinary Cardiology, 8: 55-62.
- Nappert G, Duphy E, Ruben D, Mann FA (2002). Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis. The Canadian Journal of Veterinary Research, 66: 15-18.
- Nelson RW (2009) :Small Animal Internal Medicine, fourt edition, Elsevier, China.
- Noszczyk-Nowak A (2011): NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure. Pol J Vet Sci, 14: 551-6.
- Porciello F, Rishniw WM, Herndon W, Birettoni F, Antognooni MT, Simpson KW (2008): Cardiac troponin I is elevated in dogs and cats with azotemia renal failure and in dogs with non-cardiac systemic disease. Australian Veterinary Journal, 86, 10: 390-394.
- Prittie J (2004): Canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care, 14: 167-176
- Ricchiuti V, Sharkey SW, Murakami MM, Voss EM, Apple FS (1998). Cardiac troponin I and T alterations in dog hearts with myocardial infarction: correlation with infarct size. Am J Clin Pathol, 110: 241–247.
- Robinson WF, Huxtable CR, Pass DA, Howell JM (1979). Clinical and electrocardiographic findings in suspected viral myocarditis of pups. Aust Vet J, 55: 3.
- Schober KE, Cornand C, Kirbach B, Aupperle H, Oechtering G (2002): Serum cardiac tro-ponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus. J Am Vet Med Assoc, 221: 381–388.
- Schober KE, Kirbach B, Oechtering G (1999). Noninvasive assessment of myocardial cell injury in dogs with suspected cardiac contusion. J Vet Cardiol,1: 17–25.
- Shih AC, Maisenbacher HW, Barreirinha A, Adin DB, Schmidt MK, Prosek R, Estrada AH (2009): Effect of routine cardiovascular catheterization in dogs. Journal of Veterinary Cardiology, 11: 87-92.
- Spratt DP, Mellanby RJ, Drury N, Archer J (2005): Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog. J Small Anim Pract, 46: 139-145.
- Turk J, Fales W, Miller M, Pace L, Fischer J, Johnson G, Kreeger J, Turnquist S, Pittman L, Rottinghaus A (1992). Enteric Clostridium perfringens infection associated with parvoviral enteritis in dogs: 74 cases (1987-1990). J Am Vet Med Assoc, 200: 991-4.
- Turk J, Miller M, Brown T, Fales W, Fischer J, Gosser H, Nelson S, Shaw D, Solorzano R (1990). Coliform septicemia and pulmonary disease associated with canine parvoviral enteritis: 88 cases (1987-1988). J Am Vet Med Assoc, 196: 771-3.
- Oyama MA, Sisson DD (2004). Cardiac troponin-I concentration in dogs with cardiac disease. J Vet Intern Med, 18: 831-9.
- Ozkul A, Keles I, Karaoglu T, Çabalar M, Burgu I (2002): Detection and rflp analysis of canine parvovirus (cpv) dna by polymerase chain reaction (pcr) in a dog. Turk J Vet Anim Sci, 6: 1201–1203.
Abstract
Bu çalışmada, CPV-2’li köpeklerde cTn-I konsantrasyonunun klinik öneminin değerlendirilmesi amaçlandı. Çalışmanın materyalini değişik ırk ve her iki cinsiyetten 4-10 haftalık yaşta 25’i hasta ve 25’i sağlıklı olmak üzere 50 yavru köpek oluşturdu. Sağaltım uygulamasının başlatılmasına rağmen serum cTn-I konsantrasyonu > 0.8 ng/mL olan hasta köpeklerin 12’si kliniğe getirildikten sonraki 24 saat içinde öldü. Kliniğe getirildikten sonra 24-72. saatlerde ölen 4 köpek ile sağaltım sonucu iyileşen 9 köpekte cTn-I konsantrasyonları <0.156 ng/mL (cut-off değeri) bulundu. Sağlıklı köpeklerde serum cTn-I konsantrasyonu 0,156 ng/ml değerinin (cut-off) altında saptandı. CTn-I konsantrasyonu karşılaştırıldığında ölen ve iyileşen köpekler arasında önemli farklılık saptandı (p<0.001). Serum cTn-I konsanrasyonu> 0.8 ng/mL olan köpeklerde yaşam zamanı 1 gün iken cTn-I konsantrasyonı <0.156 ng/mL olan köpeklerde ortalama yaşam süresi 2.5 gün (p<0,001) olarak hesaplandı.Serum cTn-I konsantrasyonu açısından değerlendirildiğinde yaş ortalamaları arasında istatiksel olarak önemli bir farklılık bulunmadı (p>0.05). Ölen 12 köpeğin (cTn-I > 0.8 ng/mL) nekropsisinde kalbin histopatolojik incelemesinde myokarditise bağlı patolojik değişiklikler belirlenirken ölen diğer 4 köpekte (cTn-I<0.156) kalp kasında herhangi bir patolojik değişikliğe rastlanmadı. Sonuç olarak bu çalışma serum cTn-I konsantrasyonunun 0.8 ng/mL’ nin üstünde olması kötü prognozun belirleyicisi olduğunu ve yüksek serum cTnI konsantrasyonu ile kısa yaşam süresi arasında ilişki olduğunu gösterdi
References
- Babuin L, Jaffe AS (2005): Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association , 173: 1191–1202.
- Baumwart RD, Orvalho J, Meurs KM (2007). Evaluation of serum cardiac troponin I concentration in Boxers with arrhythmogenic cardiomyopathy. Am J Vet Res, 68: 524-8. right ventricular
- DeFrancesco TC, Atkins CE, Keene BW, Coats JR, Hauck ML (2002). Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital. J Vet Intern Med, 1: 553–557.
- Diniz PPVP, Morais HSA, Breitschwerdt EB, Schwartz (2008): Serun Cardiac Troponin I Concentration in Dogs with Erlichiosis. J Vet Intern Med, 22: 1136-1143.
- Fonfara S, Loureiro J, Swift S, James R, Cripps P, Dukes-McEwan J (2010): Cardiac troponin I as a marker for severity and prognosis of cardiac disease in dogs. Vet J, 184: 334-9.
- Goddard A, Leisewitz MM (2010). Canine Parvovirus Vet Clin North Am Small Anim Pract. 4: 1041-53.
- Guglielmini C, Civitella C, Diana A, Di Tommaso M, Cipone M, Luciani A (2010): Serum Cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension. J Vet Intern Med, 24: 145-52.
- Hoskins JD (1997): Update on canine parvoviral enteritis. Vet Med, 92, 694–709.
- Lenghaus C, Studdert MJ (1982): Acute and chronic viral myocarditis. Acute diffuse nonsuppurative myocarditis and residual myocardial scarring following infection with canine parvovirus. Am J Pathol, 115: 316–319.
- Lobetti R, Dvir E, Pearson J (2002). Cardiac troponins in canine babesiosis. J Vet Intern Med, 16:63–68.
- McCandlish IAP (1999): Specific Infactions of the dog. 921-958. In: Dunn J Textbook Small Animal Medicine.
- Mellor PJ, Richard JM, Elizabeth AB, Elizabeth JV, Joy A, Michael E H (2006). High serum troponin I concentration as a marker of severe myocardial damage in a case of suspected exertional heatstroke in a dog. Journal or Veterinary Cardiology, 8: 55-62.
- Nappert G, Duphy E, Ruben D, Mann FA (2002). Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis. The Canadian Journal of Veterinary Research, 66: 15-18.
- Nelson RW (2009) :Small Animal Internal Medicine, fourt edition, Elsevier, China.
- Noszczyk-Nowak A (2011): NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure. Pol J Vet Sci, 14: 551-6.
- Porciello F, Rishniw WM, Herndon W, Birettoni F, Antognooni MT, Simpson KW (2008): Cardiac troponin I is elevated in dogs and cats with azotemia renal failure and in dogs with non-cardiac systemic disease. Australian Veterinary Journal, 86, 10: 390-394.
- Prittie J (2004): Canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care, 14: 167-176
- Ricchiuti V, Sharkey SW, Murakami MM, Voss EM, Apple FS (1998). Cardiac troponin I and T alterations in dog hearts with myocardial infarction: correlation with infarct size. Am J Clin Pathol, 110: 241–247.
- Robinson WF, Huxtable CR, Pass DA, Howell JM (1979). Clinical and electrocardiographic findings in suspected viral myocarditis of pups. Aust Vet J, 55: 3.
- Schober KE, Cornand C, Kirbach B, Aupperle H, Oechtering G (2002): Serum cardiac tro-ponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus. J Am Vet Med Assoc, 221: 381–388.
- Schober KE, Kirbach B, Oechtering G (1999). Noninvasive assessment of myocardial cell injury in dogs with suspected cardiac contusion. J Vet Cardiol,1: 17–25.
- Shih AC, Maisenbacher HW, Barreirinha A, Adin DB, Schmidt MK, Prosek R, Estrada AH (2009): Effect of routine cardiovascular catheterization in dogs. Journal of Veterinary Cardiology, 11: 87-92.
- Spratt DP, Mellanby RJ, Drury N, Archer J (2005): Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog. J Small Anim Pract, 46: 139-145.
- Turk J, Fales W, Miller M, Pace L, Fischer J, Johnson G, Kreeger J, Turnquist S, Pittman L, Rottinghaus A (1992). Enteric Clostridium perfringens infection associated with parvoviral enteritis in dogs: 74 cases (1987-1990). J Am Vet Med Assoc, 200: 991-4.
- Turk J, Miller M, Brown T, Fales W, Fischer J, Gosser H, Nelson S, Shaw D, Solorzano R (1990). Coliform septicemia and pulmonary disease associated with canine parvoviral enteritis: 88 cases (1987-1988). J Am Vet Med Assoc, 196: 771-3.
- Oyama MA, Sisson DD (2004). Cardiac troponin-I concentration in dogs with cardiac disease. J Vet Intern Med, 18: 831-9.
- Ozkul A, Keles I, Karaoglu T, Çabalar M, Burgu I (2002): Detection and rflp analysis of canine parvovirus (cpv) dna by polymerase chain reaction (pcr) in a dog. Turk J Vet Anim Sci, 6: 1201–1203.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA69HR29CC |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 1, 2013 |
| Published in Issue | Year 2013Volume: 60 Issue: 4 |