This study was performed to determine the antioxidant levels and some biochemical parameters on natural infected dogs with Toxocara canis and/or T.leonina and treated dogs. In this study three to six years old and different sexes thirty dogs were used. The dogs naturally infected with Toxocara canis and/or Toxascaris leonina were allocated in two groups as treated (n=18) and positive control (n=6), whereas dogs, not infected with helminth, were kept as a negative control (n=6). Eprinomectin with 100 µg/kg dose were orally used in treated group, while dogs in negative and positive were not treated with any drugs. Prior to treatment blood and faeces samples were collected from all dogs and sample collection was continued on day 7 and day 15 posttreatment. Blood reduced glutathione (GSH), plasma malondialdehyde (MDA), antioxidant activity (AOA), glucose, total protein, urea, creatinin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT) levels were detected. Eggs per gram faeces (EPG) was performed and the severity of infection was detected in the infected dogs. In this study, the total protein and antioxidant activity was alleviated while plasma creatinin and lipid peroxidation levels were increased in the dogs natural infected with T. canis and/or T. leonina. Treatment with suitable an anthelmintic drug this helminth parasites is effective to alleviate the oxidative damage
Akkuş İ (1995): Serbest Radikaller ve Fizyolojik Etkileri. 2.Baskı, Mimoza Yayınları, Konya.
Aksakal M, Özer E (1987): Akkaraman koyunlarında antelmentik ilaçlarla tedaviden önce ve sonra hematolojik değerler ve kan plazması vitamin E düzeyi üzerine araştırmalar. Ankara Üniv Vet Fak Derg, 34, 72-84.
Beutler E, Olga D, Barbara M R (1963): Improved method for the determination of blood glutatione. J Lab Clin Med, 61, 882-888.
Carr T P, Andersen C J, Rudel L L (1993): Enzymatic determination of triglyceride free cholesterol and total cholesterol in tissue lipid extracts. Clin Biochem, 26, 39-42.
Comhair S. A. A., Erzurum S. C (2005): The regulation and Role Of Extracellular Glutathione Peroxidase. Antioxidants & Redox Signal, 7, 72-79.
Dede S, Değer Y, Değer S, Aklan M (2000): Determination of the status of lipid peroxidation and antioksidants in sheep infected with certain endoparasites (Fasciola sp, Trichostrongylidae sp., Eimeria sp.). Turkiye Parazitol Derg, 24, 190-193.
Değer Y, Gül A, Bildik A, Dede S, Yur F, Değer S (1997): Parazitli köpeklerin bazı kan parametreleri ile plazma vitamin C düzeylerinde görülen değişiklikler. Turkiye Parazitol Derg, 21, 195-198.
Draper H H, Hardley M (1990): Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol, 186, 421-30.
El Gohari Y, Galal S H, Boulos L M, Moustafa S, Amin S M, El Talebany A M (1984): Trace elements in some parasitic diarrhea. J Egypt Soc Parasitol, 14, 179-187.
EMA/MRL/114/96 (1996): Committee for Veterinary Medicinal Products, Eprinomectin summary report (1). The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit. Available at: http://www.emea.europa. eu/pdfs/vet/mrls/011496en.pdf
Gargılı A, Tüzer E, Gülanber A, Toparlak M, Efil İ, Keleş V, Ulutaş M (1999): Efficacy of moxidectin against Toxocara canis in experimentally infected dogs. Turk J Vet Anim Sci, 23, 159–161
Gameel A A (1982): Fasciola hepatica: plasma ascorbic acid, plasma iron and iron-binding capacity in experimentally infected sheep. Z Parasitenkde, 68, 185-189.
Habluetzel A, Traldi G, Ruggieri S, Atili A R, Scuppa P, Marchetti R, Menghini G, Esposito F (2003): An estimation of Toxocara canis prevalence in dogs, environmental egg contamination and risk of human infection in the Marche region of Italy. Vet Parasitol, 113, 243-252.
Helwigh A B, Lind P, Nansen J (1999): Visceral larva migrans: migratory pattern of Toxocara canis in pigs. Int J Parasitol, 29, 559-565
Holley A E, Cheeseman K H (1993): Measuring free radical reactions in vivo. Br Med Bull, 49, 494-505.
Joreno D R (1990): Malondialdehyde and thiobarbituric acid reactivitiy as perostic indices of lipid peroxidation and peroxidative tissue injury. Free Rad Biol, 9, 515-540.
Katz D, Mazor D, Dvilansky A, Meyerstein N (1996): Effect of radiation on red cell membrane and intra cellular oxidative defense system. Free Red Res, 24, 199-204.
Kaymaz A A, Bakırel U, Gönül R, Tan H, Vuruşaner C (1999): Serum protein electrophoresis in dogs with intestinal parasites. Turk J Vet Anim Sci,23, 457-459.
Kellog E W, Fridovich I (1977): Liposome oxidation and erthrocyte lysis by enzymatically generated superoxide and hydrogen peroxide. J Biol Chem, 252, 6721-6725.
Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001): Method for the measurement of antioxidant activity in human fluids. J Clin Pathol, 54, 356-361.
Kozan E, Sevimli F K, Birdane F M, Adanır R (2008): Efficacy of eprinomectin against Toxocara canis in dogs. Parasitol Res, 102, 397–400.
Masella R, Di Benedetto R, Vari R, Filesi C, Giovannini C (2005): Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem, 16, 577-586
McTier T L, Siedek E M, Clemence R B, Wren J A, Bowman D D, Hellman K, Holbert M S, Murphy M G, Young D R, Cruthers L R, Smith D G, Shanks D J, Rowan T G, Jernigan A D (2000): Efficacy of selamectin against experimentally induced and naturally acquired ascarid (Toxocara canis and Toxascaris leonina) infections in dogs. Vet Parasitol, 91, 333-345.
Meister A, Anderson M E (1983): Glutathione. Ann Rev Biochem, 52, 711-760.
Pal B, Mitra S K, Sacmal N K, Biswas D (1995): Comparative efficacy of piperazine, vermectin and albendazole against experimentally induced Toxocara canis infection in pups. Indian Vet J, 72, 52–55
Robertson I D, Thompson R C (2002): Enteric parasitic zoonoses of domesticated dogs and cats. Microbes Infect, 4, 867-873.
Sardesai VM (1995): Role of antioxidants in health maintenance. Nutr Clin Pract, 10, 19.
Sarin K, Kumar A, Prakash A, Sharma A (1993): Oxidative stres and antioxidant defence mechanism in Plasmodium vivax malaria before and after chloquin treatment. Ind J Malariol, 30, 127-133.
Soulsby E J L (1982): Helminths, Arthropods and Protozoa of Domesticated Animals. 149-155, 7th Ed. Bailliere Tindal, London.
Thomas M J (1995): The role of free radicals and antioxidants:how do we know that they are working. Crit Rev Food Sci Nutr, 35, 21.
Urquart G M, Armour J, Duncan J L, Dunn A M, Jennings F W (1996): Veterinary Parasitology. 53-73, 2 nd Ed., Blackwell Scientific Publications, Oxford.
Vansteenhouse J L (1985): Free radicals: relation to tissue damage-a review. Vet Clin Pathol, 16, 29-35.
Yarsan E, Altınsaat Ç, Ayçiçek H, Şahindokuyucu F, Kalkan F (2003): Effects of albendazole treatment on haematological and biochemical parameters in healthy and Toxocara canis infected mice. Turk J Vet Anim Sci, 27, 1057-1063.
Yüksek N, Altuğ N, Kaya A, Ağaoğlu Z T, Göz Y, Özkan C (2006): Dose dependent effectiveness of topical selamectin on puppies with Ascaridiosis. YY Univ Vet Fak Derg, 17, 1-4
Askaridiozisli ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerinin incelenmesi
Year 2010,
Volume: 57 Issue: 2, 93 - 97, 01.06.2010
Esma Kozan
Gülcan Avcı
Feride Kırcalı Sevimli
Fatih Mehmet Birdane
Mustafa Köse
Bu çalışma Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerin belirlenmesi amacıyla yapılmıştır. Çalışma 3-6 yaşlı ve farklı cinsiyette toplam 30 sokak köpeği üzerinde yürütülmüştür. Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte olduğu tespit edilen köpekler tedavi (n=18) ve pozitif kontrol (n=6) grubu olarak ayrılmış ve herhangi bir helmint enfeksiyonu tespit edilmeyen köpekler negatif kontrol (n=6) grubu olarak kullanılmıştır. Tedavi grubundaki köpeklere Eprinomectin 100 µg/kg oral uygulanmış, negatif ve pozitif kontrol gruplarındaki köpeklere herhangi bir ilaç uygulaması yapılmamıştır. Tüm gruplardan tedavi öncesinden başlanarak tedavi sonrası 7. ve 15. günlerde kan ve dışkı örnekleri düzenli olarak alınmıştır. Tam kan indirgenmiş glutasyon (GSH), plazma malondialdehit (MDA), antioksidan aktivite (AOA), glikoz, total protein, üre, kreatinin, aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), gama-glutamil transferaz (GGT) düzeyleri ile enfekte köpeklere gram dışkı yumurta sayımı (EPG) yapılarak enfeksiyon şiddeti belirlenmiştir. Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte köpeklerde kreatinin ve lipid peroksidasyonu artarken, total protein ve antioksidan aktivitenin düştüğü ve bu helmintlerin uygun bir antelmentikle tedavi edilmesinin, oluşan oksidatif hasarı hafifletmede etkili olduğu tespit edilmiştir
Akkuş İ (1995): Serbest Radikaller ve Fizyolojik Etkileri. 2.Baskı, Mimoza Yayınları, Konya.
Aksakal M, Özer E (1987): Akkaraman koyunlarında antelmentik ilaçlarla tedaviden önce ve sonra hematolojik değerler ve kan plazması vitamin E düzeyi üzerine araştırmalar. Ankara Üniv Vet Fak Derg, 34, 72-84.
Beutler E, Olga D, Barbara M R (1963): Improved method for the determination of blood glutatione. J Lab Clin Med, 61, 882-888.
Carr T P, Andersen C J, Rudel L L (1993): Enzymatic determination of triglyceride free cholesterol and total cholesterol in tissue lipid extracts. Clin Biochem, 26, 39-42.
Comhair S. A. A., Erzurum S. C (2005): The regulation and Role Of Extracellular Glutathione Peroxidase. Antioxidants & Redox Signal, 7, 72-79.
Dede S, Değer Y, Değer S, Aklan M (2000): Determination of the status of lipid peroxidation and antioksidants in sheep infected with certain endoparasites (Fasciola sp, Trichostrongylidae sp., Eimeria sp.). Turkiye Parazitol Derg, 24, 190-193.
Değer Y, Gül A, Bildik A, Dede S, Yur F, Değer S (1997): Parazitli köpeklerin bazı kan parametreleri ile plazma vitamin C düzeylerinde görülen değişiklikler. Turkiye Parazitol Derg, 21, 195-198.
Draper H H, Hardley M (1990): Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol, 186, 421-30.
El Gohari Y, Galal S H, Boulos L M, Moustafa S, Amin S M, El Talebany A M (1984): Trace elements in some parasitic diarrhea. J Egypt Soc Parasitol, 14, 179-187.
EMA/MRL/114/96 (1996): Committee for Veterinary Medicinal Products, Eprinomectin summary report (1). The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit. Available at: http://www.emea.europa. eu/pdfs/vet/mrls/011496en.pdf
Gargılı A, Tüzer E, Gülanber A, Toparlak M, Efil İ, Keleş V, Ulutaş M (1999): Efficacy of moxidectin against Toxocara canis in experimentally infected dogs. Turk J Vet Anim Sci, 23, 159–161
Gameel A A (1982): Fasciola hepatica: plasma ascorbic acid, plasma iron and iron-binding capacity in experimentally infected sheep. Z Parasitenkde, 68, 185-189.
Habluetzel A, Traldi G, Ruggieri S, Atili A R, Scuppa P, Marchetti R, Menghini G, Esposito F (2003): An estimation of Toxocara canis prevalence in dogs, environmental egg contamination and risk of human infection in the Marche region of Italy. Vet Parasitol, 113, 243-252.
Helwigh A B, Lind P, Nansen J (1999): Visceral larva migrans: migratory pattern of Toxocara canis in pigs. Int J Parasitol, 29, 559-565
Holley A E, Cheeseman K H (1993): Measuring free radical reactions in vivo. Br Med Bull, 49, 494-505.
Joreno D R (1990): Malondialdehyde and thiobarbituric acid reactivitiy as perostic indices of lipid peroxidation and peroxidative tissue injury. Free Rad Biol, 9, 515-540.
Katz D, Mazor D, Dvilansky A, Meyerstein N (1996): Effect of radiation on red cell membrane and intra cellular oxidative defense system. Free Red Res, 24, 199-204.
Kaymaz A A, Bakırel U, Gönül R, Tan H, Vuruşaner C (1999): Serum protein electrophoresis in dogs with intestinal parasites. Turk J Vet Anim Sci,23, 457-459.
Kellog E W, Fridovich I (1977): Liposome oxidation and erthrocyte lysis by enzymatically generated superoxide and hydrogen peroxide. J Biol Chem, 252, 6721-6725.
Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001): Method for the measurement of antioxidant activity in human fluids. J Clin Pathol, 54, 356-361.
Kozan E, Sevimli F K, Birdane F M, Adanır R (2008): Efficacy of eprinomectin against Toxocara canis in dogs. Parasitol Res, 102, 397–400.
Masella R, Di Benedetto R, Vari R, Filesi C, Giovannini C (2005): Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem, 16, 577-586
McTier T L, Siedek E M, Clemence R B, Wren J A, Bowman D D, Hellman K, Holbert M S, Murphy M G, Young D R, Cruthers L R, Smith D G, Shanks D J, Rowan T G, Jernigan A D (2000): Efficacy of selamectin against experimentally induced and naturally acquired ascarid (Toxocara canis and Toxascaris leonina) infections in dogs. Vet Parasitol, 91, 333-345.
Meister A, Anderson M E (1983): Glutathione. Ann Rev Biochem, 52, 711-760.
Pal B, Mitra S K, Sacmal N K, Biswas D (1995): Comparative efficacy of piperazine, vermectin and albendazole against experimentally induced Toxocara canis infection in pups. Indian Vet J, 72, 52–55
Robertson I D, Thompson R C (2002): Enteric parasitic zoonoses of domesticated dogs and cats. Microbes Infect, 4, 867-873.
Sardesai VM (1995): Role of antioxidants in health maintenance. Nutr Clin Pract, 10, 19.
Sarin K, Kumar A, Prakash A, Sharma A (1993): Oxidative stres and antioxidant defence mechanism in Plasmodium vivax malaria before and after chloquin treatment. Ind J Malariol, 30, 127-133.
Soulsby E J L (1982): Helminths, Arthropods and Protozoa of Domesticated Animals. 149-155, 7th Ed. Bailliere Tindal, London.
Thomas M J (1995): The role of free radicals and antioxidants:how do we know that they are working. Crit Rev Food Sci Nutr, 35, 21.
Urquart G M, Armour J, Duncan J L, Dunn A M, Jennings F W (1996): Veterinary Parasitology. 53-73, 2 nd Ed., Blackwell Scientific Publications, Oxford.
Vansteenhouse J L (1985): Free radicals: relation to tissue damage-a review. Vet Clin Pathol, 16, 29-35.
Yarsan E, Altınsaat Ç, Ayçiçek H, Şahindokuyucu F, Kalkan F (2003): Effects of albendazole treatment on haematological and biochemical parameters in healthy and Toxocara canis infected mice. Turk J Vet Anim Sci, 27, 1057-1063.
Yüksek N, Altuğ N, Kaya A, Ağaoğlu Z T, Göz Y, Özkan C (2006): Dose dependent effectiveness of topical selamectin on puppies with Ascaridiosis. YY Univ Vet Fak Derg, 17, 1-4
There are 35 citations in total.
Details
Primary Language
Turkish
Subjects
Veterinary Surgery
Other ID
JA84UA45PB
Journal Section
Research Article
Authors
Esma Kozan
Gülcan Avcı
Afyon Kocatepe Üniversitesi Veteriner Fakültesi
Biyokimya Anabilim Dalı
Feride Kırcalı Sevimli
Afyon Kocatepe Üniversitesi Veteriner Fakültesi Parazitoloji Anabilim Dalı
Fatih Mehmet Birdane
Afyon Kocatepe Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalı.
Mustafa Köse
Afyon Kocatepe Üniversitesi Veteriner Fakültesi Parazitoloji Anabilim Dalı
Kozan, E., Avcı, G., Kırcalı Sevimli, F., Birdane, F. M., et al. (2010). Askaridiozisli ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerinin incelenmesi. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 57(2), 93-97. https://doi.org/10.1501/Vetfak_0000002317
AMA
Kozan E, Avcı G, Kırcalı Sevimli F, Birdane FM, Köse M. Askaridiozisli ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerinin incelenmesi. Ankara Univ Vet Fak Derg. June 2010;57(2):93-97. doi:10.1501/Vetfak_0000002317
Chicago
Kozan, Esma, Gülcan Avcı, Feride Kırcalı Sevimli, Fatih Mehmet Birdane, and Mustafa Köse. “Askaridiozisli Ve Tedavi Edilmiş köpeklerde Antioksidan düzeylerinin Ve Bazı Biyokimyasal Parametrelerinin Incelenmesi”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 57, no. 2 (June 2010): 93-97. https://doi.org/10.1501/Vetfak_0000002317.
EndNote
Kozan E, Avcı G, Kırcalı Sevimli F, Birdane FM, Köse M (June 1, 2010) Askaridiozisli ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerinin incelenmesi. Ankara Üniversitesi Veteriner Fakültesi Dergisi 57 2 93–97.
IEEE
E. Kozan, G. Avcı, F. Kırcalı Sevimli, F. M. Birdane, and M. Köse, “Askaridiozisli ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerinin incelenmesi”, Ankara Univ Vet Fak Derg, vol. 57, no. 2, pp. 93–97, 2010, doi: 10.1501/Vetfak_0000002317.
ISNAD
Kozan, Esma et al. “Askaridiozisli Ve Tedavi Edilmiş köpeklerde Antioksidan düzeylerinin Ve Bazı Biyokimyasal Parametrelerinin Incelenmesi”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 57/2 (June 2010), 93-97. https://doi.org/10.1501/Vetfak_0000002317.
JAMA
Kozan E, Avcı G, Kırcalı Sevimli F, Birdane FM, Köse M. Askaridiozisli ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerinin incelenmesi. Ankara Univ Vet Fak Derg. 2010;57:93–97.
MLA
Kozan, Esma et al. “Askaridiozisli Ve Tedavi Edilmiş köpeklerde Antioksidan düzeylerinin Ve Bazı Biyokimyasal Parametrelerinin Incelenmesi”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 57, no. 2, 2010, pp. 93-97, doi:10.1501/Vetfak_0000002317.
Vancouver
Kozan E, Avcı G, Kırcalı Sevimli F, Birdane FM, Köse M. Askaridiozisli ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerinin incelenmesi. Ankara Univ Vet Fak Derg. 2010;57(2):93-7.